Myco-Immune Ingredients & Drug Interactions
by Thorne
What is this page for?
First and foremost: checking Myco-Immune against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Myco-Immune is a dietary supplement by Thorne with 6 active ingredients. Its ingredients are commonly taken for immune support, fatigue and general well-being, stress and sleep.Based on those ingredients, 704 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Reishi Mushroom, Shiitake Mushroom, Maitake Mushroom. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Myco-Immune by Thorne
Ask about any prescription or over-the-counter medication and we check it for interactions with Myco-Immune by Thorne — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
Ask the Pharmacist
A licensed pharmacist will answer your question by email — free, usually within 24 hours.
Got it — thank you!
A licensed pharmacist will answer within 24 hours. Keep an eye on your email (worth checking spam, just in case).
HelloPharmacist Scorecard of Myco-Immune by Thorne
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Myco-Immune contains six active ingredients, all mushrooms: Reishi, Maitake, Turkey Tail, Split Gills Fungus, Caterpillar Mushroom (cordyceps), and Shiitake. These are formulated in a liquid form and work together as an immune support blend.
The product has no inactive fillers or other ingredients listed.
Does it work?
Moderate evidence
The evidence for these mushrooms is mixed and often limited. Turkey Tail Mushroom is rated Possibly Effective for cancer, but the other ingredients lack strong clinical support.
Reishi, Maitake, Turkey Tail, Cordyceps, and Shiitake are all rated with Insufficient Reliable Evidence for most of the conditions they're studied for—meaning the research hasn't yet established whether they work for those uses. This product is marketed for immune support, but the strength of evidence behind any single ingredient for that specific purpose is not detailed in the data we hold.
How safe is it?
Well-documented data
Most of these mushrooms are generally well tolerated short-term when taken orally. Common side effects are mild and gastrointestinal—dizziness, dry mouth, nausea, stomach upset, diarrhea, and rash.
Reishi can cause dizziness or insomnia in some people, and respiratory allergy to mushroom spores is possible. Shiitake, particularly when raw or inadequately prepared, can cause a rash called shiitake dermatitis and, rarely, intestinal blockage.
Pregnancy and breastfeeding: The safety data advises against all six ingredients during pregnancy and breastfeeding due to insufficient evidence. Talk with your doctor or pharmacist about whether this product is appropriate for you if you are pregnant, planning pregnancy, or breastfeeding.
Meds to double-check
Moderate interaction found
Before taking Myco-Immune, double-check these medication types with your doctor or pharmacist: antidiabetes drugs (risk of low blood sugar), antihypertensive drugs (risk of low blood pressure, Moderate severity), blood thinners or antiplatelet drugs, cyclophosphamide and tamoxifen (chemotherapy and cancer treatments), immunosuppressants, and drugs metabolized by liver enzymes CYP2D6 or CYP2C9. These are Moderate or Minor interactions, and some are theoretical — but your own medications need to be checked against this list.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Myco-Immune is a mushroom blend that interacts with blood pressure drugs, blood sugar drugs, blood thinners, cancer medications, immune-suppressing drugs, and several others. If you take any prescription medications—especially for diabetes, high blood pressure, blood clotting, cancer, or immune conditions—check with your doctor or pharmacist before starting this product.
It's generally well tolerated in otherwise healthy people, but the evidence for its immune benefits is limited.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 5 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Myco-Immune, straight from the product label.
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Myco-Immune by Thorne, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Blend | 1.6 Gram(s) | -- |
| Reishi Mushroom | 0 NP | -- |
| Maitake Mushroom | 0 NP | -- |
| Turkey Tail Mushroom | 0 NP | -- |
| Split Gills Fungus | 0 NP | -- |
| Caterpillar Mushroom | 0 NP | -- |
| Shiitake Mushroom | 0 NP | -- |
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Mushroom extract
13-19% alcohol by volume.
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Suggested use: Take 1 dropperful three times daily or as recommended by your health-care practitioner. Shake well before using.
Precautions
Tamper evident: Use only if bottle is sealed.
If pregnant, consult your health-care practitioner before using this product.
Storage
Store tightly sealed in a cool, dry place.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Myco-Immune by Thorne label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Myco-Immune by Thorne
These are the 6 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Dropperful(s) Dosage formLiquid Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Blend
- › Reishi Mushroom
- › Maitake Mushroom
- › Turkey Tail Mushroom
- › Split Gills Fungus
- › Caterpillar Mushroom
- › Shiitake Mushroom
Myco-Immune by Thorne Drug Interactions
HelloPharmacist Interaction Report
Myco-Immune by Thorne contains six active mushroom ingredients, and five of them have documented interactions with medications.
The most serious concern is with Reishi, Maitake, and Turkey Tail Mushrooms, which interact with blood sugar–lowering drugs (antidiabetes medications) at Moderate severity — they may cause low blood sugar (hypoglycemia) when combined. Altogether, these interactions span 704 individual medications.
Read the full breakdown — every affected drug type, severity by severity
Reishi, Maitake, and Turkey Tail also interact with blood pressure–lowering drugs (antihypertensive medications) at Moderate severity, potentially causing drops in blood pressure. Reishi and Maitake may increase bleeding risk with blood thinners (anticoagulant/antiplatelet drugs).
Turkey Tail has an additional Moderate interaction with cyclophosphamide (a chemotherapy drug) and tamoxifen (a breast cancer treatment), possibly changing how your body handles these drugs. Turkey Tail's polysaccharide component may also weakly inhibit a liver enzyme (CYP2C9), which could affect certain other medications.
Cordyceps (Caterpillar Mushroom) interacts with blood thinners at Moderate severity and with immune-suppressing drugs at Moderate severity, potentially interfering with transplant or autoimmune treatments. It has a Minor interaction with testosterone.
Shiitake Mushroom may interfere with immune-suppressing therapy and may affect how your liver processes certain antidepressants and other drugs metabolized by the CYP2D6 enzyme, both at Moderate severity.
We could not check Split Gills Fungus — no interaction data is on file for it. Before starting this product, check your exact medications with the search tool on this page.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Myco-Immune?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Myco-Immune interact with 704 drugs. Click any drug to see the details.
5 of the 6 ingredients in Myco-Immune interact with drugs. Each result below shows which ingredient is responsible. Reishi Mushroom Shiitake Mushroom Maitake Mushroom Caterpillar Mushroom Turkey Tail Mushroom
Amiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with Myco-Immune — through 2 ingredients. Tap an ingredient for the detail:
Maitake MushroomAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Maitake Mushroom + Amiloride, Hydrochlorothiazide interactionReishi MushroomAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Reishi Mushroom + Amiloride, Hydrochlorothiazide interactionAmitriptylineElavil
How Amitriptyline interacts with Myco-Immune — through 2 ingredients. Tap an ingredient for the detail:
Shiitake MushroomCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.
Read the full Shiitake Mushroom + Amitriptyline interactionTurkey Tail MushroomCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, the polysaccharide peptide (PSP) component of turkey tail mushroom might inhibit CYP2C9.
Read the full Turkey Tail Mushroom + Amitriptyline interactionAmitriptyline, ChlordiazepoxideLimbitrol DS
How Amitriptyline, Chlordiazepoxide interacts with Myco-Immune — through 2 ingredients. Tap an ingredient for the detail:
Shiitake MushroomCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.
Read the full Shiitake Mushroom + Amitriptyline, Chlordiazepoxide interactionTurkey Tail MushroomCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, the polysaccharide peptide (PSP) component of turkey tail mushroom might inhibit CYP2C9.
Read the full Turkey Tail Mushroom + Amitriptyline, Chlordiazepoxide interactionAmitriptyline, PerphenazineEtrafon, Etrafon-A, Etrafon-Forte, Triavil
How Amitriptyline, Perphenazine interacts with Myco-Immune — through 2 ingredients. Tap an ingredient for the detail:
Shiitake MushroomCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.
Read the full Shiitake Mushroom + Amitriptyline, Perphenazine interactionTurkey Tail MushroomCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, the polysaccharide peptide (PSP) component of turkey tail mushroom might inhibit CYP2C9.
Read the full Turkey Tail Mushroom + Amitriptyline, Perphenazine interactionAmlodipineNorliqva
How Amlodipine interacts with Myco-Immune — through 2 ingredients. Tap an ingredient for the detail:
Reishi MushroomAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Reishi Mushroom + Amlodipine interactionMaitake MushroomAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Maitake Mushroom + Amlodipine interactionAmlodipine BenzoateKaterzia
How Amlodipine Benzoate interacts with Myco-Immune — through 2 ingredients. Tap an ingredient for the detail:
Maitake MushroomAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Maitake Mushroom + Amlodipine Benzoate interactionReishi MushroomAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Reishi Mushroom + Amlodipine Benzoate interactionAmlodipine BesilateIstin
How Amlodipine Besilate interacts with Myco-Immune — through 2 ingredients. Tap an ingredient for the detail:
Reishi MushroomAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Reishi Mushroom + Amlodipine Besilate interactionMaitake MushroomAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Maitake Mushroom + Amlodipine Besilate interactionAmlodipine BesylateNorvasc
How Amlodipine Besylate interacts with Myco-Immune — through 2 ingredients. Tap an ingredient for the detail:
Maitake MushroomAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Maitake Mushroom + Amlodipine Besylate interactionReishi MushroomAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Reishi Mushroom + Amlodipine Besylate interactionAmlodipine Besylate, BenazeprilLotrel
How Amlodipine Besylate, Benazepril interacts with Myco-Immune — through 2 ingredients. Tap an ingredient for the detail:
Reishi MushroomAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Reishi Mushroom + Amlodipine Besylate, Benazepril interactionMaitake MushroomAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Maitake Mushroom + Amlodipine Besylate, Benazepril interactionAmlodipine, CelecoxibConsensi
How Amlodipine, Celecoxib interacts with Myco-Immune — through 3 ingredients. Tap an ingredient for the detail:
Maitake MushroomAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Maitake Mushroom + Amlodipine, Celecoxib interactionReishi MushroomAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Reishi Mushroom + Amlodipine, Celecoxib interactionTurkey Tail MushroomCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, the polysaccharide peptide (PSP) component of turkey tail mushroom might inhibit CYP2C9.
Read the full Turkey Tail Mushroom + Amlodipine, Celecoxib interactionAmmonium ChlorideAmmonium Chloride
How Ammonium Chloride interacts with Myco-Immune — through 2 ingredients. Tap an ingredient for the detail:
Reishi MushroomAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Reishi Mushroom + Ammonium Chloride interactionMaitake MushroomAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Maitake Mushroom + Ammonium Chloride interactionAmphetamineAdensys XR-ODT, Adzenys ER, Dyanavel XR, Mydayis
How Amphetamine interacts with Myco-Immune — through 1 ingredient. Tap an ingredient for the detail:
Shiitake MushroomCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.
Read the full Shiitake Mushroom + Amphetamine interactionAmphetamine Aspartate, Amphetamine Sulfate, Dextroamphetamine Saccharate, Dextroamphetamine SulfateAdderall, Adderall XR
How Amphetamine Aspartate, Amphetamine Sulfate, Dextroamphetamine Saccharate, Dextroamphetamine Sulfate interacts with Myco-Immune — through 1 ingredient. Tap an ingredient for the detail:
Shiitake MushroomCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.
Read the full Shiitake Mushroom + Amphetamine Aspartate, Amphetamine Sulfate, Dextroamphetamine Saccharate, Dextroamphetamine Sulfate interactionAmphetamine SulfateBenzedrine, Evekeo ODT
How Amphetamine Sulfate interacts with Myco-Immune — through 1 ingredient. Tap an ingredient for the detail:
Shiitake MushroomCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.
Read the full Shiitake Mushroom + Amphetamine Sulfate interactionAnacaulase-bcdbNexoBrid
How Anacaulase-bcdb interacts with Myco-Immune — through 2 ingredients. Tap an ingredient for the detail:
Caterpillar MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Caterpillar Mushroom + Anacaulase-bcdb interactionReishi MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi Mushroom + Anacaulase-bcdb interactionAnagrelideAgrylin
How Anagrelide interacts with Myco-Immune — through 2 ingredients. Tap an ingredient for the detail:
Reishi MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi Mushroom + Anagrelide interactionCaterpillar MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Caterpillar Mushroom + Anagrelide interactionAnifrolumab-fniaSaphnelo
How Anifrolumab-fnia interacts with Myco-Immune — through 2 ingredients. Tap an ingredient for the detail:
Shiitake MushroomImmunosuppressants Moderate
Interaction Summary
Theoretically, taking shiitake mushroom might decrease the effects of immunosuppressive therapy.
Read the full Shiitake Mushroom + Anifrolumab-fnia interactionCaterpillar MushroomImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Read the full Caterpillar Mushroom + Anifrolumab-fnia interactionAnisindioneMiradon
How Anisindione interacts with Myco-Immune — through 2 ingredients. Tap an ingredient for the detail:
Caterpillar MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Caterpillar Mushroom + Anisindione interactionReishi MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi Mushroom + Anisindione interactionAntidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
How Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interacts with Myco-Immune — through 3 ingredients. Tap an ingredient for the detail:
Turkey Tail MushroomAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking turkey tail mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Turkey Tail Mushroom + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionReishi MushroomAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Read the full Reishi Mushroom + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionMaitake MushroomAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Maitake Mushroom + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionAntithrombin IiiThrombate III
How Antithrombin Iii interacts with Myco-Immune — through 2 ingredients. Tap an ingredient for the detail:
Caterpillar MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Caterpillar Mushroom + Antithrombin Iii interactionReishi MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi Mushroom + Antithrombin Iii interactionAntithymocyte GlobulinThymoglobulin
How Antithymocyte Globulin interacts with Myco-Immune — through 2 ingredients. Tap an ingredient for the detail:
Shiitake MushroomImmunosuppressants Moderate
Interaction Summary
Theoretically, taking shiitake mushroom might decrease the effects of immunosuppressive therapy.
Read the full Shiitake Mushroom + Antithymocyte Globulin interactionCaterpillar MushroomImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Read the full Caterpillar Mushroom + Antithymocyte Globulin interactionApixabanEliquis
How Apixaban interacts with Myco-Immune — through 2 ingredients. Tap an ingredient for the detail:
Caterpillar MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Caterpillar Mushroom + Apixaban interactionReishi MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi Mushroom + Apixaban interactionAprocitentanTryvio
How Aprocitentan interacts with Myco-Immune — through 2 ingredients. Tap an ingredient for the detail:
Reishi MushroomAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Reishi Mushroom + Aprocitentan interactionMaitake MushroomAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Maitake Mushroom + Aprocitentan interactionArgatrobanArgatroban
How Argatroban interacts with Myco-Immune — through 2 ingredients. Tap an ingredient for the detail:
Reishi MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi Mushroom + Argatroban interactionCaterpillar MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Caterpillar Mushroom + Argatroban interactionAripiprazoleAbilify, Abilify Maintena, Abilify Mycite
How Aripiprazole interacts with Myco-Immune — through 1 ingredient. Tap an ingredient for the detail:
Shiitake MushroomCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.
Read the full Shiitake Mushroom + Aripiprazole interactionAripiprazole LauroxilAristada, Aristada Initio Kit
How Aripiprazole Lauroxil interacts with Myco-Immune — through 1 ingredient. Tap an ingredient for the detail:
Shiitake MushroomCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.
Read the full Shiitake Mushroom + Aripiprazole Lauroxil interactionAspirinAngettes 75, ASA, Asaphen, Aspirin, Caprin, Cartia +8 more
How Aspirin interacts with Myco-Immune — through 2 ingredients. Tap an ingredient for the detail:
Reishi MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi Mushroom + Aspirin interactionCaterpillar MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Caterpillar Mushroom + Aspirin interactionAspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #3
How Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interacts with Myco-Immune — through 3 ingredients. Tap an ingredient for the detail:
Caterpillar MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Caterpillar Mushroom + Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interactionReishi MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi Mushroom + Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interactionShiitake MushroomCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.
Read the full Shiitake Mushroom + Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interactionAspirin, ButalbitalAxotal
How Aspirin, Butalbital interacts with Myco-Immune — through 2 ingredients. Tap an ingredient for the detail:
Reishi MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi Mushroom + Aspirin, Butalbital interactionCaterpillar MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Caterpillar Mushroom + Aspirin, Butalbital interactionAspirin, Butalbital, CaffeineFiorinal
How Aspirin, Butalbital, Caffeine interacts with Myco-Immune — through 2 ingredients. Tap an ingredient for the detail:
Caterpillar MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Caterpillar Mushroom + Aspirin, Butalbital, Caffeine interactionReishi MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi Mushroom + Aspirin, Butalbital, Caffeine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Myco-Immune with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Reishi Mushroom
Anticoagulant/Antiplatelet Drugs
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
A dose of 1.5 grams daily of reishi mushroom does not seem to decrease platelet aggregation, but a higher dose of 3 grams daily does.
Antidiabetes Drugs
Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Animal research suggests that reishi mushroom decreases blood sugar. However, in patients with type 2 diabetes, taking reishi mushroom does not reduce fasting glucose levels, and its effects on glycated hemoglobin are inconsistent.
Antihypertensive Drugs
Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Reishi mushroom has shown hypotensive activity in animal research. Clinical evidence suggests that reishi mushroom reduces blood pressure in some, but not all, patients with hypertension.
Shiitake Mushroom
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.
In vitro studies suggest that the shiitake mushroom extract AHCC might induce the CYP2D6 enzyme. This effect has not been reported in humans.
Immunosuppressants
Theoretically, taking shiitake mushroom might decrease the effects of immunosuppressive therapy.
In vitro evidence suggests that shiitake mushroom extracts stimulate immune function.
Maitake Mushroom
Antidiabetes Drugs
Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that taking maitake mushroom polysaccharide (MMP) can lower blood glucose levels in patients with types 2 diabetes.
Antihypertensive Drugs
Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that maitake mushroom can lower blood pressure.
Warfarin (Coumadin)
There is limited evidence that maitake mushroom may increase the anticoagulant effects of warfarin.
In a case report, a patient previously stabilized on warfarin developed an elevated international normalized ratio (INR) of 5.1 after taking maitake mushroom (Grifron-Pro Maitake D-Fraction) 1 drop/kg daily in three divided doses for one week. The elevated INR resolved after holding warfarin for two days, then reducing the dose by 11%. It is thought that the beta-glucan constituent of maitake mushroom might cause warfarin dissociation from proteins, resulting in increased free warfarin levels and increased warfarin effects.
Caterpillar Mushroom
Anticoagulant/Antiplatelet Drugs
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
In vitro and animal research suggests that cordyceps extract inhibits platelet aggregation and function. However, this interaction has not been reported in humans.
Immunosuppressants
Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Animal and in vitro research suggests that cordyceps stimulates the immune system. However, limited clinical research suggests that taking cordyceps may lower the necessary therapeutic dose of the immunosuppressant cyclosporine, which suggests that cordyceps may have an immunosuppressive effect.
Testosterone
Theoretically, concurrent use of cordyceps and testosterone might have additive effects.
Animal research suggests that cordyceps can increase testosterone levels. The clinical significance of this finding is unclear.
Turkey Tail Mushroom
Antidiabetes Drugs
Theoretically, taking turkey tail mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that turkey tail mushroom and a polysaccharide component can have hypoglycemic effects.
Cyclophosphamide
Theoretically, the polysaccharide peptide (PSP) component of turkey tail mushroom might increase exposure to cyclophosphamide.
Some animal research shows that the PSP component of turkey tail mushroom can increase the area under the concentration-time curve (AUC) of cyclophosphamide by 44% to 50% and the half-life by 34% to 43%. This interaction could potentially increase the effects and adverse effects of cyclophosphamide. However, it is not known whether PSP affects the levels of the active metabolites of cyclophosphamide that are responsible for its clinical activity.
Tamoxifen (Nolvadex)
Theoretically, the polysaccharide peptide (PSP) component of turkey tail mushroom might interfere with the absorption of tamoxifen.
Animal research suggests that PSP increases the time to reach maximum concentration of a single dose of tamoxifen by about 9.5 hours, or 228%. When repeated doses of tamoxifen were given, the time to reach maximum concentration was increased by about 5.6 hours, or 93%. However, PSP did not affect the maximum concentration or the area under the curve of tamoxifen.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, the polysaccharide peptide (PSP) component of turkey tail mushroom might inhibit CYP2C9.
Laboratory research suggests that the PSP component of turkey tail mushroom dose-dependently inhibits CYP2C9. Theoretically, taking PSP with drugs metabolized by CYP2C9 might increase drug levels and the risk of adverse effects. However, this has not been reported in humans.
Brand information
Manufacturer and brand details for Myco-Immune, from the product label.
Myco-Immune by Thorne: Common Questions
Does Myco-Immune by Thorne interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What are these mushrooms supposed to do?
Can I take this while pregnant or breastfeeding?
What are the most common side effects?
Does this product have any fillers or additives?
I'm on blood pressure and diabetes medication. Can I take this?
How long have people been using these mushrooms?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Myco-Immune is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Myco-Immune’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Reishi Mushroom
Interacts with 375 drugsReishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits is limited or low-quality, so it should...
Read the full Reishi Mushroom monograph → Herb & supplement monographMaitake Mushroom
Interacts with 260 drugsMaitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and blood pressure effects. The human evidence...
Read the full Maitake Mushroom monograph → Herb & supplement monographTurkey Tail Mushroom
Interacts with 187 drugsTurkey tail is a woodland mushroom rich in polysaccharides like beta-glucans, and it is mainly used to support the immune system. Some of its purified extracts (PSK and PSP) have been studie...
Read the full Turkey Tail Mushroom monograph → Herb & supplement monographCordyceps
Interacts with 249 drugsCordyceps is a fungus used in traditional Chinese medicine for energy, exercise performance, and lung and immune support. Human research is limited and mostly low quality, so its benefits ar...
Read the full Cordyceps monograph → Herb & supplement monographShiitake Mushroom
Interacts with 312 drugsShiitake is a popular edible mushroom that is nutritious and safe to eat as food for most people. Some of its extracts (like lentinan and AHCC) have been studied as immune support, mainly al...
Read the full Shiitake Mushroom monograph →Sources & How We Checked
Myco-Immune's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 121 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Reishi Mushroom 17 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Tao J, Feng KY. Experimental and clinical studies on inhibitory effect of ganoderma lucidum on platelet aggregation. J Tongji Med Univ 1990;10:240-3. PubMed
- Singh AB, Gupta SK, Pereira BM, Prakash D. Sensitization to Ganoderma lucidum in patients with respiratory allergy in India. Clin Exp Allergy 1995;25:440-7.
- Lee SY, Rhee HM. Cardiovascular effects of mycelium extract of Ganoderma lucidum: inhibition of sympathetic outflow as a mechanism of its hypotensive action. Chem Pharm Bull (Tokyo) 1990;38:1359-64. PubMed
- Kwok Y, Ng KFJ, Li, CCF, et al. A prospective, randomized, double-blind, placebo-controlled study of the platelet and global hemostatic effects of Ganoderma lucidum (Ling-Zhi) in healthy volunteers. Anesth Analg 2005;101:423-6. PubMed
- Wanmuang, H., Leopairut, J., Kositchaiwat, C., Wananukul, W., and Bunyaratvej, S. Fatal fulminant hepatitis associated with Ganoderma lucidum (Lingzhi) mushroom powder. J Med Assoc Thai. 2007;90(1):179-181.
- Seto, S. W., Lam, T. Y., Tam, H. L., Au, A. L., Chan, S. W., Wu, J. H., Yu, P. H., Leung, G. P., Ngai, S. M., Yeung, J. H., Leung, P. S., Lee, S. M., and Kwan, Y. W. Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db
- Chu, T. T., Benzie, I. F., Lam, C. W., Fok, B. S., Lee, K. K., and Tomlinson, B. Study of potential cardioprotective effects of Ganoderma lucidum (Lingzhi): results of a controlled human intervention trial. Br.J.Nutr. 2012;107(7):1017-1027.
- Jin, X., Ruiz, Beguerie J., Sze, D. M., and Chan, G. C. Ganoderma lucidum (Reishi mushroom) for cancer treatment. Cochrane.Database.Syst.Rev. 2012;6:CD007731.
- Kabir, Y., Kimura, S., and Tamura, T. Dietary effect of Ganoderma lucidum mushroom on blood pressure and lipid levels in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol.(Tokyo) 1988;34(4):433-438. PubMed
- Kanmatsuse, K., Kajiwara, N., Hayashi, K., Shimogaichi, S., Fukinbara, I., Ishikawa, H., and Tamura, T. [Studies on Ganoderma lucidum. I. Efficacy against hypertension and side effects]. Yakugaku Zasshi 1985;105(10):942-947. PubMed
- Gao, Y., Lan, J., Dai, X., Ye, J., and Zhou, S. A Phase I/II Study of Ling Zhi Mushroom Ganoderma lucidum(W.Curt: Fr.) Lloyd (Aphyllophoromycetideae) Extract in Patients with Type II Diabetes Mellitus. International Journal of Medicinal Mushrooms 2004;6. DOI
- Jin H, Zhang G, Cao X, and et al. Treatment of hypertension by linzhi combined with hypotensor and its effects on arterial, arteriolar and capillary pressure and microcirculation. In: Niimi H, Xiu RJ, Sawada T, and et al. Microcirculatory Approach to Asi
- Klupp NL, Chang D, Hawke F, Kiat H, Cao H, Grant SJ, Bensoussan A. Ganoderma lucidum mushroom for the treatment of cardiovascular risk factors. Cochrane Database Syst Rev. 2015 Feb 17;2:CD007259. PubMed
- Zhao H, Zhang Q, Zhao L, Huang X, Wang J, Kang X. Spore Powder of Ganoderma lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial. Evid Based Complement Alternat Med. 2012;2012:809614.
- Pazzi F, Adsuar JC, Domínguez-Muñoz FJ, García-Gordillo MA, Gusi N, Collado-Mateo D. Ganoderma lucidum effects on mood and health-related quality of life in women with fibromyalgia. Healthcare (Basel) 2020;8(4):520. PubMed
- Kogure T, Koiwai A, Fukushi D, et al. Hypereosinophilia with hepatic nodule formation caused by Ganoderma lucidum. Intern Med 2021;60(24):3897-3903.
Maitake Mushroom 8 references
- Kabir Y, Kimura S. Dietary mushrooms reduce blood pressure in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol (Tokyo) 1989;35:91-4. PubMed
- Kabir Y, Yamaguchi M, Kimura S. Effect of shiitake (Lentinus edodes) and maitake (Grifola frondosa) mushrooms on blood pressure and plasma lipids of spontaneously hypertensive rats. J Nutr Sci Vitaminol (Tokyo) 1987;33:341-6. PubMed
- Konno S, Tortorelis DG, Fullerton SA, et al. A possible hypoglycaemic effect of maitake mushroom on Type 2 diabetic patients. Diabet Med 2001;18:1010. PubMed
- Chen JT, Tominaga K, Sato Y, et al. Maitake mushroom (Grifola frondosa) extract induces ovulation in patients with polycystic ovary syndrome: a possible monotherapy and a combination therapy after failure with first-line clomiphene citrate. J Altern Compl
- Hanselin MR, Vande Griend JP, Linnebur SA. INR elevation with maitake extract in combination with warfarin. Ann Pharmacother 2010;44:223-4. PubMed
- Talpur, N. A., Echard, B. W., Fan, A. Y., Jaffari, O., Bagchi, D., and Preuss, H. G. Antihypertensive and metabolic effects of whole Maitake mushroom powder and its fractions in two rat strains. Mol.Cell Biochem. 2002;237(1-2):129-136. PubMed
- Deng, G., Lin, H., Seidman, A., Fornier, M., D'Andrea, G., Wesa, K., Yeung, S., Cunningham-Rundles, S., Vickers, A. J., and Cassileth, B. A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: i
- Wesa KM, Cunningham-Rundles S, Klimek VM, et al. Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study. Cancer Immunol Immunother 2015;64(2):237-47. PubMed
Turkey Tail Mushroom 15 references
- Nakazato H, Koike A, Saji S, et al. Efficacy of immunochemotherapy as adjuvant treatment after curative resection of gastric cancer. Study Group of Immunochemotherapy with PSK for Gastric Cancer. Lancet 1994;343:1122-6. PubMed
- Mitomi T, Tsuchiya S, Iijima N, et al. Randomized, controlled study on adjuvant immunochemotherapy with PSK in curatively resected colorectal cancer. The Cooperative Study Group of Surgical Adjuvant Immunochemotherapy for Cancer of Colon and Rectum (Kanag DOI
- Torisu M, Hayashi Y, Ishimitsu T, et al. Significant prolongation of disease-free period gained by oral polysaccharide K (PSK) administration after curative surgical operation of colorectal cancer. Cancer Immunol Immunother 1990;31:261-8. PubMed
- Tsujitani, S., Kakeji, Y., Orita, H., Watanabe, A., Kohnoe, S., Baba, H., Anai, H., Maehara, Y., and Sugimachi, K. Postoperative adjuvant immunochemotherapy and infiltration of dendritic cells for patients with advanced gastric cancer. Anticancer Res 199
- Kojima, J., Kamata, T., and Monna, T. [Evaluation of immunochemotherapy in patients with primary liver cancer. Osaka Research Society for Liver, Gallbladder and Pancreas]. Gan To Kagaku Ryoho 1987;14(1):179-187.
- Fukuo, Y., Terashi, A., Hayashi, Y., Yano, Y., and Atarashi, J. [A clinical trial of cis-platinum (II) in combination with PSK and FT-207 in advanced stomach cancer]. Gan To Kagaku Ryoho 1985;12(4):960-965.
- Imaizumi, M., Kondo, T., Kamei, H., and Ichihashi, H. [Cooperative studies on surgical adjuvant immunochemotherapy for prevention of postoperative recurrence of gastric cancer]. Gan To Kagaku Ryoho 1984;11(1):60-68.
- Yeung JH and Or PM. Polysaccharide peptides from Coriolus versicolor competitively inhibit tolbutamide 4-hydroxylation in specific human CYP2C9 isoform and pooled human liver microsomes. Phytomedicine 2011;18(13):1170-5. PubMed
- Eliza WL, Fai CK, Chung LP. Efficacy of Yun Zhi (Coriolus versicolor) on survival in cancer patients: systematic review and meta-analysis. Recent Pat Inflamm Allergy Drug Discov 2012;6(1):78-87. PubMed
- Chan SL, Yeung JH. Effects of polysaccharide peptide (PSP) from Coriolus versicolor on the pharmacokinetics of cyclophosphamide in the rat and cytotoxicity in HepG2 cells. Food Chem Toxicol 2006;44:689-94. PubMed
- Serrano L, López AC, González SP, et al. Efficacy of a Coriolus versicolor-based vaginal gel in women with human papillomavirus-dependent cervical lesions: The PALOMA study. J Low Genit Tract Dis 2021;25(2):130-136. PubMed
- Meng F, Lin Y, Hu L, Feng W, Su P, Wu L. The therapeutic effect of Coriolus versicolor fruiting body on STZ-induced ICR diabetic mice. J Healthc Eng 2022;2022:7282453. PubMed
- Razmovski-Naumovski V, Kimble B, Laurenti D, Nammi S, Norimoto H, Chan K. Polysaccharide peptide extract from Coriolus versicolor increased T(max) of tamoxifen and maintained biochemical serum parameters, with no change in the metabolism of tamoxifen in t
- Cortés Bordoy J, de Santiago García J, Agenjo González M, et al. Effect of a multi-ingredient Coriolus-versicolor-based vaginal gel in women with HPV-dependent cervical lesions: The papilobs real-life prospective study. Cancers (Basel) 2023;15(15):3863. PubMed
- Nikolic M, Lazarevic N, Novakovic J, et al. Characterization, in vitro biological activity and in vivo cardioprotective properties of Trametes versicolor (L.:Fr.) quél. heteropolysaccharides in a rat model of metabolic syndrome. Pharmaceuticals (Basel) 20 PubMed
See these in context on the Turkey Tail Mushroom monograph →
Cordyceps 14 references
- Zhu JS, Halpern GM, Jones K. The scientific rediscovery of an ancient Chinese herbal medicine: Cordyceps sinensis: part I. J Altern Complement Med 1998;4:289-303.
- Zhu JS, Halpern GM, Jones K. The scientific rediscovery of a precious ancient Chinese herbal regimen: Cordyceps sinensis: part II. J Altern Complement Med 1998;4:429-57.
- Chen YJ, Shiao MS, Lee SS, Wang SY. Effect of Cordyceps sinensis on the proliferation and differentiation of human leukemic U937 cells. Life Sci 1997;60:2349-59. PubMed
- Zhao Y. [Inhibitory effects of alcoholic extract of Cordyceps sinensis on abdominal aortic thrombus formation in rabbits]. Chung Hua I Hsueh Tsa Chih (Taipei) 1991;71:612-5, 42.
- Chen GZ, Chen GL, Sun T, et al. Effects of Cordyceps sinensis on murine T lymphocyte subsets. Chin Med J (English) 1991;104:4-8.
- Zhu XY, Yu HY. [Immunosuppressive effect of cultured Cordyceps sinensis on cellular immune response]. Chung Hsi I Chieh Ho Tsa Chih 1990;10:485-7, 454.
- Hsu, C. C., Huang, Y. L., Tsai, S. J., Sheu, C. C., and Huang, B. M. In vivo and in vitro stimulatory effects of Cordyceps sinensis on testosterone production in mouse Leydig cells. Life Sci 9-5-2003;73(16):2127-2136. PubMed
- Ikumoto, T., Sasaki, S., Namba, H., Toyama, R., Moritoki, H., and Mouri, T. [Physiologically active compounds in the extracts from tochukaso and cultured mycelia of Cordyceps and Isaria]. Yakugaku Zasshi 1991;111(9):504-509. PubMed
- Wu, T. N., Yang, K. C., Wang, C. M., Lai, J. S., Ko, K. N., Chang, P. Y., and Liou, S. H. Lead poisoning caused by contaminated Cordyceps, a Chinese herbal medicine: two case reports. Sci.Total Environ. 4-5-1996;182(1-3):193-195. PubMed
- Hong T, Zhang M, Fan J. Cordyceps sinensis (a traditional Chinese medicine) for kidney transplant recipients (Review). Cochrane Database Syst Rev. 2015;(10):CD009698. doi: 10.1002/14651858.CD009698.pub2.
- Zhang HW, Lin ZX, Tung YS, Kwan TH, Mok CK, Leung C, Chan LS. Cordyceps sinensis (a traditional Chinese medicine) for treating chronic kidney disease (Review). Cochrane Database Syst Rev. 2014;(12):CD008353. doi: 10.1002/14651858.CD008353.pub2. PubMed
- Bee Yean O, Zoriah A. Efficacy of Cordyceps sinensis as an adjunctive treatment in hemodialysis patients: a systematic review and Meta-analysis. J Tradit Chin Med. 2019;39(1):1-14.
- Thurian D, Montani M, Stickel F. Drug-induced, mixed-type hepatitis following ingestion of Cordyceps sinensis. Int J Clin Pharmacol Ther 2022;60(2):115-120. PubMed
- Yu X, Mao Y, Shergis JL, et al. Effectiveness and safety of oral Cordyceps sinensis on stable COPD of GOLD stages 2-3: Systematic review and meta-analysis. Evid Based Complement Alternat Med. 2019;2019:4903671.
Shiitake Mushroom 67 references
- Hitosugi M, Kitamura O, Takatsu A, Yoshino Y. Autopsy case of duodenal obstruction from impacted mushroom. J Gastroenterol 1998;33:562-5. PubMed
- Hanada K, Hashimoto I. Flagellate mushroom (Shiitake) dermatitis and photosensitivity. Dermatol 1998;197:255-7. PubMed
- Levy AM, Kita H, Phillips SF, et al. Eosinophilia and gastrointestinal symptoms after ingestion of shiitake mushrooms. J Allergy Clin Immunol 1998;101:613-20. PubMed
- Murakami M, Kawabe K, Hosoi Y, et al. Decreased pulmonary perfusion in hypersensitivity pneumonitis caused by Shiitake mushroom spores. J Intern Med 1997;241:85-8. PubMed
- Matsui S, Nakazawa T, Umegae Y, Mori M. Hypersensitivity pneumonitis induced by Shiitake mushroom spores. Intern Med 1992;31:1204-6.
- Nakamura T. Shiitake (Lentinus edodes) dermatitis. Contact Dermatitis 1992;27:65-70.
- Ueda A, Obama K, Aoyama K, et al. Allergic contact dermatitis in shiitake (Lentinus edodes (Berk) Sing) growers. Contact Dermatitis 1992;26:228-33.
- Burikhanov, R. B., Wakame, K., Igarashi, Y., Wang, S., and Matsuzaki, S. Suppressive effect of active hexose correlated compound (AHCC) on thymic apoptosis induced by dexamethasone in the rat. Endocr.Regul. 2000;34(4):181-188.
- Gao, Y., Zhang, D., Sun, B., Fujii, H., Kosuna, K., and Yin, Z. Active hexose correlated compound enhances tumor surveillance through regulating both innate and adaptive immune responses. Cancer Immunol.Immunother. 2006;55(10):1258-1266. PubMed
- Ritz, B. W., Nogusa, S., Ackerman, E. A., and Gardner, E. M. Supplementation with active hexose correlated compound increases the innate immune response of young mice to primary influenza infection. J Nutr. 2006;136(11):2868-2873. PubMed
- Aviles, H., O'Donnell, P., Sun, B., and Sonnenfeld, G. Active hexose correlated compound (AHCC) enhances resistance to infection in a mouse model of surgical wound infection. Surg.Infect.(Larchmt.) 2006;7(6):527-535. PubMed
- Spierings, E. L., Fujii, H., Sun, B., and Walshe, T. A Phase I study of the safety of the nutritional supplement, active hexose correlated compound, AHCC, in healthy volunteers. J Nutr Sci Vitaminol.(Tokyo) 2007;53(6):536-539. PubMed
- Aviles, H., O'Donnell, P., Orshal, J., Fujii, H., Sun, B., and Sonnenfeld, G. Active hexose correlated compound activates immune function to decrease bacterial load in a murine model of intramuscular infection. Am J Surg. 2008;195(4):537-545. PubMed
- Ritz, B. W. Supplementation with active hexose correlated compound increases survival following infectious challenge in mice. Nutr.Rev. 2008;66(9):526-531. PubMed
- Terakawa, N., Matsui, Y., Satoi, S., Yanagimoto, H., Takahashi, K., Yamamoto, T., Yamao, J., Takai, S., Kwon, A. H., and Kamiyama, Y. Immunological effect of active hexose correlated compound (AHCC) in healthy volunteers: a double-blind, placebo-controll
- Mach, C. M., Fugii, H., Wakame, K., and Smith, J. Evaluation of active hexose correlated compound hepatic metabolism and potential for drug interactions with chemotherapy agents. J Soc Integr.Oncol. 2008;6(3):105-109.
- Wang, S., Welte, T., Fang, H., Chang, G. J., Born, W. K., O'Brien, R. L., Sun, B., Fujii, H., Kosuna, K., and Wang, T. Oral administration of active hexose correlated compound enhances host resistance to West Nile encephalitis in mice. J Nutr. 2009;139(3 PubMed
- Sumiyoshi, Y., Hashine, K., Kakehi, Y., Yoshimura, K., Satou, T., Kuruma, H., Namiki, S., and Shinohara, N. Dietary administration of mushroom mycelium extracts in patients with early stage prostate cancers managed expectantly: a phase II study. Jpn.J Cl PubMed
- Yin, Z., Fujii, H., and Walshe, T. Effects of active hexose correlated compound on frequency of CD4+ and CD8+ T cells producing interferon-gamma and/or tumor necrosis factor-alpha in healthy adults. Hum.Immunol. 2010;71(12):1187-1190.
- Lee, W. W., Lee, N., Fujii, H., and Kang, I. Active Hexose Correlated Compound promotes T helper (Th) 17 and 1 cell responses via inducing IL-1beta production from monocytes in humans. Cell Immunol. 2012;275(1-2):19-23.
- Daddaoua, A., Martinez-Plata, E., Ortega-Gonzalez, M., Ocon, B., Aranda, C. J., Zarzuelo, A., Suarez, M. D., de Medina, F. S., and Martinez-Augustin, O. The nutritional supplement Active Hexose Correlated Compound (AHCC) has direct immunomodulatory actio
- Roman, B. E., Beli, E., Duriancik, D. M., and Gardner, E. M. Short-term supplementation with active hexose correlated compound improves the antibody response to influenza B vaccine. Nutr Res. 2013;33(1):12-17. PubMed
- Uno, K., Kosuna, K., Sun, B., Fujii, H., Wakame, K., Chikumaru, S., Hosokawa, G., and Ueda, Y. Active Hexose Correlated Compound (AHCC) Improves Immunological Parameters and Performance Status of Patients with Solid Tumors. Biotherapy 2000;14(3):303-309.
- Ghoneum, M., Wimbley, M., Salem, F., McKlain, A., Attallah, N., and Gill, G. Immunomodulatory and anticancer effects of active hexose correlated compound (AHCC). Int J Immunother 1995;11:23-28.
- Thaiudom, S., Piyaniran, W., and Chutaputthi, A. A study of the efficacy of Active Hexose Correlated Compound (AHCC) in the treatment of chronic Hepatitis C patients at Phramongkutklao Hospital. The Medical News (Thailand) 2010;325:13-16.
- Smith, J. A., Hunter, R. J., Fujii, H., Wakame, K., and Wolf, J. Defining Synergistic Activity ofthe Combination of Active Hexose Correlated Compound (AHCC) with Liposomal Doxorubicin (Doxil). Presented at the 18th International Congress on Nutrition and
- Sia, G. M. and Candlish, J. K. Effects of shiitake (Lentinus edodes) extract on human neutrophils and the U937 monocytic cell line. Phytother.Res. 1999;13(2):133-137. DOI
- Fujiwara, K., Sato, T., Yonei, T., Genba, K., Nogami, N., and Yamadori, I. [A case of chronic hypersensitivity pneumonitis induced by shiitake mushroom spores]. Nihon Kokyuki.Gakkai Zasshi 2000;38(12):908-913.
- Lippert, U., Martin, V., Schwertfeger, C., Junghans, V., Ellinghaus, B., and Fuchs, T. Shiitake dermatitis. Br.J Dermatol. 2003;148(1):178-179.
- Lobanok, A. G., Babitskaia, V. G., Plenina, L. V., Puchkova, T. A., and Osadchaia, O. V. [Composition and biological activity of submerged mycelium of the xylotrophic basidiomycete Lentinus edodes]. Prikl.Biokhim.Mikrobiol. 2003;39(1):69-73. DOI
- Curnow, P. and Tam, M. Contact dermatitis to Shiitake mushroom. Australas.J.Dermatol. 2003;44(2):155-157. PubMed
- Mak, R. K. and Wakelin, S. H. Shiitake dermatitis: the first case reported from a European country. Br J Dermatol 2006;154(4):800-801. PubMed
- Sastre, J., Ibanez, M. D., Lopez, M., and Lehrer, S. B. Respiratory and immunological reactions among Shiitake (Lentinus edodes) mushroom workers. Clin.Exp.Allergy 1990;20(1):13-19.
- Liu, M., Li, J., Kong, F., Lin, J., and Gao, Y. Induction of immunomodulating cytokines by a new polysaccharide-peptide complex from culture mycelia of Lentinus edodes. Immunopharmacology 1998;40(3):187-198. PubMed
- Ade R, Sukut C, Wiser HJ, Shockman S, Buescher L. Shiitake dermatitis demonstrating Köebner phenomenon. Int J Dermatol. 2015;54(5):e179-81.
- Adler MJ, Larsen WG. Clinical variability of shiitake dermatitis. J Am Acad Dermatol. 2012 Oct;67(4):e140-1. PubMed
- Adriano AR, Acosta ML, Azulay DR, Quiroz CD, Talarico SR. Shiitake dermatitis: the first case reported in Brazil. An Bras Dermatol. 2013 May-Jun;88(3):417-9. PubMed
- Ampere A, Delhaes L, Soots J, Bart F, Wallaert B. Hypersensitivity pneumonitis induced by Shiitake mushroom spores. Med Mycol. 2012 Aug;50(6):654-7. PubMed
- Baran W, Batycka-Baran A, Maj J, Szepietowski JC. Shiitake dermatitis - now also in Poland. Acta Derm Venereol. 2015 Jan;95(1):102-3. PubMed
- Boels D, Landreau A, Bruneau C, et al. Shiitake dermatitis recorded by French Poison Control Centers - new case series with clinical observations. Clin Toxicol (Phila). 2014 Jul;52(6):625-8. PubMed
- Chu EY, Anand D, Dawn A, Elenitsas R, Adler DJ. Shiitake dermatitis: a report of 3 cases and review of the literature. Cutis. 2013 Jun;91(6):287-90.
- Corazza M, Zauli S, Ricci M, et al. Shiitake dermatitis: toxic or allergic reaction? J Eur Acad Dermatol Venereol. 2015 Jul;29(7):1449-51. PubMed
- Czarnecka AB, Kreft B, Marsch WCh. Flagellate dermatitis after consumption of Shiitake mushrooms. Postepy Dermatol Alergol. 2014 Jun;31(3):187-90. PubMed
- Dai X, Stanilka JM, Rowe CA, et al. Consuming Lentinula edodes (Shiitake) Mushrooms Daily Improves Human Immunity: A Randomized Dietary Intervention in Healthy Young Adults. J Am Coll Nutr. 2015;34(6):478-87.
- Hamer SE, Kulkarni K, Cohen SN. Shiitake dermatitis with oral ulceration and pustules. Clin Exp Dermatol. 2015 Apr;40(3):332-3. PubMed
- Hiernickel C, Metz S, Elsner P. Shiitake dermatitis: an impressive case report. J Dtsch Dermatol Ges. 2015 May;13(5):455-6. PubMed
- Karanovic S, George S, Topham E. Don't miss shiitake dermatitis: a case report. Br J Gen Pract. 2014 Aug;64(625):426-7. PubMed
- Kopp T, Mastan P, Mothes N, Tzaneva S, Stingl G, Tanew A. Systemic allergic contact dermatitis due to consumption of raw shiitake mushroom. Clin Exp Dermatol. 2009 Dec;34(8):e910-3. PubMed
- Lingström P, Zaura E, Hassan H, et al. The anticaries effect of a food extract (shiitake) in a short-term clinical study. J Biomed Biotechnol. 2012;2012:217164. PubMed
- Loo HV, Oon HH. Flagellate dermatitis following consumption of shiitake mushroom. Dermatol Reports. 2011 Oct 5;3(2):e21. PubMed
- Luber AJ, Ackerman LS. Flagellate shiitake mushroom dermatitis. Dermatol Online J. 2015 Aug 15;21(8). pii: 13030/qt7rm57553. DOI
- Mendonça CN, Silva PM, Avelleira JC, Nishimori FS, Cassia Fde F. Shiitake dermatitis. An Bras Dermatol. 2015 Mar-Apr;90(2):276-8.
- Netchiporouk E, Pehr K, Ben-Shoshan M, Billick RC, Sasseville D, Singer M. Pustular flagellate dermatitis after consumption of shiitake mushrooms. JAAD Case Rep. 2015 May 2;1(3):117-9. PubMed
- Nguyen AH, Gonzaga MI, Lim VM, Adler MJ, Mitkov MV, Cappel MA. Clinical features of shiitake dermatitis: a systematic review. Int J Dermatol. 2017 Jun;56(6):610-616. PubMed
- Poppe LM, Anders D, Kneitz H, Bröcker EB, Benoit S. Flagellate dermatitis caused by shiitake mushrooms. An Bras Dermatol. 2012 May-Jun;87(3):463-5. PubMed
- Pravettoni V, Primavesi L, Piantanida M. Shiitake mushroom (Lentinus edodes): a poorly known allergen in Western countries responsible for severe work-related asthma. Int J Occup Med Environ Health. 2014 Oct;27(5):871-4. PubMed
- Ricar J, Pizinger K, Cetkovska P. Shiitake dermatitis: a distinctive clinical entity. Int J Dermatol. 2013 Dec;52(12):1620-1. PubMed
- Shozushima M, Ohata K, Nonaka K, Matsuhashi N. Shiitake mushroom-induced ileus managed using double-balloon enteroscopy. Endoscopy. 2013;45 Suppl 2 UCTN:E437. PubMed
- Uslu U, Linkner RV. Shiitake mushroom dermatitis. Cutis. 2015 May;95(5):E11-2.
- Wang AS, Barr KL, Jagdeo J. Shiitake mushroom-induced flagellate erythema: A striking case and review of the literature. Dermatol Online J. 2013 Apr 15;19(4):5. DOI
- Tan J, Yuan K, Zuo J, et al. Two cases of small bowel obstruction due to a shiitake mushroom. Gastroenterol Rep (Oxf) 2019;7(4):298-300. doi: 10.1093/gastro/gox028. PubMed
- Boels D, Greillet C, Langrand J, et al. Shiitake dermatitis: experience of the Poison Control Centre Network in France from 2014 to 2019. Clin Toxicol (Phila) 2022. PubMed
- Miyagishima D, Inoue M, Kinjo K, et al. A case of bowel obstruction due to shiitake mushrooms: Diagnostic features on computed tomography. Intern Med 2022. PubMed
- Soga K, Mukai H, Kitae H. Management of shiitake mushroom-induced ileus using balloon enteroscopy. Dig Endosc 2022;34(4):e58-e59. PubMed
- Ma JY, Liu JW. Shiitake flagellate dermatitis. Mayo Clin Proc 2022;97(12):2192-2193. PubMed
- Booms A, Rashid Z, Al-Rubaie V, Bal A. Shiitake dermatitis: a case report of a rare mushroom-induced dermatitis in the United States. Int J Dermatol 2022. PubMed
- Sudy E, Urbina F. Shiitake dermatitis: clinical forms of presentation. Int J Dermatol 2023. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC