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Dietary supplement

Maitake SAP Ingredients & Drug Interactions

by NFH

Maitake SAP label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Maitake SAP against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Maitake SAP is a dietary supplement by NFH with 1 active ingredient. Its ingredients are commonly taken for immune support, blood sugar support in diabetes, high blood pressure.Based on those ingredients, 260 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Maitake. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Maitake SAP by NFH

Ask about any prescription or over-the-counter medication and we check it for interactions with Maitake SAP by NFH — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Maitake SAP by NFH

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Maitake SAP contains one active ingredient: maitake mushroom, a fungus used in traditional medicine and culinary cooking. The supplement form isolates bioactive compounds from the mushroom, particularly polysaccharides that are thought to support immune and metabolic function.

The capsule also contains inactive ingredients (magnesium stearate, hypromellose, and purified water) that help hold and deliver the active ingredient.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Maitake Mushroom's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: support immune system and antioxidant support.
  • We looked for evidence on: HIV/AIDS, Diabetes, Hypertension, Hyperlipidemia, Immune function, Infection prevention.
  • The closest evidence on file: Maitake Mushroom is rated "Insufficient Reliable Evidence To Rate" for Diabetes (Natural Medicines).
  • Also on file: Maitake Mushroom is rated "Insufficient Reliable Evidence To Rate" for HIV/AIDS, Hyperlipidemia, Hypertension.

The evidence for maitake mushroom is still emerging. We hold data showing insufficient reliable evidence to rate its use for allergic rhinitis (hay fever), chemotherapy-induced anemia, laryngeal cancer, and chemotherapy-induced diarrhea.

That means studies haven't yet established whether it works for these purposes — not that it doesn't work, but rather that more rigorous research is needed before we can say one way or the other.

The evidence, ingredient by ingredient Maitake Mushroom

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Maitake mushroom is generally well tolerated when you eat it as food. As a concentrated supplement, the safety data is incomplete, so use during pregnancy and breastfeeding isn't recommended — there simply isn't enough information to know whether it's safe for you or your baby.

The most common side effects in clinical trials were digestive: a small number of participants experienced diarrhea, nausea, or stomach pain. One person reported a rash and itching after two doses, though it cleared on its own without treatment.

Side effects, ingredient by ingredient Maitake Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Maitake Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 260 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start Maitake SAP, check with your doctor or pharmacist if you take blood thinners (like warfarin), blood pressure medications, or diabetes drugs. These are the medication types with documented interactions, and maitake can affect how they work.

Moderate-severity interactions have been reported with all three categories.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Maitake SAP may appeal to people exploring traditional mushroom supplements for general wellness, but it's not a first choice if you take a blood thinner, blood pressure medication, or diabetes drug — the interactions are real and potentially serious. Even if you're generally healthy, digestive upset is possible.

Talk with your doctor or pharmacist about whether this supplement makes sense for you, especially if you're on any medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Maitake SAP, straight from the product label.

Brand NFH
Barcode (UPC) 856711001979
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Jan 23, 2023
DSLD ID 273315
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Maitake SAP by NFH, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
856711001979
IngredientAmount% DV
Maitake400 mg--

Other ingredients: Magnesium Stearate, Hypromellose, Water, Purified

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Maitake SAP is used in herbal medicine to support the immune system. Maitake SAP provided antioxidant support.

Note: Polysaccharide and beta-glucan content may vary from lot to lot. Label shows tested value.

Grifola frondosa

Formulation

All ingredients listed for this product lot number have been tested by a third-party laboratory for identity, potency, and purity.

Contains no: Gluten, soy, wheat, corn, eggs, dairy, yeast, citrus, preservatives, artificial flavor or color, starch, or sugar.

This product is non-GMO and vegan friendly.

This product is non-GMO and vegan friendly.

Color, size and smell may vary from one lot to another.

Hot-water extract

Suggested/Recommended/Usage/Directions

Directions for use: Adults: Take 1 capsule daily or as directed by your healthcare practitioner. To avoid digestive upset, take with food / a meal.

Precautions

Cautions and warnings: Consult a healthcare practitioner prior to use if you suffer from an immune system disorder (e.g. crohn's disease, myasthenia gravis, multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, HIV / AIDS, etc.(, if you are taking immunosuppressants, or if you have diabetes.

Do not use if seal is broken.

Keep out of reach of children.

Storage

Note: Product is sensitive to humidity and heat; keep in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

General Statements

NPN 80047213

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Maitake SAP by NFH label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Maitake SAP label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Maitake SAP by NFH

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Maitake

Interacts with
260 drugs
400 mg per serving Form: Beta-Glucans, Polysaccharides

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and bl...

Maitake monograph & interactions

Other (inactive) ingredients: Magnesium Stearate, Hypromellose, Water, Purified. These complete the product’s ingredient list but are not active constituents.

Interaction report

Maitake SAP by NFH Drug Interactions

Want to check YOUR meds against Maitake SAP?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
260Drugs
260 Moderate

Ingredients driving the most interactions

Maitake 260

Individual Drug Interactions

The ingredients in Maitake SAP interact with 260 drugs. Click any drug to see the details.

1 of the 1 ingredient in Maitake SAP interact with drugs. Each result below shows which ingredient is responsible. Maitake

Each ingredient & the kinds of drugs it affects

For each ingredient in Maitake SAP with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Maitake3 drug types · 260 drugs

Antidiabetes Drugs

Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that taking maitake mushroom polysaccharide (MMP) can lower blood glucose levels in patients with types 2 diabetes.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that maitake mushroom can lower blood pressure.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is limited evidence that maitake mushroom may increase the anticoagulant effects of warfarin.
In a case report, a patient previously stabilized on warfarin developed an elevated international normalized ratio (INR) of 5.1 after taking maitake mushroom (Grifron-Pro Maitake D-Fraction) 1 drop/kg daily in three divided doses for one week. The elevated INR resolved after holding warfarin for two days, then reducing the dose by 11%. It is thought that the beta-glucan constituent of maitake mushroom might cause warfarin dissociation from proteins, resulting in increased free warfarin levels and increased warfarin effects.

Likelihood Possible Evidence D
Maitake full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Maitake SAP, from the product label.

NFH

See all NFH products
Name
NFH - Nutritional Fundamentals for Health, Inc.
Street Address
351 Joseph-Carrier
City
Vaudreuil
State
QC
ZipCode
J7V 5V5
Phone Number
1-866-510-3123
Web Address
nfh.ca
Pharmacist Counseling Corner

Maitake SAP by NFH: Common Questions

Does Maitake SAP by NFH interact with any medications?
Yes. Based on its ingredients, Maitake SAP has a known interaction with 260 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Maitake SAP contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Maitake SAP if I'm pregnant or breastfeeding?
The safety data for concentrated maitake supplements during pregnancy and breastfeeding isn't sufficient to say it's safe, so these aren't recommended. Talk with your doctor or pharmacist about whether it's right for your situation — they can weigh the risks and benefits for you personally.
What are the most common side effects?
Maitake is generally well tolerated, but digestive upset is the main concern: some people in clinical trials experienced diarrhea, nausea, or stomach pain. These effects were uncommon, and one person reported a rash that went away on its own.
Does maitake mushroom actually work for anything?
The research so far doesn't meet the bar to say it works for the conditions we've studied — allergic rhinitis, cancer-related anemia, diarrhea, and others. That doesn't mean it's ineffective; it means we need better evidence before we can make that claim.
Is this supplement the same as eating maitake mushrooms in food?
No. Maitake SAP is a concentrated extract, while the mushroom you'd eat as food is much less concentrated. As a food, maitake is generally well tolerated, but the safety of concentrated supplements hasn't been as thoroughly studied.
What's in the capsule besides the maitake mushroom?
The capsule contains inactive ingredients — magnesium stearate, hypromellose, and purified water — that help deliver the maitake. These are standard excipients found in many supplements.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Maitake SAP is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Maitake SAP label
Go deeper

The Full Monographs Behind Maitake SAP’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Maitake Mushroom

Interacts with 260 drugs

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and blood pressure effects. The human evidence...

Read the full Maitake Mushroom monograph →
Sources

Sources & How We Checked

Maitake SAP's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Maitake Mushroom 8 references
  1. Kabir Y, Kimura S. Dietary mushrooms reduce blood pressure in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol (Tokyo) 1989;35:91-4. PubMed
  2. Kabir Y, Yamaguchi M, Kimura S. Effect of shiitake (Lentinus edodes) and maitake (Grifola frondosa) mushrooms on blood pressure and plasma lipids of spontaneously hypertensive rats. J Nutr Sci Vitaminol (Tokyo) 1987;33:341-6. PubMed
  3. Konno S, Tortorelis DG, Fullerton SA, et al. A possible hypoglycaemic effect of maitake mushroom on Type 2 diabetic patients. Diabet Med 2001;18:1010. PubMed
  4. Chen JT, Tominaga K, Sato Y, et al. Maitake mushroom (Grifola frondosa) extract induces ovulation in patients with polycystic ovary syndrome: a possible monotherapy and a combination therapy after failure with first-line clomiphene citrate. J Altern Compl
  5. Hanselin MR, Vande Griend JP, Linnebur SA. INR elevation with maitake extract in combination with warfarin. Ann Pharmacother 2010;44:223-4. PubMed
  6. Talpur, N. A., Echard, B. W., Fan, A. Y., Jaffari, O., Bagchi, D., and Preuss, H. G. Antihypertensive and metabolic effects of whole Maitake mushroom powder and its fractions in two rat strains. Mol.Cell Biochem. 2002;237(1-2):129-136. PubMed
  7. Deng, G., Lin, H., Seidman, A., Fornier, M., D'Andrea, G., Wesa, K., Yeung, S., Cunningham-Rundles, S., Vickers, A. J., and Cassileth, B. A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: i
  8. Wesa KM, Cunningham-Rundles S, Klimek VM, et al. Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study. Cancer Immunol Immunother 2015;64(2):237-47. PubMed

See these in context on the Maitake Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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