Graviola 650 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Graviola 650 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Graviola 650 mg is a dietary supplement by Supplement Spot with 1 active ingredient. Its ingredients are commonly taken for cancer support (unproven), infections, inflammation.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Graviola powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Graviola 650 mg by Supplement Spot
Ask about any prescription or over-the-counter medication and we check it for interactions with Graviola 650 mg by Supplement Spot — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
Ask the Pharmacist
A licensed pharmacist will answer your question by email — free, usually within 24 hours.
Got it — thank you!
A licensed pharmacist will answer within 24 hours. Keep an eye on your email (worth checking spam, just in case).
HelloPharmacist Scorecard of Graviola 650 mg by Supplement Spot
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This supplement contains one active ingredient: graviola powder at 650 mg per capsule. Graviola is a fruit extract traditionally used in herbal medicine.
The capsule itself is made from gelatin, vegetable magnesium stearate, and rice flour, which are inactive ingredients that help hold the powder together and form the capsule.
Does it work?
Couldn't assess
The evidence for graviola's effectiveness isn't established in the data we hold. The conditions studied—human papillomavirus (HPV) infection, headache, use as an insect repellent, and male infertility—all lack sufficient reliable evidence to rate whether graviola actually works for them.
If you're considering this supplement for a specific health concern, it's worth discussing with your doctor what evidence exists and whether other options might be better supported.
How safe is it?
Well-documented data
Regular use of graviola raises some safety concerns. The most common side effects from oral use are stomach pain and nausea, though these are generally mild.
More rarely, long-term use has been linked to movement disorders and nerve damage (myeloneuropathy) that can resemble Parkinson disease symptoms. Lab studies also suggest possible nerve toxicity with extended use.
Additionally, even low amounts of graviola fruit or tea may worsen motor and cognitive symptoms in people who already have Parkinson disease. Graviola is not recommended during pregnancy or while breastfeeding because there isn't enough safety data.
If you're pregnant, planning to become pregnant, or breastfeeding, talk with your doctor or pharmacist before taking this product.
Meds to double-check
Moderate interaction found
Before taking Graviola 650 mg, double-check with your doctor or pharmacist if you take carbamazepine (Tegretol) for seizure control. Graviola may reduce how well this medication works.
For any other medications, use the search tool on this page to confirm there are no interactions we haven't documented.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Graviola is generally well tolerated at recommended doses, but the long-term safety data are limited and rare serious side effects have been reported. If you take carbamazepine (an anti-seizure medication), you'll need to check with your doctor or pharmacist before starting this product.
Pregnant and breastfeeding individuals should avoid it. For everyone else, discuss with your healthcare provider whether graviola makes sense for your situation.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 19, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Graviola 650 mg, straight from the product label.
| Brand | Supplement Spot |
|---|---|
| Net contents | 100 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | May 19, 2022 |
| DSLD ID | 264565 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Women (not pregnant or lactating) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Graviola 650 mg by Supplement Spot, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Graviola powder | 650 mg | -- |
Other ingredients: Gelatin, Vegetable Magnesium Stearate, Rice Flour
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Storage
Suggested use: 1 capsule taken 1 to 2 times daily preferably with meals or as directed by a healthcare professional.
Store in a cool, dry place.
Precautions
Caution: Do not exceed recommended dose. If you have questions about the advisability of taking this product, consult your physician prior to use.
This product is not intended for pregnant or nursing mothers or children under the age of 18, or persons with a known medical condition including any cardiovascular disorder, hypotension (low blood pressure), and Parkinson's disease.
This product is not intended for pregnant or nursing mothers or children under the age of 18, or persons with a known medical condition including any cardiovascular disorder, hypotension (low blood pressure), and Parkinson's disease.
This product is manufactured and packaged in a facility which may also process milk, soy, wheat, egg, peanuts, tree nuts, fish and crustacean shellfish.
Keep out of the reach of children.
Do not use if safety seal is damaged or missing.
Formulation
Supports healthy immune function
FDA Statement of Identity
Dietary Supplement
Seals/Symbols
Formulated in USA Sourced from a GMP Certified Facility Made in USA
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Formula
Graviola 650 mg per serving
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Graviola 650 mg by Supplement Spot label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Graviola 650 mg by Supplement Spot
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.
Graviola powder
Interacts with1 drug
Graviola (soursop) is a tropical fruit tree whose leaves, fruit, and bark are used in traditional medicine, especially in parts of South America, Afri...
Graviola powder monograph & interactionsOther (inactive) ingredients: Gelatin, Vegetable Magnesium Stearate, Rice Flour. These complete the product’s ingredient list but are not active constituents.
Graviola 650 mg by Supplement Spot Drug Interactions
HelloPharmacist Interaction Report
Graviola 650 mg by Supplement Spot interacts with one medication: carbamazepine (Tegretol), an anti-seizure drug.
The interaction is Moderate in severity. When graviola and carbamazepine are taken together, graviola may reduce how much carbamazepine your body absorbs and uses.
A rat study found that graviola extract lowered carbamazepine levels by up to 46%, which could make the seizure medication less effective at controlling seizures.
Read the full breakdown — every affected drug type, severity by severity
If you take carbamazepine, check with your doctor or pharmacist before starting graviola. You may need your carbamazepine dose adjusted or more frequent monitoring to make sure it's still working as intended.
Additionally, use the medication interaction search tool on this page to check your exact medications against graviola's ingredient.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Graviola 650 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Graviola 650 mg interact with 1 drug. Click any drug to see the details.
1 of the 1 ingredient in Graviola 650 mg interact with drugs. Each result below shows which ingredient is responsible. Graviola powder
CarbamazepineCarbatrol, Carnexiv, Equetro, Tegretol, Tegretol XR
How Carbamazepine interacts with Graviola 650 mg — through 1 ingredient. Tap an ingredient for the detail:
Graviola PowderCarbamazepine (tegretol) Moderate
Interaction Summary
Theoretically, graviola might decrease concentrations of carbamazepine when used concomitantly.
Read the full Graviola Powder + Carbamazepine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Graviola 650 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Graviola powder
Carbamazepine (Tegretol)
Theoretically, graviola might decrease concentrations of carbamazepine when used concomitantly.
A study in rats shows that graviola extract reduces the area under the curve of carbamazepine by 46% and maximum concentration by 35% when compared with carbamazepine alone.
Brand information
Manufacturer and brand details for Graviola 650 mg, from the product label.
Supplement Spot
See all Supplement Spot products- Name
- Supplement Spot, LLC
- Street Address
- 1828 Touby Pike
- City
- Kokomo
- State
- IN
- ZipCode
- 46901
- Phone Number
- 866-285-1998
- Web Address
- supplementspot.com
Graviola 650 mg by Supplement Spot: Common Questions
Does Graviola 650 mg by Supplement Spot interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take graviola if I'm pregnant or breastfeeding?
What are the most common side effects?
I have Parkinson disease—is graviola safe for me?
Does graviola actually work for HPV, headaches, or other conditions?
What's in the capsule besides the graviola powder?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Graviola 650 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Graviola 650 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Graviola 650 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 4 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Graviola 4 references
- Caparros-Lefebvre D, Elbaz A. Possible relation of atypical parkinsonism in the French West Indies with consumption of tropical plants: a case-control study. Caribbean Parkinsonism Study Group. Lancet 1999;354:281-6. PubMed
- Gavamukulya Y, Wamunyokoli F, El-Shemy HA. Annona muricata: Is the natural therapy to most disease conditions including cancer growing in our backyard? A systematic review of its research history and future prospects. Asian Pac J Trop Med. 2017;10(9):835- PubMed
- Abu Soukhon AA, Abu-Qatouseh L, Mansoor K, et al. Cytotoxicity Activity of Graviola Fruit Extract with Carbamazepine and Valproic Acid Show Antagonistic and Indifferent Effects. Asian Pac J Cancer Prev 2023;24(6):1869-1875. PubMed
- Cleret de Langavant L, Roze E, Petit A, et al. Annonaceae Consumption Worsens Disease Severity and Cognitive Deficits in Degenerative Parkinsonism. Mov Disord 2022;37(12):2355-2366. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC