Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Natural Female Support Ingredients & Drug Interactions

by Life Extension

Natural Female Support label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Natural Female Support against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Natural Female Support is a dietary supplement by Life Extension with 2 active ingredients. Its ingredients are commonly taken for sleep problems and insomnia, anxiety and restlessness, menopausal symptoms.Based on those ingredients, 863 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lifenol Hops (Humulus lupulus) extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Natural Female Support by Life Extension

Ask about any prescription or over-the-counter medication and we check it for interactions with Natural Female Support by Life Extension — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Natural Female Support by Life Extension

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Natural Female Support contains two active ingredients. Lifenol Hops extract, a standardized preparation from the hops plant, is the first.

The second is HMRlignan Norway Spruce extract, derived from spruce lignan. The product also contains inactive ingredients — rice flour, vegetable cellulose, and vegetable stearate — which serve as fillers and capsule material.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Hops's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: postmenopausal women nutritional support.
  • We looked for evidence on: Menopausal symptoms, Hormonal balance, Hot flashes, Night sweats.
  • The closest evidence on file: Hops is rated "Insufficient Reliable Evidence To Rate" for Menopausal symptoms (Natural Medicines).

The evidence for Lifenol Hops in this product is not established in our data. Hops has been studied for age-related cognitive decline, sexual dysfunction, anxiety, ADHD, indigestion (dyspepsia), and insomnia, but the evidence is insufficient to rate it as effective for any of these uses.

We hold no effectiveness data for the Norway Spruce extract.

The evidence, ingredient by ingredient Hops

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Hops is generally well tolerated in the short term but may cause drowsiness — don't drive or operate machinery until you know how it affects you. Long-term safety hasn't been well studied.

The safety data advises against using this product during pregnancy. While breastfeeding, safety is unknown; the data recommends avoiding it.

Occupational exposure to hops dust is linked to chronic respiratory symptoms like dry cough and bronchitis, though this typically occurs in workers handling large amounts. A small number of cases of postmenopausal bleeding have been reported with combined hops-and-soy supplements, though it's unclear which ingredient was responsible.

Side effects, ingredient by ingredient Hops

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Hops.
  • The most serious interaction on file is rated Moderate.
  • For scale: 864 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take any sedative medications (such as sleep aids or anxiety medications) — hops may add to drowsiness. If you use estrogen-based hormone therapy or birth control, confirm it's safe to combine.

Medications broken down by your liver's CYP3A4 pathway may also be affected, though the risk is minor.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Natural Female Support may appeal to people exploring botanicals for female wellness, but the evidence for hops in the uses listed here isn't established. If you take sedatives, hormone therapy, or other regular medications, talk with your doctor or pharmacist before starting — hops can interact with several drug types.

Pregnancy and breastfeeding are contraindicated; the safety data advises against it in both cases.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 22, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Natural Female Support, straight from the product label.

Brand Life Extension
Barcode (UPC) 737870122135
Net contents 30 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Apr 22, 2016
DSLD ID 58912
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult Female (18 - 50 Years), Menopause, Post-Menopause, Seniors/Mature (>50 Years) - Women ONLY
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Natural Female Support by Life Extension, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
UPC/BARCODE
737870122135
IngredientAmount% DV
Lifenol Hops (Humulus lupulus) extract120 mg--
HMRlignan Norway Spruce (Picea abies) Lignan extract56 mg--

Other ingredients: Rice Flour, Vegetable Cellulose, Vegetable Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

To report a serious adverse event or obtain product information, contact 1-866-280-2852

Scan for product info

Suggested/Recommended/Usage/Directions

Read the entire label and follow the directions carefully prior to use. DIRECTIONS: Take one (1) capsule daily in the morning with or without food, or as recommended by a healthcare practitioner.

For optimal benefit, in addition to standardized extracts of hops and plant lignans, Life Extension strongly recommends postmenopausal women take a variety of nutritional ingredients like curcumin, cruciferous vegetable extracts (e.g. sulforaphane, carnosic acid), Omega-3 fatty acids, vitamin D, and calcium-D-glucarate to support healthy estrogen metabolism and cellular integrity.

Precautions

This product should not be used in place of or as a substitute for recommendations by your healthcare professional.

WARNINGS -Keep out of reach of children

-DO NOT EXCEED THE RECOMMENDED DOSE. -Do not purchase if outer seal is broken or damaged.

-When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

Brand IP Statement(s)

Lifenol is a trademark of Naturex, Inc. HMRligan is a trademark used under sublicense from Linnea S.A.

General

Q01221D

Formula

Symptomatic Support for Menopausal and Post-Menopausal Women*

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Natural Female Support by Life Extension label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Natural Female Support label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Natural Female Support by Life Extension

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Lifenol Hops (Humulus lupulus) extract

Interacts with
863 drugs
120 mg per serving Form: 8-Prenylnaringenin

Hops are most often used for sleep and mild anxiety, frequently combined with valerian, but the human evidence is limited and not very strong. They ar...

Lifenol Hops (Humulus lupulus) extract monograph & interactions

HMRlignan Norway Spruce (Picea abies) Lignan extract

56 mg per serving Form: Hydroxymatairesinol Potassium Acetate

Other (inactive) ingredients: Rice Flour, Vegetable Cellulose, Vegetable Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Natural Female Support by Life Extension Drug Interactions

Want to check YOUR meds against Natural Female Support?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
863Drugs
289 Moderate 574 Minor

Ingredients driving the most interactions

Lifenol Hops (Humulus lupulus) extract 863

Individual Drug Interactions

The ingredients in Natural Female Support interact with 863 drugs. Click any drug to see the details.

1 of the 2 ingredients in Natural Female Support interact with drugs. Each result below shows which ingredient is responsible. Lifenol Hops (Humulus lupulus) extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Natural Female Support with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lifenol Hops (Humulus lupulus) extract4 drug types · 863 drugs

Cns Depressants

Theoretically, concomitant use of hops with sedative drugs might cause additive sedation.
Some animal research shows that hops has sedative effects.

Likelihood Possible Evidence D
Estrogens

Theoretically, concomitant use of large amounts of hops might interfere with hormone replacement therapy due to competition for estrogen receptors.
In vitro research suggests that certain hops constituents can competitively bind to estrogen receptors. However, most hops extracts contain very small amounts of these constituents.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Hops extract does not seem to affect the metabolism of CYP1A2 substrates.
In vitro research suggests that flavonoid constituents of hops inhibit CYP1A2 enzyme activity. However, a pharmacokinetic study in healthy postmenopausal patients shows that taking a standardized extract of spent hops containing prenylated phenols, as 59.5 mg twice daily for 2 weeks, does not affect levels of caffeine, a CYP1A2 probe substrate.

Likelihood Unlikely Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, hops extract might alter metabolism of CYP3A4 substrates; however, this effect may not be clinically significant.
Animal research suggests that specific constituents of hops, called lupulones, can induce hepatic CYP3A4 enzyme activity. However, a pharmacokinetic study in healthy postmenopausal patients with normal metabolism shows that taking a standardized extract of spent hops containing prenylated phenols, as 59.5 mg twice daily for 2 weeks, decreases the concentration of alprazolam, a CYP3A4 probe substrate, by 7.6%. This reduction is unlikely to be clinically relevant.

Likelihood Possible Evidence D
Lifenol Hops (Humulus lupulus) extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Natural Female Support, from the product label.

Life Extension

See all Life Extension products
Name
Quality Supplements and Vitamins, Inc.
City
Ft. Lauderdale
State
Florida
ZipCode
33309
Phone Number
1-866-280-2852
Web Address
www.lef.org
Pharmacist Counseling Corner

Natural Female Support by Life Extension: Common Questions

Does Natural Female Support by Life Extension interact with any medications?
Yes. Based on its ingredients, Natural Female Support has a known interaction with 863 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Natural Female Support contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this make me drowsy?
Yes, drowsiness is a known side effect of hops. The product is generally well tolerated short-term, but you shouldn't drive or operate machinery until you know how it affects you personally.
Can I take this while pregnant or breastfeeding?
No. The safety data advises against use during pregnancy and recommends avoiding it while breastfeeding — there isn't enough information to know it's safe.
Does this actually work for what it claims?
The evidence isn't established in our data. Hops has been studied for several conditions — including cognitive decline, sexual dysfunction, anxiety, and sleep — but we don't have reliable evidence that it's effective for any of them.
What is Lifenol Hops extract?
It's a standardized extract from the hops plant, chosen for its consistent composition of active compounds.
Can I take this with my birth control or hormone therapy?
Talk with your doctor or pharmacist first. Hops theoretically might interfere with estrogen-based therapies due to competition for estrogen receptors, though this is most likely if you take very large amounts.
What are the inactive ingredients?
The capsule contains rice flour, vegetable cellulose, and vegetable stearate — these are fillers and binding agents with no active role.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Natural Female Support label
Go deeper

The Full Monographs Behind Natural Female Support’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Hops

Interacts with 863 drugs

Hops are most often used for sleep and mild anxiety, frequently combined with valerian, but the human evidence is limited and not very strong. They are generally well tolerated when used sho...

Read the full Hops monograph →
Sources

Sources & How We Checked

Natural Female Support's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Hops 15 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Zava DT, Dollbaum CM, Blen M. Estrogen and progestin bioactivity of foods, herbs, and spices. Proc Soc Exp Biol Med 1998;217:369-78. PubMed
  4. Milligan SR, Kalita JC, Heyerick A, et al. Identification of a potent phytoestrogen in hops (Humulus lupulus L.) and beer. J Clin Endocrinol Metab 1999;84:2249-52.. PubMed
  5. Milligan SR, Kalita JC, Pocock V, et al. The endocrine activities of 8-prenylnaringenin and related hop (Humulus lupulus L.) flavonoids. J Clin Endocrinol Metab 2000;85:4912-5.. DOI
  6. Henderson MC, Miranda CL, Stevens JF, et al. In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops, Humulus lupulus. Xenobiotica 2000;30:235-51.. PubMed
  7. Mannering, G. J., Shoeman, J. A., and Deloria, L. B. Identification of the antibiotic hops component, colupulone, as an inducer of hepatic cytochrome P-4503A in the mouse. Drug Metab Dispos 1992;20(2):142-147. DOI
  8. Skorska, C., Mackiewicz, B., Gora, A., Golec, M., and Dutkiewicz, J. Health effects of inhalation exposure to organic dust in hops farmers. Ann.Univ Mariae.Curie Sklodowska [Med] 2003;58(1):459-465.
  9. Schiller, H., Forster, A., Vonhoff, C., Hegger, M., Biller, A., and Winterhoff, H. Sedating effects of Humulus lupulus L. extracts. Phytomedicine. 2006;13(8):535-541. PubMed
  10. van Hunsel, F. P. and Kampschoer, P. [Postmenopausal bleeding and dietary supplements: a possible causal relationship with hop- and soy-containing preparations]. Ned.Tijdschr.Geneeskd. 2012;156(41):A5095.
  11. Fenselau, C. and Talalay, P. Is oestrogenic activity present in hops? Food Cosmet.Toxicol. 1973;11(4):597-602. PubMed
  12. Godnic-Cvar, J., Zuskin, E., Mustajbegovic, J., Schachter, E. N., Kanceljak, B., Macan, J., Ilic, Z., and Ebling, Z. Respiratory and immunological findings in brewery workers. Am J Ind Med 1999;35(1):68-75. DOI
  13. Lee KM, Jung JS, Song DK, and et al. Effects of Humulus lupulus extract on the central nervous system in mice. Planta Med 1993;59(Suppl):A691.
  14. Assessment report on Humulus lupulus L., flos. European Medicines Agency, 2014. Available at: https://www.ema.europa.eu/en/documents/herbal-report/final-assessment-report-humulus-lupulus-l-flos_en.pdf. Accessed September 29, 2021.
  15. van Breemen RB, Chen L, Tonsing-Carter A, et al. Pharmacokinetic Interactions of a Hop Dietary Supplement with Drug Metabolism in Perimenopausal and Postmenopausal Women. J Agric Food Chem. 2020;68(18):5212-5220. PubMed

See these in context on the Hops monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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