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Dietary supplement

Malic Acid 600 mg Ingredients & Drug Interactions

by The Vitamin Shoppe

Malic Acid 600 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Malic Acid 600 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Malic Acid 600 mg is a dietary supplement by The Vitamin Shoppe with 1 active ingredient. Its ingredients are commonly taken for fibromyalgia symptoms, muscle pain and fatigue, dry mouth (used in some lozenges).Based on those ingredients, 172 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Malic Acid. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Malic Acid 600 mg by The Vitamin Shoppe

Ask about any prescription or over-the-counter medication and we check it for interactions with Malic Acid 600 mg by The Vitamin Shoppe — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Malic Acid 600 mg by The Vitamin Shoppe

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This supplement is straightforward — it contains one active ingredient, malic acid at 600 mg per capsule. Malic acid is an organic acid found naturally in fruits like apples, which is why it's sometimes called "apple acid." The capsule also contains two inactive ingredients (gelatin and magnesium stearate) that serve as the capsule shell and to keep the powder flowing so it doesn't clump.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Malic Acid's overall clinical evidence instead.

Moderate

Some clinical evidence supports Malic Acid for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Dry mouth — rated "Possibly Effective" (Natural Medicines).

The evidence for malic acid is mixed and limited. It's rated Possibly Effective for dry mouth — that's the only use where we have some supporting data.

For acne, GERD, fatigue, fibromyalgia, and psoriasis, the evidence isn't strong enough to rate either way. If you're thinking about this supplement for any of those other conditions, there isn't reliable evidence yet to show whether it works.

The evidence, ingredient by ingredient Malic Acid

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Malic acid taken by mouth appears to be well tolerated in the amounts you'd get from food. However, supplement doses of malic acid haven't been well studied in safety trials, so the long-term safety profile at these higher amounts isn't clear.

Caution is advised if you're taking a supplement dose — talk with your doctor before starting, especially if you have any ongoing health conditions. Side effects from oral malic acid are uncommon, though diarrhea and nausea have been reported in people taking a combination product with malic acid and magnesium together.

It's unclear whether malic acid or the magnesium was responsible, since magnesium itself is known to have a laxative effect at higher doses.

Side effects, ingredient by ingredient Malic Acid

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Malic Acid.
  • The most serious interaction on file is rated Moderate.
  • For scale: 172 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your blood pressure medications (antihypertensives) before starting this product. Malic acid may increase the risk of your blood pressure dropping too low when combined with these drugs.

Run your exact medications through the search tool on this page to see if any of yours are in the database.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

If you're interested in malic acid mainly for dry mouth and you don't take blood pressure medication, this is worth considering. If you're on any blood pressure drugs, clear it with your doctor or pharmacist first — they'll know whether your current regimen can tolerate the addition.

Since supplement-dose safety data is limited, it's wise to talk it over with your healthcare provider before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 26, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Malic Acid 600 mg, straight from the product label.

Brand The Vitamin Shoppe
Barcode (UPC) 766536019953
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Aug 26, 2014
DSLD ID 35992
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Malic Acid 600 mg by The Vitamin Shoppe, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
766536019953
IngredientAmount% DV
Malic Acid600 mg--

Other ingredients: Gelatin, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

DIRECTIONS: As a dietary supplement, take one (1) capsule up to twice daily, preferably with meals.

Precautions

WARNING: Consult your healthcare provider prior to use if you are pregnant, nursing, taking any medication or have any medical conditions.

KEEP OUT OF REACH OF CHILDREN.

TAMPER EVIDENT Do not use if outer seal is broken or missing.

Storage

STORE IN A COOL, DRY PLACE.

General Statements

Visit www.vitaminshoppe.com or call 1-800-223-1216 for more information and to reorder.

{QRC} learn more at vsquality.net

specialty

energy production

{capsule} actual size

General

Item No. VS-1995 1538149 EO 1

FDA Statement of Identity

dietary supplement

Formulation

gluten free dairy free soy free nut free

Does not contain: Yeast, Corn, Wheat, Gluten, Sugar, Salt, Soy, Starch, Dairy, Citrus, Fish, Preservatives, Artificial Colors or Flavors.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Malic Acid 600 mg by The Vitamin Shoppe label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Malic Acid 600 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Malic Acid 600 mg by The Vitamin Shoppe

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Malic Acid

Interacts with
172 drugs
600 mg per serving

Malic acid is a natural acid found in apples and other fruits, often combined with magnesium in supplements marketed for fibromyalgia and muscle pain....

Malic Acid monograph & interactions

Other (inactive) ingredients: Gelatin, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Malic Acid 600 mg by The Vitamin Shoppe Drug Interactions

Want to check YOUR meds against Malic Acid 600 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
172Drugs
172 Moderate

Ingredients driving the most interactions

Malic Acid 172

Individual Drug Interactions

The ingredients in Malic Acid 600 mg interact with 172 drugs. Click any drug to see the details.

1 of the 1 ingredient in Malic Acid 600 mg interact with drugs. Each result below shows which ingredient is responsible. Malic Acid

Each ingredient & the kinds of drugs it affects

For each ingredient in Malic Acid 600 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Malic Acid1 drug type · 172 drugs

Antihypertensive Drugs

Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research shows that malic acid isolated from tagetes roots can reduce mean arterial blood pressure.

Likelihood Possible Evidence D
Malic Acid full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Malic Acid 600 mg, from the product label.

The Vitamin Shoppe

See all The Vitamin Shoppe products
Name
Vitamin Shoppe, Inc.
City
Secaucus
State
NJ
ZipCode
07094
Phone Number
1-800-223-1216
Web Address
www.vitaminshoppe.com
Pharmacist Counseling Corner

Malic Acid 600 mg by The Vitamin Shoppe: Common Questions

Does Malic Acid 600 mg by The Vitamin Shoppe interact with any medications?
Yes. Based on its ingredients, Malic Acid 600 mg has a known interaction with 172 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Malic Acid 600 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is malic acid actually in food, and is this dose the same thing?
Yes, malic acid is naturally in apples and other fruits — that's why it's sometimes called apple acid. Food amounts appear safe, but this supplement delivers 600 mg per capsule, which is a much higher dose than you'd get from eating fruit. Supplement-level doses haven't been well studied, so they're a different animal safety-wise.
Can malic acid help with fibromyalgia or fatigue?
The evidence isn't strong enough to say either way. There isn't reliable data yet showing malic acid works for fibromyalgia, fatigue, or several other conditions people sometimes use it for. If you're considering it for one of those reasons, talk with your doctor about whether it makes sense for your situation.
Will this give me diarrhea?
Orally, malic acid by itself seems to be well tolerated and diarrhea is uncommon. However, some people taking a combination product with malic acid and magnesium together did report diarrhea and nausea — though it's unclear whether the malic acid or the magnesium caused it, since magnesium can have a laxative effect.
Is malic acid safe during pregnancy or while breastfeeding?
Malic acid is rated Likely Safe in pregnancy and lactation. That said, supplement-dose safety hasn't been thoroughly studied, so it's still smart to mention it to your doctor or midwife before you take it during pregnancy or while nursing.
What does malic acid actually do in the body?
It's an organic acid that's involved in energy production at the cellular level. It's found naturally in many fruits and vegetables. Beyond that, the evidence for specific health benefits is limited — we know it may help with dry mouth, but for most other uses, more research is needed.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Malic Acid 600 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Malic Acid 600 mg label
Go deeper

The Full Monographs Behind Malic Acid 600 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Malic Acid

Interacts with 172 drugs

Malic acid is a natural acid found in apples and other fruits, often combined with magnesium in supplements marketed for fibromyalgia and muscle pain. The evidence for its health benefits is...

Read the full Malic Acid monograph →
Sources

Sources & How We Checked

Malic Acid 600 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Malic Acid 7 references
  1. Russell IJ, Michalek JE, Flechas JD, Abraham GE. Treatment of fibromyalgia syndrome with Super Malic: a randomized, double blind, placebo controlled, crossover pilot study. J Rheumatol 1995;22:953-8.
  2. Fiume, Z. Final report on the safety assessment of malic acid and sodium malate. Int J Toxicol 2001;20 Suppl 1:47-55. PubMed
  3. Electronic Code of Federal Regulations. Title 21. Part 184 - Direct Food Substances Affirmed as Generally Recognized as Safe. Available at: http://www.ecfr.gov/cgi-bin/text-idx?c=ecfr&sid=786bafc6f6343634fbf79fcdca7061e1&rgn=div5&view=text&node=21:3.0.1.1
  4. Saleem R, Ahmad M, Naz A, et al. Hypotensive and toxicological study of citric acid and other constituents from Tagetes patula roots. Arch Pharm Res 2004;27(10):1037-42.
  5. Chiriac A, Brzezinski P. Topical malic acid in combination with citric acid: an option to treat recalcitrant warts. Dermatol Ther. 2015;28(6):336-8. PubMed
  6. CFR - Code of Federal Regulations Title 21 SUBCHAPTER B. 184.1069 Malic Acid. Food and Drug Administration Department Of Health And Human Services. Updated April 1, 2017. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=184.1069.
  7. Amended Safety Assessment of Malic Acid and Sodium Malate as Used in Cosmetics. Cosmetic Ingredient Review Expert Panel. Updated May 19, 2017. http://www.cir-safety.org/sites/default/files/malic%20acid.pdf. Accessed January 24, 2018.

See these in context on the Malic Acid monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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