Indole-3-carbinol - Ethinyl Estradiol, Norethindrone Interaction
Herbal: Indole-3-carbinol
Drug: Ethinyl Estradiol, Norethindrone
Brand names:
Femhrt, Loestrin 21, Ovcon 35 21, Ovcon 50 28, Necon 0.5 35 21, Tri Norinyl 21 Day, Brevicon 21 Day, Ortho-Novum 7/7/7 28, Jenest-28, Necon 1 35 21, Norinyl 1 35 21 Day, Ortho Novum 1 Plus 35, Modicon, Nelova 10/11, Norethin 1/35E, Norethin 1/35, Nelova 1/35, Norlestrin, Brevicon, Nelova 0.5/35 E, Synphasic 21 day, Synphasic 28 day, Brevicon .5/35 21 day, Brevicon .5/35 28 day, Select 1/35 21 day, Brevicon 1/35 28 day, Select 1/35 28 day, Brevicon 1/35 21 day, Demulen, Ortho-Novum, Junel 1/20, Junel Fe 1/20, Junel 1.5/30, Loestrin 21 1/20, Microgestin 1/20, Microgestin 1.5/30, Ovcon-35, Ovcon-35 Chewable, Necon 0.5/35, Necon 1/35, Necon 10/11, Necon 7/7/7, Nortrel 0.5/35, Norinyl 1+35, Nortrel 1/35, Nortrel 7/7/7, Ortho-Novum 1/35, Ortho-Novum 10/11, Ortho-Novum 7/7/7, Ovcon-50, Gencept 10/11, Aranelle, Leena, Tri-Norinyl, Loestrin 20, Loestrin 21 1.5/30
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 18, 2025
Interaction Details
Ethinyl Estradiol, Norethindrone is classified as belonging to the following category: Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Animal research shows that indole-3-carbinol induces CYP1A2 enzymes.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- He YH, Friesen MD, Ruch RJ, Schut HA. Indole-3-carbinol as a chemopreventive agent in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) carcinogenesis: inhibition of PhIP-DNA adduct formation, acceleration of PhIP metabolism, and induction of cytoch
Interaction Details
Ethinyl Estradiol, Norethindrone is classified as belonging to the following category: Estrogens
Indole-3-carbinol might interfere with the effects of estrogen therapy.
Preliminary clinical and in vitro evidence shows that indole-3-carbinol has antiestrogenic activity.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Bell MC, Crowley-Nowick P, Bradlow HL, et al. Placebo-controlled trial of indole-3-carbinol in the treatment of CIN. Gynecol Oncol 2000;78:123-9.
- Kim, Y. S. and Milner, J. A. Targets for indole-3-carbinol in cancer prevention. J.Nutr.Biochem. 2005;16(2):65-73.
- Anon. Indole-3-carbinol. Monograph. Alternative Medicine Review 2005;10(4):337-42.
- McAlindon TE, Gulin J, Chen T, et al. Indole-3-carbinol in women with SLE: effect on estrogen metabolism and disease activity. Lupus 2001;10:779-83.
Indole-3-carbinol - More Interactions
Indole-3-carbinol interacts with 292 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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