Methyl Folate 1000 Ingredients & Drug Interactions
by ProCaps
What is this page for?
First and foremost: checking Methyl Folate 1000 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Methyl Folate 1000 is a dietary supplement by ProCaps with 4 active ingredients. Its ingredients are commonly taken for sleep quality and insomnia, relaxation, cognitive function.Based on those ingredients, 2 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Glycine, Lysine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Methyl Folate 1000 by ProCaps
Ask about any prescription or over-the-counter medication and we check it for interactions with Methyl Folate 1000 by ProCaps — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Methyl Folate 1000 by ProCaps
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Methyl Folate 1000 by ProCaps contains 4 active ingredients: glycine, leucine, lysine, and methyl folate. These are amino acids and a form of B vitamin (folate) that work together to support various functions in your body.
The capsule itself is made from gelatin.
Does it work?
Couldn't assess
Glycine has possibly effective evidence for schizophrenia, but evidence is insufficient to rate it for 3-PGDH deficiency, ADHD, benign prostatic hyperplasia, or cystic fibrosis. Lysine is possibly effective for cold sores.
Leucine and methyl folate effectiveness ratings are not on file in our data.
How safe is it?
Well-documented data
Glycine is generally well tolerated at typical doses, though long-term safety data are limited and supplement use in pregnancy and breastfeeding lacks enough reliable safety data — check with your doctor before using during pregnancy or while nursing. Rare side effects include mild sedation, irritability, insomnia, fatigue, memory issues, headache, soft stools, nausea, vomiting, and upper GI discomfort; these resolve quickly if you stop taking it.
Lysine is generally well tolerated at typical doses, but high amounts may cause stomach upset and long-term safety isn't well studied. There isn't enough reliable information on supplement use during breastfeeding.
In pregnancy, lysine from food is fine, but supplement safety is not well studied — check with your doctor first. The most common side effects are abdominal pain, diarrhea, and indigestion.
Meds to double-check
Moderate interaction found
If you take clozapine (Clozaril) for schizophrenia or any 5-HT4 agonist medication, clear this product with your doctor or pharmacist first. The interaction with clozapine is moderate and may worsen schizophrenia symptoms.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Methyl Folate 1000 may be worth considering if you're looking for amino acid and B-vitamin support, but if you take clozapine for schizophrenia or a 5-HT4 agonist for gut motility, you need to check with your doctor or pharmacist first — the interactions could affect how well your medication works. Pregnant or nursing?
Talk it over with your own healthcare provider before starting.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Methyl Folate 1000, straight from the product label.
| Brand | ProCaps |
|---|---|
| Barcode (UPC) | 712540 |
| Net contents | 240 Easy-To-Swallow Capsule(s) |
| Market status | On market |
| Date entered into DSLD | May 22, 2021 |
| DSLD ID | 248078 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Methyl Folate 1000 by ProCaps, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Glycine | 0 NP | -- |
| Leucine | 0 NP | -- |
| Lysine | 0 NP | -- |
| Amino Acids Complex | 150 mg | -- |
| Methyl Folate | 1000 mcg DFE | 250% |
Other ingredients: Gelatin Capsule
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested use consume one or more capsules daily or as recommended by your physician. As with any dietary supplement, this product is most effective as part of a healthy diet and active lifestyle. For questions about the use of this product call 800.332.7799.
Formulation
For over 40 years unsurpassed purity, quality and efficacy 100% solar production Zero carbon footprint
All solar
Although often mistakenly viewed as a secondary B-vitamin, Folic Acid is required for the body's most critical functions, such as all cell replication, repair and DNA synthesis, making it essential during pregnancy and to support the health of our body's most vital organs and systems (heart, brain and immune). Plus, Methyl Folate can cross the blood-brain barrier, where it can deliver its brain and mood supportive benefits directly to the nervous system. Folic Acid is the typical form of Vitamin B9 found in supplements and fortified foods, but it must be converted to 5-MTHF to deliver its benefits. Unfortunately, a substantial percentage of Americans cannot convert Folic Acid into its active form and are thus deprived of its vital benefits. Our Methyl Folate (5-MTHF) already exists in its active form and can deliver its benefits to everyone without requiring any difficult or impossible chemical conversion. In short, our Methyl Folate 1000 overcomes the all too common biochemical obstacles that prevent so many of us from enjoying the critical benefits of this essential B-vitamin.
Contains no additives or common allergens of any kind
General Statements
We remain uniquely committed to you and the planet. You have my unwavering promise. Andrew Lessman, founder Questions?/reorders? 800.800.1200 www.ProCapsLabs.com www.HSN.com 800.944.9999 www.QVC.com 800.345.1515
Formula
1,000 mcg Methyltetrahydrofolate-5-MTHF Naturally active form of Folic Acid
Andrew Lessman's Methyl Folate 1000 delivers 1,000 mcg of 5-methyltetrahydrofolate (5-MTHF or Methyl Folate) - the active form of Vitamin B9, an essential B-vitamin also known as Folic Acid.
FDA Statement of Identity
Dietary Supplement
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Precautions
Contains no additives or common allergens of any kind
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Methyl Folate 1000 by ProCaps label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Methyl Folate 1000 by ProCaps
These are the 4 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container240 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Other (inactive) ingredients: Gelatin Capsule. These complete the product’s ingredient list but are not active constituents.
Methyl Folate 1000 by ProCaps Drug Interactions
HelloPharmacist Interaction Report
Methyl Folate 1000 by ProCaps contains two ingredients with documented interactions: glycine and lysine.
The most serious concern is glycine's moderate interaction with clozapine (Clozaril), an antipsychotic medication used for schizophrenia. A small clinical study found that adding glycine to clozapine therapy worsened schizophrenia symptoms compared with clozapine alone, though the reason for this effect isn't fully understood.
Read the full breakdown — every affected drug type, severity by severity
Lysine carries a minor interaction with 5-HT4 agonists, a class of medications that boost serotonin activity in the gut. Animal research suggests lysine may reduce how well these drugs work, though human evidence is limited.
We could not check two ingredients in this product: leucine and methyl folate — we hold no interaction data for them. Altogether, these interactions span 2 individual medications.
If you take clozapine or a 5-HT4 agonist, run your exact medications through the checker below before starting this supplement.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Methyl Folate 1000?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Methyl Folate 1000 interact with 2 drugs. Click any drug to see the details.
2 of the 4 ingredients in Methyl Folate 1000 interact with drugs. Each result below shows which ingredient is responsible. Glycine Lysine
ClozapineClozaril, Versacloz
How Clozapine interacts with Methyl Folate 1000 — through 1 ingredient. Tap an ingredient for the detail:
GlycineClozapine (clozaril) Moderate
Interaction Summary
Theoretically, glycine might decrease the effectiveness of clozapine.
Read the full Glycine + Clozapine interactionTegaserodZelnorm
How Tegaserod interacts with Methyl Folate 1000 — through 1 ingredient. Tap an ingredient for the detail:
Lysine5-ht4 Agonists Minor
Interaction Summary
Theoretically, lysine may reduce the effects of 5-HT4 agonists.
Read the full Lysine + Tegaserod interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Methyl Folate 1000 with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Glycine
Clozapine (Clozaril)
Theoretically, glycine might decrease the effectiveness of clozapine.
One small clinical study in patients with schizophrenia shows that adding glycine to clozapine therapy worsens symptoms of schizophrenia when compared with clozapine alone. The mechanism of this interaction is unclear.
Lysine
5-Ht4 Agonists
Theoretically, lysine may reduce the effects of 5-HT4 agonists.
Animal research suggests that L-lysine is a partial serotonin receptor 4 (5-HT4) antagonist and inhibits diarrhea induced by the 5-HT4 agonist, 5-hydroxytryptophane.
Brand information
Manufacturer and brand details for Methyl Folate 1000, from the product label.
ProCaps
See all ProCaps products- Name
- ProCaps Labs
- City
- Henderson
- State
- NV
- ZipCode
- 89011
- Phone Number
- 800.800.1200
- Web Address
- www.ProCapsLabs.com
Methyl Folate 1000 by ProCaps: Common Questions
Does Methyl Folate 1000 by ProCaps interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is glycine safe to use long-term?
Can I take this if I'm pregnant?
What does lysine do?
What are the side effects of this product?
Can I take this while breastfeeding?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Methyl Folate 1000 is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Methyl Folate 1000’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Glycine
Interacts with 1 drugGlycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep quality, where early research is promisin...
Read the full Glycine monograph → Herb & supplement monographLysine
Interacts with 1 drugLysine is an essential amino acid your body cannot make on its own, so it must come from food or supplements. People most often take extra lysine to try to prevent or shorten cold sores, but...
Read the full Lysine monograph →Sources & How We Checked
Methyl Folate 1000's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 12 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Glycine 5 references
- Heresco-Levy U, Javitt DC, Ermilov M, et al. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry 1999;56:29-36.. PubMed
- Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry 1999;156:145-7.. PubMed
- Gusev EI, Skvortsova VI, Dambinova SA, et al. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovasc Dis 2000;10:49-60. PubMed
- Inagawa K, Kawai N, Ono K, Sukegawa E, Tsubuku S, Takahashi M. Assessment of acute adverse effects of glycine ingestion at a high dose in human volunteers. Seikatsu Eisei. 2006; 50:27-32.
- Woods SW, Walsh BC, Hawkins KA, Miller TJ, Saksa JR, D'Souza DC, Pearlson GD, Javitt DC, McGlashan TH, Krystal JH. Glycine treatment of the risk syndrome for psychosis: report of two pilot studies. Eur Neuropsychopharmacol. 2013 Aug;23(8):931-40. PubMed
Lysine 7 references
- Thein DJ, Hurt WC. Lysine as a prophylactic agent in the treatment of recurrent herpes simplex labialis. Oral Surg Oral Med Oral Pathol 1984;58:659-66. PubMed
- McCune MA, Perry HO, Muller SA, O'Fallon WM. Treatment of recurrent herpes simplex infections with L-lysine monohydrochloride. Cutis 1984;34:366-73.
- DiGiovanna JJ, Blank H. Failure of lysine in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Arch Dermatol 1984;120:48-51. DOI
- Milman N, Scheibel J, Jessen O. Lysine prophylaxis in recurrent herpes simplex labialis: a double-blind, controlled crossover study. Acta Derm Venereol 1980;60:85-7.
- Griffith RS, Walsh DE, Myrmel KH, et al. Success of L-lysine therapy in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Dermatologica 1987;175:183-90. DOI
- Lo JC, Chertow GM, Rennke H, Seifter JL. Fanconi's syndrome and tubulointerstitial nephritis in association with L-lysine ingestion. Am J Kidney Dis 1996;28:614-7. PubMed
- Smriga M, Torii K. L-Lysine acts like a partial serotonin receptor 4 antagonist and inhibits serotonin-mediated intestinal pathologies and anxiety in rats. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15370-5.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC