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Dietary supplement

Marjoram Ingredients & Drug Interactions

by doTERRA

Marjoram label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Marjoram against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Marjoram is a dietary supplement by doTERRA with 1 active ingredient. Its ingredients are commonly taken for digestive upset, sleep and relaxation, respiratory complaints (cough, congestion).Based on those ingredients, 338 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Marjoram. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Marjoram by doTERRA

Ask about any prescription or over-the-counter medication and we check it for interactions with Marjoram by doTERRA — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Marjoram by doTERRA

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: marjoram, the herb itself in liquid form. There are no other active ingredients or inactive fillers listed.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Marjoram product and its label doesn't state a use — see Marjoram's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence on marjoram for the conditions studied isn't established in our data. We hold insufficient reliable evidence to rate it for asthma, Parkinson disease, polycystic ovary syndrome (PCOS), or dysmenorrhea.

That doesn't mean it doesn't work—just that the research we have isn't strong enough yet to say one way or the other.

The evidence, ingredient by ingredient Marjoram

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Marjoram is generally well tolerated as a food seasoning. Concentrated extracts and essential oils, though, have limited human safety data, so use caution with those forms.

In medicinal or concentrated amounts, avoid it during pregnancy—we don't have enough safety data to know it's okay. Food amounts in cooking are likely fine, but steer clear of medicinal doses until more is known.

Side effects are uncommon but possible. A few people using marjoram essential oil long-term have reported allergic skin reactions (contact dermatitis), and one case report described a woman whose skin condition (perioral dermatitis) flared after eating food seasoned with marjoram—it cleared once she stopped eating it and came back when she tried it again.

If you notice any rash or skin irritation, stop and talk to us.

Side effects, ingredient by ingredient Marjoram

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Marjoram.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 338 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications if you're on blood thinners or antiplatelet drugs (like aspirin or clopidogrel), anticholinergic medications, or cholinergic drugs before starting this product. These are the drug types with documented moderate-severity interactions with marjoram.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Marjoram as a liquid extract is an option if you're curious about its traditional uses, but the evidence on how well it works isn't solid yet. If you take blood thinners, anticholinergic drugs, or cholinergic medications, talk to your pharmacist before you start—the interactions are real.

During pregnancy, stick to food amounts only and skip medicinal doses.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 19, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Marjoram, straight from the product label.

Brand doTERRA
Net contents 5 mL; 0.16 fl. Oz.
Market status On market
Date entered into DSLD May 19, 2022
DSLD ID 267411
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Marjoram by doTERRA, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Drop(s)
Maximum serving Sizes:
1 Drop(s)
Servings per container
85
IngredientAmount% DV
Marjoram60 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

For aromatic and topical use.

Diffuse aromatically or, to apply topically, dilute with a carrier oil to minimize skin sensitivity.

Precautions

Caution: Possible skin sensitivity.

Keep out of reach of children.

If pregnant or under a doctor's care, consult your physician.

Avoid contact with eyes, inner ears, and sensitive areas.

For internal use dilute one drop in 4 fl. oz. of liquid.

Formula

Origanum majorana

FDA Statement of Identity

Essential Oil Supplement

Seals/Symbols

CPTG Certified Pure Tested Grade

General Statements

Peel back for more information.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Marjoram by doTERRA label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Marjoram label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Marjoram by doTERRA

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Drop(s) Dosage formLiquid Servings per container85 Amounts shown are per serving.

Marjoram

Interacts with
338 drugs
60 mg per serving

Marjoram is a Mediterranean kitchen herb related to oregano that is widely used in food and traditional medicine for digestive, sleep, and respiratory...

Marjoram monograph & interactions
Interaction report

Marjoram by doTERRA Drug Interactions

Want to check YOUR meds against Marjoram?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
338Drugs
338 Moderate

Ingredients driving the most interactions

Marjoram 338

Individual Drug Interactions

The ingredients in Marjoram interact with 338 drugs. Click any drug to see the details.

1 of the 1 ingredient in Marjoram interact with drugs. Each result below shows which ingredient is responsible. Marjoram

Each ingredient & the kinds of drugs it affects

For each ingredient in Marjoram with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Marjoram3 drug types · 338 drugs

Anticholinergic Drugs

In vitro research suggests that marjoram extract can inhibit acetylcholinesterase activity. Theoretically, using marjoram in medicinal amounts along with anticholinergic drugs might decrease the effectiveness of marjoram or the anticholinergic agent.
Some anticholinergic drugs include atropine, benztropine (Cogentin), biperiden (Akineton), procyclidine (Kemadrin), and trihexyphenidyl (Artane).

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

In vitro research suggests that marjoram extract inhibits platelet aggregation and adhesion. Theoretically, marjoram might increase the risk of bleeding when used in medicinal amounts along with antiplatelet or anticoagulant drugs.
Some anticoagulant or antiplatelet drugs include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.

Likelihood Possible Evidence D
Cholinergic Drugs

In vitro research suggests that marjoram extract can inhibit acetylcholinesterase activity. Theoretically, using marjoram in medicinal amounts along with cholinergic drugs might have additive effects and increase the risk of cholinergic side effects.
Cholinergic drugs include bethanechol (Urecholine), donepezil (Aricept), echothiophate (Phospholine Iodide), edrophonium (Enlon, Reversol, Tensilon), neostigmine (Prostigmin), physostigmine (Antilirium), pyridostigmine (Mestinon, Regonol), succinylcholine (Anectine, Quelicin), and tacrine (Cognex).

Likelihood Possible Evidence D
Marjoram full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Marjoram, from the product label.

doTERRA

See all doTERRA products
Name
doTERRA Intl, LLC
Street Address
389 South 1300 West
City
Pleasant Grove
State
UT
ZipCode
84062
Pharmacist Counseling Corner

Marjoram by doTERRA: Common Questions

Does Marjoram by doTERRA interact with any medications?
Yes. Based on its ingredients, Marjoram has a known interaction with 338 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Marjoram contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant?
Medicinal or concentrated amounts should be avoided in pregnancy—we don't have enough safety data yet. Food amounts are likely okay, but talk to your doctor or pharmacist for personalized advice, especially if you're considering this as a supplement rather than just cooking with it.
Can I use this if I'm breastfeeding?
We don't have safety data on file for marjoram and breastfeeding. Since we can't tell you either way, talk with your pharmacist or doctor to decide what's right for you and your baby.
Does this actually work for asthma, PCOS, or period pain?
The evidence isn't established yet. We hold insufficient reliable evidence to rate marjoram for asthma, Parkinson disease, PCOS, or dysmenorrhea—meaning the research so far isn't strong enough to say whether it helps.
What's the difference between food marjoram and this liquid extract?
Marjoram as a seasoning in your kitchen is fine and generally safe. This liquid extract is a concentrated form with limited human safety data, so it's a different animal. That's why we caution against medicinal or concentrated amounts without more research.
Can this cause skin problems?
It's uncommon, but a small number of people using marjoram essential oil long-term developed allergic skin reactions. One case report also described someone whose skin inflammation flared after eating marjoram-seasoned food. If you develop a rash or skin irritation, stop using it and let us know.
Is this safe to use with my medications?
That depends on what you take. Marjoram interacts with blood thinners, antiplatelet drugs, anticholinergic medications, and cholinergic drugs—all moderate concerns. Use the checker on this page with your exact medication list, and talk to your pharmacist before you start.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Marjoram label
Go deeper

The Full Monographs Behind Marjoram’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Marjoram

Interacts with 338 drugs

Marjoram is a Mediterranean kitchen herb related to oregano that is widely used in food and traditional medicine for digestive, sleep, and respiratory complaints. Most of its health claims r...

Read the full Marjoram monograph →
Sources

Sources & How We Checked

Marjoram's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Marjoram 11 references
  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  2. Orhan, I., Kartal, M., Kan, Y., and Sener, B. Activity of essential oils and individual components against acetyl- and butyrylcholinesterase. Z.Naturforsch.C. 2008;63(7-8):547-553.
  3. Farkas, J. Perioral dermatitis from marjoram, bay leaf and cinnamon. Contact Dermatitis 1981;7(2):121. PubMed
  4. Anderson C, Lis-Balchin M, Kirk-Smith M. Evaluation of massage with essential oils on childhood atopic eczema. Phytother Res 2000;14(6):452-6. PubMed
  5. Ou, M. C., Hsu, T. F., Lai, A. C., Lin, Y. T., and Lin, C. C. Pain relief assessment by aromatic essential oil massage on outpatients with primary dysmenorrhea: a randomized, double-blind clinical trial. J Obstet.Gynaecol.Res 2012;38(5):817-822. PubMed
  6. Chung, Y. K., Heo, H. J., Kim, E. K., Kim, H. K., Huh, T. L., Lim, Y., Kim, S. K., and Shin, D. H. Inhibitory effect of ursolic acid purified from Origanum majorana L on the acetylcholinesterase. Mol.Cells 4-30-2001;11(2):137-143. DOI
  7. Yazdanparast, R. and Shahriyary, L. Comparative effects of Artemisia dracunculus, Satureja hortensis and Origanum majorana on inhibition of blood platelet adhesion, aggregation and secretion. Vascul.Pharmacol 2008;48(1):32-37. PubMed
  8. Mohamed MS, Saad HH, and Abd El Khalek MG. Daily consumption of marjoram oil improve the health status of patients with asthma. Pakistan Journal of Nutrition. 2008;7(2):312-316. DOI
  9. Bina F, Rahimi R. Sweet marjoram: a review of ethnopharmacology, phytochemistry, and biological activities. J Evid Based Complementary Altern Med 2017;22(1):175-85.
  10. Haj-Husein I, Tukan S, Alkazaleh F. The effect of marjoram (Origanum majorana) tea on the hormonal profile of women with polycystic ovary syndrome: a randomized controlled pilot study. J Hum Nutr Diet 2016;29(1):105-11.
  11. Chahra C, Anis H, Bissene D, et al. The effect of Origanum majorana tea on motor and non-motor symptoms in patients with idiopathic Parkinson's disease: A randomized controlled pilot study. Parkinsonism Relat Disord. 2021 Oct;91:23-7. PubMed

See these in context on the Marjoram monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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