Interactions on record — worth a quick check against your medications. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

Liver Fit Ingredients & Drug Interactions

by Physician's Signature

Liver Fit label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Liver Fit against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Liver Fit is a dietary supplement by Physician's Signature with 3 active ingredients. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus acidophilus SD-5212. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Liver Fit by Physician's Signature

Ask about any prescription or over-the-counter medication and we check it for interactions with Liver Fit by Physician's Signature — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Liver Fit by Physician's Signature

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “Proprietary Live Culture Blend” is a proprietary blend — the label gives one combined amount (36 mg) without saying how much of each component you get.

Liver Fit contains three active probiotic ingredients: Lactobacillus fermentum SD-5847, Lactobacillus acidophilus SD-5212, and Lactobacillus casei casei SD-5842 — all live, beneficial bacteria meant to support digestive health. The product is made up in a capsule with inactive ingredients including microcrystalline cellulose, hydroxypropyl methylcellulose, magnesium stearate, and silicon dioxide, which are typical fillers and binders.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Lactobacillus Acidophilus's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: maintain liver regularity and integrity.
  • We looked for evidence on: Nonalcoholic fatty liver disease (NAFLD), Nonalcoholic steatohepatitis (NASH), Hepatic encephalopathy, Cholestasis, Liver function, Bile flow.
  • The closest evidence on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Cholestasis (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Nonalcoholic fatty liver disease (NAFLD), Hepatic encephalopathy, Nonalcoholic steatohepatitis (NASH).

The evidence we have is for Lactobacillus acidophilus SD-5212 alone. It's rated possibly effective for irritable bowel syndrome, Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis.

For atopic disease (allergic conditions), the data suggest it may be ineffective. There isn't enough reliable evidence to rate it for acute respiratory distress syndrome.

We don't have effectiveness data on file for the other two probiotic strains in this product.

The evidence, ingredient by ingredient Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus is generally well tolerated in healthy adults and children. However, since it contains live organisms, there's a theoretical risk — very rare — of infection in certain patients, including cases of bacteremia, sepsis, and other serious infections, usually when the bacteria move from their normal location in the gut.

Gastrointestinal side effects like bloating, flatulence, abdominal pain, and diarrhea can occur when you combine probiotics, but these are uncommon. A small number of trial participants using a similar probiotic blend reported rash and itching, though it's unclear whether L. acidophilus was the cause.

No pregnancy or breastfeeding safety data are on file for any ingredient in this product — talk with your doctor or pharmacist before use if you're pregnant or nursing.

Side effects, ingredient by ingredient Lactobacillus Acidophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lactobacillus Acidophilus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antibiotic drugs, separate them from this product — the antibiotics can reduce how well the probiotic works. Two of the three probiotic strains in Liver Fit haven't been checked for interactions with medications, so run your exact prescriptions through the search tool on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Liver Fit is a multi-strain probiotic that may help with digestive issues like IBS or antibiotic-associated diarrhea if the acidophilus strain is effective for you. If you take antibiotics, space them apart from this product.

Check your medications with the tool on this page before starting — one of the ingredients we can verify interacts with antibiotics. If you have a weakened immune system or other health concerns, ask your pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Liver Fit, straight from the product label.

Brand Physician's Signature
Barcode (UPC) 850002325027
Net contents 30 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Aug 22, 2024
DSLD ID 316962
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Liver Fit by Physician's Signature, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
850002325027
IngredientAmount% DV
Lactobacillus fermentum SD-58470 NP--
Lactobacillus acidophilus SD-52120 NP--
Proprietary Live Culture Blend36 mg--
Lactobacillus casei casei SD-58420 NP--

Other ingredients: Microcrystalline Cellulose, Hydroxypropyl Methylcellulose, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Probiotics intended to maintain liver regularity and integrity

Live culture blend 2 Billion CFU/capsule 2 Billion CFU (Colony Forming Units) per capsule at expiry.

Suggested/Recommended/Usage/Directions

Suggested use: take one capsule daily preferably with a meal.

Precautions

Caution: consult your physician prior to using this product if you are pregnant, nursing, or have any pre-existing medical conditions.

Keep out of the reach of children

Do not use if seal is broken

Brand IP Statement(s)

Rawleigh A friend of the family since 1889

Physician's Signature by W.T. Rawleigh

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Formulation

Not a significant source of total sugars or added sugars.

Suitable for Vegetarians

Storage

Store in a cool, dry place

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Liver Fit by Physician's Signature label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Liver Fit label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Liver Fit by Physician's Signature

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Live Culture Blend

36 mg per serving

Other (inactive) ingredients: Microcrystalline Cellulose, Hydroxypropyl Methylcellulose, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Liver Fit by Physician's Signature Drug Interactions

Want to check YOUR meds against Liver Fit?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Lactobacillus acidophilus SD-5212 182

Individual Drug Interactions

The ingredients in Liver Fit interact with 182 drugs. Click any drug to see the details.

1 of the 3 ingredients in Liver Fit interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus acidophilus SD-5212

Each ingredient & the kinds of drugs it affects

For each ingredient in Liver Fit with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus acidophilus SD-52121 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus SD-5212 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Liver Fit, from the product label.

Physician's Signature

See all Physician's Signature products
Name
Vitamins Direct (USA), Inc.
City
West Palm Beach
State
FL
ZipCode
33407
Phone Number
866-354-8384
Web Address
www.wtrawleigh.com
Pharmacist Counseling Corner

Liver Fit by Physician's Signature: Common Questions

Does Liver Fit by Physician's Signature interact with any medications?
Yes. Based on its ingredients, Liver Fit has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Liver Fit contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this with my antibiotic?
You can, but you'll want to space them out. Antibiotics can kill the live bacteria in Liver Fit, making the probiotic less effective. Ask your pharmacist how many hours apart to take them — usually two to four hours is enough, but it depends on the antibiotic.
Does this actually work for IBS?
The Lactobacillus acidophilus in it is rated possibly effective for IBS, meaning there's some evidence it may help, but it's not guaranteed. Results vary from person to person. Give it time and talk to your doctor if you're not seeing improvement after a few weeks.
What are the live cultures for?
Probiotics are beneficial bacteria meant to support your digestive health. This product has three different strains — each may play a slightly different role in your gut. They can help with things like IBS symptoms, antibiotic-related diarrhea, and other digestive concerns.
Could this cause side effects?
Most people tolerate it well. Bloating, flatulence, and mild abdominal discomfort can happen, especially if you're new to probiotics, but these are uncommon. A very small number of people have reported rash or itching in trials, though it's not clear the probiotic was the cause. Serious infections from the bacteria are extremely rare and mainly a concern for people with very weak immune systems.
Is it safe to use if I'm pregnant?
We don't have safety data on file for this product in pregnancy or breastfeeding. Talk with your doctor or pharmacist before you start — they can tell you whether it's right for your situation.
Are there any fillers in this?
Yes, the capsule contains microcrystalline cellulose, hydroxypropyl methylcellulose, magnesium stearate, and silicon dioxide — these are standard binder and filler materials used in most capsules.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Liver Fit label
Go deeper

The Full Monographs Behind Liver Fit’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph →
Sources

Sources & How We Checked

Liver Fit's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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