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Dietary supplement

Agaricus Blazei Mushroom Extract 500 mg Ingredients & Drug Interactions

by Swanson

Agaricus Blazei Mushroom Extract 500 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Agaricus Blazei Mushroom Extract 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Agaricus Blazei Mushroom Extract 500 mg is a dietary supplement by Swanson with 1 active ingredient. Its ingredients are commonly taken for immune support, general wellness and antioxidant, adjunct interest during cancer care.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Agaricus blazei Fruiting Bodies Mushroom Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Agaricus Blazei Mushroom Extract 500 mg by Swanson

Ask about any prescription or over-the-counter medication and we check it for interactions with Agaricus Blazei Mushroom Extract 500 mg by Swanson — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Agaricus Blazei Mushroom Extract 500 mg by Swanson

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Agaricus blazei fruiting bodies mushroom extract, 500 mg per capsule. The mushroom itself has been used in traditional medicine, and this extract version concentrates its compounds.

The inactive ingredients — hypromellose, rice bran, silica, maltodextrin, and magnesium stearate — are just the capsule material and binding agents that hold everything together.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Agaricus Mushroom's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Supports immune health from cellular level.
  • We looked for evidence on: Cancer, Chemotherapy-induced adverse effects, Hepatitis B, Crohn Disease, Ulcerative colitis, Immune function — and 3 related terms.
  • The closest evidence on file: Agaricus Mushroom is rated "Insufficient Reliable Evidence To Rate" for Cancer (Natural Medicines).
  • Also on file: Agaricus Mushroom is rated "Insufficient Reliable Evidence To Rate" for Chemotherapy-induced adverse effects, Crohn Disease, Hepatitis B, Ulcerative colitis.

The evidence for agaricus mushroom extract isn't yet established for the conditions we have data on. The effectiveness ratings for allergic rhinitis (hay fever), osteoporosis, cancer, cardiovascular disease, chemotherapy side effects, and Crohn disease all show insufficient reliable evidence — meaning we don't have enough solid research to say whether it works for any of these.

If you're thinking about using this for one of these reasons, it's worth talking with your pharmacist or doctor about what the current evidence actually supports.

The evidence, ingredient by ingredient Agaricus Mushroom

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Orally, agaricus mushroom is generally well tolerated when used as a food. The most common side effects from supplements are mild: abdominal discomfort, diarrhea, and nausea.

Rare but serious adverse effects include allergic reactions, liver damage (hepatotoxicity), and a lung condition called interstitial lung disease. A handful of cases of severe liver damage have been reported in women with cancer taking chemotherapy who also took agaricus supplements — the liver injury developed rapidly in some of those cases.

Allergic skin reactions have also been reported with certain agaricus products. Because supplement safety and long-term effects aren't well established, agaricus mushroom extract should be avoided during pregnancy and breastfeeding.

Side effects, ingredient by ingredient Agaricus Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Agaricus Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you're on any antidiabetes drugs — whether insulin, metformin, sulfonylureas, or others — check your specific medications using the tool on this page. That's the documented interaction we have data for.

Because we've only checked one ingredient and our data is limited, there may be other medication interactions we haven't found yet.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you take diabetes medication, this one's worth a careful check before you start — the interaction with blood sugar control is real. The supplement is generally tolerated for most people at typical doses, but serious liver and lung issues have been reported in rare cases, especially in patients already dealing with cancer and chemotherapy.

Talk to your pharmacist before adding this to your routine, especially if you have diabetes or any liver concerns.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Agaricus Blazei Mushroom Extract 500 mg, straight from the product label.

Brand Swanson
Barcode (UPC) 087614141220
Net contents 90 Veggie Capsule(s)
Market status On market
Date entered into DSLD Nov 22, 2024
DSLD ID 308451
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Agaricus Blazei Mushroom Extract 500 mg by Swanson, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veggie Capsule(s)
Maximum serving Sizes:
1 Veggie Capsule(s)
Servings per container
90
UPC/BARCODE
087614141220
IngredientAmount% DV
Agaricus blazei Fruiting Bodies Mushroom Extract500 mg--

Other ingredients: Hypromellose, Rice Bran, Silica, Maltodextrin, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Supports immune health from a cellular level Fortifies the body's natural immune response Excellent cellular defender

Immune support

General Statements

Science-Backed Quality Since 1969

Suggested/Recommended/Usage/Directions

Suggested use: As dietary supplement, take one veggie capsule two to three times per day with water.

Precautions

Warning: For adults. Keep out of reach of children.

Do not take this product if you are pregnant or nursing. Consult your physician before using this or any product if you are taking medication or have a medical condition.

Do not use if seal is broken.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

Agaricus Blazei Mushroom Extract 500 mg per capsule

FDA Statement of Identity

Herbal Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Agaricus Blazei Mushroom Extract 500 mg by Swanson label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Agaricus Blazei Mushroom Extract 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Agaricus Blazei Mushroom Extract 500 mg by Swanson

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Veggie Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Agaricus blazei Fruiting Bodies Mushroom Extract

Interacts with
86 drugs
500 mg per serving Form: Polysaccharides

Agaricus mushroom (often Agaricus blazei/subrufescens) is a culinary and medicinal mushroom studied mostly for possible immune and antioxidant effects...

Agaricus blazei Fruiting Bodies Mushroom Extract monograph & interactions

Other (inactive) ingredients: Hypromellose, Rice Bran, Silica, Maltodextrin, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Agaricus Blazei Mushroom Extract 500 mg by Swanson Drug Interactions

Want to check YOUR meds against Agaricus Blazei Mushroom Extract 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Agaricus blazei Fruiting Bodies Mushroom Extract 86

Individual Drug Interactions

The ingredients in Agaricus Blazei Mushroom Extract 500 mg interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in Agaricus Blazei Mushroom Extract 500 mg interact with drugs. Each result below shows which ingredient is responsible. Agaricus blazei Fruiting Bodies Mushroom Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Agaricus Blazei Mushroom Extract 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Agaricus blazei Fruiting Bodies Mushroom Extract1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking agaricus mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
In one clinical study in patients with type 2 diabetes who are stabilized on conventional oral hypoglycemic agents, 3 of 29 patients taking an agaricus mushroom extract 500 mg three times daily for 12 weeks reported hypoglycemia, compared to one of 29 patients in the placebo group.

Likelihood Possible Evidence D
Agaricus blazei Fruiting Bodies Mushroom Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Agaricus Blazei Mushroom Extract 500 mg, from the product label.

Swanson

See all Swanson products
Name
Swanson Health Products
City
Fargo
State
ND
ZipCode
58104
Phone Number
1-800-437-4148
Web Address
swanson.com
Pharmacist Counseling Corner

Agaricus Blazei Mushroom Extract 500 mg by Swanson: Common Questions

Does Agaricus Blazei Mushroom Extract 500 mg by Swanson interact with any medications?
Yes. Based on its ingredients, Agaricus Blazei Mushroom Extract 500 mg has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Agaricus Blazei Mushroom Extract 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I have type 2 diabetes?
You can, but you need to talk with your doctor or pharmacist first. The mushroom extract may lower your blood sugar, so if you're already on diabetes medication, taking both could push your levels too low. Your doctor might need to adjust your medication dose or monitor your blood sugar more closely.
What are the most common side effects?
Most people tolerate it well, but some experience mild stomach upset — abdominal discomfort, diarrhea, or nausea. These are not serious, but if they bother you, let your pharmacist know.
Is it safe to take during pregnancy or breastfeeding?
No — there isn't enough safety data, so it's best to avoid supplement doses if you're pregnant or breastfeeding. Talk with your doctor or midwife if you have questions about what to take instead.
Does this really work for hay fever, cancer, or heart disease?
The evidence isn't established yet. We have insufficient reliable data to say whether agaricus mushroom extract actually works for hay fever, osteoporosis, cancer, heart disease, chemotherapy side effects, or Crohn disease. If you're interested in it for one of these conditions, your pharmacist or doctor can discuss what research actually exists.
What's in the capsule besides the mushroom?
The capsule itself is made of hypromellose, and inside you'll also find rice bran, silica, maltodextrin, and magnesium stearate — all standard ingredients used to bind and fill capsules. None of those are actives; they're just there to hold everything together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Agaricus Blazei Mushroom Extract 500 mg is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Agaricus Blazei Mushroom Extract 500 mg label
Go deeper

The Full Monographs Behind Agaricus Blazei Mushroom Extract 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Agaricus Mushroom

Interacts with 86 drugs

Agaricus mushroom (often Agaricus blazei/subrufescens) is a culinary and medicinal mushroom studied mostly for possible immune and antioxidant effects. The human evidence is limited and not...

Read the full Agaricus Mushroom monograph →
Sources

Sources & How We Checked

Agaricus Blazei Mushroom Extract 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Agaricus Mushroom 5 references
  1. Hsu CH, Liao YL, Lin SC, et al. The mushroom Agaricus Blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: a randomized, double-blinded, and placebo-controlled clinical trial. J Altern Complement Med 2
  2. Mukai H, Watanabe T, Ando M, Katsumata N. An alternative medicine, Agaricus blazei, may have induced severe hepatic dysfunction in cancer patients. Jpn J Clin Oncol 2006;36:808-10. PubMed
  3. Ohno S, Sumiyoshi Y, Hashine K, et al. Phase I clinical study of the dietary supplement, Agaricus blazei Murill, in cancer patients in remission. Evid Based Complement Alternat Med 2011, doi 10.1155/2011/192381.
  4. Suehiro M, Katoh N, Kishimoto S. Chelitis due to Agaricus blazei Murill mushroom extract. Contact Dermatitis 2007;56(5):293-4.
  5. Iwai N, Okuda T, Sawada R, et al. Interstitial lung disease associated with Agaricus blazei Murill in a patient with pancreatic ductal adenocarcinoma receiving gemcitabine-based therapy. Case Rep Gastroenterol 2022;16(1):229-234.

See these in context on the Agaricus Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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