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Dietary supplement

Maximum Beta Glucan 400 mg Ingredients & Drug Interactions

by Supplement Spot

Capsule Category: Fiber And Other Nutrients
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Maximum Beta Glucan 400 mg is a dietary supplement by Supplement Spot with 1 active ingredient. Its ingredients are commonly taken for high cholesterol, heart health, immune support.Based on those ingredients, 293 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Beta Glucan 1,3/1,6. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Maximum Beta Glucan 400 mg by Supplement Spot

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Maximum Beta Glucan 400 mg contains a single active ingredient: beta-glucan 1,3/1,6 at 400 mg per capsule. This is a type of soluble fiber derived from yeast and fungal cell walls that's been studied for heart and cholesterol health.

The capsule also contains inactive ingredients — gelatin, rice bran powder, and magnesium stearate — which serve as the capsule shell and flow agents.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Beta-glucans's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Supports healthy immune function.
  • We looked for evidence on: Critical illness (trauma), Exercise-induced respiratory infections, Lower respiratory tract infections, Otitis media, Upper respiratory tract infection (URTI), Wound healing — and 2 related terms.
  • The closest evidence on file: Beta-glucans is rated "Insufficient Reliable Evidence To Rate" for Upper respiratory tract infection (URTI) (Natural Medicines).
  • Also on file: Beta-glucans is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced respiratory infections, Lower respiratory tract infections, Otitis media, Wound healing, and more.

Beta-glucan 1,3/1,6 is rated Likely Effective for two conditions: improving cholesterol levels (dyslipidemia) and supporting heart health in coronary heart disease. These ratings reflect solid clinical research showing that beta-glucans can help lower cholesterol and improve certain markers of cardiovascular function.

The evidence, ingredient by ingredient Beta-glucans

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Beta-glucans from food sources are generally well tolerated by most people. However, concentrated supplements like this one lack robust long-term safety data, so use caution and start conservatively if you're new to them.

Topically applied beta-glucans have caused mild skin reactions in some people, though those were self-limiting. One trial in children taking very high doses (120 mg per kilogram of body weight daily — far above this supplement's 400 mg) noted a single case of temporary liver enzyme elevation.

There's little research on this supplement dose during breastfeeding, so talk with your doctor or pharmacist if you're nursing before starting.

Side effects, ingredient by ingredient Beta-glucans

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Beta-glucans.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs.
  • For scale: 293 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist if you take blood pressure medications (antihypertensives) or immunosuppressants before starting this supplement. Both drug categories have documented Moderate-severity interactions with beta-glucans.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This supplement is worth considering if you're looking to support cholesterol and heart health and don't take blood pressure or immunosuppressant medications. If you do take either of those drug types, check with us or your pharmacist first — the interaction risk is real.

Start with your doctor or pharmacist to make sure it fits your personal health picture.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 24, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Maximum Beta Glucan 400 mg, straight from the product label.

Brand Supplement Spot
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Apr 24, 2025
DSLD ID 328358
Product type Fiber And Other Nutrients
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Maximum Beta Glucan 400 mg by Supplement Spot, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
IngredientAmount% DV
Beta Glucan 1,3/1,6400 mg--

Other ingredients: Gelatin, Rice Bran, Powder, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Take 2 capsules daily with food and water. May take up to 4 capsules daily, as needed. Take consistently each day for best results.

Precautions

Note: If you are pregnant or lactating, consult a healthcare professional before using this product.

Keep out of reach of children.

Do not use this product if the safety seal on the bottle is broken.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Supports healthy immune function

Formula

Maximum Beta Glucan 400 mg per serving

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Formulated in USA

See for yourself

Maximum Beta Glucan 400 mg by Supplement Spot label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Maximum Beta Glucan 400 mg by Supplement Spot

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Beta Glucan 1,3/1,6

Interacts with
293 drugs
400 mg per serving Form: Saccharomyces cerevisiae

Beta-glucans are natural fibers found in oats, barley, mushrooms, and yeast. The strongest evidence supports the oat and barley types for modestly low...

Beta Glucan 1,3/1,6 monograph & interactions

Other (inactive) ingredients: Gelatin, Rice Bran, Powder, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Maximum Beta Glucan 400 mg by Supplement Spot Drug Interactions

Want to check YOUR meds against Maximum Beta Glucan 400 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
293Drugs
293 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Maximum Beta Glucan 400 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Beta Glucan 1,3/1,62 drug types · 293 drugs

Antihypertensive Drugs

Theoretically, taking beta-glucans with antihypertensive drugs might increase the risk of hypotension.
Clinical research shows that taking beta-glucans may reduce systolic and diastolic blood pressure in some hypertensive individuals.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, beta-glucans might interfere with immunosuppressive therapy.
Some clinical research shows that beta-glucans have immunostimulant effects.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Maximum Beta Glucan 400 mg, from the product label.

Supplement Spot

See all Supplement Spot products
Name
Supplement Spot, LLC
Street Address
1828 Touby Pike
City
Kokomo
State
IN
ZipCode
46901
Phone Number
866-285-1998
Web Address
supplementspot.com
Pharmacist Counseling Corner

Maximum Beta Glucan 400 mg by Supplement Spot: Common Questions

Does Maximum Beta Glucan 400 mg by Supplement Spot interact with any medications?
Yes. Based on its ingredients, Maximum Beta Glucan 400 mg has a known interaction with 293 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Maximum Beta Glucan 400 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does beta-glucan actually help with cholesterol and heart health?
Yes — beta-glucan 1,3/1,6 is rated Likely Effective for both. Clinical research shows it can help improve cholesterol levels and support heart health in coronary heart disease.
What are the most common side effects?
Oral beta-glucans are generally well tolerated. The adverse effects on file relate mainly to topical (skin) use — contact dermatitis and mild skin reactions — which were uncommon and self-limited. One high-dose trial in children reported a single case of temporary liver enzyme changes, but that dose was much higher than this product.
Is it safe to take while breastfeeding?
There's not enough research on this supplement dose during breastfeeding to say either way. Talk with your doctor or pharmacist for personalized advice.
What exactly is beta-glucan 1,3/1,6?
It's a type of soluble fiber found in yeast and fungal cell walls. It's been studied for its effects on cholesterol and heart health.
Why do I need to check my blood pressure medicines before taking this?
Beta-glucans may lower blood pressure on their own. If you take a blood pressure drug, combining them could drop your pressure too low, causing dizziness or weakness.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Maximum Beta Glucan 400 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Maximum Beta Glucan 400 mg label
Go deeper

The Full Monographs Behind Maximum Beta Glucan 400 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

Maximum Beta Glucan 400 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Beta-glucans 11 references
  1. Katz, D. L., Nawaz, H., Boukhalil, J., Giannamore, V., Chan, W., Ahmadi, R., and Sarrel, P. M. Acute effects of oats and vitamin E on endothelial responses to ingested fat. Am.J.Prev.Med. 2001;20(2):124-129. PubMed
  2. Keenan, J. M., Pins, J. J., Frazel, C., Moran, A., and Turnquist, L. Oat ingestion reduces systolic and diastolic blood pressure in patients with mild or borderline hypertension: a pilot trial. J.Fam.Pract. 2002;51(4):369.
  3. Maki, K. C., Galant, R., Samuel, P., Tesser, J., Witchger, M. S., Ribaya-Mercado, J. D., Blumberg, J. B., and Geohas, J. Effects of consuming foods containing oat beta-glucan on blood pressure, carbohydrate metabolism and biomarkers of oxidative stress i
  4. Bergendiova, K., Tibenska, E., and Majtan, J. Pleuran (beta-glucan from Pleurotus ostreatus) supplementation, cellular immune response and respiratory tract infections in athletes. Eur.J.Appl.Physiol 2011;111(9):2033-2040.
  5. Talbott S, Talbott J. Effect of beta 1,3/1,6 glucan on respiratory tract infection symptoms and mood state in marathon athletes. J Sports Sci Med 2009;8(4):509-515.
  6. Feldman S, Schwartz HI Kalman DS Mayers A Kohrman HM Clemens R Krieger DR. Randomized phase II clinical trials of Wellmune WGP® for immune support during cold and flu season. The Journal of Applied Research 2009;9(1-2):30-42.
  7. McFarlin BK, Carpenter KC, Davidson T, McFarlin MA. Baker's yeast beta glucan supplementation increases salivary IgA and decreases cold/flu symptomatic days after intense exercise. J Diet Suppl. 2013;10(3):171-83. PubMed
  8. Jesenak M, Urbancek S, Majtan J, Banovcin P, Hercogova J. ß-Glucan-based cream (containing pleuran isolated from pleurotus ostreatus) in supportive treatment of mild-to-moderate atopic dermatitis. J Dermatolog Treat 2016;27(4):351-4.
  9. Mah E, Kaden VN, Kelley KM, Liska DJ. Beverage containing dispersible yeast ß-glucan decreases cold/flu symptomatic days after intense exercise: a randomized controlled trial. J Diet Suppl 2020;17(2):200-10. PubMed
  10. Zhong K, Liu Z, Lu Y, Xu X. Effects of yeast ß-glucans for the prevention and treatment of upper respiratory tract infection in healthy subjects: a systematic review and meta-analysis. Eur J Nutr. 2021. PubMed
  11. Cardenas FI, Mauguen A, Cheung IY, et al. Phase I trial of oral yeast-derived ß-glucan to enhance anti-GD2 immunotherapy of resistant high-risk neuroblastoma. Cancers (Basel) 2021;13(24):6265. PubMed

See these in context on the Beta-glucans monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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