Drug & supplement interaction

Fenugreek + Carvedilol

Carvedilol brand names: Coreg, Coreg CR.

Minor Interaction
Medically reviewed by · Updated March 2023
The bottom line Minor

Fenugreek has a minor interaction with Carvedilol. Fenugreek may also have an additive effect on blood pressure-lowering medications.

Read the full interaction report
SeverityMinor
LikelihoodPossible
EvidenceC
What do Severity, Likelihood & Evidence mean?
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Interaction report

Fenugreek and Carvedilol

Here is the interaction we found between these two, with the evidence behind it.

Minor

Antihypertensive Drugs

Why this applies to Carvedilol

Carvedilol falls under Antihypertensive Drugs — the group Fenugreek interacts with.

Fenugreek may also have an additive effect on blood pressure-lowering medications. Studies on animals have shown that fenugreek seed can decrease both systolic and diastolic blood pressure by up to 22% when combined with metoprolol. Therefore, it is essential to monitor your blood pressure regularly if you are taking fenugreek and metoprolol together or any other antihypertensive drugs.
Severity Minor Likelihood Possible Evidence C

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist: fenugreek may have a mild blood pressure-lowering effect of its own. Since carvedilol already works to relax your blood vessels and slow your heart rate, stacking the two together could add up and push your numbers a little lower than expected. We're talking about concentrated supplement doses here, not the small amount you'd sprinkle on food while cooking.

If your pressure dips too far, you might notice things like dizziness, lightheadedness (especially standing up), unusual tiredness, or a slower-than-usual pulse. This is rated a minor interaction with limited, mostly animal evidence, so don't panic. Just keep an eye on your blood pressure at home, and check with your pharmacist or doctor before adding fenugreek so we can make sure everything stays in a safe range.

Contact Dr. Brian directly if you have additional questions on this interaction

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Fenugreek Also Interacts With Other Medications

Fenugreek has 224 moderate, 164 minor known drug interactions in our database — the Carvedilol one above is one of them. If you take anything else, check it against the full list below.

Moderate 224 Minor 164 No known interaction 2,442 (incl. Carvedilol)
Taking anything else?

Check Another of Your Medications Against Fenugreek

Covers the 2,830 medications we’ve checked against Fenugreek. Pick one to open its full report.

From our Q&A

Questions About Fenugreek or Carvedilol

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Fenugreek or Carvedilol, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Carvedilol

This page covers Fenugreek only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Carvedilol page lists 211 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Grapefruit (major) and Indian Snakeroot (major).

By severity: 6 major · 171 moderate · 34 minor.

From our pharmacist’s overview on the Carvedilol page

“People take carvedilol (Coreg) for heart failure and high blood pressure, conditions where a sudden swing in pressure or heart rate matters, and its supplement list runs to 211 ingredients, so this one calls for genuine care. More than half of those entries lower blood pressure on their own, fish oil and celery seed among them, and can…”

Reviewed by 2 · Jul 18, 2026

Open the Carvedilol interaction page

One more smart check

Taking Fenugreek as Part of a Dietary Supplement Product? Check It for Interactions

We hold 2,385 real supplement products containing Fenugreek, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Fenugreek. Your product may carry other ingredients that interact with Carvedilol too, on top of Fenugreek — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Fenugreek and Carvedilol Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Fenugreek
Top 10%

#85 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Carvedilol
Top 25%

#673 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Fenugreek

What is Fenugreek?

Fenugreek
  • Blood sugar control
  • Boosting breast milk supply
  • High cholesterol
  • Digestive upset
  • Low testosterone or libido

Fenugreek is a common kitchen spice that is also taken as a supplement, mainly for blood sugar, cholesterol, and to support breast milk production. Some early research is encouraging for blood sugar, but overall the evidence is mixed and far from settled. It is generally well tolerated as food, but talk with your pharmacist or doctor before using it as a supplement, especially if you are pregnant.

Read the full Fenugreek monograph & all interactions
Medication

About Carvedilol

What Is Carvedilol Used For?

Brand names: Coreg, Coreg CR

Carvedilol is used to treat three main conditions: mild-to-severe chronic heart failure, high blood pressure (hypertension), and reduced heart pumping function (left ventricular dysfunction) in people who have survived a heart attack. For heart failure, it is usually prescribed alongside other medications such as diuretics, ACE inhibitors, and digitalis to help people live longer and reduce the chance of hospital stays.

For people who have had a heart attack and whose heart is not pumping as well as it should, carvedilol is used to lower the risk of dying from heart-related causes. For high blood pressure, it can be used on its own or combined with other blood pressure medicines.

See full Carvedilol drug information
Keep checking

Other Drugs & Fenugreek

Browse every other medication we’ve checked against Fenugreek — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
224Moderate
164Minor
2,441No known interaction
224 Moderate 164 Minor 2,441 No interaction
Moderate

224 interactions

Showing 60 of 224 moderate interactions — see all 224 on the Fenugreek page.

Minor

164 interactions

Showing 60 of 164 minor interactions — see all 164 on the Fenugreek page.

No interaction 2,441 drugs checked — show the list

We also checked Fenugreek against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,441 medications checked with no known interaction — see the full Fenugreek list.

See the full Fenugreek interactions page
See every supplement checked against Carvedilol, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Fenugreek monograph › Uses, safety, and every drug interaction in one place Carvedilol supplement interactions › Every supplement checked against Carvedilol, ranked by severity Carvedilol drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Fenugreek and Carvedilol Together: Common Questions

Can you take Fenugreek with Carvedilol?
There is only a minor interaction, which is usually not serious. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Fenugreek and Carvedilol interaction?
We rate it Minor. This interaction is generally not clinically significant, but it remains worth noting and discussing with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Carvedilol and Fenugreek?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.