Drug & supplement interaction

Fenugreek + Clonazepam

Clonazepam brand names: Klonopin, Rivotril, Ceberclon.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Fenugreek and Clonazepam in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Fenugreek and Clonazepam

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Clonazepam and Fenugreek in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Fenugreek safety at a glance

Fenugreek overall Use caution Generally well tolerated in food amounts, but supplement doses may cause side effects and aren't right for everyone.
Pregnancy Likely Unsafe When used orally in amounts greater than those found in food. Fenugreek has potential oxytoxic and uterine stimulant activity. There are case reports of congeni... Read the full pregnancy detail
Breastfeeding Possibly Safe When used orally to stimulate lactation, short-term. Although most available clinical studies lack safety testing in the lactating parent or infant, some eviden... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Pharmacist analysis

Fenugreek is generally considered relatively safe in regard to potential drug interactions.

Nevertheless, interactions are possible between fenugreek and:

  • 'Blood-thinning' drugs
  • Drugs that lower blood pressure
  • Drugs that low blood sugar

Fenugreek contains some components that can prevent blood from clotting. However, there is not enough research to confirm whether the amount of these components present in common fenugreek products can have a clinically significant effect.

Fenugreek may also have an additive effect with blood sugar-lowering medication and blood pressure-lowering medication.

All of these potential interactions are documented individually on our specific drug-herbal interaction pages.

—

Still wondering about combining Clonazepam and Fenugreek? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Clonazepam

Interactions in our licensed database are recorded against drug classes, not just single drug names. Clonazepam is filed under 5 classifications — including benzodiazepines, anticonvulsants, cns depressants. Fenugreek has documented interactions with 9 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), antidiabetes drugs (moderate) and clopidogrel (plavix) (moderate) — and none of Clonazepam’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Fenugreek Does Interact With Other Medications

Fenugreek has 224 moderate, 165 minor known drug interactions in our database — Clonazepam isn’t one of them. If you take anything else, check it against the full list below.

Moderate 224 Minor 165 No known interaction 2,441 (incl. Clonazepam)
Taking anything else?

Check Another of Your Medications Against Fenugreek

Covers the 2,830 medications we’ve checked against Fenugreek. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Fenugreek and Clonazepam May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Stomach upset / Nausea Additional detail

    Fenugreek

    “Orally, fenugreek seed can cause mild gastrointestinal symptoms, such as diarrhea, dyspepsia, abdominal distention and pain, nausea, and flatulence, especially when taken on an empty stomach.”

    Fenugreek · Natural Medicines adverse-effect record, reported in diarrhea.

    6 sources cited
    1. 622. Sharma RD, Raghuram TC, Rao NS. Effect of fenugreek seeds on blood glucose and serum lipids in type I diabetes. Eur J Clin Nutr 1990;44:301-6.
    2. 12534. Gupta A, Gupta R, Lal B. Effect of Trigonella foenum-graecum (fenugreek) seeds on glycaemic control and insulin resistance in type 2 diabetes mellitus: a double blind placebo controlled study. J Assoc Physicians India 2001;49:1057-61.
    3. 18349. Chevassus H, Gaillard JB, Farret A, et al. A fenugreek seed extract selectively reduces spontaneous fat intake in overweight subjects. Eur J Clin Pharmacol 2010;66(5):449-55. PubMed
    4. 93421. Steels E, Rao A, Vitetta L. Physiological aspects of male libido enhanced by standardized Trigonella foenum-graecum extract and mineral formulation. Phytother Res. 2011 Sep;25(9):1294-300.
    5. 96065. Gong J, Fang K, Dong H, Wang D, Hu M, Lu F. Effect of fenugreek on hyperglycaemia and hyperlipidemia in diabetes and prediabetes: A meta-analysis. J Ethnopharmacol. 2016 Dec 24;194:260-268. PubMed
    6. 96068. Ouzir M, El Bairi K, Amzazi S. Toxicological properties of fenugreek (Trigonella foenum graecum). Food Chem Toxicol. 2016 Oct;96:145-54. PubMed

    Clonazepam

    Listed in the ADVERSE REACTIONS section of the FDA label for Clonazepam. Read the label on DailyMed ›

  • Swelling Additional detail

    Fenugreek

    “Fenugreek can cause allergic reactions when used orally and topically, and when the powder is inhaled. Orally, fenugreek has caused bronchospasm, diarrhea, and itching, and skin reactions severe enough to require intravenous human immunoglobulin. Topically, fenugreek paste has resulted in facial swelling, wheezing, and numbness around the head.”

    Fenugreek · Natural Medicines adverse-effect record, reported in asthma.

    2 sources cited
    1. 719. Patil SP, Niphadkar PV, Bapat MM. Allergy to fenugreek (Trigonella foenum graecum). Ann Allergy Asthma Immunol 1997;78:297-300. PubMed
    2. 96068. Ouzir M, El Bairi K, Amzazi S. Toxicological properties of fenugreek (Trigonella foenum graecum). Food Chem Toxicol. 2016 Oct;96:145-54. PubMed

    Clonazepam

    Listed in the ADVERSE REACTIONS section of the FDA label for Clonazepam. Read the label on DailyMed ›

  • Dizziness / Headache Additional detail

    Fenugreek

    “Orally, loss of consciousness has occurred in a 5 week-old infant drinking tea made from fenugreek. Dizziness and headaches have been reported in clinical research of fenugreek extract. However, these events are rare.”

    Fenugreek · Natural Medicines adverse-effect record, reported in vertigo.

    3 sources cited
    1. 9782. Sewell AC, Mosandl A, Bohles H. False diagnosis of maple syrup urine disease owing to ingestion of herbal tea. N Engl J Med 1999;341:769.. PubMed
    2. 49551. Abdel-Barry, J. A., Abdel-Hassan, I. A., Jawad, A. M., and al Hakiem, M. H. Hypoglycaemic effect of aqueous extract of the leaves of Trigonella foenum-graecum in healthy volunteers. East Mediterr.Health J 2000;6(1):83-88. DOI
    3. 93419. Rao A, Steels E, Inder WJ, Abraham S, Vitetta L. Testofen, a specialised Trigonella foenum-graecum seed extract reduces age-related symptoms of androgen decrease, increases testosterone levels and improves sexual function in healthy aging males in a doubl

    Clonazepam

    Listed in the ADVERSE REACTIONS section of the FDA label for Clonazepam. Read the label on DailyMed ›

  • Diarrhea Additional detail

    Fenugreek

    Recorded for Fenugreek in the same Natural Medicines adverse-effect record shown under Stomach upset / Nausea above.

    Clonazepam

    Listed in the ADVERSE REACTIONS section of the FDA label for Clonazepam. Read the label on DailyMed ›

Reported for Fenugreek but not commonly for Clonazepam: fainting, an allergic reaction, stomach pain and wheezing.

Effects for Clonazepam come from the ADVERSE REACTIONS section of its FDA label; effects for Fenugreek come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Fenugreek in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally in amounts greater than those found in food. Fenugreek has potential oxytoxic and uterine stimulant activity. There are case reports of congenital malformations, including hydrocephalus, anencephaly, cleft palate, and spina bifida, after consumption of fenugreek seeds during pregnancy. Consumption of fenugreek immediately prior to delivery may cause the neonate to have unusual body odor. Although this does not appear to cause long-term sequelae, it may be misdiagnosed as maple syrup urine disease.

Lactation Possibly Safe

When used orally to stimulate lactation, short-term. Although most available clinical studies lack safety testing in the lactating parent or infant, some evidence suggests that taking fenugreek 1725 mg three times daily orally for 21 days does not cause negative side effects in the infant.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Fenugreek or Clonazepam

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Fenugreek or Clonazepam, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Clonazepam

This page covers Fenugreek only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Clonazepam page lists 206 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Grapefruit (major).

By severity: 9 major · 158 moderate · 39 minor.

From our pharmacist’s overview on the Clonazepam page

“Clonazepam (Klonopin) slows brain activity to control seizures and panic, and most of what interacts with it pushes in one of two directions: deepening that sedation or changing how much drug is in your blood. This is a list to approach carefully.”

Reviewed by 2 · Jul 18, 2026

Open the Clonazepam interaction page

One more smart check

Taking Fenugreek as Part of a Dietary Supplement Product? Check It for Interactions

We hold 2,385 real supplement products containing Fenugreek, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Fenugreek. Even though Fenugreek itself has no known interaction with Clonazepam, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Fenugreek and Clonazepam Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Fenugreek
Top 10%

#85 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Clonazepam
Top 5%

#44 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Fenugreek reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Fenugreek and Clonazepam records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Fenugreek

What is Fenugreek?

Fenugreek
  • Blood sugar control
  • Boosting breast milk supply
  • High cholesterol
  • Digestive upset
  • Low testosterone or libido

Fenugreek is a common kitchen spice that is also taken as a supplement, mainly for blood sugar, cholesterol, and to support breast milk production. Some early research is encouraging for blood sugar, but overall the evidence is mixed and far from settled. It is generally well tolerated as food, but talk with your pharmacist or doctor before using it as a supplement, especially if you are pregnant.

Trigonella foenum-graecum · Fabaceae · Seeds and leaves · Capsules, powder, seeds, tea, extracts, and as a culinary spice

An interaction check asks whether these two react with each other — it does not ask whether Fenugreek is a good idea for someone in your situation. Here is what our Fenugreek record says about it on its own.

Fenugreek: dosing

There is no official standardized dose for fenugreek, and the right amount depends on the product and reason for use. Studies have used a wide range of doses and different preparations, so there is no single agreed-upon amount.The best approach is to follow the directions on the product label and not exceed them.

From our Fenugreek monograph — the full record covers uses, side effects and every documented interaction.

Read the full Fenugreek monograph & all interactions
Medication

About Clonazepam

What Is Clonazepam Used For?

Brand names: Klonopin, Rivotril, Ceberclon

Clonazepam is approved to treat several types of seizures — including Lennox-Gastaut syndrome (a severe form of epilepsy), akinetic seizures (sudden loss of muscle tone), myoclonic seizures (sudden muscle jerks), and absence seizures (brief lapses of awareness) in patients who haven't responded to other medicines.

It is also approved for panic disorder, with or without agoraphobia (fear of situations that might cause panic). Panic disorder involves repeated, unexpected panic attacks along with ongoing worry about having more attacks.

Most-Reported Side Effects for Clonazepam

From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 10,473 reports
Nausea 9,818 reports
Anxiety 8,896 reports
Headache 8,763 reports
Depression 8,232 reports
See full Clonazepam drug information
Keep checking

Other Drugs & Fenugreek

Browse every other medication we’ve checked against Fenugreek — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
224Moderate
165Minor
2,440No known interaction
224 Moderate 165 Minor 2,440 No interaction
Moderate

224 interactions

Showing 60 of 224 moderate interactions — see all 224 on the Fenugreek page.

Minor

165 interactions

Showing 60 of 165 minor interactions — see all 165 on the Fenugreek page.

No interaction 2,440 drugs checked — show the list

We also checked Fenugreek against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,440 medications checked with no known interaction — see the full Fenugreek list.

See the full Fenugreek interactions page
See every supplement checked against Clonazepam, ranked by severity
Evidence & sources

Fenugreek References

The 30 references that drive our Fenugreek monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Madar Z, Thorne R. Dietary fiber. Prog Food Nutr Sci 1987;11:153-74.
  2. Sharma RD, Raghuram TC, Rao NS. Effect of fenugreek seeds on blood glucose and serum lipids in type I diabetes. Eur J Clin Nutr 1990;44:301-6.
  3. Patil SP, Niphadkar PV, Bapat MM. Allergy to fenugreek (Trigonella foenum graecum). Ann Allergy Asthma Immunol 1997;78:297-300. PubMed
  4. Lambert J, Cormier J. Potential interaction between warfarin and boldo-fenugreek. Pharmacotherapy 2001;21:509-12. PubMed
  5. Bordia A, Verma SK, Srivastava KC. Effect of ginger (Zingiber officinale Rosc.) and fenugreek (Trigonella foenumgraecum L.) on blood lipids, blood sugar and platelet aggregation in patients with coronary artery disease. Prostaglandins Leukot Essent Fatty PubMed
  6. Yalcin SS, Tekinalp G, Ozalp I. Peculiar odor of traditional food and maple syrup urine disease. Pediatr Int 1999;41:108-9. PubMed
  7. Sewell AC, Mosandl A, Bohles H. False diagnosis of maple syrup urine disease owing to ingestion of herbal tea. N Engl J Med 1999;341:769.. PubMed
  8. Abdo MS, al-Kafawi AA. Experimental studies on the effect of Trigonella foenum-graecum (abstract). Planta Med 1969;17:14-8.
  9. Gupta A, Gupta R, Lal B. Effect of Trigonella foenum-graecum (fenugreek) seeds on glycaemic control and insulin resistance in type 2 diabetes mellitus: a double blind placebo controlled study. J Assoc Physicians India 2001;49:1057-61.
  10. Gabay MP. Galactogogues: medications that induce lactation. J Hum Lact 2002;18:274-9. PubMed
  11. Chevassus H, Gaillard JB, Farret A, et al. A fenugreek seed extract selectively reduces spontaneous fat intake in overweight subjects. Eur J Clin Pharmacol 2010;66(5):449-55. PubMed
  12. Turkyilmaz C, Onal E, Hirfanoglu IM, et al. The effect of galactagogue herbal tea on breast milk production and short-term catch-up of birth weight in the first week of life. J Altern Complement Med 2011;17(2):139-42. PubMed
  13. Swafford S, Berens P. Effect of fenugreek on breast milk volume. Abstract presented at: 5th International Meeting of the Academy of Breastfeeding Medicine; September 11-13,2000, Tucson, Arizona.
  14. Abdel-Barry, J. A., Abdel-Hassan, I. A., Jawad, A. M., and al Hakiem, M. H. Hypoglycaemic effect of aqueous extract of the leaves of Trigonella foenum-graecum in healthy volunteers. East Mediterr.Health J 2000;6(1):83-88. DOI
  15. Parvizpur, A., Ahmadiani, A., and Kamalinejad, M. Probable role of spinal purinoceptors in the analgesic effect of Trigonella foenum (TFG) leaves extract. J Ethnopharmacol 3-8-2006;104(1-2):108-112. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Fenugreek and Clonazepam Together: Common Questions

Is it safe to take Fenugreek with Clonazepam?
We do not list a known interaction between Fenugreek and Clonazepam. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Fenugreek and Clonazepam have any of the same side effects?
Yes — our sources link each of them separately to 6 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Fenugreek and Clonazepam combination checked?
Interactions in our licensed database are recorded against drug classes. Clonazepam is filed under 5 classifications, and Fenugreek has documented interactions with 9 drug classes — none of Clonazepam's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Fenugreek interact with any other medications?
Yes. Fenugreek has 389 documented drug interactions in our database — Clonazepam is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Clonazepam interact with any supplements?
Yes. Clonazepam has documented interactions with 206 supplements in our database — Fenugreek is not one of them. The Clonazepam interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Fenugreek monograph Uses, safety profile, and every drug interaction in one place Clonazepam drug information The full plain-English guide to this medication Clonazepam supplement interactions Every supplement checked against Clonazepam, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 30 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Clonazepam and Fenugreek?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.