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Dietary supplement

Nitrosigine 750 mg Ingredients & Drug Interactions

by Swanson

Nitrosigine 750 mg label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Nitrosigine 750 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Nitrosigine 750 mg is a dietary supplement by Swanson with 2 active ingredients. Its ingredients are commonly taken for preventing or treating low potassium (hypokalemia), supporting healthy blood pressure, muscle cramps.Based on those ingredients, 62 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Potassium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Nitrosigine 750 mg by Swanson

Ask about any prescription or over-the-counter medication and we check it for interactions with Nitrosigine 750 mg by Swanson — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Nitrosigine 750 mg by Swanson

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Nitrosigine 750 mg is a two-ingredient product. The first is Arginine Silicate Inositol, a compound form of the amino acid arginine combined with silica and inositol.

The second is potassium, an essential mineral your body needs for heart rhythm, muscle function, and nerve signaling. The tablet also contains several inactive ingredients (binders, fillers, and a coating) to hold it together.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: promotes nitric oxide production and circulatory health.
  • We looked for evidence on: Endothelial function, Blood flow, Vascular health, Hypertension.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The product facts we hold do not include effectiveness ratings for either ingredient in this formulation, so we cannot tell you whether the evidence supports its use for any specific health goal.

The evidence, ingredient by ingredient Potassium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Potassium from food is safe, but potassium supplements require caution — they can build up to dangerous levels in your bloodstream, especially if you have kidney disease. The most common side effects when taken by mouth are mild stomach upset: abdominal pain, nausea, diarrhea, belching, and flatulence.

High potassium levels are rare but serious and can cause heart rhythm problems, low blood pressure, confusion, or even cardiac arrest. For pregnancy and breastfeeding, dietary potassium is fine, but do not use potassium supplements during pregnancy or while breastfeeding without talking to your doctor or pharmacist first.

There isn't enough safety data on the other ingredient during pregnancy or breastfeeding, so check with your healthcare provider before taking this product if you're pregnant or nursing.

Side effects, ingredient by ingredient Potassium

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Potassium.
  • The most serious interaction on file is rated Moderate.
  • For scale: 62 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Nitrosigine, check with your pharmacist if you use potassium-sparing diuretics, ACE inhibitors, or angiotensin receptor blockers (ARBs). All three carry a Moderate risk of dangerously high blood potassium when combined with this supplement.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you take a blood pressure or heart medication — especially potassium-sparing diuretics, ACE inhibitors, or ARBs — do not start this product without checking with your pharmacist first. If you have kidney disease or are pregnant or breastfeeding, talk to your doctor before using it.

For everyone else, know that potassium supplements can cause stomach upset and require careful dosing.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 7, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Nitrosigine 750 mg, straight from the product label.

Brand Swanson
Barcode (UPC) 087614029030
Net contents 60 Tablet(s)
Market status On market
Date entered into DSLD Jan 7, 2019
DSLD ID 185139
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Nitrosigine 750 mg by Swanson, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
UPC/BARCODE
087614029030
IngredientAmount% DV
Arginine Silicate Inositol750 mg--
Potassium30 mg1%

Other ingredients: Dicalcium Phosphate, Stearic Acid, Microcrystalline Cellulose, Hydroxypropyl Cellulose, Magnesium Stearate, Aqueous Film-Coating, Croscarmellose Sodium, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Promotes nitric oxide production Patented complex that supports heart and circulatory health Maintains energy metabolism Science-Backed Quality Since 1969

Cardiovascular Support

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take one tablet one to two times per day with water.

Brand IP Statement(s)

Nitrosigine is a registered trademark of Nutrition 21, LLC., and is protected by U.S. patents: #5,707,970; #6,156,735; #6,344,444; and #7,576,132.

Precautions

Warning: For adults only.

Consult your physician before using this or any product if you are pregnant or nursing, taking medication or have a medical condition.

Keep out of reach of children.

Do not use if seal is broken.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

Arginine Silicate Inositol

FDA Statement of Identity

Dietary Supplement

General

SWU903 Rev 0 05 05 18

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Nitrosigine 750 mg by Swanson label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Nitrosigine 750 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Nitrosigine 750 mg by Swanson

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Arginine Silicate Inositol

750 mg per serving

Potassium

Interacts with
62 drugs
30 mg per serving Form: Nitrosigine

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...

Potassium monograph & interactions

Other (inactive) ingredients: Dicalcium Phosphate, Stearic Acid, Microcrystalline Cellulose, Hydroxypropyl Cellulose, Magnesium Stearate, Aqueous Film-Coating, Croscarmellose Sodium, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Nitrosigine 750 mg by Swanson Drug Interactions

Want to check YOUR meds against Nitrosigine 750 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
62Drugs
62 Moderate

Ingredients driving the most interactions

Potassium 62

Individual Drug Interactions

The ingredients in Nitrosigine 750 mg interact with 62 drugs. Click any drug to see the details.

1 of the 2 ingredients in Nitrosigine 750 mg interact with drugs. Each result below shows which ingredient is responsible. Potassium

Each ingredient & the kinds of drugs it affects

For each ingredient in Nitrosigine 750 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Potassium3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C
Potassium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Nitrosigine 750 mg, from the product label.

Swanson

See all Swanson products
Name
Swanson Health Products
City
Fargo
State
ND
ZipCode
58104
Phone Number
1-800-437-4148
Web Address
swanson.com
Pharmacist Counseling Corner

Nitrosigine 750 mg by Swanson: Common Questions

Does Nitrosigine 750 mg by Swanson interact with any medications?
Yes. Based on its ingredients, Nitrosigine 750 mg has a known interaction with 62 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Nitrosigine 750 mg contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Nitrosigine if I have kidney disease?
No — potassium can build up to dangerous levels in people with kidney problems. Talk to your doctor or pharmacist before taking any potassium supplement if you have kidney disease.
What are the most common side effects?
Mild stomach trouble: belly pain, nausea, diarrhea, belching, and gas. Serious side effects from high potassium levels are rare but can include heart rhythm problems and confusion.
Is Nitrosigine safe to take while pregnant or breastfeeding?
Potassium from food during pregnancy and breastfeeding is fine, but we don't have enough data to say whether potassium supplements are safe. Talk to your doctor or pharmacist for personalized advice.
Does this product have any fillers?
Yes — it contains inactive ingredients including dicalcium phosphate, stearic acid, microcrystalline cellulose, and magnesium stearate, along with a film coating to make it easier to swallow.
What is Arginine Silicate Inositol?
It's a compound form of arginine (an amino acid), silica, and inositol combined together. We don't have interaction or effectiveness data on file for it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Nitrosigine 750 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Nitrosigine 750 mg label
Go deeper

The Full Monographs Behind Nitrosigine 750 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Potassium

Interacts with 62 drugs

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...

Read the full Potassium monograph →
Sources

Sources & How We Checked

Nitrosigine 750 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Potassium 12 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Gennaro A. Remington: The Science and Practice of Pharmacy. 19th ed. Lippincott: Williams & Wilkins, 1996.
  3. Whelton PK, He J, Cutler JA, et al. Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical trials. JAMA 1997;277:1624-32. PubMed
  4. Phillips, C. O., Kashani, A., Ko, D. K., Francis, G., and Krumholz, H. M. Adverse effects of combination angiotensin II receptor blockers plus angiotensin-converting enzyme inhibitors for left ventricular dysfunction: a quantitative review of data from ra DOI
  5. Altieri, P. I., Herrero, C., Suero, R., and Ortiz, A. Bleeding duodenal ulcer in a patient taking slow-releasing potassium tablets. Bol.Asoc.Med P.R. 1977;69(8):276.
  6. Raf, L. E. Enteric-coated potassium chloride tablets and ulcer of the small intestine. Acta Chir Scand Suppl 1967;(374):1-87.
  7. Potassium chloride oral solution [package insert]. Allentown, PA: Lehigh Valley Technologies, Inc.; 2014.
  8. Potassium chloride injection [package insert]. Lake Forest, IL: Hospira Inc.; 2009.
  9. Patel RB, Tannenbaum S, Viana-Tejedor A, et al. Serum potassium levels, cardiac arrhythmias, and mortality following non-ST-elevation myocardial infarction or unstable angina: insights from MERLIN-TIMI 36. Eur Heart J Acute Cardiovasc Care 2017 Feb;6(1):1 PubMed
  10. Malta D, Arcand J, Ravindran A, Floras V, Allard JP, Newton GE. Adequate intake of potassium does not cause hyperkalemia in hypertensive individuals taking medications that antagonize the renin angiotensin aldosterone system. Am J Clin Nutr 2016 Oct;104(4 PubMed
  11. Keskin M, Kaya A, Tatlisu MA, et al. The effect of serum potassium level on in-hospital and long-term mortality in ST elevation myocardial infarction. Int J cardiol. 2016 Oct 15;221:505-10.
  12. Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad

See these in context on the Potassium monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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