Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Mood Ingredients & Drug Interactions

by Host Defense Mushrooms Mycobenefits

Mood label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Mood against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Mood is a dietary supplement by Host Defense Mushrooms Mycobenefits with 6 active ingredients. Its ingredients are commonly taken for anxiety and stress, relaxation and calm, sleep support.Based on those ingredients, 1,434 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Ashwagandha Root Extract, L-Theanine, 5-Hydroxytryptophan. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Mood by Host Defense Mushrooms Mycobenefits

Ask about any prescription or over-the-counter medication and we check it for interactions with Mood by Host Defense Mushrooms Mycobenefits — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Mood by Host Defense Mushrooms Mycobenefits

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains six active ingredients. L-Theanine is an amino acid that may support calm focus.

5-Hydroxytryptophan (5-HTP) is a compound your body uses to make serotonin, which influences mood and sleep. Ashwagandha Root Extract is an herbal adaptogen traditionally used for stress and sleep.

Lion's Mane is a medicinal mushroom studied for cognition. Holy Basil Aerial Parts Extract is an herbal ingredient used in traditional medicine for stress and wellness.

Reishi is included but we hold no interaction data for it. The product also contains pullulan, an inactive ingredient used as a capsule material.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Mood support and emotional calm.
  • We looked for evidence on: Anxiety, Generalized anxiety disorder (GAD), Depression, Panic disorder, Emotional wellness, Stress management — and 1 related terms.
  • The strongest evidence on file: 5-htp is rated "Possibly Effective" for Depression (Natural Medicines).
  • Also on file: Ashwagandha is rated "Possibly Effective" for Anxiety, Generalized anxiety disorder (GAD), Stress.
  • Also on file: 5-htp is rated "Insufficient Reliable Evidence To Rate" for Anxiety, Panic disorder.

L-Theanine is possibly effective for cognitive function, but evidence is insufficient to rate it for age-related cognitive decline, Alzheimer's disease, anxiety, OCD, or cancer. 5-HTP is possibly effective for depression but appears possibly ineffective for Down syndrome; evidence is insufficient for Alzheimer's disease, panic disorder, or cerebellar ataxia.

Ashwagandha is possibly effective for insomnia, anxiety, and stress, including generalized anxiety disorder, but evidence is insufficient for bipolar disorder. Lion's Mane lacks sufficient evidence for Alzheimer's disease, anxiety, athletic performance, cancer, or cognitive function.

Holy Basil's evidence is insufficient for generalized anxiety disorder, asthma, headache, respiratory infections, dental plaque, or diabetes.

The evidence, ingredient by ingredient Theanine 5-htp Ashwagandha Lion's Mane Mushroom Reishi Mushroom Holy Basil

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-Theanine is generally well tolerated for short-term use in healthy adults, but long-term safety hasn't been well studied. Reported adverse effects include headaches, drowsiness, increased sleep duration, and increased dream activity.

There isn't enough safety data to use it during pregnancy or while breastfeeding. 5-HTP is generally well tolerated short-term but works on serotonin, so use with care and professional guidance.

Common side effects are dose-dependent gastrointestinal complaints (nausea, vomiting, abdominal pain, diarrhea), dizziness, fatigue, headache, and insomnia; rare serious effects include aggression, hallucinations, and mania. Avoid during pregnancy and breastfeeding due to insufficient safety information.

Ashwagandha is generally well tolerated short-term, though quality and long-term safety data are limited. Gastrointestinal upset, nausea, and vomiting can occur but are uncommon at typical doses; rare serious concerns include acute liver failure and, in one case report, reversible cerebral vasoconstriction (a blood vessel issue).

Avoid during pregnancy because of traditional concerns about miscarriage; insufficient data for breastfeeding. Lion's Mane is generally well tolerated as a food, but supplement safety long-term is unstudied.

Minor side effects include gastrointestinal discomfort, nausea, and skin rash. Avoid during pregnancy and breastfeeding due to insufficient data.

Holy Basil is generally well tolerated short-term, though high-quality long-term data are limited. Loose stools and nausea occur in a small number of users.

Animal data raise pregnancy concerns, so avoid during pregnancy; insufficient information for breastfeeding.

Side effects, ingredient by ingredient Theanine 5-htp Ashwagandha Lion's Mane Mushroom Reishi Mushroom Holy Basil

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 6 of the 6 matched ingredients can interact with medications — 5-htp, Reishi Mushroom, Ashwagandha, Theanine, Holy Basil, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; Parkinson's medications.
  • For scale: 1,435 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check if you use blood pressure medications (Moderate), sedating drugs or benzodiazepines (Moderate), blood thinners or antiplatelet drugs (Moderate), diabetes medications (Moderate), serotonergic drugs like antidepressants (Moderate), immune-suppressing drugs (Moderate), thyroid hormones (Moderate), carbidopa for Parkinson's disease (Moderate), or pentobarbital (Moderate). These are the drug types with documented interactions; Minor interactions with liver-toxic drugs and CYP1A2 substrates are also possible.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a multi-ingredient mood and cognition supplement with both well-studied and under-studied components. If you take blood pressure medications, blood thinners, diabetes medications, sedating drugs, immune-suppressing medications, thyroid hormones, or serotonergic drugs (antidepressants, certain pain or migraine medications), check your exact medications with the tool on this page before starting.

Talk with your pharmacist or doctor if you're pregnant, breastfeeding, or have liver concerns.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Mood, straight from the product label.

Brand Host Defense Mushrooms Mycobenefits
Barcode (UPC) 633422493701
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Aug 22, 2025
DSLD ID 335815
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Mood by Host Defense Mushrooms Mycobenefits, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
633422493701
IngredientAmount% DV
Calories5 Calorie(s)--
L-Theanine100 mg--
5-Hydroxytryptophan50 mg--
Ashwagandha Root Extract250 mg--
Lion's Mane200 mg--
Reishi200 mg--
Holy Basil Aerial Parts Extract200 mg--

Other ingredients: Pullulan

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take 2 capsules once per day. Can be taken with food or on an empty stomach or as recommended by your healthcare professional.

Precautions

Caution: If you have a medical condition, gastrointestinal disorder, or are taking medications (esp. antidepressants) consult a physician before using this product. Not intended for use if pregnant or breastfeeding.

May cause drowsiness.

Keep out of reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Mood Peaceful - Centered - Tranquil

Non GMO - Vegan - Gluten free

Non GMO - Vegan - Gluten free

Formula

Mushroom Mycelium Complex Ashwagandha Reishi Lion's Mane L-Theanine

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Mood by Host Defense Mushrooms Mycobenefits label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Mood label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Mood by Host Defense Mushrooms Mycobenefits

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Theanine

Interacts with
565 drugs
100 mg per serving

Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without strong dro...

L-Theanine monograph & interactions

5-Hydroxytryptophan

Interacts with
398 drugs
50 mg per serving Form: Griffonia simplicifolia seed extract

5-HTP is a compound your body uses to make serotonin, and people take it as a supplement hoping to improve mood, sleep, and headaches. Some early rese...

5-Hydroxytryptophan monograph & interactions

Ashwagandha Root Extract

Interacts with
1,372 drugs
250 mg per serving

Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evid...

Ashwagandha Root Extract monograph & interactions

Lion's Mane

Interacts with
327 drugs
200 mg per serving Form: Hericium erinaceus

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and...

Lion's Mane monograph & interactions

Reishi

Interacts with
375 drugs
200 mg per serving Form: Ganoderma lucidum s.l.

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits...

Reishi monograph & interactions

Holy Basil Aerial Parts Extract

Interacts with
212 drugs
200 mg per serving Form: Ocimum sanctum Aerial Parts Extract

Holy basil (tulsi) is a traditional Ayurvedic herb most often used today for stress and general wellness, but the human evidence is mostly small and p...

Holy Basil Aerial Parts Extract monograph & interactions

Other (inactive) ingredients: Pullulan. These complete the product’s ingredient list but are not active constituents.

Interaction report

Mood by Host Defense Mushrooms Mycobenefits Drug Interactions

Want to check YOUR meds against Mood?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,434Drugs
1,128 Moderate 306 Minor

Ingredients driving the most interactions

Ashwagandha Root Extract 1,372
L-Theanine 565
5-Hydroxytryptophan 398
Reishi 375
Lion's Mane 327

Individual Drug Interactions

The ingredients in Mood interact with 1,434 drugs. Click any drug to see the details.

6 of the 6 ingredients in Mood interact with drugs. Each result below shows which ingredient is responsible. Ashwagandha Root Extract L-Theanine 5-Hydroxytryptophan Reishi Lion's Mane Holy Basil Aerial Parts Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Mood with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Ashwagandha Root Extract10 drug types · 1,372 drugs

Antidiabetes Drugs

Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
There is preliminary clinical evidence suggesting that ashwagandha might lower blood glucose levels. Theoretically, ashwagandha might have additive effects when used with antidiabetes drugs and increase the risk of hypoglycemia.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Animal research suggests that ashwagandha might lower systolic and diastolic blood pressure. Theoretically, ashwagandha might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.

Likelihood Possible Evidence D
Benzodiazepines

Theoretically, taking ashwagandha might increase the sedative effects of benzodiazepines.
There is preliminary evidence that ashwagandha might have an additive effect with diazepam (Valium) and clonazepam (Klonopin). This may also occur with other benzodiazepines.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Ashwagandha seems to have sedative effects. Theoretically, this may potentiate the effects of barbiturates, other sedatives, and anxiolytics.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Ashwagandha has been linked to cases of acute hepatitis, liver failure, hepatic encephalopathy, autoimmune hepatitis, the need for liver transplantation, and death due to liver failure.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Ashwagandha has demonstrated immunostimulant effects in humans. Animal research has shown that ashwagandha can attenuate the immunosuppression caused by cyclophosphamide.

Likelihood Possible Evidence D
Thyroid Hormone

Ashwagandha might increase the effects and adverse effects of thyroid hormone.
Concomitant use of ashwagandha with thyroid hormones may cause additive therapeutic and adverse effects. Preliminary clinical research and animal studies suggest that ashwagandha boosts thyroid hormone synthesis and secretion. In one clinical study, ashwagandha increased triiodothyronine (T3) and thyroxine (T4) levels by 41.5% and 19.6%, respectively, and reduced serum TSH levels by 17.4% from baseline in adults with subclinical hypothyroidism.

Likelihood Probable Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that ashwagandha extract induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that ashwagandha extract induces CYP3A4 enzymes.

Likelihood Possible Evidence D
Serotonergic Drugs

Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors. However, there is no evidence to suggest that ashwagandha increases the risk of serotonin-related effects, and there have been no published case reports of serotonin syndrome when combined with other serotonergic drugs. Nevertheless, due to the lack of extensive studies on the matter and the fact that ashwagandha appears to affect serotonergic pathways, it would be prudent to exercise caution when combining it with drugs that affect serotonin. [References: - Effects of Withania somnifera (Ashwaga ndha) on Stress and the Stress-Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Curr Neuropharmacol. 2021 Sep 14; 19: 1468–1495. - A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/]

Likelihood Possible Evidence C
Ashwagandha Root Extract full monograph & interactions

L-Theanine3 drug types · 565 drugs

Antihypertensive Drugs

Theanine might lower blood pressure, potentiating the effects of antihypertensive drugs.
Animal research shows that theanine can lower blood pressure in spontaneously hypertensive animals. Theoretically, concomitant use of theanine and antihypertensive drugs might potentiate the antihypertensive activity.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, theanine might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Theoretically, theanine may compete with glutamate and/or increase plasma gamma-aminobutyric acid (GABA) levels, which could cause CNS depression. In one clinical study, some subjects taking oral theanine reported drowsiness.

Likelihood Unlikely Evidence D
Serotonergic Drugs

Clinical studies regarding the effects of L-theanine on serotonin levels are conflicting. Some studies suggest it can increase serotonin levels in the brain while others report that it may decrease them. Nevertheless, there have been no reports of l-theanine being a causative agent in serotonergic-related side effects or serotonin syndrome.

Likelihood Unlikely Evidence C
L-Theanine full monograph & interactions

5-Hydroxytryptophan3 drug types · 398 drugs

Carbidopa (Lodosyn)

Combining 5-HTP and carbidopa can increase the risk of serotonergic side effects.
Carbidopa is sometimes used with 5-HTP to minimize peripheral 5-HTP metabolism and boost the amount that reaches the brain. However, this combination might also increase the risk of some side effects including hypomania, restlessness, rapid speech, anxiety, insomnia, and aggressiveness. Combining carbidopa and 5-HTP might also increase the risk of scleroderma-like skin changes due to elevated serotonin levels.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
In clinical trials, 5-HTP has been associated with drowsiness and somnolence.

Likelihood Possible Evidence D
Serotonergic Drugs

Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
5-HTP can increase serotonin levels and cause serotonergic effects. Theoretically, combining serotonergic drugs with 5-HTP might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders. However, serotonin syndrome with 5-HTP has not yet been reported in humans. Monitor patients for signs of serotonin syndrome and other serotonergic side effects if using 5-HTP with serotonergic drugs.

Likelihood Possible Evidence D
5-Hydroxytryptophan full monograph & interactions

Reishi3 drug types · 375 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
A dose of 1.5 grams daily of reishi mushroom does not seem to decrease platelet aggregation, but a higher dose of 3 grams daily does.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Animal research suggests that reishi mushroom decreases blood sugar. However, in patients with type 2 diabetes, taking reishi mushroom does not reduce fasting glucose levels, and its effects on glycated hemoglobin are inconsistent.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Reishi mushroom has shown hypotensive activity in animal research. Clinical evidence suggests that reishi mushroom reduces blood pressure in some, but not all, patients with hypertension.

Likelihood Possible Evidence D
Reishi full monograph & interactions

Lion's Mane3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lion's mane mushroom can reduce serum glucose and increase serum insulin.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.

Likelihood Possible Evidence D
Lion's Mane full monograph & interactions

Holy Basil Aerial Parts Extract3 drug types · 212 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, holy basil seed oil might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Animal research shows that holy basil seed oil can prolong bleeding time, possibly due to inhibition of platelet aggregation. However, it is not known if this occurs in humans.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, holy basil might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Small clinical studies show that taking holy basil can decrease fasting blood glucose and other measures of glycemic control in patients with type 2 diabetes.

Likelihood Possible Evidence B
Pentobarbital (Nembutal)

Theoretically, holy basil seed oil might increase the sedative effects of pentobarbital.
Animal research shows that holy basil seed oil increases pentobarbitone-induced sleeping time. However, it is not known if this occurs in humans or if this applies to other barbiturates or sedatives.

Likelihood Possible Evidence D
Holy Basil Aerial Parts Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Mood, from the product label.

Host Defense Mushrooms Mycobenefits

See all Host Defense Mushrooms Mycobenefits products
Name
Fungi Perfecti, LLC
Street Address
PO Box 7634
City
Olympia
State
WA
ZipCode
98507
Phone Number
877-504-6926
Web Address
Hostdefense.com
Pharmacist Counseling Corner

Mood by Host Defense Mushrooms Mycobenefits: Common Questions

Does Mood by Host Defense Mushrooms Mycobenefits interact with any medications?
Yes. Based on its ingredients, Mood has a known interaction with 1,434 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Mood contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant or breastfeeding?
The safety data advises against use during pregnancy for most ingredients — L-Theanine and 5-HTP lack sufficient data, Ashwagandha carries traditional miscarriage concerns, Lion's Mane and Holy Basil have insufficient data. None have adequate breastfeeding safety information. Talk with your doctor or pharmacist for personalized advice.
What does L-Theanine do?
L-Theanine is an amino acid that is possibly effective for cognitive function. It may also have mild sedative effects theoretically, though clinical evidence is limited.
Will this help my mood or anxiety?
5-HTP is possibly effective for depression. Ashwagandha is possibly effective for anxiety and stress. L-Theanine, Lion's Mane, and Holy Basil lack sufficient evidence to rate them for anxiety or mood disorders.
What are the most common side effects?
L-Theanine may cause headaches, drowsiness, or increased dream activity. 5-HTP commonly causes dose-dependent gastrointestinal upset (nausea, vomiting, diarrhea), fatigue, and headache. Ashwagandha and Holy Basil may cause gastrointestinal upset at typical doses. Lion's Mane may cause gastrointestinal discomfort or nausea.
Is this product safe for long-term use?
Long-term safety is not well studied for any of these ingredients. L-Theanine, Ashwagandha, and Holy Basil are generally well tolerated short-term in healthy adults, but quality long-term data are limited. Talk with your pharmacist about your individual situation.
What's 5-HTP?
5-Hydroxytryptophan (5-HTP) is a compound your body naturally makes and uses to produce serotonin, which affects mood and sleep. It's possibly effective for depression but carries Moderate-severity interaction risks with certain medications, particularly serotonergic drugs.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Mood label
Go deeper

The Full Monographs Behind Mood’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Theanine

Interacts with 565 drugs

Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without strong drowsiness. Early research suggests it may...

Read the full Theanine monograph → Herb & supplement monograph

5-htp

Interacts with 398 drugs

5-HTP is a compound your body uses to make serotonin, and people take it as a supplement hoping to improve mood, sleep, and headaches. Some early research is promising, but the overall evide...

Read the full 5-htp monograph → Herb & supplement monograph

Ashwagandha

Interacts with 1,372 drugs

Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evidence is still limited. It is generally w...

Read the full Ashwagandha monograph → Herb & supplement monograph

Lion's Mane Mushroom

Interacts with 327 drugs

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as...

Read the full Lion's Mane Mushroom monograph → Herb & supplement monograph

Reishi Mushroom

Interacts with 375 drugs

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits is limited or low-quality, so it should...

Read the full Reishi Mushroom monograph → Herb & supplement monograph

Holy Basil

Interacts with 212 drugs

Holy basil (tulsi) is a traditional Ayurvedic herb most often used today for stress and general wellness, but the human evidence is mostly small and preliminary. It is generally well tolerat...

Read the full Holy Basil monograph →
Sources

Sources & How We Checked

Mood's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 101 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Theanine 6 references
  1. Yokogoshi H, Kobayashi M. Hypotensive effect of gamma-glutamylethylamide in spontaneously hypertensive rats. Life Sci 1998;62:1065-8.
  2. Haskell, C. F., Kennedy, D. O., Milne, A. L., Wesnes, K. A., and Scholey, A. B. The effects of L-theanine, caffeine and their combination on cognition and mood. Biol.Psychol. 2008;77(2):113-122. PubMed
  3. Yokogoshi, H., Kato, Y., Sagesaka, Y. M., Takihara-Matsuura, T., Kakuda, T., and Takeuchi, N. Reduction effect of theanine on blood pressure and brain 5-hydroxyindoles in spontaneously hypertensive rats. Biosci.Biotechnol.Biochem. 1995;59(4):615-618. PubMed
  4. Lyon MR, Kapoor MP, Juneja LR. The effects of L-theanine (Suntheanine®) on objective sleep quality in boys with attention deficit hyperactivity disorder (ADHD): a randomized, double-blind, placebo-controlled clinical trial. Altern Med Rev. 2011;16(4):348-
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5-htp 32 references
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Ashwagandha 32 references
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Lion's Mane Mushroom 6 references
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See these in context on the Lion's Mane Mushroom monograph →

Reishi Mushroom 17 references
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Holy Basil 8 references
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See these in context on the Holy Basil monograph →

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