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Dietary supplement

Maitake Ingredients & Drug Interactions

by Pure Essence MyPure

Maitake label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Maitake against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Maitake is a dietary supplement by Pure Essence MyPure with 1 active ingredient. Its ingredients are commonly taken for immune support, blood sugar support in diabetes, high blood pressure.Based on those ingredients, 260 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic Maitake Mushroom extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Maitake by Pure Essence MyPure

Ask about any prescription or over-the-counter medication and we check it for interactions with Maitake by Pure Essence MyPure — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Maitake by Pure Essence MyPure

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: organic maitake mushroom extract. Maitake is a medicinal fungus that's been studied for immune support and metabolic effects.

The capsule itself uses HPMC as an inactive ingredient (a plant-based capsule material).

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Maitake Mushroom's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Supports immune response and healthy blood sugar.
  • We looked for evidence on: Diabetes, Hypertension, Hyperlipidemia, HIV/AIDS, Coronavirus disease 2019 (COVID-19), Chronic fatigue syndrome (CFS) — and 2 related terms.
  • The closest evidence on file: Maitake Mushroom is rated "Insufficient Reliable Evidence To Rate" for Chronic fatigue syndrome (CFS) (Natural Medicines).
  • Also on file: Maitake Mushroom is rated "Insufficient Reliable Evidence To Rate" for Diabetes, HIV/AIDS, Hyperlipidemia, Hypertension, and more.

The evidence for maitake mushroom is still limited. The product facts we hold don't show established proof that it works for hay fever, chemotherapy-related side effects like anemia or diarrhea, laryngeal cancer, or chronic fatigue syndrome — each has insufficient reliable evidence to rate.

If you're considering this for a specific health reason, your pharmacist can help you weigh what research does exist outside our data.

The evidence, ingredient by ingredient Maitake Mushroom

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Maitake mushroom is generally well tolerated when eaten as a food, though supplement safety hasn't been fully studied. The most common side effects reported in clinical trials were gastrointestinal — a small number of participants experienced diarrhea, nausea, or stomach pain, and one person developed a rash that cleared on its own.

Because there isn't enough safety data, concentrated supplements like this one should be avoided during pregnancy and while breastfeeding.

Side effects, ingredient by ingredient Maitake Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Maitake Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 260 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications against maitake before you start, especially if you take warfarin (a blood thinner), any blood pressure medication, or any diabetes drug. All three categories have documented moderate-severity interactions with this extract.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This single-ingredient maitake extract may appeal to those looking for immune or metabolic support, but it's not right for you if you take warfarin, blood pressure medications, or diabetes drugs without checking first. Talk with your pharmacist about your exact medications before starting — that's the safest way forward.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Maitake, straight from the product label.

Brand Pure Essence MyPure
Barcode (UPC) 659670916021
Net contents 60 Vegi-Cap(s)
Market status On market
Date entered into DSLD Jul 23, 2020
DSLD ID 231048
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Organic, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Maitake by Pure Essence MyPure, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
659670916021
IngredientAmount% DV
organic Maitake Mushroom extract500 mg--

Other ingredients: HPMC

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Non GMO

Vegan

Gluten Free

Organic ingredients

100% purity & potency guarantee

Supports immune response & healthy blood sugar levels

Does not contain: Wheat, milk, tree nuts, peanuts, soy, eggs, fish, shellfish

Every batch is lab tested for cleanliness, purity and potency. Maitake supports: Healthy immune function Healthy blood sugar levels Antioxidant systems

General Statements

90 day Money back guarantee

2 months supply

Please recycle

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

2018 All rights reserved

Formula

MyPure Maitake provides 500 mg of our premium, certified organic, whole maitake 1:1 mushroom extract to deliver pure, highly bioavailable maitake nutrition.

Suggested/Recommended/Usage/Directions

Suggested Use: One capsule daily.

Storage

Storage: Keep closed in a cool, dry place.

Precautions

Caution: Keep all supplements out of children's reach.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Made in USA

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Maitake by Pure Essence MyPure label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Maitake label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Maitake by Pure Essence MyPure

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Organic Maitake Mushroom extract

Interacts with
260 drugs
500 mg per serving Form: Beta-(1,3/1,6)-D-Glucans

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and bl...

Organic Maitake Mushroom extract monograph & interactions

Other (inactive) ingredients: HPMC. These complete the product’s ingredient list but are not active constituents.

Interaction report

Maitake by Pure Essence MyPure Drug Interactions

Want to check YOUR meds against Maitake?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
260Drugs
260 Moderate

Ingredients driving the most interactions

organic Maitake Mushroom extract 260

Individual Drug Interactions

The ingredients in Maitake interact with 260 drugs. Click any drug to see the details.

1 of the 1 ingredient in Maitake interact with drugs. Each result below shows which ingredient is responsible. organic Maitake Mushroom extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Maitake with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

organic Maitake Mushroom extract3 drug types · 260 drugs

Antidiabetes Drugs

Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that taking maitake mushroom polysaccharide (MMP) can lower blood glucose levels in patients with types 2 diabetes.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that maitake mushroom can lower blood pressure.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is limited evidence that maitake mushroom may increase the anticoagulant effects of warfarin.
In a case report, a patient previously stabilized on warfarin developed an elevated international normalized ratio (INR) of 5.1 after taking maitake mushroom (Grifron-Pro Maitake D-Fraction) 1 drop/kg daily in three divided doses for one week. The elevated INR resolved after holding warfarin for two days, then reducing the dose by 11%. It is thought that the beta-glucan constituent of maitake mushroom might cause warfarin dissociation from proteins, resulting in increased free warfarin levels and increased warfarin effects.

Likelihood Possible Evidence D
organic Maitake Mushroom extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Maitake, from the product label.

Pure Essence MyPure

See all Pure Essence MyPure products
Name
Pure Essence Laboratories, Inc.
Street Address
P.O. Box 95397
City
Las Vegas
State
NV
ZipCode
89193
Web Address
www.pureessencelabs.com
Pharmacist Counseling Corner

Maitake by Pure Essence MyPure: Common Questions

Does Maitake by Pure Essence MyPure interact with any medications?
Yes. Based on its ingredients, Maitake has a known interaction with 260 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Maitake contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
The safety data isn't there yet for concentrated maitake supplements during pregnancy or breastfeeding. Talk with your doctor or midwife — they know your situation and can advise you personally.
What are the side effects?
Maitake is generally easy on the stomach, but a small number of people in clinical trials reported gastrointestinal effects like diarrhea, nausea, or stomach pain. One person developed a rash that went away on its own.
Does this really work for (immune support/fatigue/cancer)?
The evidence we hold shows insufficient reliable data to say whether maitake works for the conditions we have on file — hay fever, chemotherapy side effects, or chronic fatigue. You'd want to talk with your doctor about what research exists and whether it's right for your situation.
What is maitake mushroom?
Maitake is a medicinal fungus that's been studied for its effects on immunity and blood sugar. This product is a concentrated extract of that mushroom.
How many active ingredients are in this?
Just one — organic maitake mushroom extract. The capsule itself is made from plant-based material (HPMC).

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Maitake is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Maitake label
Go deeper

The Full Monographs Behind Maitake’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Maitake Mushroom

Interacts with 260 drugs

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and blood pressure effects. The human evidence...

Read the full Maitake Mushroom monograph →
Sources

Sources & How We Checked

Maitake's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Maitake Mushroom 8 references
  1. Kabir Y, Kimura S. Dietary mushrooms reduce blood pressure in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol (Tokyo) 1989;35:91-4. PubMed
  2. Kabir Y, Yamaguchi M, Kimura S. Effect of shiitake (Lentinus edodes) and maitake (Grifola frondosa) mushrooms on blood pressure and plasma lipids of spontaneously hypertensive rats. J Nutr Sci Vitaminol (Tokyo) 1987;33:341-6. PubMed
  3. Konno S, Tortorelis DG, Fullerton SA, et al. A possible hypoglycaemic effect of maitake mushroom on Type 2 diabetic patients. Diabet Med 2001;18:1010. PubMed
  4. Chen JT, Tominaga K, Sato Y, et al. Maitake mushroom (Grifola frondosa) extract induces ovulation in patients with polycystic ovary syndrome: a possible monotherapy and a combination therapy after failure with first-line clomiphene citrate. J Altern Compl
  5. Hanselin MR, Vande Griend JP, Linnebur SA. INR elevation with maitake extract in combination with warfarin. Ann Pharmacother 2010;44:223-4. PubMed
  6. Talpur, N. A., Echard, B. W., Fan, A. Y., Jaffari, O., Bagchi, D., and Preuss, H. G. Antihypertensive and metabolic effects of whole Maitake mushroom powder and its fractions in two rat strains. Mol.Cell Biochem. 2002;237(1-2):129-136. PubMed
  7. Deng, G., Lin, H., Seidman, A., Fornier, M., D'Andrea, G., Wesa, K., Yeung, S., Cunningham-Rundles, S., Vickers, A. J., and Cassileth, B. A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: i
  8. Wesa KM, Cunningham-Rundles S, Klimek VM, et al. Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study. Cancer Immunol Immunother 2015;64(2):237-47. PubMed

See these in context on the Maitake Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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