Mind Soother Lavender Ingredients & Drug Interactions
by Herb Pharm
What is this page for?
First and foremost: checking Mind Soother Lavender against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Mind Soother Lavender is a dietary supplement by Herb Pharm with 6 active ingredients. Its ingredients are commonly taken for anxiety and stress, sleep problems, relaxation and calming.Based on those ingredients, 1,279 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Kava Rhizome, Root Extract, Bacopa Aerial Parts Extract, Passionflower Aerial Parts Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Mind Soother Lavender by Herb Pharm
Ask about any prescription or over-the-counter medication and we check it for interactions with Mind Soother Lavender by Herb Pharm — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
Ask the Pharmacist
A licensed pharmacist will answer your question by email — free, usually within 24 hours.
Got it — thank you!
A licensed pharmacist will answer within 24 hours. Keep an eye on your email (worth checking spam, just in case).
HelloPharmacist Scorecard of Mind Soother Lavender by Herb Pharm
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Mind Soother Lavender contains 6 ingredients, including a proprietary extract blend. The active components are lavender flower extract and lavender essential oil (both forms of the same plant), kava rhizome and root extract, bacopa aerial parts extract, and passion flower aerial parts extract.
We could not check albizia bark extract, as we hold no data on file for it. The inactive ingredients are cane alcohol, distilled water, and glycerin.
Does it work?
Moderate evidence
The evidence for this product's ingredients is mixed and limited. Lavender has possibly effective evidence for dysmenorrhea (period pain) but is possibly ineffective for cancer-related pain; evidence is insufficient to rate it for alopecia areata, pre-procedural anxiety, and cancer-related fatigue.
Passion flower is possibly effective for insomnia and pre-procedural anxiety. For kava, the evidence for generalized anxiety disorder is possibly ineffective, and evidence is insufficient for insomnia, sexual arousal, and epilepsy.
Bacopa shows insufficient evidence for cognitive function, Alzheimer disease, ADHD, back pain, sexual dysfunction, and cognitive impairment. Overall, the evidence isn't established in our data for most of the uses these ingredients are marketed for.
How safe is it?
Well-documented data
Lavender is generally well tolerated, though the essential oil form is toxic if swallowed and can irritate skin in some people. Common side effects from oral use include headache, nausea, constipation, diarrhea, and breath odor.
Kava is generally well tolerated but has been linked to over 100 cases of liver injury, particularly with long-term use, and is banned or restricted in some countries. Common kava side effects include drowsiness, dizziness, dry mouth, headache, and memory problems; tremors were 3.2 times more common in one trial than placebo.
Bacopa is generally well tolerated in studies, though side effects in trials have included gastrointestinal upset (12-30% of users), headache, nausea, and drowsiness. Passion flower is well tolerated short-term but causes drowsiness; rare cases of severe nausea, vomiting, and heart rhythm changes have been reported.
Safety data for long-term use of this product is limited. The product contains alcohol (cane alcohol).
Meds to double-check
Major interaction found
Before taking this product, check with your pharmacist if you use any CNS depressants—sedatives, sleeping pills, anti-anxiety medications, or opioid pain relievers. Kava is the main concern here (Major severity with CNS depressants).
You should also double-check medications that are broken down by your liver through CYP2C19, CYP2C9, CYP2E1, or CYP3A4 pathways, as well as haloperidol, ropinirole, anticholinergic drugs, and cholinergic drugs. Do not use this product if you have liver disease or are pregnant or breastfeeding.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.
Mind Soother Lavender is designed for relaxation and sleep, but it contains kava and other CNS depressants that carry real interaction risks—especially with sedatives, anti-anxiety drugs, and pain medications. If you take any prescription medication or have liver concerns, talk to your pharmacist before starting this.
The evidence that it actually works for anxiety or sleep is mixed at best.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 5 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 24, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Mind Soother Lavender, straight from the product label.
| Brand | Herb Pharm |
|---|---|
| Barcode (UPC) | 090700004583 |
| Net contents | 4 Fluid Ounce(s); 120 mL |
| Market status | On market |
| Date entered into DSLD | Jul 24, 2025 |
| DSLD ID | 334858 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Mind Soother Lavender by Herb Pharm, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Extract Blend | 625 mg | -- |
| Albizia Bark Extract | 0 NP | -- |
| Lavender Flower Extract | 0 NP | -- |
| Kava Rhizome, Root Extract | 0 NP | -- |
| Bacopa Aerial Parts Extract | 0 NP | -- |
| Passionflower Aerial Parts Extract | 0 NP | -- |
| Lavender Essential Oil | 0 NP | -- |
Other ingredients: Cane Alcohol, Water, Distilled, Glycerin
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested use Shake well before using. Adults: Add 1 squeeze of the dropper bulb to 2 oz. of water or juice, 2 to 5 times per day. Best taken between meals.
Precautions
Caution: FDA advises that a potential risk of rare, but severe, liver injury may be associated with Kava. Stop use and see a doctor if liver symptoms occur (unusual fatigue, abdominal pain, appetite loss, dark urine, pale stools, yellow eyes or skin). Do not take with alcoholic beverages. Excessive use may briefly impair ability to drive or operate machinery.
Ask a healthcare professional before use if you have, or have had, liver problems, frequently use alcoholic beverages, or are taking any medication. Not for use by persons under 18 years of age, or by pregnant or breastfeeding women.
Not for use by persons under 18 years of age, or by pregnant or breastfeeding women. Keep Out of the Reach of Children.
Storage
Store away from heat & light.
Formulation
Nervous system
Gluten free
FDA Statement of Identity
Herbal Supplement
This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Mind Soother Lavender by Herb Pharm label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Mind Soother Lavender by Herb Pharm
These are the 6 active ingredients this product is made of. Select any to open its full monograph.
Serving size0.7 mL Dosage formLiquid Servings per container168 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Extract Blend
- › Albizia Bark Extract
- › Lavender Flower Extract
- › Kava Rhizome, Root Extract
- › Bacopa Aerial Parts Extract
- › Passionflower Aerial Parts Extract
- › Lavender Essential Oil
Other (inactive) ingredients: Cane Alcohol, Water, Distilled, Glycerin. These complete the product’s ingredient list but are not active constituents.
Mind Soother Lavender by Herb Pharm Drug Interactions
HelloPharmacist Interaction Report
Mind Soother Lavender by Herb Pharm contains several ingredients with documented interactions, so you'll want to check your medications before starting it.
The most serious concern is kava, which can have Major interactions with CNS depressants (drugs that slow your brain and nervous system) — combining them can cause additive sedation and impair motor control. CNS depressants include sedatives, sleep aids, anti-anxiety medications, and some pain relievers.
Read the full breakdown — every affected drug type, severity by severity
The product also contains kava, bacopa, and two forms of lavender, which all interact with a range of other drug types at Moderate or Minor severity. Kava specifically affects how your body metabolizes certain medications through several liver enzyme pathways (CYP2C19, CYP2C9, CYP2E1, and others) and may increase levels of drugs processed this way.
It also has documented interactions with haloperidol (an antipsychotic) and ropinirole (a Parkinson's medication). Bacopa theoretically affects multiple liver enzymes (CYP1A2, CYP2C19, CYP2C9, CYP3A4) and may interact with anticholinergic and cholinergic medications.
Passion flower and both lavender forms interact with CNS depressants at Moderate severity, and passion flower has Minor interactions with CYP3A4 substrates and certain transporter proteins. We could not check one ingredient, albizia bark extract, as we hold no data for it.
Altogether, these interactions span 1,258 individual medications. Use the search tool on this page to check your exact medications against this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Mind Soother Lavender?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Mind Soother Lavender interact with 1,279 drugs. Click any drug to see the details.
4 of the 6 ingredients in Mind Soother Lavender interact with drugs. Each result below shows which ingredient is responsible. Kava Rhizome, Root Extract Bacopa Aerial Parts Extract Passionflower Aerial Parts Extract Lavender Flower Extract
Belladonna Alkaloids, Ergotamine Tartrate, PhenobarbitalBel Tabs, Bellamine-S, Bellaphen-S, Duragal S, Phenarbal S, Spastrin
How Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital interacts with Mind Soother Lavender — through 4 ingredients. Tap an ingredient for the detail:
Kava Rhizome, Root ExtractCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates Major
Interaction Summary
Combining kava with CNS depressants can have additive sedative effects.
Read the full Kava Rhizome, Root Extract + Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital interactionPassionflower Aerial Parts ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
Read the full Passionflower Aerial Parts Extract + Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital interactionBacopa Aerial Parts ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Anticholinergic Drugs Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Bacopa Aerial Parts Extract + Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital interactionLavender Essential OilCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Lavender Essential Oil + Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital interactionBelladonna Alkaloids, PhenobarbitalBarbidonna, Donnatal
How Belladonna Alkaloids, Phenobarbital interacts with Mind Soother Lavender — through 4 ingredients. Tap an ingredient for the detail:
Kava Rhizome, Root ExtractCns Depressants Major
Interaction Summary
Combining kava with CNS depressants can have additive sedative effects.
Read the full Kava Rhizome, Root Extract + Belladonna Alkaloids, Phenobarbital interactionLavender Essential OilCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Lavender Essential Oil + Belladonna Alkaloids, Phenobarbital interactionBacopa Aerial Parts ExtractAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, concurrent use might decrease the effectiveness of both agents.
Read the full Bacopa Aerial Parts Extract + Belladonna Alkaloids, Phenobarbital interactionPassionflower Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Aerial Parts Extract + Belladonna Alkaloids, Phenobarbital interactionBelladonna Extract, PhenobarbitalBelap
How Belladonna Extract, Phenobarbital interacts with Mind Soother Lavender — through 4 ingredients. Tap an ingredient for the detail:
Kava Rhizome, Root ExtractCns Depressants Major
Interaction Summary
Combining kava with CNS depressants can have additive sedative effects.
Read the full Kava Rhizome, Root Extract + Belladonna Extract, Phenobarbital interactionBacopa Aerial Parts ExtractAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, concurrent use might decrease the effectiveness of both agents.
Read the full Bacopa Aerial Parts Extract + Belladonna Extract, Phenobarbital interactionLavender Essential OilCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Lavender Essential Oil + Belladonna Extract, Phenobarbital interactionPassionflower Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Aerial Parts Extract + Belladonna Extract, Phenobarbital interactionBelladonna, Caffeine, Ergotamine, PentobarbitalMicomp PB
How Belladonna, Caffeine, Ergotamine, Pentobarbital interacts with Mind Soother Lavender — through 4 ingredients. Tap an ingredient for the detail:
Kava Rhizome, Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cns Depressants +1 Major
Interaction Summary
It is unclear if kava inhibits CYP1A2; research is conflicting.
Read the full Kava Rhizome, Root Extract + Belladonna, Caffeine, Ergotamine, Pentobarbital interactionPassionflower Aerial Parts ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
Read the full Passionflower Aerial Parts Extract + Belladonna, Caffeine, Ergotamine, Pentobarbital interactionLavender Essential OilCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Lavender Essential Oil + Belladonna, Caffeine, Ergotamine, Pentobarbital interactionBacopa Aerial Parts ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Anticholinergic Drugs +1 Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Bacopa Aerial Parts Extract + Belladonna, Caffeine, Ergotamine, Pentobarbital interactionBelladonna, Ergotamine Tartrate, Phenobarbital
How Belladonna, Ergotamine Tartrate, Phenobarbital interacts with Mind Soother Lavender — through 4 ingredients. Tap an ingredient for the detail:
Kava Rhizome, Root ExtractCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates Major
Interaction Summary
Combining kava with CNS depressants can have additive sedative effects.
Read the full Kava Rhizome, Root Extract + Belladonna, Ergotamine Tartrate, Phenobarbital interactionLavender Essential OilCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Lavender Essential Oil + Belladonna, Ergotamine Tartrate, Phenobarbital interactionBacopa Aerial Parts ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Anticholinergic Drugs Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Bacopa Aerial Parts Extract + Belladonna, Ergotamine Tartrate, Phenobarbital interactionPassionflower Aerial Parts ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
Read the full Passionflower Aerial Parts Extract + Belladonna, Ergotamine Tartrate, Phenobarbital interactionBelladonna, Ergotamine, PhenobarbitalBellergal-S
How Belladonna, Ergotamine, Phenobarbital interacts with Mind Soother Lavender — through 4 ingredients. Tap an ingredient for the detail:
Kava Rhizome, Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants Major
Interaction Summary
It is unclear if kava inhibits CYP3AA; research is conflicting.
Read the full Kava Rhizome, Root Extract + Belladonna, Ergotamine, Phenobarbital interactionBacopa Aerial Parts ExtractAnticholinergic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concurrent use might decrease the effectiveness of both agents.
Read the full Bacopa Aerial Parts Extract + Belladonna, Ergotamine, Phenobarbital interactionLavender Essential OilCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Lavender Essential Oil + Belladonna, Ergotamine, Phenobarbital interactionPassionflower Aerial Parts ExtractCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Aerial Parts Extract + Belladonna, Ergotamine, Phenobarbital interactionBelladonna, OpiumB & O Supprettes
How Belladonna, Opium interacts with Mind Soother Lavender — through 4 ingredients. Tap an ingredient for the detail:
Kava Rhizome, Root ExtractCns Depressants Major
Interaction Summary
Combining kava with CNS depressants can have additive sedative effects.
Read the full Kava Rhizome, Root Extract + Belladonna, Opium interactionPassionflower Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Aerial Parts Extract + Belladonna, Opium interactionBacopa Aerial Parts ExtractAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, concurrent use might decrease the effectiveness of both agents.
Read the full Bacopa Aerial Parts Extract + Belladonna, Opium interactionLavender Essential OilCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Lavender Essential Oil + Belladonna, Opium interactionBelladonna, PhenobarbitalBellophen, Susano
How Belladonna, Phenobarbital interacts with Mind Soother Lavender — through 4 ingredients. Tap an ingredient for the detail:
Kava Rhizome, Root ExtractCns Depressants Major
Interaction Summary
Combining kava with CNS depressants can have additive sedative effects.
Read the full Kava Rhizome, Root Extract + Belladonna, Phenobarbital interactionLavender Essential OilCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Lavender Essential Oil + Belladonna, Phenobarbital interactionBacopa Aerial Parts ExtractAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, concurrent use might decrease the effectiveness of both agents.
Read the full Bacopa Aerial Parts Extract + Belladonna, Phenobarbital interactionPassionflower Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Aerial Parts Extract + Belladonna, Phenobarbital interactionBellafoline, Caffeine, Ergotamine Tartrate, PentobarbitalCafergot PB
How Bellafoline, Caffeine, Ergotamine Tartrate, Pentobarbital interacts with Mind Soother Lavender — through 4 ingredients. Tap an ingredient for the detail:
Kava Rhizome, Root ExtractCns Depressants, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Major
Interaction Summary
Combining kava with CNS depressants can have additive sedative effects.
Read the full Kava Rhizome, Root Extract + Bellafoline, Caffeine, Ergotamine Tartrate, Pentobarbital interactionPassionflower Aerial Parts ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
Read the full Passionflower Aerial Parts Extract + Bellafoline, Caffeine, Ergotamine Tartrate, Pentobarbital interactionBacopa Aerial Parts ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP1A2 substrates.
Read the full Bacopa Aerial Parts Extract + Bellafoline, Caffeine, Ergotamine Tartrate, Pentobarbital interactionLavender Essential OilCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Lavender Essential Oil + Bellafoline, Caffeine, Ergotamine Tartrate, Pentobarbital interactionBellafoline, PhenobarbitalBelladenal, Belladenal-S
How Bellafoline, Phenobarbital interacts with Mind Soother Lavender — through 3 ingredients. Tap an ingredient for the detail:
Kava Rhizome, Root ExtractCns Depressants Major
Interaction Summary
Combining kava with CNS depressants can have additive sedative effects.
Read the full Kava Rhizome, Root Extract + Bellafoline, Phenobarbital interactionPassionflower Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Aerial Parts Extract + Bellafoline, Phenobarbital interactionLavender Essential OilCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Lavender Essential Oil + Bellafoline, Phenobarbital interactionBenactyzine, MeprobamateDeprol
How Benactyzine, Meprobamate interacts with Mind Soother Lavender — through 3 ingredients. Tap an ingredient for the detail:
Kava Rhizome, Root ExtractCns Depressants Major
Interaction Summary
Combining kava with CNS depressants can have additive sedative effects.
Read the full Kava Rhizome, Root Extract + Benactyzine, Meprobamate interactionLavender Essential OilCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Lavender Essential Oil + Benactyzine, Meprobamate interactionPassionflower Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Aerial Parts Extract + Benactyzine, Meprobamate interactionBenzhydrocodone, AcetaminophenApadaz
How Benzhydrocodone, Acetaminophen interacts with Mind Soother Lavender — through 4 ingredients. Tap an ingredient for the detail:
Kava Rhizome, Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +4 Major
Interaction Summary
It is unclear if kava inhibits CYP1A2; research is conflicting.
Read the full Kava Rhizome, Root Extract + Benzhydrocodone, Acetaminophen interactionPassionflower Aerial Parts ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
Read the full Passionflower Aerial Parts Extract + Benzhydrocodone, Acetaminophen interactionBacopa Aerial Parts ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Anticholinergic Drugs +1 Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP1A2 substrates.
Read the full Bacopa Aerial Parts Extract + Benzhydrocodone, Acetaminophen interactionLavender Essential OilCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Lavender Essential Oil + Benzhydrocodone, Acetaminophen interactionBrexanoloneZulresso
How Brexanolone interacts with Mind Soother Lavender — through 3 ingredients. Tap an ingredient for the detail:
Kava Rhizome, Root ExtractCns Depressants Major
Interaction Summary
Combining kava with CNS depressants can have additive sedative effects.
Read the full Kava Rhizome, Root Extract + Brexanolone interactionPassionflower Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Aerial Parts Extract + Brexanolone interactionLavender Essential OilCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Lavender Essential Oil + Brexanolone interactionBromazepamLectopam
How Bromazepam interacts with Mind Soother Lavender — through 3 ingredients. Tap an ingredient for the detail:
Kava Rhizome, Root ExtractCns Depressants Major
Interaction Summary
Combining kava with CNS depressants can have additive sedative effects.
Read the full Kava Rhizome, Root Extract + Bromazepam interactionPassionflower Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Aerial Parts Extract + Bromazepam interactionLavender Essential OilCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Lavender Essential Oil + Bromazepam interactionBuprenorphineBrixadi, Butrans, Sublocade, Subutex
How Buprenorphine interacts with Mind Soother Lavender — through 4 ingredients. Tap an ingredient for the detail:
Kava Rhizome, Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants Major
Interaction Summary
It is unclear if kava inhibits CYP3AA; research is conflicting.
Read the full Kava Rhizome, Root Extract + Buprenorphine interactionPassionflower Aerial Parts ExtractCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Aerial Parts Extract + Buprenorphine interactionBacopa Aerial Parts ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Bacopa Aerial Parts Extract + Buprenorphine interactionLavender Essential OilCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Lavender Essential Oil + Buprenorphine interactionBuprenorphine HydrochlorideBelbuca, Probuphine
How Buprenorphine Hydrochloride interacts with Mind Soother Lavender — through 4 ingredients. Tap an ingredient for the detail:
Kava Rhizome, Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants Major
Interaction Summary
It is unclear if kava inhibits CYP3AA; research is conflicting.
Read the full Kava Rhizome, Root Extract + Buprenorphine Hydrochloride interactionLavender Essential OilCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Lavender Essential Oil + Buprenorphine Hydrochloride interactionBacopa Aerial Parts ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Bacopa Aerial Parts Extract + Buprenorphine Hydrochloride interactionPassionflower Aerial Parts ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
Read the full Passionflower Aerial Parts Extract + Buprenorphine Hydrochloride interactionBuprenorphine Hydrochloride, Naloxone HydrochlorideBunavail
How Buprenorphine Hydrochloride, Naloxone Hydrochloride interacts with Mind Soother Lavender — through 4 ingredients. Tap an ingredient for the detail:
Kava Rhizome, Root ExtractCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates Major
Interaction Summary
Combining kava with CNS depressants can have additive sedative effects.
Read the full Kava Rhizome, Root Extract + Buprenorphine Hydrochloride, Naloxone Hydrochloride interactionPassionflower Aerial Parts ExtractCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Aerial Parts Extract + Buprenorphine Hydrochloride, Naloxone Hydrochloride interactionBacopa Aerial Parts ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Bacopa Aerial Parts Extract + Buprenorphine Hydrochloride, Naloxone Hydrochloride interactionLavender Essential OilCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Lavender Essential Oil + Buprenorphine Hydrochloride, Naloxone Hydrochloride interactionBuprenorphine, NaloxoneCassipa, Zubsolv
How Buprenorphine, Naloxone interacts with Mind Soother Lavender — through 4 ingredients. Tap an ingredient for the detail:
Kava Rhizome, Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants Major
Interaction Summary
It is unclear if kava inhibits CYP3AA; research is conflicting.
Read the full Kava Rhizome, Root Extract + Buprenorphine, Naloxone interactionPassionflower Aerial Parts ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
Read the full Passionflower Aerial Parts Extract + Buprenorphine, Naloxone interactionLavender Essential OilCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Lavender Essential Oil + Buprenorphine, Naloxone interactionBacopa Aerial Parts ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Bacopa Aerial Parts Extract + Buprenorphine, Naloxone interactionBuprenorphine/naloxoneSuboxone
How Buprenorphine/naloxone interacts with Mind Soother Lavender — through 4 ingredients. Tap an ingredient for the detail:
Kava Rhizome, Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants Major
Interaction Summary
It is unclear if kava inhibits CYP3AA; research is conflicting.
Read the full Kava Rhizome, Root Extract + Buprenorphine/naloxone interactionLavender Essential OilCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Lavender Essential Oil + Buprenorphine/naloxone interactionBacopa Aerial Parts ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Bacopa Aerial Parts Extract + Buprenorphine/naloxone interactionPassionflower Aerial Parts ExtractCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Aerial Parts Extract + Buprenorphine/naloxone interactionButabarbital SodiumButisol Sodium, Sarisol #2
How Butabarbital Sodium interacts with Mind Soother Lavender — through 3 ingredients. Tap an ingredient for the detail:
Kava Rhizome, Root ExtractCns Depressants Major
Interaction Summary
Combining kava with CNS depressants can have additive sedative effects.
Read the full Kava Rhizome, Root Extract + Butabarbital Sodium interactionPassionflower Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Aerial Parts Extract + Butabarbital Sodium interactionLavender Essential OilCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Lavender Essential Oil + Butabarbital Sodium interactionButabarbital, Phenobarbital, SecobarbitalS.B.P.
How Butabarbital, Phenobarbital, Secobarbital interacts with Mind Soother Lavender — through 3 ingredients. Tap an ingredient for the detail:
Kava Rhizome, Root ExtractCns Depressants Major
Interaction Summary
Combining kava with CNS depressants can have additive sedative effects.
Read the full Kava Rhizome, Root Extract + Butabarbital, Phenobarbital, Secobarbital interactionLavender Essential OilCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Lavender Essential Oil + Butabarbital, Phenobarbital, Secobarbital interactionPassionflower Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Aerial Parts Extract + Butabarbital, Phenobarbital, Secobarbital interactionButalbital, Phenobarbital, SecobarbitalTribarb
How Butalbital, Phenobarbital, Secobarbital interacts with Mind Soother Lavender — through 3 ingredients. Tap an ingredient for the detail:
Kava Rhizome, Root ExtractCns Depressants Major
Interaction Summary
Combining kava with CNS depressants can have additive sedative effects.
Read the full Kava Rhizome, Root Extract + Butalbital, Phenobarbital, Secobarbital interactionPassionflower Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Aerial Parts Extract + Butalbital, Phenobarbital, Secobarbital interactionLavender Essential OilCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Lavender Essential Oil + Butalbital, Phenobarbital, Secobarbital interactionButorphanolStadol
How Butorphanol interacts with Mind Soother Lavender — through 3 ingredients. Tap an ingredient for the detail:
Kava Rhizome, Root ExtractCns Depressants Major
Interaction Summary
Combining kava with CNS depressants can have additive sedative effects.
Read the full Kava Rhizome, Root Extract + Butorphanol interactionLavender Essential OilCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Lavender Essential Oil + Butorphanol interactionPassionflower Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Aerial Parts Extract + Butorphanol interactionCaffeine, Diphenhydramine, Ergotamine (prescription Drug)Ergodryl
How Caffeine, Diphenhydramine, Ergotamine (prescription Drug) interacts with Mind Soother Lavender — through 4 ingredients. Tap an ingredient for the detail:
Kava Rhizome, Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Major
Interaction Summary
It is unclear if kava inhibits CYP3AA; research is conflicting.
Read the full Kava Rhizome, Root Extract + Caffeine, Diphenhydramine, Ergotamine (prescription Drug) interactionPassionflower Aerial Parts ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
Read the full Passionflower Aerial Parts Extract + Caffeine, Diphenhydramine, Ergotamine (prescription Drug) interactionBacopa Aerial Parts ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Anticholinergic Drugs +1 Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Bacopa Aerial Parts Extract + Caffeine, Diphenhydramine, Ergotamine (prescription Drug) interactionLavender Essential OilCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Lavender Essential Oil + Caffeine, Diphenhydramine, Ergotamine (prescription Drug) interactionCamphor, Hyoscyamine, Passif, Phenobarbital, Scopolamine, ValerianNevrotose #3
How Camphor, Hyoscyamine, Passif, Phenobarbital, Scopolamine, Valerian interacts with Mind Soother Lavender — through 4 ingredients. Tap an ingredient for the detail:
Kava Rhizome, Root ExtractCns Depressants Major
Interaction Summary
Combining kava with CNS depressants can have additive sedative effects.
Read the full Kava Rhizome, Root Extract + Camphor, Hyoscyamine, Passif, Phenobarbital, Scopolamine, Valerian interactionPassionflower Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Aerial Parts Extract + Camphor, Hyoscyamine, Passif, Phenobarbital, Scopolamine, Valerian interactionBacopa Aerial Parts ExtractAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, concurrent use might decrease the effectiveness of both agents.
Read the full Bacopa Aerial Parts Extract + Camphor, Hyoscyamine, Passif, Phenobarbital, Scopolamine, Valerian interactionLavender Essential OilCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Lavender Essential Oil + Camphor, Hyoscyamine, Passif, Phenobarbital, Scopolamine, Valerian interactionCannabidiol (prescription Drug)Epidiolex
How Cannabidiol (prescription Drug) interacts with Mind Soother Lavender — through 4 ingredients. Tap an ingredient for the detail:
Kava Rhizome, Root ExtractCns Depressants, Cytochrome P450 2c19 (cyp2c19) Substrates +2 Major
Interaction Summary
Combining kava with CNS depressants can have additive sedative effects.
Read the full Kava Rhizome, Root Extract + Cannabidiol (prescription Drug) interactionLavender Essential OilCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Lavender Essential Oil + Cannabidiol (prescription Drug) interactionBacopa Aerial Parts ExtractCytochrome P450 2c19 (cyp2c19) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP2C19 substrates.
Read the full Bacopa Aerial Parts Extract + Cannabidiol (prescription Drug) interactionPassionflower Aerial Parts ExtractCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Aerial Parts Extract + Cannabidiol (prescription Drug) interactionCarbamazepineCarbatrol, Carnexiv, Equetro, Tegretol, Tegretol XR
How Carbamazepine interacts with Mind Soother Lavender — through 4 ingredients. Tap an ingredient for the detail:
Kava Rhizome, Root ExtractCns Depressants, Hepatotoxic Drugs +1 Major
Interaction Summary
Combining kava with CNS depressants can have additive sedative effects.
Read the full Kava Rhizome, Root Extract + Carbamazepine interactionLavender Essential OilCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Lavender Essential Oil + Carbamazepine interactionPassionflower Aerial Parts ExtractCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Aerial Parts Extract + Carbamazepine interactionBacopa Aerial Parts ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Bacopa Aerial Parts Extract + Carbamazepine interactionCelecoxib, TramadolSeglentis
How Celecoxib, Tramadol interacts with Mind Soother Lavender — through 4 ingredients. Tap an ingredient for the detail:
Kava Rhizome, Root ExtractCytochrome P450 2c9 (cyp2c9) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Major
Interaction Summary
Theoretically, kava might increase levels of CYP2C9 substrates.
Read the full Kava Rhizome, Root Extract + Celecoxib, Tramadol interactionPassionflower Aerial Parts ExtractCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Aerial Parts Extract + Celecoxib, Tramadol interactionBacopa Aerial Parts ExtractCytochrome P450 2c9 (cyp2c9) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, bacopa might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Bacopa Aerial Parts Extract + Celecoxib, Tramadol interactionLavender Essential OilCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Lavender Essential Oil + Celecoxib, Tramadol interactionCenobamateXcopri
How Cenobamate interacts with Mind Soother Lavender — through 3 ingredients. Tap an ingredient for the detail:
Kava Rhizome, Root ExtractCns Depressants Major
Interaction Summary
Combining kava with CNS depressants can have additive sedative effects.
Read the full Kava Rhizome, Root Extract + Cenobamate interactionPassionflower Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Aerial Parts Extract + Cenobamate interactionLavender Essential OilCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Lavender Essential Oil + Cenobamate interactionCetirizineCetirizine, Quzyttir, Zyrtec
How Cetirizine interacts with Mind Soother Lavender — through 3 ingredients. Tap an ingredient for the detail:
Kava Rhizome, Root ExtractCns Depressants Major
Interaction Summary
Combining kava with CNS depressants can have additive sedative effects.
Read the full Kava Rhizome, Root Extract + Cetirizine interactionPassionflower Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Aerial Parts Extract + Cetirizine interactionLavender Essential OilCns Depressants Moderate
Interaction Summary
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Read the full Lavender Essential Oil + Cetirizine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Mind Soother Lavender with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Kava Rhizome, Root Extract
Cns Depressants
Combining kava with CNS depressants can have additive sedative effects.
Kava has CNS depressant effects. Concomitant use of kava with other CNS depressants can increase the risk of drowsiness and motor reflex depression. Clinical practice guidelines from a joint taskforce of the World Federation of Societies of Biological Psychiatry (WFSBP) and the Canadian Network for Mood and Anxiety Treatments (CANMAT) recommend that CNS depressants, including alcohol and benzodiazepines, not be used with kava.
Alcohol (Ethanol)
Combining kava with alcohol may increase the risk of sedation and/or hepatotoxicity.
Kava has CNS depressant effects. Concomitant use of kava with other CNS depressants can increase the risk of drowsiness and motor reflex depression. Additionally, kava has been associated with over 100 cases of hepatotoxicity. There is some concern that kava can adversely affect the liver, especially when used in combination with hepatotoxic drugs. Clinical practice guidelines from a joint taskforce of the World Federation of Societies of Biological Psychiatry (WFSBP) and the Canadian Network for Mood and Anxiety Treatments (CANMAT) recommend that alcohol not be used with kava.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, kava might increase levels of CYP2C19 substrates.
In vitro research shows that kava significantly inhibits CYP2C19 enzymes. This effect has not yet been reported in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, kava might increase levels of CYP2C9 substrates.
In vitro research shows that kava significantly inhibits CYP2C9 enzymes. This effect has not yet been reported in humans.
Cytochrome P450 2E1 (Cyp2E1) Substrates
Kava might increase levels of CYP2E1 substrates.
In a clinical study in healthy volunteers, taking kava 1000 mg twice daily (containing a daily dose of 138 mg kavalactones) for 28 days inhibited the metabolism of CYP2E1 substrates.
Haloperidol (Haldol)
Combining kava and haloperidol might increase the risk of cardiovascular adverse effects and hypoxia.
Atrial flutter and hypoxia has been reported for a patient who received intramuscular injections of haloperidol and lorazepam after using kava orally. The side effects were attributed to kava-induced inhibition of CYP2D6, but might also have been related to additive adverse effects with the concomitant use of haloperidol, lorazepam, and kava.
Hepatotoxic Drugs
Theoretically, using kava with hepatotoxic drugs might increase the risk of liver damage.
Kava has been linked with over 100 cases of hepatotoxicity. Most cases occur with excessive and prolonged use. There is some concern that kava can adversely affect the liver, especially when used in combination with hepatotoxic drugs.
P-Glycoprotein Substrates
It is unclear if kava inhibits P-glycoprotein (P-gp); research is conflicting.
In vitro research shows that kava can inhibit P-gp efflux. However, a clinical study in healthy volunteers shows that taking kava standardized to provide 225 mg kavalactones daily for 14 days does not affect the pharmacokinetics of digoxin, a P-gp substrate. It is possible that the use of other P-gp substrates or higher doses of kava might still inhibit P-gp.
Ropinirole (Requip)
Taking kava with ropinirole might increase the risk for dopaminergic toxicity.
A case of visual hallucinations and paranoid delusions has been reported for a patient who used kava in combination with ropinirole. The adverse effects were attributed to kava-induced inhibition of CYP1A2, which may have reduced the metabolism of ropinirole, resulting in excessive dopaminergic stimulation.
Cytochrome P450 1A2 (Cyp1A2) Substrates
It is unclear if kava inhibits CYP1A2; research is conflicting.
Although in vitro research and a case report suggest that kava inhibits CYP1A2, more robust clinical evidence shows that kava has no effect on CYP1A2. In a clinical study in healthy volunteers, taking kava 1000 mg twice daily (containing a daily dose of 138 mg kavalactones) for 28 days had no effect on CYP1A2 activity.
Cytochrome P450 2D6 (Cyp2D6) Substrates
It is unclear if kava inhibits CYP1A2; research is conflicting.
In vitro research shows that kava extract significantly inhibits CYP2D6. However, clinical research shows that kava does not affect the metabolism of CYP2D6 substrates in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
It is unclear if kava inhibits CYP3AA; research is conflicting.
Although in vitro research suggests that kava inhibits CYP3A4, more robust clinical evidence shows that kava has no effect on CYP3A4. In a clinical study in healthy volunteers, taking kava 1000 mg twice daily (containing a daily dose of 138 mg kavalactones) for 28 days had no effect on CYP3A4 activity.
Bacopa Aerial Parts Extract
Anticholinergic Drugs
Theoretically, concurrent use might decrease the effectiveness of both agents.
Bacopa seems to inhibit acetylcholinesterase and might increase acetylcholine levels, which could counteract the effects of anticholinergic drugs. Similarly, anticholinergic drugs might counteract the cholinergic effects of bacopa.
Cevimeline (Evoxac)
Theoretically, bacopa might increase the effects and adverse effects of cevimeline.
In one case, a 58-year-old female taking cevimeline long-term for Sjogren syndrome experienced hyperhidrosis, malaise, nausea, and tachycardia shortly after taking a single dose of bacopa. Symptoms resolved after two days. Cevimeline is metabolized by cytochrome P450 (CYP) 2D6 and CYP3A4, and researchers theorize that bacopa may have inhibited these isoenzymes. However, it is unclear if bacopa causes clinically significant inhibition of either CYP2D6 or CYP3A4.
Cholinergic Drugs
Theoretically, concurrent use of bacopa with other cholinergic drugs might have additive effects.
Bacopa seems to inhibit acetylcholinesterase and might increase acetylcholine levels. Theoretically, this could result in additive cholinergic effects when used with cholinergic drugs.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, bacopa might increase the levels and adverse effects of CYP1A2 substrates.
Research on the effects of bacopa extracts on CYP1A2 enzymes is conflicting. Some in vitro evidence shows that bacopa extract can moderately and non-competitively inhibit CYP1A2, while other in vitro evidence suggests that any effect is unlikely to be clinically significant.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, bacopa might increase the levels and adverse effects of CYP2C19 substrates.
In vitro evidence suggests that bacopa extract can moderately and non-competitively inhibit CYP2C19 enzymes. It is not known whether this is clinically significant.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, bacopa might increase the levels and adverse effects of CYP2C9 substrates.
Research on the effect of bacopa extracts on CYP2C9 enzymes is conflicting. Some in vitro evidence suggests that bacopa extract can moderately and non-competitively inhibit CYP2C9, while other in vitro evidence suggests that any effect is unlikely to be clinically significant.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, bacopa might increase the levels and adverse effects of CYP3A4 substrates.
Research on the effects of bacopa extracts on CYP3A4 enzymes is conflicting. Some in vitro evidence suggests that bacopa extract can moderately and competitively inhibit CYP3A4, while other in vitro evidence suggests that any effect is unlikely to be clinically significant.
Thyroid Hormone
Theoretically, bacopa might have additive effects when used with thyroid hormone.
Animal research suggests that bacopa increases thyroxine (T4) levels in mice by about 40%.
Passionflower Aerial Parts Extract
Cns Depressants
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Research in animals and humans shows that passion flower has sedative effects which can be additive when used with sedative medications like lorazepam.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
In vitro research suggests that passion flower can induce CYP3A4 enzymes, albeit to a much lower degree than rifampin, a known CYP3A4 inducer.
Organic Anion-Transporting Polypeptide Substrates (Oatp)
Theoretically, passion flower might reduce the bioavailability of OATP2B1 and OATP1A2 substrates.
In vitro research shows that the passion flower constituents apigenin and vitexin inhibit OATP2B1 and OATP1A2. This inhibition may be dose-dependent. One specific high-flavonoid passion flower extract (Valverde) seems to inhibit OATP2B1 and OATP1A2, while another extract with a lower flavonoid concentration (Arkocaps) shows less potent inhibition. OATPs are responsible for the uptake of drugs and other compounds into the body; however, the specific activities of OATP2B1 and OATP1A2 are not well characterized.
Lavender Flower Extract
Cns Depressants
Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Laboratory research suggests that lavender has sedative effects. However, clinical studies in patients taking oral lavender oil (Silexan) 160 mg for 10 weeks or taking lavender flower powder 1 gram daily for 2 months have not reported side effects of drowsiness, sedation, or sleepiness. There is still some concern that higher doses or different preparations of lavender might have additive effects with CNS depressant medications.
Brand information
Manufacturer and brand details for Mind Soother Lavender, from the product label.
Herb Pharm
See all Herb Pharm products- Name
- Herb Pharm
- City
- Williams
- State
- OR
- ZipCode
- 97544
- Phone Number
- 800-348-4372
- Web Address
- www.herb-pharm.com
Mind Soother Lavender by Herb Pharm: Common Questions
Does Mind Soother Lavender by Herb Pharm interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is it safe to take this while I'm pregnant or breastfeeding?
What are the most common side effects?
Does this product actually work for anxiety or sleep?
Why does it contain alcohol?
What's kava, and why is it a concern?
Can I use this with my blood pressure or heart medication?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Mind Soother Lavender is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Mind Soother Lavender’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Lavender
Interacts with 248 drugsLavender is a fragrant herb most popular for promoting relaxation, easing anxiety, and supporting sleep, with some encouraging evidence for a standardized oral lavender oil product for anxie...
Read the full Lavender monograph → Herb & supplement monographKava
Interacts with 1,166 drugsKava is a Pacific Island plant traditionally used to promote relaxation and ease anxiety, and some studies suggest it may help mild anxiety. However, kava has been linked to rare but serious...
Read the full Kava monograph → Herb & supplement monographBacopa
Interacts with 930 drugsBacopa is an Ayurvedic herb most often used for memory and thinking. Some small studies suggest it may modestly help memory when taken regularly for several weeks, but the evidence is limite...
Read the full Bacopa monograph → Herb & supplement monographPassion Flower
Interacts with 836 drugsPassion flower is a traditional calming herb that many people use for anxiety and sleep. Early studies hint it may help with mild anxiety and restlessness, but the evidence is limited and mo...
Read the full Passion Flower monograph →Sources & How We Checked
Mind Soother Lavender's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 122 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Lavender 20 references
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
- Akhondzadeh S, Kashani L, Fotouhi A, et al. Comparison of Lavandula angustifolia Mill. tincture and imipramine in the treatment of mild to moderate depression: a double-blind, randomized trial. Prog Neuropsychopharmacol Biol Psychiatry 2003;27:123-7. PubMed
- Varma S, Blackford S, Statham BN, Blackwell A. Combined contact allergy to tea tree oil and lavender oil complicating chronic vulvovaginitis. Contact Dermatitis 2000;42:309-10.
- Coulson IH and Khan AS. Facial 'pillow' dermatitis due to lavender oil allergy. Contact Dermatitis 1999;41(2):111. PubMed
- Woelk, H. and Schlafke, S. A multi-center, double-blind, randomised study of the Lavender oil preparation Silexan in comparison to Lorazepam for generalized anxiety disorder. Phytomedicine. 2010;17(2):94-99. PubMed
- Kasper, S., Gastpar, M., Muller, W. E., Volz, H. P., Moller, H. J., Dienel, A., and Schlafke, S. Silexan, an orally administered Lavandula oil preparation, is effective in the treatment of 'subsyndromal' anxiety disorder: a randomized, double-blind, plac
- Uehleke, B., Schaper, S., Dienel, A., Schlaefke, S., and Stange, R. Phase II trial on the effects of Silexan in patients with neurasthenia, post-traumatic stress disorder or somatization disorder. Phytomedicine. 6-15-2012;19(8-9):665-671. PubMed
- Brandao FM. Occupational allergy to lavender oil. Contact Dermatitis 1986;15(4):249-250. PubMed
- Rademaker M. Allergic contact dermatitis from lavender fragrance in Difflam gel. Contact Dermatitis 1994;31(1):58-59. PubMed
- Kasper S, Gastpar M, Müller WE, et al. Lavender oil preparation Silexan is effective in generalized anxiety disorder--a randomized, double-blind comparison to placebo and paroxetine. Int J Neuropsychopharmacol. 2014 Jun;17(6):859-69. PubMed
- Farshbaf-Khalili A, Kamalifard M, Namadian M. Comparison of the effect of lavender and bitter orange on anxiety in postmenopausal women: A triple-blind, randomized, controlled clinical trial. Complement Ther Clin Pract 2018;31:132-8. PubMed
- Bingham LJ, Tam MM, Palmer AM, Cahill JL, Nixon RL. Contact allergy and allergic contact dermatitis caused by lavender: A retrospective study from an Australian clinic. Contact Dermatitis. 2019;81(1):37-42. PubMed
- Donelli D, Antonelli M, Bellinazzi C, Gensini GF, Firenzuoli F. Effects of lavender on anxiety: A systematic review and meta-analysis. Phytomedicine. 2019;65:153099. PubMed
- Firoozeei TS, Feizi A, Rezaeizadeh H, Zargaran A, Roohafza HR, Karimi M. The antidepressant effects of lavender (Lavandula angustifolia Mill.): A systematic review and meta-analysis of randomized controlled clinical trials. Complement Ther Med 2021;59:102 PubMed
- Kodama T, Watanabe T, Mataki N, Kanoh S, Kichikawa Y. Acute eosinophilic pneumonia following aromatherapy with essential oil. Respir Med Case Rep 2022;37:101657. PubMed
- Barbaud A, Kurihara F, Raison-Peyron N, et al. Allergic contact dermatitis from essential oil in consumer products: Mode of uses and value of patch-tests with an essential oil series. Results of a French study of the DAG (dermato-allergy group of the Fren
- Ozer H, Sayan ZA, Baloglu I, Ozturk Y, Yonet F, Turkmen K. Unknown criminals for kidney: Acute interstitial nephritis due to lavender tea. Explore (NY) 2023. PubMed
- Kasper S, Volz HP, Möller HJ, et al. Lavender oil preparation Silexan is effective in mild-to-moderate major depression: a randomized, placebo- and reference-controlled trial. Eur Arch Psychiatry Clin Neurosci 2024. PubMed
- Simaei SR, Askari VR, Rostami M, et al. Lavender and metformin effectively propagate progesterone levels in patients with polycystic ovary syndrome: A randomized, double-blind clinical trial. Fitoterapia 2023;172:105720. PubMed
Kava 71 references
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Strahl S, Ehret V, Dahm HH, Maier KP. [Necrotizing hepatitis after taking herbal medication]. Dtsch Med Wochenschr 1998;123:1410-4.
- Spillane PK, et al. Neurological manifestations of kava intoxication. Med J Aust 1997;167:172-3. PubMed
- Swensen JN. Man convicted of driving under the influence of kava. Salt Lake City, UT: Deseret News, 1996.
- Pittler MH, Ernst E. Efficacy of kava extract for treating anxiety: systematic review and meta-analysis. J Clin Psychopharmacol 2000;20:84-9. PubMed
- Volz HP, Kieser M. Kava-kava extract WS 1490 versus placebo in anxiety disorders--a randomized placebo-controlled 25-week outpatient trial. Pharmacopsychiatry 1997;30:1-5. PubMed
- Heinze HJ, Munthe TF, Steitz J, Matzke M. Pharmacopsychological effects of oxazepam and kava-extract in a visual search paradigm assessed with event-related potentials. Pharmacopsychiatry 1994;27:224-30. PubMed
- Munte TF, Heinze HJ, Matzke M, Steitz J. Effects of oxazepam and an extract of kava roots (Piper methysticum) on event-related potentials in a word recognition task. Neuropsychobiology 1993;27:46-53.
- Wheatley D. Stress-induced insomnia treated with kava and valerian: singly and in combination. Hum Psychopharmacol 2001;16:353-6. PubMed
- Schelosky L, Raffaup C, Jendroska K, Poewe W. Kava and dopamine antagonism. J Neurol Neurosurg Psychiatry 1995;58:639-40. PubMed
- Norton SA, Ruze P. Kava dermopathy. J Am Acad Dermatol 1994;31:89-97.
- Pizzorno JE, Murray MT, eds. Textbook of Natural Medicine. 2nd ed. Edinburgh:Churchill Livingstone, 1999.
- Mathews JD, Riley MD, Fejo L, et al. Effects of heavy usage of kava on physical health: Summary of a pilot survey in an aboriginal community. Med J Aust 1988;148:548-55.
- Escher M, Desmeules J, Giostra E, Mentha G. Hepatitis associated with Kava, a herbal remedy for anxiety. BMJ 2001;322:139.
- Russmann S, Lauterburg BH, Helbling A. Kava hepatotoxicity [letter]. Ann Intern Med 2001;135:68-9.
- Liver Toxicity With Kava. Pharmacist's Letter/Prescriber's Letter. January 2001.
- Consultation letter MLX 286: Proposals to prohibit the herbal ingredient Kava-Kava (Piper methysticum) in unlicensed medicines. Medicines Control Agency, United Kingdom, July 19, 2002.
- Meseguer E, Taboada R, Sanchez V, et al. Life-threatening parkinsonism induced by kava-kava. Mov Disord 2002;17:195-6. PubMed
- Ruze P. Kava-induced dermopathy: a niacin deficiency? Lancet 1990;335:1442-5. PubMed
- Singh YN. Kava: an overview. J Ethnopharmacol 1992;37:13-45.
- Bilia AR, Gallori S, Vincieri FF. Kava-kava and anxiety: growing knowledge about the efficacy and safety. Life Sci 2002;70:2581-97. PubMed
- Wooltorton E. Herbal kava: reports of liver toxicity. CMAJ 2002;166:777.
- Mathews JM, Etheridge AS, Black SR. Inhibition of human cytochrome P450 activities by kava extract and kavalactones. Drug Metab Dispos 2002;30:1153-7. PubMed
- Logan JL, Ahmed J. Critical hypokalemic renal tubular acidosis due to Sjogren's syndrome: association with the purported immune stimulant echinacea. Clin Rheumatol 2003;22:158-9.
- Teschke R, Gaus W, Loew D. Kava extracts: safety and risks including rare hepatotoxicity. Phytomedicine 2003;10:440-6. PubMed
- Schmidt P, Boehncke WH. Delayed-type hypersensitivity reaction to kava-kava extract. Contact Dermatitis 2000;42:363-4.
- Schulze J, Raasch W, Siegers CP. Toxicity of kava pyrones, drug safety and precautions--a case study. Phytomedicine 2003;10:68-73.. PubMed
- Pittler MH, Ernst E. Kava extract for treating anxiety. Cochrane Database Syst Rev 2003;(1):CD003383.
- Cairney S, Maruff P, Clough AR, et al. Saccade and cognitive impairment associated with kava intoxication. Hum Psychopharmacol 2003;18:525-33. PubMed
- Moulds RF, Malani J. Kava: herbal panacea or liver poison? Med J Aust 2003;178:451-3. PubMed
- Gow PJ, Connelly NJ, Hill RL, et al. Fatal fulminant hepatic failure induced by a natural therapy containing kava. Med J Aust 2003;178:442-3. PubMed
- Unger M, Frank A. Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. Rapid Commun Mass Spectrom 2004;1 PubMed
- Gurley BJ, Gardner SF, Hubbard MA, et al. In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes. Clin Pharmacol Ther 2005;77:415-26. PubMed
- Weiss J, Sauer A, Frank A, Unger M. Extracts and kavalactones of Piper methysticum G. Forst (kava-kava) inhibit P-glycoprotein in vitro. Drug Metab Dispos 2005;33:1580-3. PubMed
- Gurley BJ, Swain A, Barone GW, et al. Effect of goldenseal (Hydrastis canadensis) and kava kava (Piper methysticum) supplementation on digoxin pharmacokinetics in humans. Drug Metab Dispos 2007;35:240-5. PubMed
- Gurley BJ, Swain A, Hubbard MA, et al. Clinical assessement of CYP2D6-mediated herb-drug interactions in humans: Effects of milk-thistle, black cohosh, goldenseal, kava kava, St. John's wort, and Echinacea. Mol Nutr Food Res 2008;52:755-63.
- Li XZ, Ramzan I. Role of ethanol in kava hepatotoxicity. Phytother Res 2010;24:475-80. PubMed
- Bodkin R, Schneider S, Rekkerth D, et al. Rhabdomyolysis associated with kava ingestion. Am J Emerg Med 2012;30:635.el-3. PubMed
- Donadio V, Bonsi P, Zele I, et al. Myoglobinuria after ingestion of extracts of guarana, Ginkgo biloba and kava. Ginkgo biloba and kava. Neurol Sci 2000;21:124. PubMed
- Sarris J, Kavanagh DJ, Byrne G, et al. The Kava Anxiety Depression Spectrum Study (KADSS): a randomized, placebo-controlled crossover trial using an aqueous extract of Piper methysticum. Psychopharmacology 2009;205:399-407. PubMed
- Hannam S, Murray M, Romani L, Tuicakau M, J Whitfeld M. Kava dermopathy in Fiji: an acquired ichthyosis? Int J Dermatol 2014;53(12):1490-4. PubMed
- Huynh JC, Asgari MM, Moore MM. Sebotropic eruption associated with use of oral kava kava supplement. Clin Exp Dermatol 2014;39(7):816-8. PubMed
- Teschke R, Sarris J, Schweitzer I. Kava hepatotoxicity in traditional and modern use: the presumed Pacific kava paradox hypothesis revisited. Br J Clin Pharmacol 2012;73(2):170-4. PubMed
- Scherer, J. Kava-kava extract in anxiety disorders: an outpatient observational study. Adv.Ther. 1998;15(4):261-269.
- Humberston, C. L., Akhtar, J., and Krenzelok, E. P. Acute hepatitis induced by kava kava. J Toxicol.Clin Toxicol. 2003;41(2):109-113. PubMed
- Schmidt, M. Are kavalactones the hepatotoxic principle of kava extracts? The pitfalls of the glutathione theory. J Altern Complement Med 2003;9(2):183-187. PubMed
- Stickel, F., Baumuller, H. M., Seitz, K., Vasilakis, D., Seitz, G., Seitz, H. K., and Schuppan, D. Hepatitis induced by Kava (Piper methysticum rhizoma). J Hepatol. 2003;39(1):62-67. PubMed
- Grace, R. Kava-induced urticaria. J Am Acad Dermatol 2005;53(5):906. PubMed
- Christl, S. U., Seifert, A., and Seeler, D. Toxic hepatitis after consumption of traditional kava preparation. J.Travel.Med. 2009;16(1):55-56. PubMed
- Teschke, R., Genthner, A., and Wolff, A. Kava hepatotoxicity: comparison of aqueous, ethanolic, acetonic kava extracts and kava-herbs mixtures. J.Ethnopharmacol. 6-25-2009;123(3):378-384. PubMed
- Jappe, U., Franke, I., Reinhold, D., and Gollnick, H. P. Sebotropic drug reaction resulting from kava-kava extract therapy: a new entity? J Am Acad Dermatol. 1998;38(1):104-106. PubMed
- Gessner B and Cnota P. Extract of the kava-kava rhizome in comparison with diazepam and placebo. Z Phytother 1994;15(1):30-37.
- Johnson D, Frauendorf A, Stecker K, and et al. Neurophysiological active profile and tolerance of kava extract WS 1490, A pilot study with randomized evaluation. TW Neurolgie Psychiatrie 1991;5(6):349-354.
- Keller F and Klohs M. A review of the chemistry and pharmacology of the constituents of Piper methysticum. Lloydia 1963;26:1-15.
- Siegers CP, Honold E, Krall B, and et al. Results of the drug monitoring L 1090 with Laitan capsules. Arztl Forsch 1992;39:7-11.
- Chanwai, L. G. Kava toxicity. Emergency Medicine 2002;12:142-145.
- Leung, N. Acute urinary retention secondary to kava ingestion. Emerg Med Australas 2004;16(1):94. PubMed
- Teschke R. Kava hepatotoxicity: pathogenetic aspects and prospective considerations. Liver Int 2010;30(9):1270-9. PubMed
- Toohey TP, Lu BY, Wada C. Toxic effects of psychotropics related to possible p450 enzyme inhibition by kava:report of 2 cases. Prim Care Companion CNS Disord 2013;15(5). PubMed
- Ostermayer D. News: Kava, Popular as Alcohol Alternative, May Cause Toxicity. Emerg Med News. 2016;38(1B).
- Kuchta K, Schmidt M, Nahrstedt A. German Kava Ban Lifted by Court: The Alleged Hepatotoxicity of Kava (Piper methysticum) as a Case of Ill-Defined Herbal Drug Identity, Lacking Quality Control, and Misguided Regulatory Politics. Planta Med. 2015;81(18):16 PubMed
- Schmidt M. German Court Ruling Reverses Kava Ban; German Regulatory Authority Appeals Decision. HerbalEGram. 2014;11(7).
- Wainiqolo I, Kool B, Nosa V, Ameratunga S. Is driving under the influence of kava associated with motor vehicle crashes? A systematic review of the epidemiological literature. Aust N Z J Public Health 2015;39(5):495-9. PubMed
- Wainiqolo I, Kafoa B, Kool B, et al. Driving following kava use and road traffic injuries: a population-based case-control study in Fiji (TRIP 14). PLoS One 2016;11(3):e0149719. PubMed
- Asher GN, Corbett AH, Hawke RL. Common Herbal Dietary Supplement-Drug Interactions. Am Fam Physician. 2017;96(2):101-107.
- Sarris J, Byrne GJ, Bousman CA, et al. Kava for generalised anxiety disorder: A 16-week double-blind, randomised, placebo-controlled study. Aust N Z J Psychiatry. 2020 Mar;54(3):288-297. PubMed
- Aporosa AS, Atkins M, Brunton R. Kava drinking in traditional settings: towards understanding effects on cognitive function. Hum Psychopharmacol. 2020;35(2):e2725. PubMed
- Sarris J, Ravindran A, Yatham LN, et al. Clinician guidelines for the treatment of psychiatric disorders with nutraceuticals and phytoceuticals: The World Federation of Societies of Biological Psychiatry (WFSBP) and Canadian Network for Mood and Anxiety T
- Aporosa S', Ballard H, Pandey R, McCarthy MJ. The impact of traditional kava (Piper methysticum) use on cognition: Implications for driver fitness. J Ethnopharmacol 2022;291:115080. PubMed
- Savage K, Sarris J, Hughes M, et al. Neuroimaging insights: Kava's (Piper methysticum) effect on dorsal anterior cingulate cortex GABA in generalized anxiety disorder. Nutrients 2023;15(21):4586. PubMed
- du Plessis Nisbet J, Xie D, Thompson R, Wark K, Lamrock E, Scurry J. Kava-induced dermatitis: A detailed histopathological analysis. Australas J Dermatol 2024. PubMed
Bacopa 12 references
- Stough C, Lloyd J, Clarke J, et al. The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. Psychopharmacology 2001;156:481-4..
- Yadav SK, Jain AK, Tripathi SN, Gupta JP. Irritable bowel syndrome: therapeutic evaluation of indigenous drugs. Indian J Med Res 1989;90:496-503..
- Morgan A, Stevens J. Does Bacopa monnieri improve memory performance in older persons? Results of a randomized, placebo-controlled, double-blind trial. J Altern Complement Med 2010;16:753-9.
- Kar, A., Panda, S., and Bharti, S. Relative efficacy of three medicinal plant extracts in the alteration of thyroid hormone concentrations in male mice. J Ethnopharmacol. 2002;81(2):281-285. PubMed
- Mukherjee, G. D. and Dey, C. D. Clinical trial on Brahmi. I. J.Exp.Med.Sci. 1966;10(1):5-11.
- Kar A, Pandit S, Mukherjee K, Bahadur S, Mukherjee PK. Safety assessment of selected medicinal food plants used in Ayurveda through CYP450 enzyme inhibition study. J Sci Food Agric 2017;97(1):333-40. doi: 10.1002/jsfa.7739. PubMed
- Kongkeaw C, Dilokthornsakul P, Thanarangsarit P, et al. Meta-analysis of randomized controlled trials on cognitive effects of Bacopa monnieri extract. J Ethnopharmacol 2014;151(1):528-35. PubMed
- Ramasamy S, Kiew LV, Chung LY. Inhibition of human cytochrome P450 enzymes by Bacopa monnieri standardized extract and constituents. Molecules 2014;19(2):2588-601. PubMed
- Prabhakar S, Vishnu VY, Modi M, et al. Efficacy of Bacopa monnieri (Brahmi) and donepezil in Alzheimer's disease and mild cognitive impairment: a randomized double-blind parallel phase 2b study. Ann Indian Acad Neurol 2020;23(6):767-73. PubMed
- Acquarulo B, Tandon P, Macica CM. Suspected cholinergic toxicity due to cevimeline hydrochloride and Bacopa monnieri interaction: a case report. J Med Case Rep 2022;16(1):253. PubMed
- Keegan AP, Stough C, Paris D, et al. Bacopa monnieri supplementation has no effect on serum brain-derived neurotrophic factor levels but beneficially modulates nuclear factor kappa B and cyclic AMP response element-binding protein levels in healthy elderl
- Yaworski AM, Blyumin M, Chang T, Mammen AL, Greene M. Necrotizing myopathy with elevated anti-HMGCR antibodies following exposure to the supplement Bacopa. Muscle Nerve 2023;67(2):E1-E3.
Passion Flower 19 references
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Fisher AA, Purcell P, Le Couteur DG. Toxicity of Passiflora incarnata L. J Toxicol Clin Toxicol 2000;38:63-6.
- Akhondzadeh S, Naghavi HR, Shayeganpour A, et al. Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam. J Clin Pharm Ther 2001;26:363-7. PubMed
- Farnsworth N, Bingel A, Cordell G, et al. Potential value of plants as sources of new antifertility agents I. J Pharm Sci 1975;64:535-98. DOI
- Mori A, Hasegawa K, Murasaki M, et al. Clinical evaluation of Passiflamin (passiflora extract) on neurosis - multicenter double blind study in comparison with mexazolam. Rinsho Hyoka (Clinical Evaluation) 1993;21:383-440.
- Miyasaka LS, Atallah AN, Soares BG. Passiflora for anxiety disorder. Cochrane Database Syst Rev 2007;(1):CD004518. DOI
- Speroni E., Minghetti A. Neuropharmacological activity of extracts from Passiflora incarnata. Planta Med. 1988;54:488-91.
- Capasso A., Sorrentino L. Pharmacological studies on the sedative and hypnotic effect of Kava kava and Passiflora extracts combination. Phytomedicine. 2005;12:39-45. PubMed
- Carrasco MC, Vallejo JR, Pardo-de-Santayana M, et al. Interactions of Valeriana officinalis L. and Passiflora incarnata L. in a patient treated with lorazepam. Phytother Res. 2009 Dec;23:1795-6.
- Smith, G. W., Chalmers, T. M., and Nuki, G. Vasculitis associated with herbal preparation containing Passiflora extract. Br J Rheumatol. 1993;32(1):87-88.
- Soulimani, R., Younos, C., Jarmouni, S., Bousta, D., Misslin, R., and Mortier, F. Behavioural effects of Passiflora incarnata L. and its indole alkaloid and flavonoid derivatives and maltol in the mouse. J Ethnopharmacol. 1997;57(1):11-20. PubMed
- Nojoumi M, Ghaeli P, Salimi S, Sharifi A, Raisi F. Effects of Passion Flower Extract, as an Add-On Treatment to Sertraline, on Reaction Time in Patients ?with Generalized Anxiety Disorder: A Double-Blind Placebo-Controlled Study. Iran J Psychiatry. 2016;1
- Rokhtabnak F, Ghodraty MR, Kholdebarin A, et al. Comparing the Effect of Preoperative Administration of Melatonin and Passiflora incarnata on Postoperative Cognitive Disorders in Adult Patients Undergoing Elective Surgery. Anesth Pain Med. 2016;7(1):e4123 PubMed
- Dantas LP, de Oliveira-Ribeiro A, de Almeida-Souza LM, Groppo FC. Effects of passiflora incarnata and midazolam for control of anxiety in patients undergoing dental extraction. Med Oral Patol Oral Cir Bucal. 2017;22(1):e95-e101. PubMed
- Ozturk Z, Kalayci CC. Pregnancy outcomes in psychiatric patients treated with passiflora incarnata. Complement Ther Med. 2018 Feb;36:30-32. PubMed
- da Cunha RS, Amorim KS, Gercina AC, et al. Herbal medicines as anxiolytics prior to third molar surgical extraction. A randomized controlled clinical trial. Clin Oral Investig. 2020. PubMed
- Schäfer AM, Gilgen PM, Spirgi C, et al. Constituents of Passiflora incarnata, but Not of Valeriana officinalis, Interact with the Organic Anion Transporting Polypeptides (OATP)2B1 and OATP1A2. Planta Med. 2021. PubMed
- Mazzari ALDA, Lacerda MG, Milton FA, et al. In vitro effects of European and Latin-American medicinal plants in CYP3A4 gene expression, glutathione levels, and P-glycoprotein activity. Front Pharmacol 2022;13:826395. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC