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Dietary supplement

Maitake Ingredients & Drug Interactions

by Pure Essence MyPure

Maitake label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Maitake against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Maitake is a dietary supplement by Pure Essence MyPure with 1 active ingredient. Its ingredients are commonly taken for immune support, blood sugar support in diabetes, high blood pressure.Based on those ingredients, 260 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Maitake Mushroom Fruiting Body Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Maitake by Pure Essence MyPure

Ask about any prescription or over-the-counter medication and we check it for interactions with Maitake by Pure Essence MyPure — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Maitake by Pure Essence MyPure

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: maitake mushroom fruiting body extract. Maitake is a medicinal mushroom traditionally used in Asian medicine; the extract concentrates its compounds into supplement form.

The capsule also contains hydroxypropyl methylcellulose, an inactive ingredient that forms the capsule shell.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Maitake Mushroom's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Supports immune response.
  • We looked for evidence on: Allergic rhinitis (hay fever), Chemotherapy-induced anemia, Chemotherapy-induced diarrhea, Chemotherapy-induced leukopenia, Chemotherapy-induced nausea and vomiting (CINV), Chemotherapy-related fatigue — and 4 related terms.
  • The closest evidence on file: Maitake Mushroom is rated "Insufficient Reliable Evidence To Rate" for Allergic rhinitis (hay fever) (Natural Medicines).
  • Also on file: Maitake Mushroom is rated "Insufficient Reliable Evidence To Rate" for Chemotherapy-induced anemia, Chemotherapy-induced diarrhea, Chronic fatigue syndrome (CFS), Chemotherapy-related fatigue, and more.

The evidence we hold for maitake mushroom doesn't establish that it works for any of the conditions listed — allergic rhinitis (hay fever), chemotherapy-induced anemia, laryngeal cancer, chemotherapy-induced diarrhea, and chronic fatigue syndrome are all rated as having insufficient reliable evidence to rate. That means the research so far hasn't been strong or complete enough to draw firm conclusions.

If you're considering maitake for a specific health goal, talk with your pharmacist or doctor about what the current evidence actually supports.

The evidence, ingredient by ingredient Maitake Mushroom

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Maitake mushroom taken by mouth is generally well tolerated when used as food, though concentrated supplements haven't been fully studied for safety. The most common side effects in clinical trials were gastrointestinal — diarrhea and stomach pain — and they occurred in a small number of participants.

One person reported a rash and itching after two doses, which cleared on its own without treatment; nausea was also reported occasionally. There isn't enough safety data to know whether concentrated maitake supplements are safe during pregnancy or while breastfeeding, so the safety data advises against use in both.

Talk with your pharmacist or doctor if you're pregnant, planning to become pregnant, or nursing.

Side effects, ingredient by ingredient Maitake Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Maitake Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 260 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start this product, check your medications if you take warfarin (Coumadin) or any blood thinner, blood pressure medication, or diabetes drug. Maitake can intensify the effects of all three categories, potentially causing dangerously low blood pressure or blood sugar, or excessive blood thinning.

No other medication interactions are documented for the ingredient we checked.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Maitake mushroom extract is generally well tolerated by mouth, but it's not an ingredient to start without checking your medications first — especially if you take blood thinners, blood pressure drugs, or diabetes medications. The evidence for what it actually does isn't established yet.

Run your exact medications through the checker on this page, and talk with your pharmacist if you have questions.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Maitake, straight from the product label.

Brand Pure Essence MyPure
Barcode (UPC) 659670916014
Net contents 30 Vegi-Cap(s)
Market status On market
Date entered into DSLD Feb 23, 2025
DSLD ID 327519
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Organic, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Maitake by Pure Essence MyPure, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
659670916014
IngredientAmount% DV
Maitake Mushroom Fruiting Body Extract500 mg--

Other ingredients: Hydroxypropyl Methylcellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Non GMO Gluten Free

Vegan

Organic ingredients

Supports immune response

Every batch is lab tested for cleanliness, purity and potency. Maitake supports: Healthy Immune Function Antioxidant Systems

Every batch is lab tested for cleanliness, purity and potency. Maitake supports: Healthy Immune Function Antioxidant Systems

Does not contain: wheat, milk, tree nuts, peanuts, soy, eggs, fish, shellfish

Seals/Symbols

Vegan 100% Purity & Potency Guarantee 90 Day Money Back Guarantee

Made in USA

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Copyright 2018 All rights Reserved

Formula

MyPure Maitake provides 500 mg of our premium, certified organic, whole Maitake 1:1 mushroom extract to deliver pure, highly bioavailable maitake nutrition.

Suggested/Recommended/Usage/Directions

Suggested use: One capsule daily.

Storage

Storage: Keep closed in a cool, dry place.

Precautions

Caution: Keep all supplements out of children's reach.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

Please recycle

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Maitake by Pure Essence MyPure label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Maitake label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Maitake by Pure Essence MyPure

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Maitake Mushroom Fruiting Body Extract

Interacts with
260 drugs
500 mg per serving Form: Beta-(1,3)(1,6)-D-Glucans

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and bl...

Maitake Mushroom Fruiting Body Extract monograph & interactions

Other (inactive) ingredients: Hydroxypropyl Methylcellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Maitake by Pure Essence MyPure Drug Interactions

Want to check YOUR meds against Maitake?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
260Drugs
260 Moderate

Ingredients driving the most interactions

Maitake Mushroom Fruiting Body Extract 260

Individual Drug Interactions

The ingredients in Maitake interact with 260 drugs. Click any drug to see the details.

1 of the 1 ingredient in Maitake interact with drugs. Each result below shows which ingredient is responsible. Maitake Mushroom Fruiting Body Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Maitake with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Maitake Mushroom Fruiting Body Extract3 drug types · 260 drugs

Antidiabetes Drugs

Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that taking maitake mushroom polysaccharide (MMP) can lower blood glucose levels in patients with types 2 diabetes.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that maitake mushroom can lower blood pressure.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is limited evidence that maitake mushroom may increase the anticoagulant effects of warfarin.
In a case report, a patient previously stabilized on warfarin developed an elevated international normalized ratio (INR) of 5.1 after taking maitake mushroom (Grifron-Pro Maitake D-Fraction) 1 drop/kg daily in three divided doses for one week. The elevated INR resolved after holding warfarin for two days, then reducing the dose by 11%. It is thought that the beta-glucan constituent of maitake mushroom might cause warfarin dissociation from proteins, resulting in increased free warfarin levels and increased warfarin effects.

Likelihood Possible Evidence D
Maitake Mushroom Fruiting Body Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Maitake, from the product label.

Pure Essence MyPure

See all Pure Essence MyPure products
Name
Pure Essence Laboratories, Inc.
Street Address
P.O. Box 95397
City
Las Vegas
State
NV
ZipCode
89193
Web Address
PureEssenceLabs.com
Pharmacist Counseling Corner

Maitake by Pure Essence MyPure: Common Questions

Does Maitake by Pure Essence MyPure interact with any medications?
Yes. Based on its ingredients, Maitake has a known interaction with 260 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Maitake contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on blood pressure medication?
Not without checking first. Maitake lowers blood pressure, and combining it with blood pressure drugs could push your numbers too low. Talk with your pharmacist or doctor before starting — they can help you decide if it's safe and whether your doses need adjusting.
What does maitake mushroom actually do?
The evidence we have isn't strong enough yet to say it works for any of the conditions it's marketed for — hay fever, cancer-related side effects, or chronic fatigue are all listed as insufficiently studied. We know animal research shows it can lower blood pressure and some clinical research shows it can lower blood sugar, but that's different from proving it treats a disease.
Is it safe to take while pregnant?
There isn't enough safety data to know, so concentrated maitake supplements aren't recommended during pregnancy. If you're pregnant or planning to become pregnant, talk with your pharmacist or doctor before considering this product.
What side effects might I have?
Most common are stomach problems — diarrhea and stomach pain — though they were uncommon in the clinical trials we have data for. A few people reported nausea, and one person had a rash and itching that went away on its own. Stop and talk with your pharmacist if anything bothers you.
Can I take this with diabetes medication?
Not without checking first. Maitake can lower blood sugar, and combining it with diabetes drugs raises the risk of your blood sugar dropping too far. Your pharmacist or doctor needs to know before you start.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Maitake is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Maitake label
Go deeper

The Full Monographs Behind Maitake’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Maitake Mushroom

Interacts with 260 drugs

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and blood pressure effects. The human evidence...

Read the full Maitake Mushroom monograph →
Sources

Sources & How We Checked

Maitake's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Maitake Mushroom 8 references
  1. Kabir Y, Kimura S. Dietary mushrooms reduce blood pressure in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol (Tokyo) 1989;35:91-4. PubMed
  2. Kabir Y, Yamaguchi M, Kimura S. Effect of shiitake (Lentinus edodes) and maitake (Grifola frondosa) mushrooms on blood pressure and plasma lipids of spontaneously hypertensive rats. J Nutr Sci Vitaminol (Tokyo) 1987;33:341-6. PubMed
  3. Konno S, Tortorelis DG, Fullerton SA, et al. A possible hypoglycaemic effect of maitake mushroom on Type 2 diabetic patients. Diabet Med 2001;18:1010. PubMed
  4. Chen JT, Tominaga K, Sato Y, et al. Maitake mushroom (Grifola frondosa) extract induces ovulation in patients with polycystic ovary syndrome: a possible monotherapy and a combination therapy after failure with first-line clomiphene citrate. J Altern Compl
  5. Hanselin MR, Vande Griend JP, Linnebur SA. INR elevation with maitake extract in combination with warfarin. Ann Pharmacother 2010;44:223-4. PubMed
  6. Talpur, N. A., Echard, B. W., Fan, A. Y., Jaffari, O., Bagchi, D., and Preuss, H. G. Antihypertensive and metabolic effects of whole Maitake mushroom powder and its fractions in two rat strains. Mol.Cell Biochem. 2002;237(1-2):129-136. PubMed
  7. Deng, G., Lin, H., Seidman, A., Fornier, M., D'Andrea, G., Wesa, K., Yeung, S., Cunningham-Rundles, S., Vickers, A. J., and Cassileth, B. A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: i
  8. Wesa KM, Cunningham-Rundles S, Klimek VM, et al. Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study. Cancer Immunol Immunother 2015;64(2):237-47. PubMed

See these in context on the Maitake Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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