Interactions on record — worth a quick check against your medications. Based on 4 of 7 ingredients. Check your meds →
Dietary supplement

Noxadrene Extreme Ingredients & Drug Interactions

by NewtonEverett

Noxadrene Extreme label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Noxadrene Extreme against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Noxadrene Extreme is a dietary supplement by NewtonEverett with 7 active ingredients. Its ingredients are commonly taken for muscle recovery and sports performance, gut health and 'leaky gut', recovery from severe illness or injury.Based on those ingredients, 453 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Arginine Hydrochloride, Tribulus terrestris, L-Glutamine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Noxadrene Extreme by NewtonEverett

Ask about any prescription or over-the-counter medication and we check it for interactions with Noxadrene Extreme by NewtonEverett — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Noxadrene Extreme by NewtonEverett

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 7 of its 7 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Noxadrene Extreme contains 7 active ingredients. L-Glutamine and L-Arginine Hydrochloride are amino acids that support muscle function and recovery.

Creatine Complex boosts energy in muscle cells and may support athletic performance and muscle strength. Tribulus terrestris is a plant extract traditionally used for sexual function and athletic performance.

Three other ingredients — A-AKG, OKG, and GKG — appear on the label but we hold no data on them. The tablet also contains inactive ingredients (fillers and binders) including calcium carbonate, stearic acid, dicalcium phosphate, microcrystalline cellulose, magnesium stearate, croscarmellose sodium, silicon dioxide, pharmaceutical glaze, and aqueous film coating.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: muscle strength and workout recovery support.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, Muscle breakdown, Muscle strength, Physical performance, Postoperative recovery — and 4 related terms.
  • The strongest evidence on file: Creatine is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Creatine is rated "Possibly Effective" for Muscle strength, Sarcopenia.
  • Also on file: Glutamine is rated "Possibly Effective" for Postoperative recovery.

The evidence for Noxadrene Extreme's ingredients is mixed. L-Glutamine is effective for sickle cell disease and possibly effective for HIV/AIDS-related wasting, postoperative recovery, and critical illness from trauma.

L-Arginine has no effectiveness ratings in our data. Creatine Complex is possibly effective for muscle strength, athletic performance, and sarcopenia (age-related muscle loss), though it was rated possibly ineffective for Huntington disease and osteopenia.

Tribulus terrestris is possibly effective for sexual dysfunction but possibly ineffective for athletic performance, with insufficient evidence to rate it for benign prostatic hyperplasia. We hold no effectiveness data for A-AKG, OKG, or GKG.

The evidence, ingredient by ingredient Glutamine L-arginine Creatine Tribulus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-Glutamine is generally well tolerated in healthy adults but should only be used under medical supervision by people with kidney or liver disease. Most common side effects are gastrointestinal — belching, bloating, flatulence, nausea, diarrhea, and constipation — plus headache and musculoskeletal pain.

Dizziness, headache, and in rare cases mania have been reported. L-Glutamine is likely safe in pregnancy and lactation.

L-Arginine is generally well tolerated short-term but safety for long-term self-treatment is not well established; use only under medical supervision. Common side effects are abdominal pain, bloating, nausea, diarrhea, headache, insomnia, and flushing.

When inhaled, it can inflame airways. Creatine Complex is generally well tolerated but should be used carefully by those with kidney issues; common side effects are dehydration, diarrhea, muscle cramps, water retention, and gastrointestinal upset.

Safety in pregnancy and lactation has not been established — avoid use. Tribulus terrestris is often well tolerated short-term but quality and long-term safety data are limited; serious but rare cases of liver and kidney injury, seizures, and erection problems have been reported.

Safety data advises against use in pregnancy and lactation.

Side effects, ingredient by ingredient Glutamine L-arginine Creatine Tribulus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 4 matched ingredients can interact with medications — Tribulus, L-arginine, Glutamine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; seizure medications; diabetes medications; lithium.
  • For scale: 453 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Noxadrene Extreme, double-check with your own doctor or pharmacist if you take blood pressure medications (including ACE inhibitors or ARBs), potassium-sparing diuretics (water pills that preserve potassium), blood thinners or antiplatelet drugs, diabetes medications, seizure medications (anticonvulsants), or lithium. L-Arginine may also interact with isoproterenol and sildenafil (Viagra).

Altogether, Moderate interactions are documented across these medication types.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Noxadrene Extreme is marketed for muscle performance and recovery, which fits its creatine and amino acid content. But L-Arginine and Tribulus both carry multiple Moderate interactions with blood pressure and diabetes medications, plus other drugs — so this is not a "grab and go" product.

If you take any prescription medication, talk with your own doctor or pharmacist before starting it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Noxadrene Extreme, straight from the product label.

Brand NewtonEverett
Barcode (UPC) 818423027364
Net contents 30 Pack(s)
Market status On market
Date entered into DSLD Jan 25, 2020
DSLD ID 213154
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Noxadrene Extreme by NewtonEverett, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
7 Tablet(s)
Maximum serving Sizes:
7 Tablet(s)
Servings per container
30
UPC/BARCODE
818423027364
IngredientAmount% DV
L-Glutamine1000 mg--
L-Arginine Hydrochloride15 mg--
A-AKG2985 mg--
OKG75 mg--
GKG75 mg--
Creatine Complex3334 mg--
Tribulus terrestris1000 mg--

Other ingredients: Calcium Carbonate, Stearic Acid, Dicalcium Phosphate, Microcrystalline Cellulose, Vegetable Magnesium Stearate, Croscarmellose Sodium, Silicon Dioxide, Pharmaceutical Glaze, Aqueous Film Coating

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Noxadrene + Creatine Complex & L-Glutamine

Creatine Boost

Formulation

Strength & Recovery

Muscle Mass

Muscle Mass Complete Scientific Formula 8484 mg blend per pack

General Statements

Noxadrene Extreme is a scientifically formulated workout blend that combines the power of original Noxadrene with powerful muscle support and recovery ingredients, including a creatine protein complex to support your workout goals, and l-glutamine, the most abundant amino acid in muscle tissue. Nitric oxide is known as the muscle's "cell signaling" molecule as it plays a role in oxygen delivery, blood flow, power output, and nutrient delivery to support muscle strength, recovery, and a powerful pump. The ingredients found in this formula have been know to help boost levels of this nitric oxide to promote your best lift ever!

Sports/Fitness

Suggested/Recommended/Usage/Directions

Suggested Use: 1 packet taken 1 to 2 times daily with water on an empty stomach or as directed by a health care professional. Do not exceed two (2) packets per day. It may be advisable to take this product in cycles: 4 to 6 weeks on, then 4 to 6 weeks off.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Precautions

Warning: Keep out of reach of children.

Do not use if safety seal is damaged or missing.

Storage

Store in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Noxadrene Extreme by NewtonEverett label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Noxadrene Extreme label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Noxadrene Extreme by NewtonEverett

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size7 Tablet(s) Dosage formTablet Or Pill Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Glutamine

Interacts with
50 drugs
1000 mg per serving

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle c...

L-Glutamine monograph & interactions

L-Arginine Hydrochloride

Interacts with
403 drugs
15 mg per serving

L-arginine is an amino acid that the body uses to make nitric oxide, a substance that helps blood vessels relax and widen. It is popularly used for bl...

L-Arginine Hydrochloride monograph & interactions

A-AKG

2985 mg per serving

OKG

75 mg per serving

GKG

75 mg per serving

Creatine Complex

No known
interactions
3334 mg per serving Form: Creatine Alpha-ketoglutarate, Creatine Monohydrate, Creatine Pyruvate

Creatine is one of the most studied sports supplements, with solid evidence that it can boost strength and performance during short, high-intensity ac...

Creatine Complex monograph & interactions

Tribulus terrestris

Interacts with
259 drugs
1000 mg per serving

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims...

Tribulus terrestris monograph & interactions

Other (inactive) ingredients: Calcium Carbonate, Stearic Acid, Dicalcium Phosphate, Microcrystalline Cellulose, Vegetable Magnesium Stearate, Croscarmellose Sodium, Silicon Dioxide, Pharmaceutical Glaze, Aqueous Film Coating. These complete the product’s ingredient list but are not active constituents.

Interaction report

Noxadrene Extreme by NewtonEverett Drug Interactions

Want to check YOUR meds against Noxadrene Extreme?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
453Drugs
445 Moderate 8 Minor

Ingredients driving the most interactions

L-Arginine Hydrochloride 403
Tribulus terrestris 259
L-Glutamine 50

Individual Drug Interactions

The ingredients in Noxadrene Extreme interact with 453 drugs. Click any drug to see the details.

3 of the 7 ingredients in Noxadrene Extreme interact with drugs. Each result below shows which ingredient is responsible. L-Arginine Hydrochloride Tribulus terrestris L-Glutamine

Each ingredient & the kinds of drugs it affects

For each ingredient in Noxadrene Extreme with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Arginine Hydrochloride9 drug types · 403 drugs

Ace Inhibitors (Aceis)

Theoretically, concomitant use of L-arginine and ACE inhibitors may increase the risk for hypotension and hyperkalemia.
Combining L-arginine with some antihypertensive drugs, especially ACE inhibitors, seems to have additive vasodilating and blood pressure-lowering effects. Furthermore, ACE inhibitors can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients. Theoretically, concomitant use of ACE inhibitors with L-arginine may increases the risk of hyperkalemia.

Likelihood Probable Evidence D
Angiotensin Receptor Blockers (Arbs)

Theoretically, concomitant use of L-arginine and ARBs may increase the risk of hypotension and hyperkalemia.
L-arginine increases nitric oxide, which causes vasodilation. Combining L-arginine with ARBs seems to increase L-arginine-induced vasodilation. Furthermore, ARBs can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients. Theoretically, concomitant use of ARBs with L-arginine may increases the risk of hyperkalemia.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of bleeding.
Preliminary research suggests that L-arginine infusions reduce platelet aggregation in humans. The clinical significance of this effect is unclear.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, concomitant use of L-arginine might have additive effects with antidiabetes drugs.
Preliminary clinical research shows that L-arginine decreases blood glucose levels in patients with type 2 diabetes.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
L-arginine increases nitric oxide, which causes vasodilation. Clinical evidence shows that L-arginine can reduce blood pressure in some individuals with hypertension. Furthermore, combining L-arginine with some antihypertensive drugs seems to have additive vasodilating and blood pressure-lowering effects.

Likelihood Probable Evidence D
Isoproterenol (Isuprel)

Theoretically, concurrent use of isoproterenol and L-arginine might result in additive effects and hypotension.
Preliminary clinical evidence suggests that L-arginine enhances isoproterenol-induced vasodilation in patients with essential hypertension or a family history of essential hypertension.

Likelihood Probable Evidence D
Potassium-Sparing Diuretics

Theoretically concomitant use of potassium-sparing diuretics with L-arginine may increases the risk of hyperkalemia.
Potassium-sparing diuretics can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients.

Likelihood Possible Evidence D
Sildenafil (Viagra)

Theoretically, concurrent use of sildenafil and L-arginine might increase the risk for hypotension.
In vivo, concurrent use of L-arginine and sildenafil has resulted in increased vasodilation. Theoretically, concurrent use might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
Testosterone

Theoretically, concomitant use of L-arginine and testosterone might have additive effects.
In clinical research, L-arginine increases the level of testosterone in male patients with erectile dysfunction. The clinical significance of this finding is unclear.

Likelihood Possible Evidence D
L-Arginine Hydrochloride full monograph & interactions

Tribulus terrestris3 drug types · 259 drugs

Antidiabetes Drugs

Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that Tribulus can lower blood glucose levels in adults with type 2 diabetes who are taking antidiabetes medications.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that tribulus can lower blood pressure by inhibiting angiotensin-converting enzyme (ACE). Tribulus has also demonstrated hypotensive effects in pre-hypertensive adults.

Likelihood Possible Evidence D
Lithium

Theoretically, tribulus might increase the levels and clinical effects of lithium.
Tribulus is thought to have diuretic properties. Due to these potential diuretic effects, tribulus might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Tribulus terrestris full monograph & interactions

L-Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
L-Glutamine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Noxadrene Extreme, from the product label.

NewtonEverett

See all NewtonEverett products
Name
Newton-Everett Biotech
Street Address
PO Box 27793
City
Scottsdale
State
AZ
ZipCode
85255
Phone Number
866.593.3424
Web Address
www.newton-everett.com
Pharmacist Counseling Corner

Noxadrene Extreme by NewtonEverett: Common Questions

Does Noxadrene Extreme by NewtonEverett interact with any medications?
Yes. Based on its ingredients, Noxadrene Extreme has a known interaction with 453 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Noxadrene Extreme contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or nursing?
L-Glutamine is likely safe in both pregnancy and lactation. L-Arginine is possibly safe in pregnancy but safety during lactation is not rated. Creatine Complex has not been studied in pregnancy or lactation — the safety data advises against use in both. Tribulus terrestris carries possibly unsafe ratings in pregnancy and is not recommended while breastfeeding. Talk with your doctor or pharmacist about your situation before starting.
What are the most common side effects?
The most common side effects come from L-Glutamine and L-Arginine: stomach upset (nausea, diarrhea, bloating, pain), headache, and flushing. Creatine may cause dehydration, muscle cramps, and water retention. Most people tolerate these ingredients, but GI upset is fairly common at higher doses.
Is this safe if I have kidney disease?
L-Glutamine and Creatine Complex both require caution in kidney disease and should only be used under medical supervision. If you have any kidney issues, discuss this product with your doctor or pharmacist before taking it.
Will this help my athletic performance?
Creatine Complex is possibly effective for athletic performance and muscle strength. Tribulus terrestris was rated possibly ineffective for athletic performance, so the evidence doesn't support it for that goal. The other ingredients don't have effectiveness ratings for athletic use in our data.
What is L-Arginine for?
L-Arginine is an amino acid that supports blood vessel function and nitric oxide production. Our data shows no specific effectiveness ratings for it, but it's included for its role in muscle support and recovery.
Why can't you tell me about A-AKG, OKG, and GKG?
We hold no interaction or effectiveness data on these three ingredients, so we can't tell you how they work or whether they interact with your medications. Your doctor or pharmacist may be able to help you research them.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Noxadrene Extreme is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Noxadrene Extreme label
Go deeper

The Full Monographs Behind Noxadrene Extreme’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glutamine

Interacts with 50 drugs

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...

Read the full Glutamine monograph → Herb & supplement monograph

L-arginine

Interacts with 403 drugs

L-arginine is an amino acid that the body uses to make nitric oxide, a substance that helps blood vessels relax and widen. It is popularly used for blood pressure, erectile dysfunction, and...

Read the full L-arginine monograph → Herb & supplement monograph

Creatine

Creatine is one of the most studied sports supplements, with solid evidence that it can boost strength and performance during short, high-intensity activities like weightlifting and sprintin...

Read the full Creatine monograph → Herb & supplement monograph

Tribulus

Interacts with 259 drugs

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims is weak and inconsistent. It is general...

Read the full Tribulus monograph →
Sources

Sources & How We Checked

Noxadrene Extreme's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 173 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

L-arginine 66 references
  1. Sapienza MA, Kharitonov SA, Horvath I, et al. Effect of inhaled L-arginine on exhaled nitric oxide in normal and asthmatic subjects. Thorax 1998;53:172-5.
  2. Clarkson P, Adams MR, Powe AJ, et al. Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults. J Clin Invest 1996;97:1989-94. PubMed
  3. Tenenbaum A, Fisman EZ, Motro M. L-arginine: Rediscovery in progress. Cardiology 1998;90:153-9.
  4. Brittenden J, Park KGM, Heys SD, et al. L-Arginine stimulates host defenses in patients with breast cancer. Surgery 1994;115:205-12.
  5. Korting GE, Smith SD, Wheeler MA, et al. A randomized double-blind trial of oral L-arginine for treatment of interstitial cystitis. J Urol 1999;161:558-65. DOI
  6. Rector TS, Bank AJ, Mullen KA, et al. Randomized, double-blind, placebo-controlled study of supplemental oral L-arginine in patients with heart failure. Circulation 1996;93:2135-41.
  7. Siani A, Pagano E, Iacone R, et al. Blood pressure and metabolic changes during dietary L-arginine supplementation in humans. Am J Hypertens 2000;13:547-51. PubMed
  8. Cheng JW, Balwin SN. L-arginine in the management of cardiovascular diseases. Ann Pharmacother 2001;35:755-64. PubMed
  9. Wallace AW, Tom WL. Interaction of L-arginine and phosphodiesterase inhibitors in vasodilation of the porcine internal mammary artery. Anesth Analg 2000;90:840-6. DOI
  10. Huynh NT, Tayek JA. Oral arginine reduces systemic blood pressure in type 2 diabetes: its potential role in nitric oxide generation. J Am Coll Nutr 2002;21:422-7.. PubMed
  11. Staff AC, Berge L, Haugen G, et al. Dietary supplementation with L-arginine or placebo in women with pre-eclampsia. Acta Obstet Gynecol Scand 2004;83:103-7.
  12. Resnick DJ, Softness B, Murphy AR, et al. Case report of an anaphylactoid reaction to arginine. Ann Allergy Asthma Immunol 2002;88:67-8. PubMed
  13. Anon. Arginine hydrochloride injection (marketed as R-Gene 10). FDA Drug Safety Newsletter 2009;2(2):16-18. Available at: www.fda.gov/Drugs/DrugSafety/DrugSafetyNewsletter/default.htm.
  14. Higashi Y, Oshima T, Sasaki S, et. al. Angiotensin-converting enzyme inhibition, but not calcium antagonism, improves a response of the renal vasculature to L-arginine in patients with essential hypertension. Hypertension. 1998 Jul;32(1):16-24.
  15. Facchinetti, F., Longo, M., Piccinini, F., Neri, I., and Volpe, A. L-arginine infusion reduces blood pressure in preeclamptic women through nitric oxide release. J Soc Gynecol.Investig. 1999;6(4):202-207. DOI
  16. de Gouw, H. W., Verbruggen, M. B., Twiss, I. M., and Sterk, P. J. Effect of oral L-arginine on airway hyperresponsiveness to histamine in asthma. Thorax 1999;54(11):1033-1035. PubMed
  17. Komers, R., Komersova, K., Kazdova, L., Ruzickova, J., and Pelikanova, T. Effect of ACE inhibition and angiotensin AT1 receptor blockade on renal and blood pressure response to L-arginine in humans. J Hypertens. 2000;18(1):51-59. PubMed
  18. Cartledge, J. J., Davies, A. M., and Eardley, I. A randomized double-blind placebo-controlled crossover trial of the efficacy of L-arginine in the treatment of interstitial cystitis. BJU.Int. 2000;85(4):421-426.
  19. Sozykin, A. V., Noeva, E. A., Balakhonova, T. V., Pogorelova, O. A., and Men'shikov, M. I. [Effect of L-arginine on platelet aggregation, endothelial function adn exercise tolerance in patients with stable angina pectoris]. Ter.Arkh. 2000;72(8):24-27.
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See these in context on the L-arginine monograph →

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Tribulus 10 references
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See these in context on the Tribulus monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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