Meta I-3-C Ingredients & Drug Interactions
by Metagenics
What is this page for?
First and foremost: checking Meta I-3-C against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Meta I-3-C is a dietary supplement by Metagenics with 2 active ingredients. Its ingredients are commonly taken for estrogen and hormone balance support, breast and cervical health, prostate health.Based on those ingredients, 384 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Rosemary (Rosmarinus officinalis) leaf extract, Indole-3-Carbinol. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Meta I-3-C by Metagenics
Ask about any prescription or over-the-counter medication and we check it for interactions with Meta I-3-C by Metagenics — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Meta I-3-C by Metagenics
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Meta I-3-C contains 2 active ingredients. Indole-3-carbinol is a compound derived from cruciferous vegetables like broccoli and cabbage.
Rosemary leaf extract comes from the rosemary plant and is used for its antioxidant and potential cognitive benefits. The capsule also contains inactive ingredients — maltodextrin, magnesium stearate, and silica — that help form and stabilize the supplement.
Does it work?
Not established
The evidence for indole-3-carbinol is not established in our data. We hold insufficient reliable evidence to rate it for breast cancer, colorectal cancer, cervical dysplasia, liver disease, or fibromyalgia.
Rosemary is possibly effective for memory, but the evidence for age-related cognitive decline and nonalcoholic fatty liver disease (NAFLD) is insufficient to rate. If you're considering this product for a specific health goal, ask your doctor or pharmacist whether the evidence supports its use for your situation.
How safe is it?
Well-documented data
Indole-3-carbinol is generally well tolerated when taken by mouth, though diarrhea, nausea, rash, tremor, and unsteadiness have been reported — especially imbalance and tremor at higher doses. The supplement should be avoided during pregnancy and breastfeeding because hormone effects and safety data are insufficient.
Rosemary is safe in normal food amounts, but concentrated extracts require caution. The safety data advises against medicinal doses during pregnancy.
Topical rosemary can trigger allergic reactions, dermatitis, or photosensitivity in sensitive people, and the undiluted oil may cause seizures. There isn't enough safety data on medicinal doses during breastfeeding.
Meds to double-check
Moderate interaction found
Before you start Meta I-3-C, check whether you take blood thinners or antiplatelet drugs (including aspirin), estrogen-based hormonal contraceptives or hormone therapy, diabetes medications, salicylate-containing pain relievers like Trilisate or Disalcid, or medications processed through the liver (CYP1A2 substrates). Talk with your doctor or pharmacist about whether this product is right for you.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
Meta I-3-C is mainly a concern if you take blood thinners, estrogen therapy, diabetes medications, or drugs metabolized through the liver. If any of those apply to you, talk with your doctor or pharmacist before starting — the product may affect how those medications work.
It should be avoided during pregnancy and breastfeeding. For anyone else, check your specific medications on this page and confirm with your healthcare provider before taking it.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 24, 2017.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Meta I-3-C, straight from the product label.
| Brand | Metagenics |
|---|---|
| Net contents | 180 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Feb 24, 2017 |
| DSLD ID | 71038 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Meta I-3-C by Metagenics, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Indole-3-Carbinol | 150 mg | -- |
| Rosemary (Rosmarinus officinalis) leaf extract | 50 mg | -- |
Other ingredients: Capsule, Maltodextrin, Magnesium Stearate, Silica
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)
Meta I-3-C is designed to promote healthy estrogen metabolism and balance by featuring indole-3-carbinol (I3C), a naturally occurring compound found in cruciferous vegetables such as broccoli, Brussels sprouts, and cabbage.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Suggested/Recommended/Usage/Directions
Directions: Take one capsule twice daily with food or as directed by your healthcare practitioner.
Precautions
Caution: Not recommended for pregnant or nursing women. If taking medication, consult your healthcare practitioner before use.
Keep out of the reach of children.
Formulation
Formulated to Exclude: Wheat, gluten, soy, dairy products, nuts, tree nuts, fish, crustacean shellfish, colors, artificial sweeteners, and preservatives.
This product is gluten free and vegetarian.
General Statements
Genetic potential through nutrition
Through its ability to promote the breakdown of estrogen to its beneficial, protective metabolite-2-hydroxyestrone-indole-3-carbinol may be a safe and effective way to help achieve beneficial balance in estrogen metabolism.
Formula
Stabilized Indole-3-Carbinol
FDA Statement of Identity
Dietary Supplement
General
LME041J PROD. I3CCAP180
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Meta I-3-C by Metagenics label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Meta I-3-C by Metagenics
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container180 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Indole-3-Carbinol
Interacts with294 drugs
Indole-3-carbinol (I3C) is a compound formed when you eat cruciferous vegetables like broccoli and cabbage, and it is sold as a supplement mainly for...
Indole-3-Carbinol monograph & interactionsRosemary (Rosmarinus officinalis) leaf extract
Interacts with372 drugs
Rosemary is a fragrant Mediterranean herb that is safe and flavorful in normal food amounts. Some early research suggests possible benefits for memory...
Rosemary (Rosmarinus officinalis) leaf extract monograph & interactionsOther (inactive) ingredients: Capsule, Maltodextrin, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.
Meta I-3-C by Metagenics Drug Interactions
HelloPharmacist Interaction Report
Meta I-3-C by Metagenics can interact with several medication types through its indole-3-carbinol and rosemary leaf extract content.
The most serious concerns are moderate-severity interactions with blood thinners (anticoagulants) and antiplatelet drugs — both ingredients may increase bleeding risk, and rosemary also interacts with salicylate-containing pain relievers like aspirin and choline magnesium trisalicylate (Trilisate).
Read the full breakdown — every affected drug type, severity by severity
Indole-3-carbinol may speed up how your liver breaks down certain medications used for conditions like heart problems and depression (CYP1A2 substrates), potentially making them less effective. It can also interfere with estrogen therapy.
Rosemary adds a minor interaction with those same liver-processed drugs and raises a theoretical risk of low blood sugar (hypoglycemia) if you take diabetes medications.
Although we've outlined the main categories, the specifics depend on your exact prescriptions. Altogether, these interactions span 384 individual medications.
Use the medication checker on this page to see if any of yours are listed, and talk with your doctor or pharmacist before starting this product if you take blood thinners, hormonal contraceptives, diabetes drugs, or any heart or psychiatric medications.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Meta I-3-C?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Meta I-3-C interact with 384 drugs. Click any drug to see the details.
2 of the 2 ingredients in Meta I-3-C interact with drugs. Each result below shows which ingredient is responsible. Rosemary (Rosmarinus officinalis) leaf extract Indole-3-Carbinol
Empagliflozin, Linagliptin, Metformin HydrochlorideTrijardy XR
How Empagliflozin, Linagliptin, Metformin Hydrochloride interacts with Meta I-3-C — through 1 ingredient. Tap an ingredient for the detail:
Rosemary (rosmarinus Officinalis) Leaf ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking rosemary with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Rosemary (rosmarinus Officinalis) Leaf Extract + Empagliflozin, Linagliptin, Metformin Hydrochloride interactionEmpagliflozin, MetforminSynjardy
How Empagliflozin, Metformin interacts with Meta I-3-C — through 1 ingredient. Tap an ingredient for the detail:
Rosemary (rosmarinus Officinalis) Leaf ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking rosemary with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Rosemary (rosmarinus Officinalis) Leaf Extract + Empagliflozin, Metformin interactionEmpagliflozin, Metformin HydrochlorideSynjardy XR
How Empagliflozin, Metformin Hydrochloride interacts with Meta I-3-C — through 1 ingredient. Tap an ingredient for the detail:
Rosemary (rosmarinus Officinalis) Leaf ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking rosemary with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Rosemary (rosmarinus Officinalis) Leaf Extract + Empagliflozin, Metformin Hydrochloride interactionEnasidenibIdhifa
How Enasidenib interacts with Meta I-3-C — through 2 ingredients. Tap an ingredient for the detail:
Indole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Enasidenib interactionRosemary (rosmarinus Officinalis) Leaf ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Rosemary (rosmarinus Officinalis) Leaf Extract + Enasidenib interactionEnoxaparinLovenox
How Enoxaparin interacts with Meta I-3-C — through 2 ingredients. Tap an ingredient for the detail:
Rosemary (rosmarinus Officinalis) Leaf ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rosemary may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Rosemary (rosmarinus Officinalis) Leaf Extract + Enoxaparin interactionIndole-3-carbinolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Indole-3-carbinol + Enoxaparin interactionEphedrine Sulfate, Hydroxyzine, TheophyllineHydroxy Compound
How Ephedrine Sulfate, Hydroxyzine, Theophylline interacts with Meta I-3-C — through 2 ingredients. Tap an ingredient for the detail:
Indole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Ephedrine Sulfate, Hydroxyzine, Theophylline interactionRosemary (rosmarinus Officinalis) Leaf ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Rosemary (rosmarinus Officinalis) Leaf Extract + Ephedrine Sulfate, Hydroxyzine, Theophylline interactionEphedrine, Guaifenesin, Phenobarbital, TheophyllineMudrane GG
How Ephedrine, Guaifenesin, Phenobarbital, Theophylline interacts with Meta I-3-C — through 2 ingredients. Tap an ingredient for the detail:
Indole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Ephedrine, Guaifenesin, Phenobarbital, Theophylline interactionRosemary (rosmarinus Officinalis) Leaf ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Rosemary (rosmarinus Officinalis) Leaf Extract + Ephedrine, Guaifenesin, Phenobarbital, Theophylline interactionEphedrine, Hydroxyzine, TheophyllineAmi Rax, Marax
How Ephedrine, Hydroxyzine, Theophylline interacts with Meta I-3-C — through 2 ingredients. Tap an ingredient for the detail:
Indole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Ephedrine, Hydroxyzine, Theophylline interactionRosemary (rosmarinus Officinalis) Leaf ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Rosemary (rosmarinus Officinalis) Leaf Extract + Ephedrine, Hydroxyzine, Theophylline interactionEptifibatideIntegrilin
How Eptifibatide interacts with Meta I-3-C — through 2 ingredients. Tap an ingredient for the detail:
Indole-3-carbinolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Indole-3-carbinol + Eptifibatide interactionRosemary (rosmarinus Officinalis) Leaf ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rosemary may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Rosemary (rosmarinus Officinalis) Leaf Extract + Eptifibatide interactionErtugliflozinSteglatro
How Ertugliflozin interacts with Meta I-3-C — through 1 ingredient. Tap an ingredient for the detail:
Rosemary (rosmarinus Officinalis) Leaf ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking rosemary with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Rosemary (rosmarinus Officinalis) Leaf Extract + Ertugliflozin interactionErtugliflozin, Metformin HydrochlorideSegluromet
How Ertugliflozin, Metformin Hydrochloride interacts with Meta I-3-C — through 1 ingredient. Tap an ingredient for the detail:
Rosemary (rosmarinus Officinalis) Leaf ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking rosemary with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Rosemary (rosmarinus Officinalis) Leaf Extract + Ertugliflozin, Metformin Hydrochloride interactionEsomeprazole, NaproxenVimovo
How Esomeprazole, Naproxen interacts with Meta I-3-C — through 2 ingredients. Tap an ingredient for the detail:
Rosemary (rosmarinus Officinalis) Leaf ExtractAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, rosemary may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Rosemary (rosmarinus Officinalis) Leaf Extract + Esomeprazole, Naproxen interactionIndole-3-carbinolAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Indole-3-carbinol + Esomeprazole, Naproxen interactionEsterified EstrogensEstratab, Menest
How Esterified Estrogens interacts with Meta I-3-C — through 1 ingredient. Tap an ingredient for the detail:
Indole-3-carbinolEstrogens Moderate
Interaction Summary
Indole-3-carbinol might interfere with the effects of estrogen therapy.
Read the full Indole-3-carbinol + Esterified Estrogens interactionEsterified Estrogens, MethyltestosteroneEstratest
How Esterified Estrogens, Methyltestosterone interacts with Meta I-3-C — through 1 ingredient. Tap an ingredient for the detail:
Indole-3-carbinolEstrogens Moderate
Interaction Summary
Indole-3-carbinol might interfere with the effects of estrogen therapy.
Read the full Indole-3-carbinol + Esterified Estrogens, Methyltestosterone interactionEstradiolDivigel, Elestrin, Estrace, Estraderm, Estring, Evamist +6 more
How Estradiol interacts with Meta I-3-C — through 2 ingredients. Tap an ingredient for the detail:
Indole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates, Estrogens Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Estradiol interactionRosemary (rosmarinus Officinalis) Leaf ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Rosemary (rosmarinus Officinalis) Leaf Extract + Estradiol interactionEstradiol, MedroxyprogesteroneDivitren
How Estradiol, Medroxyprogesterone interacts with Meta I-3-C — through 2 ingredients. Tap an ingredient for the detail:
Indole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates, Estrogens Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Estradiol, Medroxyprogesterone interactionRosemary (rosmarinus Officinalis) Leaf ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Rosemary (rosmarinus Officinalis) Leaf Extract + Estradiol, Medroxyprogesterone interactionEstradiol, Norethindrone AcetateActivella
How Estradiol, Norethindrone Acetate interacts with Meta I-3-C — through 2 ingredients. Tap an ingredient for the detail:
Indole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates, Estrogens Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Estradiol, Norethindrone Acetate interactionRosemary (rosmarinus Officinalis) Leaf ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Rosemary (rosmarinus Officinalis) Leaf Extract + Estradiol, Norethindrone Acetate interactionEstradiol, NorgestimateOrtho-Prefest
How Estradiol, Norgestimate interacts with Meta I-3-C — through 2 ingredients. Tap an ingredient for the detail:
Indole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates, Estrogens Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Estradiol, Norgestimate interactionRosemary (rosmarinus Officinalis) Leaf ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Rosemary (rosmarinus Officinalis) Leaf Extract + Estradiol, Norgestimate interactionEstradiol, ProgesteroneBijuvanda
How Estradiol, Progesterone interacts with Meta I-3-C — through 2 ingredients. Tap an ingredient for the detail:
Indole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates, Estrogens Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Estradiol, Progesterone interactionRosemary (rosmarinus Officinalis) Leaf ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Rosemary (rosmarinus Officinalis) Leaf Extract + Estradiol, Progesterone interactionEstrogenEstrogen
How Estrogen interacts with Meta I-3-C — through 2 ingredients. Tap an ingredient for the detail:
Indole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates, Estrogens Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Estrogen interactionRosemary (rosmarinus Officinalis) Leaf ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Rosemary (rosmarinus Officinalis) Leaf Extract + Estrogen interactionEstroneOrtho-Est
How Estrone interacts with Meta I-3-C — through 1 ingredient. Tap an ingredient for the detail:
Indole-3-carbinolEstrogens Moderate
Interaction Summary
Indole-3-carbinol might interfere with the effects of estrogen therapy.
Read the full Indole-3-carbinol + Estrone interactionEstropipateOgen, Ortho EST
How Estropipate interacts with Meta I-3-C — through 1 ingredient. Tap an ingredient for the detail:
Indole-3-carbinolEstrogens Moderate
Interaction Summary
Indole-3-carbinol might interfere with the effects of estrogen therapy.
Read the full Indole-3-carbinol + Estropipate interactionEthiny Estradiol, LevonorgestrelLogynon, Microgynon 30 ED
How Ethiny Estradiol, Levonorgestrel interacts with Meta I-3-C — through 2 ingredients. Tap an ingredient for the detail:
Indole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates, Estrogens Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Ethiny Estradiol, Levonorgestrel interactionRosemary (rosmarinus Officinalis) Leaf ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Rosemary (rosmarinus Officinalis) Leaf Extract + Ethiny Estradiol, Levonorgestrel interactionEthinyl EstradiolEstinyl
How Ethinyl Estradiol interacts with Meta I-3-C — through 2 ingredients. Tap an ingredient for the detail:
Indole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates, Estrogens Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Ethinyl Estradiol interactionRosemary (rosmarinus Officinalis) Leaf ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Rosemary (rosmarinus Officinalis) Leaf Extract + Ethinyl Estradiol interactionEthinyl Estradiol, DesogestrelApri, Cesia, Cyclessa, Gedarel, Kariva, Linessa +4 more
How Ethinyl Estradiol, Desogestrel interacts with Meta I-3-C — through 2 ingredients. Tap an ingredient for the detail:
Indole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates, Estrogens Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Ethinyl Estradiol, Desogestrel interactionRosemary (rosmarinus Officinalis) Leaf ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Rosemary (rosmarinus Officinalis) Leaf Extract + Ethinyl Estradiol, Desogestrel interactionEthinyl Estradiol, DrospirenoneYaz
How Ethinyl Estradiol, Drospirenone interacts with Meta I-3-C — through 2 ingredients. Tap an ingredient for the detail:
Indole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates, Estrogens Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Ethinyl Estradiol, Drospirenone interactionRosemary (rosmarinus Officinalis) Leaf ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Rosemary (rosmarinus Officinalis) Leaf Extract + Ethinyl Estradiol, Drospirenone interactionEthinyl Estradiol, Ethynodiol DiacetateDemulen 1/35, Demulen 1/50, Demulen Compack, Kelnor 1/35, Zovia, Zovia 1/35 +1 more
How Ethinyl Estradiol, Ethynodiol Diacetate interacts with Meta I-3-C — through 2 ingredients. Tap an ingredient for the detail:
Indole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates, Estrogens Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Ethinyl Estradiol, Ethynodiol Diacetate interactionRosemary (rosmarinus Officinalis) Leaf ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Rosemary (rosmarinus Officinalis) Leaf Extract + Ethinyl Estradiol, Ethynodiol Diacetate interactionEthinyl Estradiol, LevonorgestrelAlesse, Alesse 21, Alesse 28, Aviane, Enpresse, Jolessa +18 more
How Ethinyl Estradiol, Levonorgestrel interacts with Meta I-3-C — through 2 ingredients. Tap an ingredient for the detail:
Indole-3-carbinolEstrogens, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Indole-3-carbinol might interfere with the effects of estrogen therapy.
Read the full Indole-3-carbinol + Ethinyl Estradiol, Levonorgestrel interactionRosemary (rosmarinus Officinalis) Leaf ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Rosemary (rosmarinus Officinalis) Leaf Extract + Ethinyl Estradiol, Levonorgestrel interactionEthinyl Estradiol, NorethindroneAranelle, Brevicon, Brevicon .5/35 21 day, Brevicon .5/35 28 day, Brevicon 1/35 21 day, Brevicon 1/35 28 day +50 more
How Ethinyl Estradiol, Norethindrone interacts with Meta I-3-C — through 2 ingredients. Tap an ingredient for the detail:
Indole-3-carbinolEstrogens, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Indole-3-carbinol might interfere with the effects of estrogen therapy.
Read the full Indole-3-carbinol + Ethinyl Estradiol, Norethindrone interactionRosemary (rosmarinus Officinalis) Leaf ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Rosemary (rosmarinus Officinalis) Leaf Extract + Ethinyl Estradiol, Norethindrone interactionEthinyl Estradiol, Norethindrone, Ferrous FumarateEstrostep Fe, Femcon FE, Junel Fe 1.5/30, Loestrin Fe, Loestrin Fe 1.5/30, Loestrin Fe 1/20 +3 more
How Ethinyl Estradiol, Norethindrone, Ferrous Fumarate interacts with Meta I-3-C — through 2 ingredients. Tap an ingredient for the detail:
Indole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates, Estrogens Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Ethinyl Estradiol, Norethindrone, Ferrous Fumarate interactionRosemary (rosmarinus Officinalis) Leaf ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Rosemary (rosmarinus Officinalis) Leaf Extract + Ethinyl Estradiol, Norethindrone, Ferrous Fumarate interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Meta I-3-C with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Rosemary (Rosmarinus officinalis) leaf extract
Anticoagulant/Antiplatelet Drugs
Theoretically, rosemary may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that rosemary inhibits platelet aggregation.
Antidiabetes Drugs
Theoretically, taking rosemary with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research shows that rosemary extract can decrease blood glucose levels in diabetic models. However, research in humans is conflicting. Although rosemary powder decreased blood glucose levels in healthy adults, no change in blood glucose levels was seen in adults with type 2 diabetes, most of whom were taking antidiabetes drugs.
Aspirin
Theoretically, rosemary might have additive effects with salicylate-containing drugs such as aspirin.
Rosemary is reported to contain salicylates.
Choline Magnesium Trisalicylate (Trilisate)
Theoretically, rosemary might have additive effects with salicylate-containing drugs such as choline magnesium trisalicylate.
Rosemary is reported to contain salicylate.
Salsalate (Disalcid)
Theoretically, rosemary might have additive effects with salicylate-containing drugs such as salsalate.
Rosemary is reported to contain salicylate.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that rosemary induces CYP1A2 enzymes. This effect has not been reported in humans.
Indole-3-Carbinol
Anticoagulant/Antiplatelet Drugs
Theoretically, indole-3-carbinol might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
In vitro research shows that indole-3-carbinol inhibits platelet aggregation.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Animal research shows that indole-3-carbinol induces CYP1A2 enzymes.
Estrogens
Indole-3-carbinol might interfere with the effects of estrogen therapy.
Preliminary clinical and in vitro evidence shows that indole-3-carbinol has antiestrogenic activity.
Brand information
Manufacturer and brand details for Meta I-3-C, from the product label.
Metagenics
See all Metagenics products- Name
- Metagenics
- City
- Aliso Viejo
- State
- CA
- ZipCode
- 92656
- Phone Number
- 1 800 692 9400
- Web Address
- www.metagenics.com
Meta I-3-C by Metagenics: Common Questions
Does Meta I-3-C by Metagenics interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this while I'm pregnant or breastfeeding?
What side effects might I experience?
Is this product backed by strong evidence?
Does rosemary extract in this product come from food or a supplement form?
What is indole-3-carbinol and where does it come from?
Should I worry about interactions if I'm not on any medications?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Meta I-3-C’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Indole-3-carbinol
Interacts with 294 drugsIndole-3-carbinol (I3C) is a compound formed when you eat cruciferous vegetables like broccoli and cabbage, and it is sold as a supplement mainly for hormone-related and cell-protective effe...
Read the full Indole-3-carbinol monograph → Herb & supplement monographRosemary
Interacts with 372 drugsRosemary is a fragrant Mediterranean herb that is safe and flavorful in normal food amounts. Some early research suggests possible benefits for memory, mood, and hair growth, but the evidenc...
Read the full Rosemary monograph →Sources & How We Checked
Meta I-3-C's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 29 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Indole-3-carbinol 9 references
- Rosen CA, Woodson GE, Thompson JW, et al. Preliminary results of the use of indole-3-carbinol for recurrent respiratory papillomatosis. Otolaryngol Head Neck Surg 1998;118:810-5. PubMed
- Bell MC, Crowley-Nowick P, Bradlow HL, et al. Placebo-controlled trial of indole-3-carbinol in the treatment of CIN. Gynecol Oncol 2000;78:123-9. PubMed
- He YH, Friesen MD, Ruch RJ, Schut HA. Indole-3-carbinol as a chemopreventive agent in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) carcinogenesis: inhibition of PhIP-DNA adduct formation, acceleration of PhIP metabolism, and induction of cytoch
- Kim, Y. S. and Milner, J. A. Targets for indole-3-carbinol in cancer prevention. J.Nutr.Biochem. 2005;16(2):65-73. PubMed
- Anon. Indole-3-carbinol. Monograph. Alternative Medicine Review 2005;10(4):337-42.
- McAlindon TE, Gulin J, Chen T, et al. Indole-3-carbinol in women with SLE: effect on estrogen metabolism and disease activity. Lupus 2001;10:779-83. PubMed
- Reed GA, Peterson KS, Smith HJ, et al. A phase I study of indole-3-carbinol in women: tolerability and effects. Cancer Epidemiol Biomarkers Prev 2005;14:1953-60. PubMed
- Bradlow HL, Michnovicz JJ, Halper M, et al. Long-term responses of women to indole-3-carbinol or a high fiber diet. Cancer Epidemiol Biomarkers Prev 1994;3:591-5.
- Paliwal P, Chauhan G, Gautam D, Dash D, Patne SCU, Krishnamurthy S. Indole-3-carbinol improves neurobehavioral symptoms in a cerebral ischemic stroke model. Naunyn Schmiedebergs Arch Pharmacol. 2018;391(6):613-625. PubMed
Rosemary 20 references
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- Foster S, Tyler VE. Tyler's Honest Herbal: A Sensible Guide to the Use of Herbs and Related Remedies. 3rd ed., Binghamton, NY: Haworth Herbal Press, 1993.
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Cartier LC, Lehrer A, Malo JL. Occupational asthma caused by aromatic herbs. Allergy 1996;51:647-9. DOI
- Burkhard PR, Burkhardt K, Haenggeli CA, Landis T. Plant-induced seizures: reappearance of an old problem. J Neurol 1999;246:667-70. PubMed
- Swain AR, Dutton SP, Truswell AS. Salicylates in foods. J Am Diet.Assoc 1985;85(8):950-60. DOI
- Zhu BT, Loder DP, Cai MX, et al. Dietary administration of an extract from rosemary leaves enhances the liver microsomal metabolism of endogenous estrogens and decreases their uterotropic action in CD-1 mice. Carcinogenesis 1998;19(10):1821-7. PubMed
- Debersac P, Heydel JM, Amiot MJ, et al. Induction of cytochrome P450 and/or detoxication enzymes by various extracts of rosemary: description of specific patterns. Food Chem Toxicol 2001;39(9):907-18. PubMed
- Debersac P, Vernevaut MF, Amiot MJ, et al. Effects of a water-soluble extract of rosemary and its purified component rosmarinic acid on xenobiotic-metabolizing enzymes in rat liver. Food Chem Toxicol 2001;39(2):109-17. PubMed
- Lee JJ, Jin YR, Lee JH, et al. Antiplatelet activity of carnosic acid, a phenolic diterpene from Rosmarinus officinalis. Planta Med 2007;73(2):121-7.
- Yamamoto J, Yamada K, Naemura A, et al. Testing various herbs for antithrombotic effect. Nutrition 2005;21(5):580-7. PubMed
- Naemura A, Ura M, Yamashita T, et al. Long-term intake of rosemary and common thyme herbs inhibits experimental thrombosis without prolongation of bleeding time. Thromb Res 2008;122(4):517-22. PubMed
- Lee JJ, Jin YR, Lim Y, et al. Antiplatelet activity of carnosol is mediated by the inhibition of TXA2 receptor and cytosolic calcium mobilization. Vascul Pharmacol 2006;45:148-53. PubMed
- Bakirel, T., Bakirel, U., Keles, O. U., Ulgen, S. G., and Yardibi, H. In vivo assessment of antidiabetic and antioxidant activities of rosemary (Rosmarinus officinalis) in alloxan-diabetic rabbits. J Ethnopharmacol 2-28-2008;116(1):64-73. PubMed
- Erenmemisoglu, A., Saraymen, R., and Ustun, S. Effect of a Rosmarinus officinalis leave extract on plasma glucose levels in normoglycaemic and diabetic mice. Pharmazie 1997;52(8):645-646.
- Valones MAA, Silva ICG, Gueiros LAM, Leão JC, Caldas AF Jr, Carvalho AAT. Clinical assessment of rosemary-based toothpaste (Rosmarinus officinalis Linn.): A randomized controlled double-blind study. Braz Dent J. 2019;30(2):146-151. PubMed
- Quirarte-Báez SM, Zamora-Perez AL, Reyes-Estrada CA, et al. A shortened treatment with rosemary tea (rosmarinus officinalis) instead of glucose in patients with diabetes mellitus type 2 (TSD). J Popul Ther Clin Pharmacol. 2019;26(4):e18-e28.
- Al Jamal A. Effect of rosemary (Rosmarinus officinalis) on lipid profiles and blood glucose in human diabetic patients (type-2). African J. Biochem. Res. 2014;8(8):147-50. DOI
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC