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Dietary supplement

Mulberry Leaf 1,000 mg Ingredients & Drug Interactions

by Nutritional Concepts

Mulberry Leaf 1,000 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Mulberry Leaf 1,000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Mulberry Leaf 1,000 mg is a dietary supplement by Nutritional Concepts with 1 active ingredient. Its ingredients are commonly taken for blood sugar support, high cholesterol, weight management.Based on those ingredients, 87 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Mulberry. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Mulberry Leaf 1,000 mg by Nutritional Concepts

Ask about any prescription or over-the-counter medication and we check it for interactions with Mulberry Leaf 1,000 mg by Nutritional Concepts — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Mulberry Leaf 1,000 mg by Nutritional Concepts

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: white mulberry leaf, supplied at 1,000 mg per capsule. Mulberry leaf is a plant extract used in traditional and supplement medicine, typically to support blood sugar and cholesterol levels.

The capsule also contains inactive ingredients—rice powder, gelatin, and vegetable magnesium stearate—which are standard binders and capsule materials.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient White Mulberry product and its label doesn't state a use — see White Mulberry's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for white mulberry leaf is insufficient to establish whether it works for any of the conditions it's marketed for—including hair loss (androgenic alopecia), bone health, cold prevention, blood sugar control, and cholesterol support. While some research suggests it may lower blood glucose in the body, we don't hold reliable evidence that it's effective for diabetes management or any other use in the data we have on file.

The evidence, ingredient by ingredient White Mulberry

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

White mulberry leaf is generally well tolerated when taken orally. The most common side effects are mild and digestive: bloating, constipation, loose stools, and gas.

In one clinical trial at 4.6 grams three times daily, about half of participants reported bloating or flatulence, a quarter had loose stools, and one in five had constipation—but these effects often lessened over the course of the 12-week study, suggesting they may be temporary for some people. During pregnancy and breastfeeding, there isn't enough safety data on medicinal amounts of white mulberry leaf, so the safety data advises against it.

If you're pregnant, nursing, or planning to become pregnant, talk with your doctor or pharmacist about whether this product is right for you.

Side effects, ingredient by ingredient White Mulberry

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — White Mulberry.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 87 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take antidiabetes drugs or medications that are OCT2 substrates (kidney-transport medications, including metformin). White mulberry leaf can lower blood sugar and may slow how your kidneys clear certain drugs, raising their levels in your body and increasing side effects.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Mulberry Leaf 1,000 mg may appeal to you if you're interested in traditional plant support for blood sugar or cholesterol, but the evidence to back those uses isn't established yet. If you take any diabetes medication or any drug that uses the kidney transporter OCT2 (including metformin), you should check with your doctor or pharmacist before starting this product—the interaction risk is real, and blood sugar monitoring may be needed.

Pregnant and breastfeeding people should avoid it. It's a good idea to run this through your healthcare provider to make sure it fits your personal situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Mulberry Leaf 1,000 mg, straight from the product label.

Brand Nutritional Concepts
Barcode (UPC) 095234951600
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Apr 23, 2020
DSLD ID 217257
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Mulberry Leaf 1,000 mg by Nutritional Concepts, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
095234951600
IngredientAmount% DV
Mulberry1000 mg--

Other ingredients: Rice powder, Gelatin Capsule, Vegetable Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Mulberries are tiny yet powerful berries that are now considered a 'super food'.

Suggested/Recommended/Usage/Directions

Directions: For adults, take one (1) capsule daily, preferably with a meal, or as directed by a health care professional.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Keep out of reach of children.

Caution: Pregnant or lactating women should consult a doctor before use.

If you are under medical supervision, please consult a doctor before use. Discontinue use and consult a doctor if any adverse reactions occur.

Storage

Store in a cool, dry place.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Mulberry Leaf 1,000 mg by Nutritional Concepts label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Mulberry Leaf 1,000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Mulberry Leaf 1,000 mg by Nutritional Concepts

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Mulberry

Interacts with
87 drugs
1000 mg per serving

White mulberry leaf is most studied for helping blunt the rise in blood sugar after meals, but the human evidence is limited and not strong. It is gen...

Mulberry monograph & interactions

Other (inactive) ingredients: Rice powder, Gelatin Capsule, Vegetable Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Mulberry Leaf 1,000 mg by Nutritional Concepts Drug Interactions

Want to check YOUR meds against Mulberry Leaf 1,000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
87Drugs
87 Moderate

Ingredients driving the most interactions

Mulberry 87

Individual Drug Interactions

The ingredients in Mulberry Leaf 1,000 mg interact with 87 drugs. Click any drug to see the details.

1 of the 1 ingredient in Mulberry Leaf 1,000 mg interact with drugs. Each result below shows which ingredient is responsible. Mulberry

Each ingredient & the kinds of drugs it affects

For each ingredient in Mulberry Leaf 1,000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Mulberry2 drug types · 87 drugs

Antidiabetes Drugs

Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Clinical research shows that white mulberry leaf can lower blood glucose levels. Advise patients to monitor glucose levels closely.

Likelihood Possible Evidence D
Organic Cation Transporter 2 (Oct2) Substrates

Theoretically, white mulberry leaf might slow the elimination and increase the adverse effects of drugs which are OCT2 substrates.
Animal research shows that coadministration of white mulberry leaf extract with metformin, an OCT2 substrate, slows the renal elimination of metformin via inhibition of OCT2 activity. OCT2 is expressed in the kidneys and is responsible for transporting cationic drugs into tubular epithelial cells in order to be excreted in the urine.

Likelihood Possible Evidence D
Mulberry full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Mulberry Leaf 1,000 mg, from the product label.

Nutritional Concepts

See all Nutritional Concepts products
Name
Nutritional Concepts
City
Farmingdale
State
NY
ZipCode
11735
Phone Number
800-777-2200
Pharmacist Counseling Corner

Mulberry Leaf 1,000 mg by Nutritional Concepts: Common Questions

Does Mulberry Leaf 1,000 mg by Nutritional Concepts interact with any medications?
Yes. Based on its ingredients, Mulberry Leaf 1,000 mg has a known interaction with 87 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Mulberry Leaf 1,000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Mulberry Leaf if I'm pregnant or breastfeeding?
No. There isn't enough safety data on medicinal amounts of white mulberry leaf during pregnancy and breastfeeding, so the safety data advises against it. Talk with your doctor or pharmacist about your options if you're pregnant, nursing, or planning to become pregnant.
What side effects does this supplement have?
Most side effects are mild and digestive: bloating, gas, loose stools, or constipation. In clinical trials, these happened in a minority of people and often went away over time. White mulberry leaf is generally well tolerated overall.
Does Mulberry Leaf actually help with blood sugar?
Some research shows white mulberry leaf may lower blood glucose in the body, but we don't hold reliable evidence that it works for diabetes management. The evidence for its use is insufficient, so it's not proven effective for blood sugar control yet.
Can I take this if I'm on metformin?
You should check with your doctor or pharmacist first. Animal research shows white mulberry leaf can slow how your kidneys clear metformin, potentially raising its level in your body. Your healthcare provider can tell you whether it's safe for you.
Does this product have fillers?
Yes. Besides the active white mulberry leaf, the capsule contains rice powder, gelatin, and vegetable magnesium stearate—standard inactive ingredients that help hold the supplement together.
Will this help with my cholesterol?
The evidence for white mulberry leaf and cholesterol is insufficient, so we don't have reliable proof that it works for that purpose. If you're interested in supporting your cholesterol, talk with your doctor or pharmacist about options with stronger evidence.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Mulberry Leaf 1,000 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Mulberry Leaf 1,000 mg label
Go deeper

The Full Monographs Behind Mulberry Leaf 1,000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

White Mulberry

Interacts with 87 drugs

White mulberry leaf is most studied for helping blunt the rise in blood sugar after meals, but the human evidence is limited and not strong. It is generally well tolerated as a food and tea,...

Read the full White Mulberry monograph →
Sources

Sources & How We Checked

Mulberry Leaf 1,000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

White Mulberry 6 references
  1. Andallu B, Suryakantham V, Lakshmi Srikanthi B, Reddy GK. Effect of mulberry (Morus indica L.) therapy on plasma and erythrocyte membrane lipids in patients with type 2 diabetes. Clin Chim Acta 2001;314:47-53. PubMed
  2. Mudra M, Ercan-Fang N, Zhong L, et al. Influence of mulberry leaf extract on the blood glucose and breath hydrogen response to ingestion of 75 g sucrose by type 2 diabetic and control subjects. Diabetes Care 2007;30:1272-4. PubMed
  3. Kimura T, Nakagawa K, Kubota H, et al. Food-grade mulberry powder enriched with 1-deoxynojirimycin suppresses the elevation of postprandial blood glucose in humans. J Agric Food Chem 2007;55:5869-74. PubMed
  4. Huh HW, Na YG, Bang KH, et al. Extended intake of mulberry leaf extract delayed metformin elimination via inhibiting the organic cation transporter 2. Pharmaceutics. 2020;12(1):49. PubMed
  5. Thaipitakwong T, Supasyndh O, Rasmi Y, Aramwit P. A randomized controlled study of dose-finding, efficacy, and safety of mulberry leaves on glycemic profiles in obese persons with borderline diabetes. Complement Ther Med. 2020;49:102292. PubMed
  6. Thondre PS, Lightowler H, Ahlstrom L, Gallagher A. Mulberry leaf extract improves glycaemic response and insulaemic response to sucrose in healthy subjects: results of a randomized, double blind, placebo-controlled study. Nutr Metab (Lond) 2021;18(1):41. PubMed

See these in context on the White Mulberry monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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