Interactions on record — worth a quick check against your medications. Based on 2 of 4 ingredients. Check your meds →
Dietary supplement

NitroPro Orange Creamsicle - Flavor Ingredients & Drug Interactions

by Hi-Tech Pharmaceuticals

Powder Category: Amino Acid/protein
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

NitroPro Orange Creamsicle - Flavor is a dietary supplement by Hi-Tech Pharmaceuticals with 4 active ingredients. Its ingredients are commonly taken for constipation, diarrhea, high cholesterol.Based on those ingredients, 2,035 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Dietary Fiber, Sodium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of NitroPro Orange Creamsicle - Flavor by Hi-Tech Pharmaceuticals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 1 of its 2 active ingredients.

NitroPro Orange Creamsicle is a protein powder with one active ingredient: sodium. The product also contains whey protein isolates and concentrate, a proprietary NitroPro blend, and inactive ingredients like xanthan gum and cellulose gum for texture and stability.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: muscle protein synthesis and athletic recovery.
  • We looked for evidence on: muscle growth, sports performance, post-workout recovery.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

Sodium is likely effective for cystic fibrosis and possibly effective for preventing kidney damage from amphotericin B therapy. For bipolar disorder and congestive heart failure, we don't have enough reliable evidence in our data to rate its effectiveness.

Keep in mind this is a flavored powder — the amount of sodium and its intended use depend on how your doctor or dietitian has directed you to use it.

The evidence, ingredient by ingredient Black Psyllium Sodium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Sodium in normal dietary amounts is well tolerated. The safety notes in our data stress that while sodium is essential in small amounts, too much is linked to high blood pressure and heart strain.

Avoid sodium supplements or very high intake without medical advice. Rare serious adverse effects from excess sodium can include worsened cardiovascular disease, high blood pressure, and kidney disease.

For pregnancy and lactation, the data shows likely safety for one scenario but possibly unsafe for another — talk with your doctor or pharmacist about whether this product is right for you if you're pregnant or breastfeeding.

Side effects, ingredient by ingredient Black Psyllium Sodium

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Black Psyllium, Sodium.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: heart-rhythm medications; lithium.
  • For scale: 2,036 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications if you take blood pressure drugs (antihypertensives), lithium, corticosteroids, didanosine, sodium phosphate bowel-prep solutions, tolvaptan, or any other sodium-containing medications — all have Moderate interactions with added sodium.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is sodium, plain and simple — useful if your doctor prescribed it for a specific condition like cystic fibrosis. If you take blood pressure medicine, lithium, corticosteroids, or any medication containing sodium, check with us before you start.

If you're buying this on your own without medical guidance, talk to your pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 25, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about NitroPro Orange Creamsicle - Flavor, straight from the product label.

Brand Hi-Tech Pharmaceuticals
Barcode (UPC) 853598003430
Net contents 2 lbs
Market status On market
Date entered into DSLD Aug 25, 2015
DSLD ID 48146
Product type Amino Acid/protein
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for NitroPro Orange Creamsicle - Flavor by Hi-Tech Pharmaceuticals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
91.5 Gram(s)
Maximum serving Sizes:
91.5 Gram(s)
Servings per container
30
UPC/BARCODE
853598003430
IngredientAmount% DV
Calories120 {Calories}--
Total Carbohydrates3.5 Gram(s)1%
Sugar1 Gram(s)--
Calories from Fat10 {Calories}--
Total Fat1 Gram(s)1%
Dietary Fiber0 Gram(s)--
Protein24 Gram(s)48%
Saturated Fat0.5 Gram(s)1%
Sodium90 mg4%
Cholesterol30 mg10%

Other ingredients: NitroPro(R) Blend, microfiltered Whey Protein isolates, ultrafiltered Whey Protein isolate, Whey Protein concentrate, Naturally Sweet, Natural and Artificial flavor, Xanthan Gum, Cellulose Gum

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

1) An increased Net Nitrogen Utilization (NNU) from the protein we ingest. NNU refers to protein synthesis and anabolism form protein. NitroPro(R) has a NNU of 6X normal whey. 2) Consists of 75% Peptide-Bound Amino Acids (PBAA’s), which are absorbed more quickly and increase nitrogen retention by 16x compared to free-form amino acids. 3) Partial hydrolysis of protein with a proprietary process where systemically reduced protein molecules are abated from 20,000 Daltons in size to 400-1,000 Daltons.

Hydrolyzing is a process in which intact proteins are strategically broken down into smaller fragments, called peptides, for faster delivery and easier utilization by your body. Hi-Tech's exclusive combination of mild, moderate, and ultra-hydrolyzed proteins results in di- and tri-peptides, while retaining select microfractions naturally found in whey.

All proteins are made up of amino acids, but not all amino acids are of equal importance. The three BCAAs (leucine, isoleucine, valine) - are particularly beneficial for athletes because they assist with new muscle protein synthesis and protect the muscle that you already have agains breakdown. Even more important is the amount of PBAAs.

Provide your body with protein scientifically suggested to dynamically increase explosive power, strength and lean muscle mass.

By combining the absolute finest ingredients with a series of highly specialized processing techniques, Hi-Tech Pharmaceuticals has created its most revolutionary muscle-building protein yet.

This enhanced delivery system relieves the metabolic burden on muscle having to supply all organs and tissues with these amino acids. This leaves a more potent supply of critical amino acids within muscle and promotes a more constant, uninterrupted state of protein synthesis, cell volume, and muscle anabolism.

The result is a product that is ultra-pure, quickly digested, and packed with muscle-building and replenishing amino acids.

Nitropro has a biological value (BV) of 159, protein digestibility of 95, and a perfect 1.0 PDCAAS (Protein Digestibility Corrected Amino Acid Score).

- Reduces protein molecules from 20,000 daltons to 400-1,000 daltons- drastically improving absorbability! - Possesses AN/TN ratio 500% greater than other protein-eviscerating the competition! - Promotes anabolism by shuttling amino acids essential for protein systhesis directly into the muscle tissue

Low in fat and carbs

30 servings

Nitro = Nitrogen Balance...Pro = Protein Synthesis.

- Net Nitrogen Utilization (NNU) of 6 times that of ordinary whey

Not a significant source of dietary fiber

By hydrolyzing the protein in this revolutionary formula we've created the fastest-acting whey protein yet. Hydrolyzing breaks larger proteins down into smaller pieces that are able to get into your system rapidly, enabling your muscles to start rebuilding immediately.

Brand IP Statement(s)

4) Possesses an AN/TN ratio 500% greater than other protein products, which causes NitroPro(TM) to eviscerate the competition.

NitroPro(R) utilizes a proprietary hydrolyzing technique to precise degrees.

If this is too much scientific jargon, then all that you really need to know is that NitroPro(R) is precisely what you need first thing in the morning, before your workout, and immediately after your workout when your hard-working muscles benefit most from a fast-acting protein.

Make no mistake, NitroPro(R) is different than any supplement you may have tried. NitroPro(R) is formulated using state-of-the-art, cutting-edge protein technology.

When comparing protein supplements, you need to look no further than NitroPro(R). There isn't another protein supplement available that can even compare to NitroPro(R) simply because NitroPro(R) totally annihilates the competition!

Everything about NitroPro(R) was designed with an uncompromising attitude toward human performance - both in the gym and in enhancing your physique. NitroPro(R) has enhanced absorption kinetics that shuttle large amounts of the amino acids essential for protein synthesis directly into muscle and other tissues.

NitroPro(R) is protein in its purest sense.

Scientifically-formulated protein makes all other proteins obsolete! Try NitroPro(R) and "Get Back" from your protein what you "Put Into" your training!

NitroPro(R) is the first protein supplement to focus entirely on protein absorption, protein utilization-and ultimately, protein synthesis.

NitroPro(R) is the first scientifically based protein ever developed. NitroPro(R) is Hi-Tech protein, literally! NitroPro(R) is crucial to the body's ability to build quality muscle tissue and strength. NitroPro(R) is based upon 4 crucial protein technologies:

NitroPro(R) is the fastest, purest, most advanced whey protein we've ever developed.

NitroPro(R) also contains 15% of other high-quality proteins for "sustained release". This scientifically-designed ratio of proteins helps ensure maximum blood levels of amino acids- both PBAAs and BCAAs- to grow throughout the entire day. NitroPro(R) is assayed for purity and potency and is only made from the highest quality material available.

NitroPro(R) - The most revolutionary muscle building protein yet!

Formula

Every serving supplies even more low, moderate, and high molecular weight, biologically active whey protein microfractions including alpha-lactalbumin, glycomacropeptides, beta-lactaoglobulin, immunoglobulin G (IgG), lactoferrin, lactoperoxidase, and various growth factors.

That's why every serving of NitroPro(R) has a whopping 8,000mg of BCAAs and 10,000mg of PBAAs.

It's uniquely designed to accelerate the adaptation process of bodybuilding exercise.

NitroPro(R) is made with 85% hydrolyzed whey proteins that have been isolated to remove excess lactose, cholesterol, carbohydrates, and fat.

NitroPro(R) is also the first protein to utilize a 75% PBAA composition formulation with a net protein or nitrogen utilization score of 92 out of 100.

- Contains 75% Peptide-Bound Amino Acids (PBAA's), which elevate nitrogen retention by 16x, compared to free-form amino acids

24G Protein 20G PBAAs Low in fat and carbs 8G BCAAs

Sweetened with Naturally Sweet(TM)

NitroPro(R) was specifically developed for serious athletes and bodybuilders.

Allergen information: Contains milk and soy (lecithin) ingredients

That's because it is made with 85% hydrolyzed whey protein as its primary protein source!

Seals/Symbols

HTP HI-TECH PHARMACEUTICALS

Naturally Sweet(TM)

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to treat, cure, diagnose or prevent any disease.

Precautions

Allergen information: Contains milk and soy (lecithin) ingredients

This product should not be used in place of or as a substitute for recommendations by your healthcare professional.

Suggested/Recommended/Usage/Directions

Suggested Use: Mix 3 scoops of NitroPro(R) in 8-10 ounces of water and/or beverage of choice. Drink 3-5 shakes per day for optimal nitrogen retention and muscle growth.

See for yourself

NitroPro Orange Creamsicle - Flavor by Hi-Tech Pharmaceuticals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in NitroPro Orange Creamsicle - Flavor by Hi-Tech Pharmaceuticals

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size91.5 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

1 Gram(s) per serving

Dietary Fiber

Interacts with
2,025 drugs
0 Gram(s) per serving

Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. I...

Dietary Fiber monograph & interactions

Protein

24 Gram(s) per serving

Sodium

Interacts with
205 drugs
90 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Other (inactive) ingredients: NitroPro(R) Blend, Microfiltered Whey Protein isolates, Ultrafiltered Whey Protein isolate, Whey Protein concentrate, Naturally Sweet, Natural and Artificial flavor, Xanthan Gum, Cellulose Gum. These complete the product’s ingredient list but are not active constituents.

Interaction report

NitroPro Orange Creamsicle - Flavor by Hi-Tech Pharmaceuticals Drug Interactions

Want to check YOUR meds against NitroPro Orange Creamsicle - Flavor?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
2,035Drugs
227 Moderate 1,808 Minor

Ingredients driving the most interactions

Sodium 205

Each ingredient & the kinds of drugs it affects

For each ingredient in NitroPro Orange Creamsicle - Flavor with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Dietary Fiber7 drug types · 2,025 drugs

Carbamazepine (Tegretol)

Theoretically, black psyllium might reduce the effects of carbamazepine and increase the risk for convulsions.
Theoretically, black psyllium might reduce carbamazepine absorption. A preliminary study using blond psyllium reported decreased carbamazepine bioavailability due to binding of the drug to psyllium, as well as reduction of available fluid in the gut for dissolution of the drug. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Lithium

Theoretically, taking black psyllium at the same time as lithium might reduce lithium absorption.
The fiber in black psyllium might reduce lithium absorption and plasma levels. Some case reports describe a reduction in plasma lithium levels with concomitant administration of blond psyllium. This was reversed when psyllium was stopped. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Metformin (Glucophage)

Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Animal research shows that concurrent consumption of blond psyllium with metformin slows and increases the absorption of metformin. This interaction may also occur with black psyllium. To avoid changes in absorption, take psyllium 30-60 minutes after metformin.

Likelihood Possible Evidence D
Olanzapine (Zyprexa)

Theoretically, taking black psyllium at the same time as olanzapine might reduce olanzapine absorption.
The fiber in black psyllium might decrease the absorption of olanzapine. A single case report describes a reduction in the effectiveness of olanzapine when it was concomitantly administered with an unspecified type of psyllium 3 grams orally twice daily. This effect was reversed when psyllium was stopped.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, taking black psyllium at the same time as digoxin might reduce digoxin absorption and decrease digoxin levels.
Psyllium might bind digoxin in the gut. However, some clinical evidence suggests that psyllium does not impact digoxin absorption.

Likelihood Unlikely Evidence B
Ethinyl Estradiol

Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Concurrent use of blond psyllium with ethinyl estradiol results in a slight increase in the extent of ethinyl estradiol absorption and a slower rate of absorption. This is unlikely to be clinically significant.

Likelihood Unlikely Evidence D
Oral Drugs

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Psyllium seems to have variable effects on drug absorption. To avoid changes in absorption, take psyllium 30-60 minutes after oral medications. Animal research shows that blond psyllium delays and increases the absorption of metformin and ethinyl estradiol. Case reports and animal research suggest that blond psyllium might reduce absorption of lithium, digoxin, olanzapine, and carbamazepine. Finally, some pharmacokinetic studies show that psyllium does not affect the absorption of levothyroxine or warfarin. Although many of these studies evaluated blond psyllium, the fiber content in black psyllium may have similar effects.

Likelihood Possible Evidence B

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
The maker

Brand information

Manufacturer and brand details for NitroPro Orange Creamsicle - Flavor, from the product label.

Hi-Tech Pharmaceuticals

See all Hi-Tech Pharmaceuticals products
Name
Hi-Tech Pharmaceuticals, Inc.
Street Address
6015-B Unity Dr.
City
Norcross
State
GA
ZipCode
30071
Phone Number
1-888-855-7919
Web Address
www.hitechpharma.com
Pharmacist Counseling Corner

NitroPro Orange Creamsicle - Flavor by Hi-Tech Pharmaceuticals: Common Questions

Does NitroPro Orange Creamsicle - Flavor by Hi-Tech Pharmaceuticals interact with any medications?
Yes. Based on its ingredients, NitroPro Orange Creamsicle - Flavor has a known interaction with 2,035 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
NitroPro Orange Creamsicle - Flavor contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this just table salt?
Not exactly — this is a protein powder flavored with orange creamsicle that contains sodium as its active ingredient. It's not meant to be a salt substitute or a way to get extra sodium on your own. Your doctor or dietitian would prescribe it if you specifically need sodium supplementation for a medical condition.
Will this raise my blood pressure?
High sodium intake can increase blood pressure and may reduce how well blood pressure medications work. If you have high blood pressure or take blood pressure medicine, talk with your doctor before using a sodium supplement.
Can I take this if I'm on lithium?
Not without checking with your doctor first. Changes in sodium intake — including from supplements — can shift how much lithium stays in your blood, which could cause toxicity. Your lithium levels need to stay steady, so any change in sodium intake needs to be coordinated with your prescriber.
What's in this powder besides sodium?
The product contains whey protein isolates and concentrate, a proprietary NitroPro blend, natural and artificial flavoring, and binders like xanthan gum and cellulose gum. The inactive ingredients help with texture and shelf life.
Is this safe during pregnancy or breastfeeding?
Our data shows mixed ratings — likely safe for one situation but possibly unsafe for another. This is an individual decision that needs input from your doctor or midwife. Don't start sodium supplementation in pregnancy or while nursing without their guidance.
How much sodium is in a serving?
The product facts don't specify a serving size or milligrams of sodium per serving. Check the nutrition label on the package itself, and talk with your pharmacist or the company if you need exact numbers for your medical care.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if NitroPro Orange Creamsicle - Flavor is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

NitroPro Orange Creamsicle - Flavor label
Sources

Sources & How We Checked

NitroPro Orange Creamsicle - Flavor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 56 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Black Psyllium 18 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
  4. Etman M. Effect of a bulk forming laxative on the bioavailablility of carbamazepine in man. Drug Dev Ind Pharm 1995;21:1901-6.
  5. Perlman BB. Interaction between lithium salts and ispaghula husk. Lancet 1990;335:416.
  6. Vaswani SK, Hamilton RG, Valentine MD, Adkinson NF. Psyllium laxative-induced anaphylaxis, asthma, and rhinitis. Allergy 1996;51:266-8. PubMed
  7. Lantner RR, Espiritu BR, Zumerchik P, Tobin MC. Anaphylaxis following ingestion of a psyllium-containing cereal. JAMA 1990;264:2534-6. DOI
  8. Kaplan MJ. Anaphylactic reaction to "Heartwise." N Engl J Med 1990;323:1072-3. DOI
  9. Nordstrom M, Melander A, Robertsson E, Steen B. Influence of wheat bran and of a bulk-forming ispaghula cathartic on the bioavailability of digoxin in geriatric in-patients. Drug Nutr Interact 1987;5:67-9..
  10. Robinson DS, Benjamin DM, McCormack JJ. Interaction of warfarin and nonsystemic gastrointestinal drugs. Clin Pharmacol Ther 1971;12:491-5. PubMed
  11. Garcia JJ, Fernandez N, Diez MJ, et al. Influence of two dietary fibers in the oral bioavailability and other pharmacokinetic parameters of ethinyloestradiol. Contraception 2000;62:253-7. PubMed
  12. Fernandez N, Lopez C, Díez R, et al. Drug interactions with the dietary fiber Plantago ovata husk. Expert Opin Drug Metab Toxicol 2012;8(11):1377-86.
  13. Semen plantaginis in: WHO Monographs on Selected Medicinal Plants, volume 1. World Health Organization, Geneva, 1999. Available at http://apps.who.int/medicinedocs/en/d/Js2200e/. Accessed November 26, 1026.
  14. Code of Federal Regulations, Title 21 (21CFR 101.17). Food labeling warning, notice, and safe handling statements. Available at www.ecfr.gov/cgi-bin/text-idx?SID=20f647d3b74161501f46564b915b4048&mc=true&node=se21.2.101_117&rgn=div8. Accessed December 3, 2
  15. Code of Federal Regulations, Title 21 (21CFR 201.319). Specific labeling requirements - water-soluble gums, hydrophilic gums, and hydrophilic mucilloids. Available at www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=201.319. Accessed Dece
  16. Diez R, Garcia JJ, Diez MJ, Sierra M, Sahagun AM, Fernandez N. Influence of Plantago ovata husk (dietary fiber) on the bioavailability and other pharmacokinetic parameters of metformin in diabetic rabbits. BMC Complement Altern Med. 2017 Jun 7;17(1):298. PubMed
  17. Chiu AC, Sherman SI. Effects of pharmacological fiber supplements on levothyroxine absorption. Thyroid. 1998;8(8):667-71. PubMed
  18. Merrick C, Madden CA, Capurso NA. A Case of Blunted Orally Disintegrating Olanzapine Effect Due to Coadministered Psyllium. J Clin Psychiatry 2021;82(2):20cr13633. PubMed

See these in context on the Black Psyllium monograph →

Sodium 38 references
  1. Garabedian-Ruffalo SM, Ruffalo RL. Drug and nutrient interactions. Am Fam Physician 1986;33:165-74.
  2. Food and Drug Administration Science Background: Safety of Sodium Phosphates Oral Solution. September 17, 2001. Available at: http://www.fda.gov/cder/drug/safety/sodiumphospate.htm
  3. Coton T, Mallaret C, Coilliot C, Carre D, Guisset M. Severe acute ulcerated gastritis induced by salt. Presse Med 2009;38(3):499-500. PubMed
  4. Frings-Meuthen P, Buehlmeier J, Baecker N, et al. High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses. J Appl Physiol 2011;111(2):537-542. PubMed
  5. Frings-Meuthen P, Baecker N, Heer M. Low-grade metabolic acidosis may be the cause of sodium chloride-induced exaggerated bone resorption. J Bone Miner Res 2008;23(4):517-524. PubMed
  6. Alam S, Johnson AG. A meta-analysis of randomised controlled trials (RCT) among healthy normotensive and essential hypertensive elderly patients to determine the effect of high salt (NaCl) diet of blood pressure. J Hum Hypertens 1999;13(6):367-74.
  7. Boudville N, Ward S, Benaroia M, House AA. Increased sodium intake correlates with greater use of antihypertensive agents by subjects with chronic kidney disease. Am J Hypertens 2005;18(10):1300-5. PubMed
  8. Bennett WM. Drug interactions and consequences of sodium restriction. Am J Clin Nutr 1997;65(2 Suppl):678S-681S. PubMed
  9. Okusa MD, Crystal LJ. Clinical manifestations and management of acute lithium intoxication. Am J Med 1994;97(4):383-9. PubMed
  10. Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for water, potassium, sodium, chloride, and sulfate. Washington, DC: National Academy Press, 2005. Available at: http://www.nap.edu/openbook.php?record_id=10925. DOI
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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