Major interaction on record — check this product against your medications before combining. Based on 3 of 8 ingredients. Check your meds →
Dietary supplement

Nitro-Tech Hardcore Vanilla Ice Cream Milkshake Ingredients & Drug Interactions

by MuscleTech

Nitro-Tech Hardcore Vanilla Ice Cream Milkshake label
See full label image
Liquid Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Nitro-Tech Hardcore Vanilla Ice Cream Milkshake against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Nitro-Tech Hardcore Vanilla Ice Cream Milkshake is a dietary supplement by MuscleTech with 8 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 2,183 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Dietary Fiber, Sodium, Calcium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Nitro-Tech Hardcore Vanilla Ice Cream Milkshake by MuscleTech

Ask about any prescription or over-the-counter medication and we check it for interactions with Nitro-Tech Hardcore Vanilla Ice Cream Milkshake by MuscleTech — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Nitro-Tech Hardcore Vanilla Ice Cream Milkshake by MuscleTech

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 3 of its 20 active ingredients.
  • “SynthePro:” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Nitro Infusion Complex” is a proprietary blend — the label gives one combined amount (970 mg) without saying how much of each component you get.
  • “Nitroxen:” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Nitro-Tech Hardcore contains 19 active and inactive ingredients. The active amino acids and compounds are L-glutamine, sodium, calcium, L-leucine, alpha-lipoic acid, L-isoleucine, L-methionine, taurine, L-phenylalanine, L-valine, L-histidine, L-threonine, lactoferrin, N-acetyl L-cysteine, L-lysine monohydrochloride, glutamine peptides, American ginseng extract, D-myo inositol, and D-pinitol.

The inactive ingredients — fillers and binders like cellulose gum, carrageenan, and dimethylpolysiloxane — make up the rest of the formulation.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: builds lean muscle fast with musclebuilding protein.
  • We looked for evidence on: Athletic performance, Muscle growth, Strength, Sports nutrition.
  • The closest evidence on file: Glutamine is rated "Possibly Ineffective" for Athletic performance (Natural Medicines).
  • Also on file: Lysine is rated "Insufficient Reliable Evidence To Rate" for Athletic performance, Muscle strength.
  • Also on file: Alpha-lipoic Acid is rated "Insufficient Reliable Evidence To Rate" for Muscle strength.

The evidence for this product's ingredients is mixed. L-glutamine is effective for sickle cell disease and possibly effective for HIV/AIDS-related wasting and postoperative recovery.

Calcium is effective for preventing kidney failure and treating low blood calcium (hypocalcemia), and likely effective for osteoporosis. N-acetyl L-cysteine is effective for acetaminophen poisoning and possibly effective for bronchitis.

Lactoferrin is possibly effective for sepsis and pregnancy-related iron deficiency. American ginseng is possibly effective for upper respiratory infections.

Inositol is possibly effective for polycystic ovary syndrome (PCOS) and metabolic syndrome. However, alpha-lipoic acid, L-phenylalanine, L-threonine, and L-lysine are rated only "possibly effective" for their claimed conditions, and L-methionine, L-histidine, and taurine have insufficient evidence or show possibly ineffective ratings.

The evidence we hold does not establish this product as an effective supplement for muscle building or general fitness.

The evidence, ingredient by ingredient Sodium Calcium Black Psyllium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 14 of the 15 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 15 of 15.
  • General safety write-ups exist for 15 of 15.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-glutamine, sodium, calcium, and lactoferrin are generally well tolerated at recommended doses. L-glutamine may cause belching, bloating, constipation, diarrhea, flatulence, gastrointestinal pain, headache, and nausea; rare cases of mania or hypomania have been reported in people with bipolar disorder.

Sodium in excess can worsen high blood pressure and heart disease. Calcium can cause constipation, diarrhea, and flatulence, and very high intakes over 2,000 mg daily are associated with an increased prostate cancer risk.

Alpha-lipoic acid can lower blood sugar and is best used under medical guidance; it should be avoided during pregnancy and breastfeeding due to insufficient safety data. L-phenylalanine should be avoided in supplement doses during pregnancy and breastfeeding.

N-acetyl L-cysteine is generally well tolerated at typical doses but should be discussed with a healthcare provider. American ginseng should be avoided during pregnancy and breastfeeding.

L-threonine and L-lysine may cause headache and gastrointestinal upset; L-lysine pregnancy and breastfeeding safety is not well studied. Taurine is generally well tolerated short-term but long-term safety is less certain; it occurs naturally in breast milk, though supplement safety while breastfeeding is not well studied.

Side effects, ingredient by ingredient Sodium Calcium Black Psyllium

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 12 of the 15 matched ingredients can interact with medications — Black Psyllium, Lysine, Inositol, Phenylalanine, Alpha-lipoic Acid, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; seizure medications; immunosuppressants / transplant drugs; cancer treatments; diabetes medications; heart-rhythm medications; lithium; Parkinson's medications.
  • For scale: 2,184 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your pharmacist or doctor if you take any of the following: HIV integrase inhibitors (dolutegravir, elvitegravir, raltegravir), the antibiotic ceftriaxone given intravenously, levodopa for Parkinson's disease, nitroglycerin (intravenous or transdermal), NMDA antagonists, blood pressure medications, warfarin or other blood thinners, lithium, thyroid hormone like levothyroxine, corticosteroids, baclofen, MAOIs, chemotherapy drugs (alkylating agents or antitumor antibiotics), or diabetes medications. No interactions are documented for L-leucine, L-isoleucine, L-valine, or D-pinitol in the data we hold.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

This is a high-protein milkshake formulated with amino acids and several active botanical and nutrient ingredients. If you take any blood pressure medications, blood thinners, HIV drugs, Parkinson's medications, psychiatric medications, or diabetes medications, you need to check your exact prescriptions against the interaction data before starting this product.

Talk with your pharmacist or doctor before taking this — especially if you're pregnant, breastfeeding, or have kidney or liver disease.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 16 of 20 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 23, 2011.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Nitro-Tech Hardcore Vanilla Ice Cream Milkshake, straight from the product label.

Brand MuscleTech
Barcode (UPC) 631656800203
Net contents 15 fl. Oz.; 444 mL
Market status On market
Date entered into DSLD Dec 23, 2011
DSLD ID 2923
Product type Other Combinations
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Nitro-Tech Hardcore Vanilla Ice Cream Milkshake by MuscleTech, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
15 fl. Oz.
Maximum serving Sizes:
15 fl. Oz.
Servings per container
1
UPC/BARCODE
631656800203
IngredientAmount% DV
Calories190 Calorie(s)--
Total Carbohydrates7 Gram(s)2%
L-Glutamine0 NP--
Sugar2 Gram(s)--
Calories from Fat10 Calorie(s)--
Protein40 g90%
Saturated Fat0.5 Gram(s)3%
Sodium85 mg4%
Cholesterol30 mg10%
Calcium672 mg67%
L-Leucine0 NP--
Alpha Lipoic Acid0 NP--
L-Isoleucine0 NP--
L-Methionine0 NP--
Taurine0 NP--
Total Fat1 Gram(s)2%
L-Phenylalanine0 NP--
L-Valine0 NP--
L-Histidine0 NP--
L-Threonine0 NP--
Trans Fat0 Gram(s)--
Dietary Fiber2 Gram(s)8%
Lactoferrin0 NP--
N-Acetyl L-Cysteine0 NP--
L-Lysine Monohydrochloride0 NP--
Glutamine Peptides0 NP--
SynthePro:0 NP--
American Ginseng extract0 NP--
Nitro Infusion Complex970 mg--
Nitroxen:0 NP--
Insulogen:0 NP--
D-Myo Inositol0 NP--
D-Pinitol0 NP--

Other ingredients: filtered Water, Protein Blend (Amino Acid/Protein), Cellulose Gum, Natural and Artificial flavors, Sucralose, Dipotassium Phosphate, Acesulfame-Potassium, Carrageenan, Dimethylpolysiloxane

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Anabolically infused with ~ Musclebuilding amino acid peptides ~ Muscle growth accelerators ~ Anabolic nitrogen drivers

Research and development

World's #1 selling musclebuilding protein

~ Builds lean muscle fast ~ Immediate anabolic effects ~ Real milkshake taste

Naturally & artificially flavored

This advanced technology harnesses the anabolic power of protein with a cutting-edge rapid-delivery system for maximum protein synthesis and accelerated growth.

With diet and weight training.

Made in the U.S.A. from international and domestic ingredients.

Best if used by date on can.

Return for refund where applicable

Brand IP Statement(s)

Powered by Nanomolecular Nitrogen Delivery

Nitro-Tech Hardcore is the world's #1 selling musclebuilding protein developed by the best scientific minds in the supplement industry - Team MuscleTech researchers. Regular protein drinks don't measure up. Nitro-Tech Hardcore is engineered with a cutting-edge matrix called the Nitrogen Delivery System.

Based on America's #1 selling protein powder, Nitro-Tech Hardcore advanced musclebuilding protein drinks are supercharged with revolutionary Nanomolecular Nitrogen Delivery. Noting works like the Nitro-Tech Hardcore!

INZITOL is a registered trademark of Humanetics Corp.

The Nitro-Tech trademark is owned by Nitro US Trademark Ltd. All other trademarks are owned by their respective company and used under license.

2008. U.S. patents pending.

Formula

~ 40 g of musclebuilding Protein

Contains wheat ingredients

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Notice: Use this product as a food supplement only. Do not use for weight reduction.

Contains wheat ingredients

Suggested/Recommended/Usage/Directions

Directions: Drink 1-3 servings (cans) of Nitro-Tech Hardcore daily. For enhanced taste, serve cold. Shake gently before use.

Storage

Refrigerate after opening and do not freeze. Keep below 80(0)F. Contents under pressure.

General

4210US

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Nitro-Tech Hardcore Vanilla Ice Cream Milkshake by MuscleTech label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Nitro-Tech Hardcore Vanilla Ice Cream Milkshake label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Nitro-Tech Hardcore Vanilla Ice Cream Milkshake by MuscleTech

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size15 fl. Oz. Dosage formLiquid Servings per container1 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

2 Gram(s) per serving

Protein

40 g per serving

Sodium

Interacts with
205 drugs
85 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Calcium

Interacts with
168 drugs
672 mg per serving

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet f...

Calcium monograph & interactions

Dietary Fiber

Interacts with
2,025 drugs
2 Gram(s) per serving

Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. I...

Dietary Fiber monograph & interactions

Nitro Infusion Complex

970 mg per serving
  • › SynthePro:
  • › Nitroxen:
  • › Insulogen:

Other (inactive) ingredients: Filtered Water, Protein Blend (Amino Acid/Protein), Cellulose Gum, Natural and Artificial flavors, Sucralose, Dipotassium Phosphate, Acesulfame-Potassium, Carrageenan, Dimethylpolysiloxane. These complete the product’s ingredient list but are not active constituents.

Interaction report

Nitro-Tech Hardcore Vanilla Ice Cream Milkshake by MuscleTech Drug Interactions

Want to check YOUR meds against Nitro-Tech Hardcore Vanilla Ice Cream Milkshake?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,183Drugs
18 Major 697 Moderate 1,468 Minor

Ingredients driving the most interactions

Dietary Fiber 2,025
Sodium 205
Calcium 168

Individual Drug Interactions

The ingredients in Nitro-Tech Hardcore Vanilla Ice Cream Milkshake interact with 2,183 drugs. Click any drug to see the details.

3 of the 8 ingredients in Nitro-Tech Hardcore Vanilla Ice Cream Milkshake interact with drugs. Each result below shows which ingredient is responsible. Dietary Fiber Sodium Calcium

Each ingredient & the kinds of drugs it affects

For each ingredient in Nitro-Tech Hardcore Vanilla Ice Cream Milkshake with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Dietary Fiber7 drug types · 2,025 drugs

Carbamazepine (Tegretol)

Theoretically, black psyllium might reduce the effects of carbamazepine and increase the risk for convulsions.
Theoretically, black psyllium might reduce carbamazepine absorption. A preliminary study using blond psyllium reported decreased carbamazepine bioavailability due to binding of the drug to psyllium, as well as reduction of available fluid in the gut for dissolution of the drug. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Lithium

Theoretically, taking black psyllium at the same time as lithium might reduce lithium absorption.
The fiber in black psyllium might reduce lithium absorption and plasma levels. Some case reports describe a reduction in plasma lithium levels with concomitant administration of blond psyllium. This was reversed when psyllium was stopped. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Metformin (Glucophage)

Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Animal research shows that concurrent consumption of blond psyllium with metformin slows and increases the absorption of metformin. This interaction may also occur with black psyllium. To avoid changes in absorption, take psyllium 30-60 minutes after metformin.

Likelihood Possible Evidence D
Olanzapine (Zyprexa)

Theoretically, taking black psyllium at the same time as olanzapine might reduce olanzapine absorption.
The fiber in black psyllium might decrease the absorption of olanzapine. A single case report describes a reduction in the effectiveness of olanzapine when it was concomitantly administered with an unspecified type of psyllium 3 grams orally twice daily. This effect was reversed when psyllium was stopped.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, taking black psyllium at the same time as digoxin might reduce digoxin absorption and decrease digoxin levels.
Psyllium might bind digoxin in the gut. However, some clinical evidence suggests that psyllium does not impact digoxin absorption.

Likelihood Unlikely Evidence B
Ethinyl Estradiol

Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Concurrent use of blond psyllium with ethinyl estradiol results in a slight increase in the extent of ethinyl estradiol absorption and a slower rate of absorption. This is unlikely to be clinically significant.

Likelihood Unlikely Evidence D
Oral Drugs

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Psyllium seems to have variable effects on drug absorption. To avoid changes in absorption, take psyllium 30-60 minutes after oral medications. Animal research shows that blond psyllium delays and increases the absorption of metformin and ethinyl estradiol. Case reports and animal research suggest that blond psyllium might reduce absorption of lithium, digoxin, olanzapine, and carbamazepine. Finally, some pharmacokinetic studies show that psyllium does not affect the absorption of levothyroxine or warfarin. Although many of these studies evaluated blond psyllium, the fiber content in black psyllium may have similar effects.

Likelihood Possible Evidence B
Dietary Fiber full monograph & interactions

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions

Calcium18 drug types · 168 drugs

Ceftriaxone (Rocephin)

Co-administration of intravenous calcium and ceftriaxone can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys.
Avoid administering intravenous calcium in any form, such as parenteral nutrition or Lactated Ringers, within 48 hours of intravenous ceftriaxone. Case reports in neonates show that administering intravenous ceftriaxone and calcium can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys. In several cases, neonates have died as a result of this interaction. So far there are no reports in adults; however, there is still concern that this interaction might occur in adults.

Likelihood Probable Evidence D
Dolutegravir (Tivicay)

Calcium seems to reduce levels of dolutegravir.
Advise patients to take dolutegravir either 2 hours before or 6 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium carbonate 1200 mg concomitantly with dolutegravir 50 mg reduces plasma levels of dolutegravir by almost 40%. Calcium appears to decrease levels of dolutegravir through chelation.

Likelihood Probable Evidence B
Elvitegravir (Vitekta)

Calcium seems to reduce levels of elvitegravir.
Advise patients to take elvitegravir either 2 hours before or 2 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium along with elvitegravir can reduce blood levels of elvitegravir through chelation.

Likelihood Probable Evidence B
Aluminum

Calcium citrate might increase aluminum absorption and toxicity. Other types of calcium do not increase aluminum absorption.
Calcium citrate can increase the absorption of aluminum when taken with aluminum hydroxide. The increase in aluminum levels may become toxic, particularly in individuals with kidney disease. However, the effect of calcium citrate on aluminum absorption is due to the citrate anion rather than calcium cation. Calcium acetate does not appear to increase aluminum absorption.

Likelihood Possible Evidence B
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Calcium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and calcium can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, calcium containing products.

Likelihood Probable Evidence D
Bisphosphonates

Calcium reduces the absorption of bisphosphonates.
Advise patients to take bisphosphonates at least 30 minutes before calcium, but preferably at a different time of day. Calcium supplements decrease absorption of bisphosphonates.

Likelihood Probable Evidence C
Calcipotriene (Dovonex)

Taking calcipotriene with calcium might increase the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with calcium supplements might increase the risk of hypercalcemia.

Likelihood Possible Evidence B
Digoxin (Lanoxin)

Using intravenous calcium with digoxin might increase the risk of fatal cardiac arrhythmias.
Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. However, one retrospective analysis of clinical data suggests that intravenous calcium does not increase the risk of dysrhythmias or mortality in patients receiving digoxin.

Likelihood Possible Evidence B
Diltiazem (Cardizem, Others)

Theoretically, calcium may reduce the therapeutic effects of diltiazem.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, calcium might increase this risk of hypercalcemia and reduce the effectiveness of diltiazem.

Likelihood Probable Evidence D
Levothyroxine (Synthroid, Others)

Calcium seems to reduce the absorption and effectiveness of levothyroxine.
Advise patients to take levothyroxine and calcium supplements at least 4 hours apart. Calcium reduces levothyroxine absorption, probably by forming insoluble complexes. Calcium carbonate supplements reduce effectiveness of levothyroxine in patients with hypothyroidism.

Likelihood Probable Evidence B
Lithium

Theoretically, concomitant use of calcium and lithium may increase this risk of hypercalcemia.
Clinical research suggests that long-term use of lithium may cause hypercalcemia in 10% to 60% of patients. Theoretically, concomitant use of lithium and calcium supplements may further increase this risk.

Likelihood Possible Evidence B
Quinolone Antibiotics

Calcium seems to reduce the absorption of quinolone antibiotics.
Advise patients to take oral quinolones at least 2 hours before or 4-6 hours after calcium supplements or calcium-fortified foods. Taking calcium at the same time as oral quinolones can reduce quinolone absorption. Calcium binds to quinolones in the gut.

Likelihood Probable Evidence B
Raltegravir (Isentress)

Calcium may reduce levels of raltegravir.
Pharmacokinetic research shows that taking a single dose of calcium carbonate 3000 mg along with raltegravir 400 mg twice daily modestly decreases the mean area under the curve of raltegravir, but the decrease does not necessitate a dose adjustment of raltegravir. However, a case of elevated HIV-1 RNA levels and documented resistance to raltegravir has been reported for a patient taking calcium carbonate 1 gram three times daily plus vitamin D3 (cholecalciferol) 400 IU three times daily in combination with raltegravir 400 mg twice daily for 11 months. It is thought that calcium reduced raltegravir levels by chelation, leading to treatment failure.

Likelihood Possible Evidence B
Sotalol (Betapace)

Calcium seems to reduce the absorption of sotalol.
Advise patients to separate doses by at least 2 hours before or 4-6 hours after calcium. Calcium appears to reduce the absorption of sotalol, probably by forming insoluble complexes.

Likelihood Possible Evidence B
Tetracycline Antibiotics

Calcium seems to reduce the absorption of tetracycline antibiotics.
Advise patients to take oral tetracyclines at least 2 hours before, or 4-6 hours after calcium supplements. Taking calcium at the same time as oral tetracyclines can reduce tetracycline absorption. Calcium binds to tetracyclines in the gut.

Likelihood Probable Evidence C
Thiazide Diuretics

Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.
Thiazides reduce calcium excretion by the kidneys. Using thiazides along with moderately large amounts of calcium carbonate increases the risk of milk-alkali syndrome (hypercalcemia, metabolic alkalosis, renal failure). Patients may need to have their serum calcium levels and/or parathyroid function monitored regularly.

Likelihood Probable Evidence C
Verapamil (Calan, Others)

Theoretically, calcium may reduce the therapeutic effects of verapamil.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, use of calcium supplements may increase this risk of hypercalcemia and reduce the effectiveness of verapamil.

Likelihood Probable Evidence D
Calcium Channel Blockers

Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.
Intravenous calcium is used to decrease the effects of calcium channel blockers in the management of overdose. Intravenous calcium gluconate has been used before intravenous verapamil (Isoptin) to prevent or reduce the hypotensive effects without affecting the antiarrhythmic effects. But there is no evidence that dietary or supplemental calcium when taken orally interacts with calcium channel blockers.

Likelihood Unlikely Evidence D
Calcium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Nitro-Tech Hardcore Vanilla Ice Cream Milkshake, from the product label.

MuscleTech

See all MuscleTech products
Name
Iovate Health Sciences U.S.A. Inc.
Street Address
3880 Jeffrey Blvd
City
Blasdell
State
NY
ZipCode
14219
Phone Number
1-800-246-3261
Web Address
www.MuscleTech.com
Pharmacist Counseling Corner

Nitro-Tech Hardcore Vanilla Ice Cream Milkshake by MuscleTech: Common Questions

Does Nitro-Tech Hardcore Vanilla Ice Cream Milkshake by MuscleTech interact with any medications?
Yes. Based on its ingredients, Nitro-Tech Hardcore Vanilla Ice Cream Milkshake has a known interaction with 2,183 medications, including 18 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Nitro-Tech Hardcore Vanilla Ice Cream Milkshake contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take if I'm pregnant or breastfeeding?
Several ingredients have insufficient safety data or are flagged for pregnancy and breastfeeding. L-glutamine, sodium, calcium, L-methionine, lactoferrin, and D-myo inositol are rated likely safe or possibly safe, but alpha-lipoic acid, L-phenylalanine, and American ginseng should be avoided. Talk to your doctor or pharmacist before taking this product while pregnant or breastfeeding — they can review all the ingredients and help you decide.
Can this lower my blood sugar?
Yes, potentially. Alpha-lipoic acid, American ginseng, and inositol may all lower blood glucose levels. If you take diabetes medications, combining them with this product could increase the risk of low blood sugar (hypoglycemia). Check with your doctor or pharmacist before taking this product alongside any blood sugar medication.
What amino acids are in this milkshake?
It contains L-glutamine, L-leucine, L-isoleucine, L-methionine, L-phenylalanine, L-valine, L-histidine, L-threonine, L-lysine monohydrochloride, and glutamine peptides — a mix of essential and non-essential amino acids that support muscle protein synthesis.
Is this proven to build muscle?
The ingredients in this product have been studied for various health conditions, but we hold no evidence data showing this specific milkshake formulation is effective for muscle building or athletic performance. The amino acids and other compounds have established uses in other areas — amino acids support protein synthesis in general, but the data we have doesn't confirm effectiveness for this product's stated muscle-building claims.
What side effects should I watch for?
Common side effects from the amino acids include nausea, constipation, diarrhea, bloating, headache, and gastrointestinal upset. L-glutamine has rare reports of mania or hypomania in people with bipolar disorder. Alpha-lipoic acid may cause headache or nausea. Stop taking it and contact your doctor if you experience severe headache, chest pain, unusual mood changes, or any serious adverse effect.
Does this contain sodium, and is that a problem?
Yes, sodium is listed as an ingredient. High sodium intake can raise blood pressure and reduce the effectiveness of blood pressure medications. If you have high blood pressure or take antihypertensive drugs, discuss this product with your doctor or pharmacist first to make sure the sodium content is safe for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Nitro-Tech Hardcore Vanilla Ice Cream Milkshake label
Go deeper

The Full Monographs Behind Nitro-Tech Hardcore Vanilla Ice Cream Milkshake’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Calcium

Interacts with 168 drugs

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet falls short. Most people do best getting...

Read the full Calcium monograph → Herb & supplement monograph

Black Psyllium

Interacts with 2,025 drugs

Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. It is best known and most studied for rel...

Read the full Black Psyllium monograph →
Sources

Sources & How We Checked

Nitro-Tech Hardcore Vanilla Ice Cream Milkshake's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 365 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
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  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Sodium 38 references
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  4. Frings-Meuthen P, Buehlmeier J, Baecker N, et al. High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses. J Appl Physiol 2011;111(2):537-542. PubMed
  5. Frings-Meuthen P, Baecker N, Heer M. Low-grade metabolic acidosis may be the cause of sodium chloride-induced exaggerated bone resorption. J Bone Miner Res 2008;23(4):517-524. PubMed
  6. Alam S, Johnson AG. A meta-analysis of randomised controlled trials (RCT) among healthy normotensive and essential hypertensive elderly patients to determine the effect of high salt (NaCl) diet of blood pressure. J Hum Hypertens 1999;13(6):367-74.
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  17. Mente A, O'Donnell M, Rangarajan S, et al. Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension: a pooled analysis of data from four studies. Lancet. 2016;388(10043):465-75. PubMed
  18. Moosavian SP, Haghighatdoost F, Surkan PJ, Azadbakht L. Salt and obesity: a systematic review and meta-analysis of observational studies. Int J Food Sci Nutr. 2017;68(3):265-277. PubMed
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  20. Poggio R, Gutierrez L, Matta MG, Elorriaga N, Irazola V, Rubinstein A. Daily sodium consumption and CVD mortality in the general population: systematic review and meta-analysis of prospective studies. Public Health Nutr. 2015;18(4):695-704. PubMed
  21. Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad
  22. Mahtani KR, Heneghan C, Onakpoya I, et al. Reduced Salt Intake for Heart Failure: A Systematic Review. JAMA Intern Med. 2018 Dec 1;178(12):1693-1700. PubMed
  23. Yancy CW. Sodium Restriction in Heart Failure: Too Much Uncertainty-Do the Trials. JAMA Intern Med. 2018 Dec 1;178(12):1700-1701. PubMed
  24. He FJ, Campbell NRC, Ma Y, MacGregor GA, Cogswell ME, Cook NR. Errors in estimating usual sodium intake by the Kawasaki formula alter its relationship with mortality: implications for public health. Int J Epidemiol. 2018;47(6):1784-1795. PubMed
  25. Murthy K, Ondrey GJ, Malkani N, et al. THE EFFECTS OF HYPONATREMIA ON BONE DENSITY AND FRACTURES: A SYSTEMATIC REVIEW AND META-ANALYSIS. Endocr Pract. 2019;25(4):366-378. PubMed
  26. Messerli FH, Hofstetter L, Syrogiannouli L, et al. Sodium intake, life expectancy, and all-cause mortality. Eur Heart J 2021;42(21):2103-2112. PubMed
  27. Graudal NA, Hubeck-Graudal T, Jurgens G. Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol, and triglyceride. Cochrane Database Syst Rev 2020;12(12):CD004022. PubMed
  28. Giatti S, Santos RB, Aielo AN, et al. Association of sodium with obstructive sleep apnea. The ELSA-Brasil study. Ann Am Thorac Soc 2021;18(3):502-510. PubMed
  29. Nan X, Lu H, Wu J, et al. The interactive association between sodium intake, alcohol consumption and hypertension among elderly in northern China: a cross-sectional study. BMC Geriatr 2021;21(1):135. PubMed
  30. Kyozuka H, Fukusda T, Murata T, et al. Impact of preconception sodium intake on hypertensive disorders of pregnancy: The Japan Environment and Children's study. Pregnancy Hypertens 2021;23:66-72. PubMed
  31. Zhao L, Ogden CL, Yang Q, et al. Association of usual sodium intake with obesity among US children and adolescents, NHANES 2009-2016. Obesity (Silver Spring) 2021;29(3):587-594. PubMed
  32. Ma Y, He FJ, Sun Q, et al. 24-Hour urinary sodium and potassium excretion and cardiovascular risk. N Engl J Med 2022;386(3):252-263. PubMed
  33. Liu J, Yang X, Zhang P, et al. Association of urinary sodium excretion and left ventricular hypertrophy in people with type 2 diabetes mellitus: A cross-sectional study. Front Endocrinol (Lausanne) 2021;12:728493. PubMed
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  35. Wang DD, Li Y, Nguyen XT, et al. Dietary sodium and potassium intake and risk of non-fatal cardiovascular diseases: The million veteran program. Nutrients 2022;14(5):1121. PubMed
  36. Kwak JH, Park CH, Eun CS, et al. The associations of dietary intake of high sodium and low zinc with gastric cancer mortality: A prospective cohort study in Korea. Nutr Cancer 2022;74(10):3501-3508. PubMed
  37. George S, Maiti R, Mishra BR, Jena M, Mohapatra D. Effect of regulated add-on sodium chloride intake on stabilization of serum lithium concentration in bipolar disorder: A randomized controlled trial. Bipolar Disord 2023;25(1):66-75. PubMed
  38. Zhou TL, Schütten MTJ, Kroon AA, et al. Urinary Sodium Excretion and Salt Intake Are Not Associated With Blood Pressure Variability in a White General Population. J Am Heart Assoc 2023;12(1):e026578. PubMed

See these in context on the Sodium monograph →

Calcium 62 references
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See these in context on the Calcium monograph →

Alpha-lipoic Acid 48 references
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Phenylalanine 23 references
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Histidine 3 references
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Lactoferrin 6 references
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Lysine 7 references
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American Ginseng 12 references
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Inositol 14 references
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