Interactions on record — worth a quick check against your medications. Based on 4 of 5 ingredients. Check your meds →
Dietary supplement

Maxon Pure Strength Ingredients & Drug Interactions

by iSatori

Maxon Pure Strength label
See full label image
Other (e.g. Tea Bag) Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Maxon Pure Strength against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Maxon Pure Strength is a dietary supplement by iSatori with 5 active ingredients. Its ingredients are commonly taken for heartburn and indigestion (antacid), athletic performance (exercise buffer), urine alkalinization.Based on those ingredients, 542 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Fenugreek, Agmatine Sulfate, Sodium Bicarbonate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Maxon Pure Strength by iSatori

Ask about any prescription or over-the-counter medication and we check it for interactions with Maxon Pure Strength by iSatori — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Maxon Pure Strength by iSatori

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 4 of its 5 active ingredients.

Maxon Pure Strength contains 5 active ingredients. Sodium bicarbonate, a common alkaline salt used to neutralize acid, sits alongside creatine (HPLC Verified Creatine HCl), a compound that supports muscle energy production.

The formula also includes elevATP, fenugreek seed extract — traditionally used in cooking and shown to have effects on blood sugar and sexual function — and agmatine sulfate, a compound derived from the amino acid arginine. The remaining ingredients are inactive fillers and binders: microcrystalline cellulose, corn starch, croscarmellose sodium, crospovidone, stearic acid, hydroxypropylcellulose, vegetable magnesium stearate, silicon dioxide, and a red film coating.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: strength and muscle performance.
  • We looked for evidence on: Athletic performance, Cognitive function, Muscle strength, Physical performance, Muscle breakdown, Exercise endurance — and 3 related terms.
  • The strongest evidence on file: Creatine is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Creatine is rated "Possibly Effective" for Muscle strength.
  • Also on file: Sodium Bicarbonate is rated "Possibly Effective" for Athletic performance.

Sodium bicarbonate is possibly effective for athletic performance and possibly ineffective for cardiac arrest and ischemia-reperfusion injury. Creatine is possibly effective for muscle strength and athletic performance, and possibly ineffective for Huntington disease and weak bones (osteopenia).

Fenugreek is possibly effective for sexual function and diabetes. Agmatine's effectiveness is insufficiently studied — we hold no reliable evidence rating it for any condition.

The evidence for elevATP is not on file.

The evidence, ingredient by ingredient Sodium Bicarbonate Creatine Fenugreek Agmatine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Sodium bicarbonate is generally well tolerated in small, occasional amounts, but it's high in sodium and risky if overused or used long-term; occasional antacid use may be acceptable if you check with your doctor first. Common mild side effects are abdominal pain, bloating, diarrhea, flatulence, nausea, and vomiting.

Serious effects are rare but include metabolic alkalosis with dizziness, headache, loss of consciousness, and in rare cases seizures or coma — these happen with excessive use (tablespoons daily or a box of baking soda weekly). Creatine is generally well tolerated in healthy adults; those with kidney issues should be careful.

Common side effects include dehydration, diarrhea, muscle cramps, and water retention. Pregnancy and breastfeeding safety have not been established, so avoid use.

Fenugreek is generally well tolerated in food amounts, but supplement doses may cause abdominal pain, bloating, diarrhea, nausea, and flatulence. Severe allergic reactions (angioedema, bronchospasm, shock) are rare.

Supplement amounts may affect the uterus, so avoid medicinal use during pregnancy; it's often used to boost milk supply but discuss with your provider first. Agmatine appears well tolerated short-term, but long-term human safety isn't well studied.

Common side effects are diarrhea, indigestion, and nausea. Avoid during pregnancy and breastfeeding — there isn't enough safety data.

Side effects, ingredient by ingredient Sodium Bicarbonate Creatine Fenugreek Agmatine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 4 matched ingredients can interact with medications — Fenugreek, Sodium Bicarbonate, Agmatine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 542 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you're on blood thinners or antiplatelet drugs (fenugreek may add to their effect), blood pressure medications (sodium bicarbonate and agmatine may lower it further), diabetes drugs (fenugreek and agmatine may increase the risk of low blood sugar), corticosteroids, water pills, heart medications, caffeine compounds, aspirin, bowel-moving drugs, pseudoephedrine, theophylline, warfarin, clopidogrel, metoprolol, phenytoin, or sildenafil. No interactions are documented for elevATP, as we hold no data on it.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Maxon Pure Strength is an athletic-performance supplement backed by some evidence for creatine and sodium bicarbonate, with less-established benefits for its other ingredients. If you take any blood pressure medications, blood thinners, diabetes drugs, heart medications, corticosteroids, water pills, or seizure drugs, this product warrants a close look at your exact prescriptions before you start.

Talk it over with your doctor or pharmacist — they know your full medication list and can spot conflicts we might miss.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 22, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Maxon Pure Strength, straight from the product label.

Brand iSatori
Barcode (UPC) 883488003967
Net contents 84 Rapid Release Caplet(s)
Market status On market
Date entered into DSLD Apr 22, 2016
DSLD ID 58314
Product type Other Combinations
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Maxon Pure Strength by iSatori, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4 Rapid Release Caplet(s)
Maximum serving Sizes:
4 Rapid Release Caplet(s)
Servings per container
21
UPC/BARCODE
883488003967
IngredientAmount% DV
Sodium Bicarbonate150 mg--
elevATP150 mg--
HPLC Verified Creatine HCl1500 mg--
Fenugreek0 mg--
Agmatine Sulfate500 mg--

Other ingredients: Microcrystalline Cellulose, Corn Starch, Croscarmellose Sodium, Crospovidone, Stearic Acid, Hydroxypropylcellulose, Vegetable Magnesium Stearate, Silicon Dioxide, Red Film Coating

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Powered by elevATP & TORABOLIC HEALTHY MITOCHONDRIAL ENERGY

The addition of AGMAFLOW Agmatine Sulfate and Sodium Bicarbonate are used to help increase blood flow and nutrient delivery to the exerted muscle, for even greater potential gains.

2015 iSatori, Inc.,

TORABOLIC is a registered trademark of INDUS Biotech and is used under license. elevATP, patent-pending, is a registered trademark of FutureCeuticals, Inc.

In an 8-week study using the same amount of TORABOLIC as found in MAXON PURE STRENGTH, subjects gained an average of 20 pounds on their max bench press and 187 pounds on the max leg press, for a total of 207 pounds (82% increase vs. placebo).

MAXON PURE STRENGTH is designed to help you maximize your strength gains.

In another groundbreaking clinical study, the same dosage of elevATP used in MAXON PURE STRENGTH has been shown to significantly increase adenosine triphosphate (ATP) levels within 60 minutes.

General Statements

ADVANCED STRENGTH STIMULATOR

STRENGTH - POWER - MUSCLE

For scientific studies on ingredients in MAXON, visit iSatori.com/maxon

If you or your doctor has any questions about this product, please call 1-866-688-7679.

(Stock Symbol: “IFIT”)

Made in the USA in a GMP Facility.

In the gym or on the field - strength is king.

With three of the most potent, clinically researched strength-building ingredients in the industry, MAXON PURE STRENGTH sets a new standard in sports supplements.

ATP is the body's primary energy source for muscular contraction of skeletal muscle, which further research has shown could lead to greater gains in strength and power.

Creatine HCL is a time-tested powerhouse that helps the Creatine ATP cycle recover faster to help maximize every grueling set and rep.

FDA Statement of Identity

DIETARY SUPPLEMENT

Suggested/Recommended/Usage/Directions

DIRECTIONS FOR USE: As a dietary supplement, adults take four Rapid Release Caplets approximately 30-45 minutes before your workout. On non-training days, take four Rapid Release Caplets during the day on an empty stomach. Read the entire label before use, and follow the provided directions.

General

200515

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat cure, or prevent any disease.

Precautions

WARNING: KEEP OUT OF REACH OF CHILDREN. Not intended for individuals under the age of 18 unless instructed by a doctor.

Do not use this product if you are pregnant, nursing, or contemplating pregnancy.

Discontinue use and consult a medical doctor if you experience any unusual symptoms. WARNING for California residents only: This product contains substances known to the state of California to cause cancer, birth defects, and other reproductive harm.

Do not use if packaging has been tampered with.

Storage

Store in a cool, dry place (60(0)F to 80(0)F).

Seals/Symbols

MADE IN THE USA

Manufactured in a GMP Facility

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Maxon Pure Strength by iSatori label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Maxon Pure Strength label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Maxon Pure Strength by iSatori

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size4 Rapid Release Caplet(s) Dosage formOther (e.g. Tea Bag) Servings per container21 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sodium Bicarbonate

Interacts with
257 drugs
150 mg per serving

Sodium bicarbonate (baking soda) is a simple compound most often used as a fast-acting antacid and, in sports, as a buffer that may help with short, h...

Sodium Bicarbonate monograph & interactions

ElevATP

150 mg per serving Form: Ancient Peat, Apple Extract

HPLC Verified Creatine HCl

No known
interactions
1500 mg per serving

Creatine is one of the most studied sports supplements, with solid evidence that it can boost strength and performance during short, high-intensity ac...

HPLC Verified Creatine HCl monograph & interactions

Fenugreek

Interacts with
389 drugs
0 mg per serving Form: Trigimannose

Fenugreek is a common kitchen spice that is also taken as a supplement, mainly for blood sugar, cholesterol, and to support breast milk production. So...

Fenugreek monograph & interactions

Agmatine Sulfate

Interacts with
258 drugs
500 mg per serving

Agmatine is a compound your body makes from the amino acid arginine, and it is sold mainly as a workout and 'pump' supplement. Human evidence for most...

Agmatine Sulfate monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Corn Starch, Croscarmellose Sodium, Crospovidone, Stearic Acid, Hydroxypropylcellulose, Vegetable Magnesium Stearate, Silicon Dioxide, Red Film Coating. These complete the product’s ingredient list but are not active constituents.

Interaction report

Maxon Pure Strength by iSatori Drug Interactions

Want to check YOUR meds against Maxon Pure Strength?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
542Drugs
542 Moderate

Ingredients driving the most interactions

Fenugreek 389
Agmatine Sulfate 258
Sodium Bicarbonate 257

Individual Drug Interactions

The ingredients in Maxon Pure Strength interact with 542 drugs. Click any drug to see the details.

3 of the 5 ingredients in Maxon Pure Strength interact with drugs. Each result below shows which ingredient is responsible. Fenugreek Agmatine Sulfate Sodium Bicarbonate

Each ingredient & the kinds of drugs it affects

For each ingredient in Maxon Pure Strength with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Fenugreek9 drug types · 389 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Some of the constituents in fenugreek have antiplatelet effects in animal and in vitro research. However, common fenugreek products might not contain sufficient concentrations of these constituents for clinical effects. A clinical study in patients with coronary artery disease or diabetes shows that taking fenugreek seed powder 2.5 grams twice daily for 3 months does not affect platelet aggregation, fibrinolytic activity, or fibrinogen levels .

Likelihood Unlikely Evidence B
Antidiabetes Drugs

Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Clinical research shows that fenugreek seed can reduce fasting blood glucose and 2-hour postprandial glucose levels in adults with type 2 diabetes.

Likelihood Probable Evidence B
Clopidogrel (Plavix)

Theoretically, fenugreek seed might alter the clinical effects of clopidogrel by inhibiting its conversion to the active form.
Animal research shows that fenugreek seed 200 mg/kg daily for 14 days increases the maximum serum concentration of clopidogrel by 21%. It is unclear how this affects the pharmacokinetics of the active metabolite of clopidogrel; however, this study found that concomitant use of fenugreek seed and clopidogrel prolonged bleeding time by an additional 11%.

Likelihood Possible Evidence D
Metoprolol (Toprol)

Theoretically, fenugreek seed might have additive hypotensive effects when used with metoprolol.
Animal research shows that fenugreek seed 300 mg/kg daily for 2 weeks decreases systolic and diastolic blood pressure by 9% and 11%, respectively, when administered alone, and by 15% and 22%, respectively, when given with metoprolol 10 mg/kg.

Likelihood Probable Evidence B
Phenytoin (Dilantin)

Theoretically, fenugreek might decrease plasma levels of phenytoin.
Animal research shows that taking fenugreek seeds for 1 week decreases maximum concentrations and the area under the curve of a single dose of phenytoin by 44% and 72%, respectively. This seems to be related to increased clearance. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Sildenafil (Viagra)

Theoretically, concurrent use of sildenafil and fenugreek might reduce levels and therapeutic effects of sildenafil.
Animal research shows that taking fenugreek seeds for 1 week reduces maximum concentrations and the area under the curve of a single dose of sildenafil by 27% and 48%, respectively. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Theophylline

Theoretically, fenugreek may reduce the levels and clinical effects of theophylline.
Animal research shows that fenugreek 50 grams daily for 7 days reduces the maximum serum concentration (Cmax) of theophylline by 28% and the area under the plasma drug concentration-time curve (AUC) by 22%.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, fenugreek might have additive effects with warfarin and increase the international normalized ratio (INR).
Some fenugreek constituents have antiplatelet effects, although these might not be present in concentrations that are clinically significant. In one case report, a patient taking warfarin experienced an increased INR when starting to take fenugreek in combination with boldo.

Likelihood Possible Evidence D
Antihypertensive Drugs

Fenugreek may also have an additive effect on blood pressure-lowering medications. Studies on animals have shown that fenugreek seed can decrease both systolic and diastolic blood pressure by up to 22% when combined with metoprolol. Therefore, it is essential to monitor your blood pressure regularly if you are taking fenugreek and metoprolol together or any other antihypertensive drugs.

Likelihood Possible Evidence C
Fenugreek full monograph & interactions

Agmatine Sulfate2 drug types · 258 drugs

Antidiabetes Drugs

Theoretically, agmatine might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal and in vitro research suggest that agmatine has mild hypoglycemic effects.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research suggests that agmatine can modestly decrease heart rate and blood pressure.

Likelihood Possible Evidence D
Agmatine Sulfate full monograph & interactions

Sodium Bicarbonate14 drug types · 257 drugs

Aminoglycoside Antibiotics

Theoretically, sodium bicarbonate may increase the risk for hypokalemia in patients receiving aminoglycosides.
Orally, use of excessive sodium bicarbonate (such as the intake of "tablespoons" of sodium bicarbonate daily or up to one box of baking soda weekly) has been associated with cases of hypokalemia. Furthermore, when administered intravenously, the most common complication of sodium bicarbonate is hypokalemia. Nephrotoxicity caused by aminoglycosides may lead to increased urinary losses of various electrolytes, including potassium.

Likelihood Possible Evidence D
Amphotericin-B (Abelcet, Others)

Theoretically, sodium bicarbonate may increase the risk for hypokalemia in patients receiving amphotericin B.
Orally, use of excessive sodium bicarbonate (such as the intake of "tablespoons" of sodium bicarbonate daily or up to one box of baking soda weekly) has been associated with cases of hypokalemia. Furthermore, when administered intravenously, the most common complication of sodium bicarbonate is hypokalemia. Amphotericin B increases urinary potassium losses due to toxic effects on renal tubular epithelium. Hypokalemia can occur in up to 50% of patients.

Likelihood Possible Evidence D
Aspirin

Theoretically, sodium bicarbonate may reduce the levels and clinical effects of aspirin.
In humans, oral or intravenous administration of sodium bicarbonate increases salicylate elimination. Although the exact mechanism of this effect is not clear, some researchers hypothesize that sodium bicarbonate increases urinary pH, which increases salicylate ionization and subsequent excretion by the kidneys. In patients with urine pH of about 5.5, renal clearance of salicylate is approximately 55 mL/min. When urine pH is increased with oral sodium bicarbonate to about 7.5, renal clearance of salicylate increases to approximately 100 mL/min. Similarly, urine alkalinization with sodium bicarbonate increases the mean total body clearance of salicylate by approximately 60% compared with urine acidification.

Likelihood Probable Evidence B
Beta-Adrenergic Agonists

Theoretically, sodium bicarbonate may increase the risk for hypokalemia in patients taking beta-adrenergic agonists.
Orally, use of excessive sodium bicarbonate (such as the intake of "tablespoons" of sodium bicarbonate daily or up to one box of baking soda weekly) has been associated with cases of hypokalemia. Furthermore, the most common adverse effect of intravenous sodium bicarbonate is hypokalemia. Oral, parenteral, or inhaled beta-adrenergic agonists can reduce serum potassium levels, especially during acute use of high doses.

Likelihood Possible Evidence D
Cefpodoxime Proxetil (Vantin)

Theoretically, sodium bicarbonate might reduce the levels and clinical effects of cefpodoxime.
Cefpodoxime proxetil is an oral prodrug that is de-esterified in the intestine to the active drug cefpodoxime. Drugs or supplements that increase gastric pH can inhibit the activation of cefpodoxime proxetil and reduce the peak plasma concentrations of cefpodoxime. In humans, taking sodium bicarbonate 12.6 grams orally along with cefpodoxime proxetil 200 mg reduces peak plasma concentrations and area under the plasma concentration-time curve (AUC) of cefpodoxime by 35% to 50%.

Likelihood Probable Evidence B
Chlorpropamide (Diabinese)

Theoretically, sodium bicarbonate might reduce the levels and clinical effects of chlorpropamide.
The elimination of chlorpropamide by the kidneys depends strongly on urine pH. At a pH of 5, the renal clearance of chlorpropamide ranges from 0.5 to 3 mL/hr. At a pH of 8, renal clearance of chlorpropamide ranges from 500 to 1000 mL/hr. When taken in combination with oral sodium bicarbonate, the elimination half-life of chlorpropamide is shortened from 49.7 to 12.8 hours and urinary excretion of chlorpropamide is increased four-fold.

Likelihood Probable Evidence B
Cisplatin (Platinol-Aq)

Theoretically, sodium bicarbonate may increase the risk of hypokalemia in patients receiving cisplatin.
Orally, use of excessive sodium bicarbonate (such as the intake of "tablespoons" of sodium bicarbonate daily or up to one box of baking soda weekly) has been associated with cases of hypokalemia. Furthermore, the most common complication of intravenous sodium bicarbonate is hypokalemia. Cisplatin can cause renal tubular damage, with increased losses of electrolytes including potassium.

Likelihood Possible Evidence D
Corticosteroids

Theoretically, sodium bicarbonate may increase the risk of hypokalemia in patients taking corticosteroids.
Orally, use of excessive sodium bicarbonate (such as the intake of "tablespoons" of sodium bicarbonate daily or up to one box of baking soda weekly) has been associated with cases of hypokalemia. Furthermore, the most common intravenous complication of sodium bicarbonate is hypokalemia. Some glucocorticoids (corticosteroids) can also cause hypokalemia by causing sodium retention, resulting in compensatory renal potassium excretion. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Loop Diuretics

Theoretically, sodium bicarbonate may increase the risk of hypokalemia in patients taking loop diuretics.
Loop diuretics increase urinary potassium excretion. Orally, use of excessive sodium bicarbonate (such as the intake of "tablespoons" of sodium bicarbonate daily or up to one box of baking soda weekly) has been associated with cases of hypokalemia. Furthermore, the most common complication of intravenous sodium bicarbonate is hypokalemia.

Likelihood Possible Evidence D
Methylxanthines

Theoretically, sodium bicarbonate may increase the risk of hypokalemia in patients taking methylxanthines.
Orally, use of excessive sodium bicarbonate (such as the intake of "tablespoons" of sodium bicarbonate daily or up to one box of baking soda weekly) has been associated with cases of hypokalemia. Furthermore, the most common complication of intravenous sodium bicarbonate is hypokalemia. Theophylline and related drugs can reduce serum potassium levels, possibly by increasing intracellular uptake of potassium. Hypokalemia is most likely to occur after acute overdose of these drugs. However, reduced potassium levels can occur with therapeutic doses, and the incidence and degree of hypokalemia increases with increasing serum theophylline levels.

Likelihood Possible Evidence D
Pseudoephedrine (Sudafed)

Theoretically, sodium bicarbonate may increase levels and adverse effects of pseudoephedrine.
In humans, intravenous or oral administration of sodium bicarbonate can increase urinary pH. Clinical evidence shows that urine alkalinization increases the serum elimination half-life of pseudoephedrine by approximately 10-fold. In one patient with persistently alkaline urine, treatment with pseudoephedrine resulted in hallucinations and personality changes.

Likelihood Probable Evidence B
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related adverse effects.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium bicarbonate, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Stimulant Laxatives

Theoretically, sodium bicarbonate may increase the risk of hypokalemia in patients taking stimulant laxatives.
Long-term use of stimulant laxatives, or acute use of high doses (e.g., in bowel-cleansing regimens), can result in potassium loss and hypokalemia. Orally, use of excessive sodium bicarbonate (such as intake of "tablespoons" of sodium bicarbonate daily or up to one box of baking soda weekly) has been associated with cases of hypokalemia. Furthermore, the most common complication of intravenous sodium bicarbonate is hypokalemia.

Likelihood Possible Evidence D
Thiazide Diuretics

Theoretically, sodium bicarbonate may increase the risk of hypokalemia in patients taking thiazide diuretics.
Thiazide diuretics increase urinary potassium excretion. Orally, use of excessive sodium bicarbonate (such as the intake of "tablespoons" of sodium bicarbonate daily or up to one box of baking soda weekly) has been associated with cases of hypokalemia. Furthermore, the most common complication of intravenous sodium bicarbonate is hypokalemia.

Likelihood Possible Evidence D
Sodium Bicarbonate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Maxon Pure Strength, from the product label.

iSatori

See all iSatori products
Name
iSatori
Street Address
15000 W. 6th Ave., Ste. 202
City
Golden
State
CO
ZipCode
80401
Phone Number
1-866-688-7679
Web Address
www.iSatori.com
Pharmacist Counseling Corner

Maxon Pure Strength by iSatori: Common Questions

Does Maxon Pure Strength by iSatori interact with any medications?
Yes. Based on its ingredients, Maxon Pure Strength has a known interaction with 542 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Maxon Pure Strength contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take if I'm pregnant or breastfeeding?
Sodium bicarbonate is rated possibly unsafe in pregnancy. Creatine safety hasn't been established in pregnancy — it's best avoided. Fenugreek is likely unsafe in pregnancy but possibly safe for lactation. Agmatine doesn't have enough data either way — avoid it. Talk with your doctor or pharmacist about your specific situation before using this product.
What's the main purpose of each ingredient?
Sodium bicarbonate neutralizes acid and is shown possibly effective for athletic performance. Creatine supports muscle strength and athletic performance. Fenugreek is possibly effective for sexual function and blood sugar control. Agmatine is insufficiently studied for any specific use. elevATP's evidence isn't on file.
Can this product cause low blood potassium?
Yes, sodium bicarbonate — especially when used in large amounts — can cause low blood potassium (hypokalemia), particularly if you're also taking corticosteroids, water pills, heart medications, caffeine compounds, or bowel-moving drugs. Excessive use is the concern (like tablespoons daily), not typical supplement doses, but you should ask your doctor first.
What are the most common side effects?
The most common side effects come from sodium bicarbonate and include abdominal pain, bloating, diarrhea, flatulence, nausea, and vomiting — mostly with larger doses. Creatine may cause dehydration, diarrhea, muscle cramps, and water retention. Fenugreek and agmatine can cause bloating, diarrhea, and nausea.
Will this work for me?
That depends on why you're taking it. Creatine has solid evidence for muscle strength and athletic performance. Sodium bicarbonate is possibly effective for athletic performance. Fenugreek is possibly effective for sexual function and diabetes. Agmatine has insufficient evidence, and elevATP's evidence isn't on file. Talk with your doctor about whether it fits your goals.
Does this interact with blood thinners like warfarin?
Yes — fenugreek in this product theoretically has additive effects with warfarin and other blood thinners or antiplatelet drugs, increasing bleeding risk. This is a Moderate-severity interaction. Check your exact medications with your doctor or pharmacist before you start.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Maxon Pure Strength label
Go deeper

The Full Monographs Behind Maxon Pure Strength’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sodium Bicarbonate

Interacts with 257 drugs

Sodium bicarbonate (baking soda) is a simple compound most often used as a fast-acting antacid and, in sports, as a buffer that may help with short, high-intensity exercise. It is generally...

Read the full Sodium Bicarbonate monograph → Herb & supplement monograph

Creatine

Creatine is one of the most studied sports supplements, with solid evidence that it can boost strength and performance during short, high-intensity activities like weightlifting and sprintin...

Read the full Creatine monograph → Herb & supplement monograph

Fenugreek

Interacts with 389 drugs

Fenugreek is a common kitchen spice that is also taken as a supplement, mainly for blood sugar, cholesterol, and to support breast milk production. Some early research is encouraging for blo...

Read the full Fenugreek monograph → Herb & supplement monograph

Agmatine

Interacts with 258 drugs

Agmatine is a compound your body makes from the amino acid arginine, and it is sold mainly as a workout and 'pump' supplement. Human evidence for most of its claimed benefits is limited and...

Read the full Agmatine monograph →
Sources

Sources & How We Checked

Maxon Pure Strength's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 168 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sodium Bicarbonate 49 references
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  15. Kung M, White JR, Burki NK. The effect of subcutaneously administered terbutaline on serum potassium in asymptomatic adult asthmatics. Am Rev Respir Dis 1984;129:329-32..
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  18. Crane J, Burgess CD, Graham AN, Maling TJB. Hypokalemic and electrocardiographic effects of aminophylline and salbutamol in obstructive airways disease. NZ Med J 1987;100:309-11. DOI
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  21. Flack JM, Ryder KW, Strickland D, Whang R. Metabolic correlates of theophylline therapy: a concentration-related phenomenon. Ann Pharmacother 1994;28:175-9.. PubMed
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  26. Bjornson DC, Stephenson SR. Cisplatin-induced massive renal tubular failure with wastage of serum electrolytes. Clin Pharm 1983;2;80-3.
  27. Clegg, A. J., Loveman, E., Gospodarevskaya, E., Harris, P., Bird, A., Bryant, J., Scott, D. A., Davidson, P., Little, P., and Coppin, R. The safety and effectiveness of different methods of earwax removal: a systematic review and economic evaluation. Heal PubMed
  28. Carr, A. J., Hopkins, W. G., and Gore, C. J. Effects of acute alkalosis and acidosis on performance: a meta-analysis. Sports Med 2011;41(10):801-814. PubMed
  29. Proudfoot, A. T., Krenzelok, E. P., and Vale, J. A. Position Paper on urine alkalinization. J Toxicol Clin Toxicol 2004;42(1):1-26. PubMed
  30. Fitzgibbons, L. J. and Snoey, E. R. Severe metabolic alkalosis due to baking soda ingestion: case reports of two patients with unsuspected antacid overdose. J Emerg Med 1999;17(1):57-61. PubMed
  31. Barna, P. Sodium bicarbonate: burst stomachs and high sodium. J Clin Gastroenterol 1986;8(6):697-698.
  32. Mastrangelo, M. R. and Moore, E. W. Spontaneous rupture of the stomach in a healthy adult man after sodium bicarbonate ingestion. Ann Intern Med 1984;101(5):649-650. PubMed
  33. Hughes, G. S., Heald, D. L., Barker, K. B., Patel, R. K., Spillers, C. R., Watts, K. C., Batts, D. H., and Euler, A. R. The effects of gastric pH and food on the pharmacokinetics of a new oral cephalosporin, cefpodoxime proxetil. Clin Pharmacol Ther 1989; PubMed
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  35. Proudfoot AT, Krenzelok EP, Brent J, Vale JA. Does urine alkalinization increase salicylate elimination? If so, why? Toxicol Rev 2003;22(3):129-36. PubMed
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  39. Zer M, Chaimoff C, Dintsman M. Spontaneous rupture of the stomach following ingestion of sodium bicarbonate. Arch Surg 1970;101(4):532-3. PubMed
  40. Brismar B, Strandberg A, Wiklund B. Stomach rupture following ingestion of sodium bicarbonate. Acta Chir Scand Suppl 1986;530:97-9.
  41. Thomas SH, Stone CK. Acute toxicity from baking soda ingestion. Am J Emerg Med 1994;12(1):57-9. PubMed
  42. Food and Drug Administration Department of Health and Human Services. 21 CFR Part 331. Antacid Drug Products for Over-the-Counter Human Use; Amendment to Antacid Final Monograph; Proposed Rule. Federal Register. 1994;59(22):5060-5065.
  43. Gonzalez J, Hogg R. Metabolic alkalosis secondary to baking soda treatment of a diaper rash. Pediatrics. 1981;67:820-822. DOI
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  47. Hilton NP, Leach NK, Craig MM, Sparks SA, McNaughton LR. Enteric-coated sodium bicarbonate attenuates gastrointestinal side-effects. Int J Sport Nutr Exerc Metab. 2019 Nov 21:1-7. PubMed
  48. Grgic J, Pedisic Z, Saunders B, et al. International society of sports nutrition position stand: sodium bicarbonate and exercise performance. J Int Soc Sports Nutr 2021;18(1):61. PubMed
  49. Hughes A, Brown A, Valento M. Hemorrhagic encephalopathy from acute baking soda ingestion. West J Emerg Med. 2016;17(5):619-22. PubMed

See these in context on the Sodium Bicarbonate monograph →

Creatine 86 references
  1. Koshy KM, Griswold E, Schneeberger EE. Interstitial nephritis in a patient taking creatine. N Engl J Med 1999;340:814-5. PubMed
  2. Vahedi K, Domingo V, Amarenco P, Bousser MG. Ischemic stroke in a sportsman who consumed MaHuang extract and creatine monohydrate for bodybuilding. J Neurol Neurosurg Psychiatr 2000;68:112-3.
  3. Greenhaff P. Renal dysfunction accompanying oral creatine supplements. Lancet 1998;352:233-4. PubMed
  4. Vandenberghe K, Goris M, Van Hecke P, et al. Long-term creatine intake is beneficial to muscle performance during resistance training (abstract). J Appl Physiol 1997;83:2055-63. PubMed
  5. Hultman E, Soderlund K, Timmons JA, et al. Muscle creatine loading in men. J Appl Physiol 1996;81:232-7. PubMed
  6. Pritchard NR, Kalra PA. Renal dysfunction accompanying oral creatine supplements. Lancet 1998;351:1252-3. PubMed
  7. Poortmans JR, Auquier H, Renaut V, et al. Effect of short-term creatine supplementation on renal responses in men (abstract). Eur J Appl Physiol Occup Physiol 1997;76:566-7. PubMed
  8. Poortmans JR, Francaux M. Long-term oral creatine supplementation does not impair renal function in healthy athletes. Med Sci Sports Exerc 1999;31:1108-10. PubMed
  9. Mihic S, MacDonald JR, McKenzie S, Tarnopolsky MA. Acute creatine loading increases fat-free mass, but does not affect blood pressure, plasma creatinine, or CK activity in men and women. Med Sci Sports Exerc 2000;32:291-6. PubMed
  10. Rawson ES, Wehnert ML, Clarkson PM. Effects of 30 days of creatine ingestion in older men. Eur J Appl Physiol Occup Physiol 1999;80:139-44. PubMed
  11. Earnest CP, Almada AL, Mitchell TL. High-performance capillary electrophoresis-pure creatine monohydrate reduces blood lipids in men and women. Clin Sci (Colch) 1996;91:113-8. PubMed
  12. Juhn MS. Oral creatine supplementation. Separating fact from hype. Phys Sportsmed 1999;27:47-50,53-54,56,61,89. PubMed
  13. Juhn MS, O'Kane JW, Vinci DM. Oral creatine supplementation in male collegiate athletes: a survey of dosing habits and side effects. J Am Diet Assoc 1999;99:593-5.
  14. Green AL, Hultman E, Macdonald IA, et al. Carbohydrate ingestion augments skeletal muscle creatine accumulation during creatine supplementation in humans. Am J Physiol 1996;271:E821-6. PubMed
  15. Balsom PD, Soderlund K, Sjodin B, Ekblom B. Skeletal muscle metabolism during short duration high-intensity exercise: influence of creatine supplementation. Acta Physiol Scand 1995;154:303-10. PubMed
  16. Snow RJ, McKenna MJ, Selig SE, et al. Effect of creatine supplementation on sprint exercise performance and muscle metabolism. (abstract) J Appl Physiol 1998;84:1667-73. PubMed
  17. McNaughton LR, Dalton B, Tarr J. The effects of creatine supplementation on high-intensity exercise performance in elite performers. (abstract) Eur J Appl Physiol Occup Physiol 1998;78:236-40. PubMed
  18. Groeneveld GJ, Veldink JH, van der Tweel I, et al. A randomized sequential trial of creatine in amyotrophic lateral sclerosis. Ann Neurol 2003;53:437-45. . PubMed
  19. Robinson SJ. Acute quadriceps compartment syndrome and rhabdomyolysis in a weight lifter using high-dose creatine supplementation. J Am Board Fam Pract 2000;13:134-7. PubMed
  20. Kammer RT. Lone atrial fibrillation associated with creatine monohydrate supplementation. Pharmacotherapy 2005;25:762-4. PubMed
  21. Gualano B, Ugrinowitsch C, Novaes RB, et al. Effects of creatine supplementation on renal function: a randomized, double-blind, placebo-controlled clinical trial. Eur J Appl Physiol 2008;103:33-40. PubMed
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  26. Volek, J. S., Duncan, N. D., Mazzetti, S. A., Putukian, M., Gomez, A. L., and Kraemer, W. J. No effect of heavy resistance training and creatine supplementation on blood lipids. Int J Sport Nutr.Exerc.Metab 2000;10(2):144-156. PubMed
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See these in context on the Fenugreek monograph →

Agmatine 3 references
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See these in context on the Agmatine monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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