Interactions on record — worth a quick check against your medications. Based on 4 of 6 ingredients. Check your meds →
Dietary supplement

NR6 Ingredients & Drug Interactions

by Xtendlife

NR6 label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking NR6 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

NR6 is a dietary supplement by Xtendlife with 6 active ingredients. Its ingredients are commonly taken for heart and blood vessel health, antioxidant support, anti-aging.Based on those ingredients, 1,155 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Piperine, Trans-Resveratrol, Nicotinamide Riboside Chloride. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against NR6 by Xtendlife

Ask about any prescription or over-the-counter medication and we check it for interactions with NR6 by Xtendlife — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of NR6 by Xtendlife

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Oct 1, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

NR6 contains 6 active ingredients: folate, dimethylglycine HCl, trans-resveratrol, piperine (from black pepper), vitamin B12, and nicotinamide riboside chloride. These work together as a cellular energy and antioxidant blend.

The product also contains two inactive ingredients—hydroxypropylmethyl cellulose and water—which serve as the capsule and binding materials.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: cellular energy support.
  • We looked for evidence on: Fatigue, Athletic performance, Cognitive function, Mitochondrial myopathies, Energy metabolism, NAD+ metabolism — and 1 related terms.
  • The closest evidence on file: Resveratrol is rated "Insufficient Reliable Evidence To Rate" for Cognitive function (Natural Medicines).
  • Also on file: Resveratrol is rated "Insufficient Reliable Evidence To Rate" for Mitochondrial myopathies.
  • Also on file: Black Pepper is rated "Insufficient Reliable Evidence To Rate" for Athletic performance, Fatigue.

Evidence for NR6's ingredients is mixed. Trans-resveratrol is possibly effective for obesity and allergic rhinitis (hay fever), but possibly ineffective for cardiovascular disease and high cholesterol.

Piperine has insufficient evidence to rate it for hay fever, asthma, athletic performance, headache, depression, or diarrhea. Vitamin B12 is effective for B12 deficiency itself and possibly effective for canker sores and nerve pain, but the other conditions NR6 targets don't have established ratings in our data.

Nicotinamide riboside has insufficient evidence for all the conditions we hold data on—including age-related macular degeneration, Alzheimer's disease, athletic performance, fatty liver disease, and heart failure. For folate and dimethylglycine HCl, we have no effectiveness ratings on file.

The evidence, ingredient by ingredient Resveratrol Black Pepper Vitamin B12 Nicotinamide Riboside

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Trans-resveratrol is generally well tolerated at typical supplement doses, but higher doses may cause diarrhea, digestive discomfort, and loose stools. Resveratrol isn't recommended in concentrated supplement form during pregnancy or breastfeeding due to insufficient safety data, though food sources are fine.

Piperine (black pepper) is safe as a food spice; concentrated supplements should be used cautiously and avoided in pregnancy or breastfeeding without medical advice. Common side effects from higher doses include burning aftertaste and indigestion.

Vitamin B12 is very safe—the body removes excess through urine and there's no established upper limit—and is actually needed in pregnancy and breastfeeding at recommended amounts. Nicotinamide riboside appears well tolerated short-term, but long-term safety isn't fully known; avoid it in pregnancy and breastfeeding due to limited safety data.

Reported side effects include bloating, muscle pain, nausea, itching, and temporary stool changes.

Side effects, ingredient by ingredient Resveratrol Black Pepper Vitamin B12 Nicotinamide Riboside

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Resveratrol, Black Pepper, Vitamin B12, Nicotinamide Riboside.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; lithium.
  • For scale: 1,156 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking NR6, check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (like warfarin, clopidogrel, or aspirin)—trans-resveratrol may increase bleeding risk. Also double-check if you're on propranolol, nevirapine, rifampin, phenytoin, cyclosporine, theophylline, atorvastatin, or pentobarbital, as piperine may raise their blood levels.

If you take blood pressure medications, nicotinamide riboside might add a lowering effect. If you're on metformin for diabetes, the vitamin B12 in this product may help—but still confirm the timing and dose with your pharmacist.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

NR6 is designed as a cellular energy and antioxidant supplement, and some of its ingredients have modest evidence for obesity and allergies. However, it carries multiple Moderate-severity interactions—especially with blood thinners, heart medications, and certain antiretrovirals—and you should check your exact medications before starting.

Vitamin B12 supplementation may help if you're on metformin and have low B12. Talk with your own doctor or pharmacist about whether this product fits your health needs and medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about NR6, straight from the product label.

Brand Xtendlife
Barcode (UPC) 9421904523425
Net contents 30 Vege Capsule(s)
Market status On market
Date entered into DSLD Sep 25, 2024
DSLD ID 318037
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for NR6 by Xtendlife, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
9421904523425
IngredientAmount% DV
Folate150 mcg37%
Dimethylglycine HCl100 mg--
Trans-Resveratrol100 mg--
Piperine10 mg--
Vitamin B1224 mcg1000%
Nicotinamide Riboside Chloride300 mg--

Other ingredients: Hydroxypropylmethyl Cellulose, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions For Use Adults: Take 1 capsule per day.

Formula

Xtend-Life NR6 includes a synergistic combination of ingredients to support optimal cellular energy.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Cellular Energy Support

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Best Quality Guarantee

NewZealand.com Licence No.100055

General Statements

USA/Canada Ph: 1888 487 9304

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

NR6 by Xtendlife label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

NR6 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in NR6 by Xtendlife

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Folate

150 mcg per serving Form: Calcium L-5-Methyltetrahydrofolate

Dimethylglycine HCl

100 mg per serving

Trans-Resveratrol

Interacts with
822 drugs
100 mg per serving Form: Japanese Knotweed

Resveratrol is a plant compound found in red grapes, berries, and peanuts that is popular for heart health, anti-aging, and antioxidant support. While...

Trans-Resveratrol monograph & interactions

Piperine

Interacts with
1,019 drugs
10 mg per serving Form: Black Pepper

Black pepper is a common kitchen spice that is generally safe in the amounts used in food. Its extract, piperine, is mostly added to supplements to he...

Piperine monograph & interactions

Vitamin B12

Interacts with
20 drugs
24 mcg per serving Form: Cobamamide

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Vitamin B12 monograph & interactions

Nicotinamide Riboside Chloride

Interacts with
172 drugs
300 mg per serving

Nicotinamide riboside (NR) is a form of vitamin B3 that the body converts into NAD+, a molecule involved in cellular energy and repair. Early human st...

Nicotinamide Riboside Chloride monograph & interactions

Other (inactive) ingredients: Hydroxypropylmethyl Cellulose, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

NR6 by Xtendlife Drug Interactions

Want to check YOUR meds against NR6?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,155Drugs
1,030 Moderate 125 Minor

Ingredients driving the most interactions

Piperine 1,019
Trans-Resveratrol 822
Nicotinamide Riboside Chloride 172
Vitamin B12 20

Individual Drug Interactions

The ingredients in NR6 interact with 1,155 drugs. Click any drug to see the details.

4 of the 6 ingredients in NR6 interact with drugs. Each result below shows which ingredient is responsible. Piperine Trans-Resveratrol Nicotinamide Riboside Chloride Vitamin B12

Each ingredient & the kinds of drugs it affects

For each ingredient in NR6 with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Piperine17 drug types · 1,019 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, black pepper might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
In vitro research shows that piperine, a constituent of black pepper, seems to inhibit platelet aggregation. This has not been reported in humans.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, black pepper might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research shows that piperine, a constituent of black pepper, can reduce blood glucose levels. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence D
Atorvastatin (Lipitor)

Theoretically, black pepper might increase blood levels of atorvastatin.
Animal research shows that taking piperine, a constituent of black pepper, 35 mg/kg can increase the maximum serum concentration of atorvastatin three-fold. This has not been reported in humans.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically, black pepper might increase the effects and side effects of cyclosporine.
In vitro research shows that piperine, a constituent of black pepper, increases the bioavailability of cyclosporine. This has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, black pepper might increase levels of drugs metabolized by CYP2D6.
In vitro research suggests that some constituents of black pepper inhibit CYP2D6. This has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.
In vitro research and pharmacokinetic simulation data suggest that piperine, a constituent of black pepper, as well as the pepper fruit seem to inhibit CYP3A4. This has not been reported in humans.

Likelihood Possible Evidence D
Lithium

Theoretically, black pepper might increase blood levels of lithium due to its diuretic effects. The dose of lithium might need to be reduced.
Black pepper is thought to have diuretic properties.

Likelihood Probable Evidence D
Nevirapine (Viramune)

Black pepper might increase blood levels of nevirapine.
Clinical research shows that piperine, a constituent of black pepper, increases the plasma concentration of nevirapine. However, no adverse effects were observed in this study.

Likelihood Probable Evidence D
P-Glycoprotein Substrates

Theoretically, black pepper might increase levels of P-glycoprotein substrates.
In vitro research shows that piperine, a constituent of black pepper, seems to inhibit P-glycoprotein.

Likelihood Possible Evidence D
Pentobarbital (Nembutal)

Theoretically, black pepper might increase the sedative effects of pentobarbital.
Animal research shows that piperine, a constituent of black pepper, increases pentobarbital-induced sleeping time.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

Black pepper might increase blood levels of phenytoin.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption, slow elimination, and increase levels of phenytoin. Taking a single dose of black pepper 1 gram along with phenytoin seems to double the serum concentration of phenytoin. Consuming a soup with black pepper providing piperine 44 mg/200 mL of soup along with phenytoin also seems to increase phenytoin levels when compared with consuming the same soup without black pepper.

Likelihood Possible Evidence B
Propranolol (Inderal)

Black pepper might increase blood levels of propranolol.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and slow elimination of propranolol.

Likelihood Possible Evidence B
Rifampin (Rifadin)

Black pepper might increase blood levels of rifampin.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and serum levels of rifampin.

Likelihood Possible Evidence B
Theophylline

Black pepper might increase blood levels of theophylline.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and slow elimination of theophylline.

Likelihood Possible Evidence D
Amoxicillin (Amoxil, Trimox)

Theoretically, black pepper might increase the effects and side effects of amoxicillin.
Animal research shows that taking piperine, a constituent of black pepper, with amoxicillin increases plasma levels of amoxicillin. This has not been reported in humans.

Likelihood Possible Evidence D
Carbamazepine (Tegretol)

Theoretically, black pepper might increase blood levels of carbamazepine, potentially increasing the effects and side effects of carbamazepine.
One clinical study in patients taking carbamazepine 300 mg or 500 mg twice daily shows that taking a single 20 mg dose of purified piperine, a constituent of black pepper, increases carbamazepine levels. Piperine may increase carbamazepine absorption by increasing blood flow to the GI tract, increasing the surface area of the small intestine, or inhibiting cytochrome P450 3A4 (CYP3A4) in the gut wall. Absorption was significantly increased by 7-10 mcg/mL/hour. The time to eliminate carbamazepine was also increased by 4-8 hours. Although carbamazepine levels were increased, this did not appear to increase side effects. In vitro research also shows that piperine can increase carbamazepine levels by 11% in a time-dependent manner.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, black pepper might decrease levels and clinical effects of drugs metabolized by CYP1A2.
In vitro research suggests that black pepper induces CYP1A2. This has not been reported in humans.

Likelihood Possible Evidence D
Piperine full monograph & interactions

Trans-Resveratrol5 drug types · 822 drugs

Anticoagulant/Antiplatelet Drugs

Resveratrol may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Resveratrol seems to have antiplatelet effects.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, resveratrol might increase levels of drugs metabolized by CYP1A2.
In vitro research shows that resveratrol can inhibit CYP1A2 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, resveratrol might increase levels of drugs metabolized by CYP2C19.
In vitro research shows that resveratrol can inhibit CYP2C19 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Resveratrol might increase levels of drugs metabolized by CYP2E1.
In vitro research suggests that resveratrol inhibits CYP2E1 isoenzyme. Also, a pharmacokinetic study shows that taking resveratrol 500 mg daily for 10 days prior to taking a single dose of chlorzoxazone 250 mg increases the maximum concentration of chlorzoxazone by about 54%, the area under the curve of chlorzoxazone by about 72%, and the half-life of chlorzoxazone by about 35%. Chlorzoxazone is used as a probe drug for CYP2E1.

Likelihood Probable Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
In vitro research shows that resveratrol can inhibit the CYP3A4 enzyme. However, clinical research shows that taking resveratrol 3000 mg daily for 8 weeks does not necessitate dose adjustments to medications metabolized by CYP3A4.

Likelihood Possible Evidence D
Trans-Resveratrol full monograph & interactions

Nicotinamide Riboside Chloride1 drug type · 172 drugs

Antihypertensive Drugs

Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
One small clinical study suggests that nicotinamide riboside can modestly reduce blood pressure in hypertensive patients. However, other clinical research did not find a reduction in blood pressure when compared with control.

Likelihood Possible Evidence D
Nicotinamide Riboside Chloride full monograph & interactions

Vitamin B121 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Vitamin B12 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for NR6, from the product label.

Xtendlife

See all Xtendlife products
Name
Natural Products (NZ) LTD Member of the Xtend-Life Group
Street Address
12 Mary Muller Drive
City
Christchurch
ZipCode
8022
Phone Number
+64 3 384 2116
Web Address
www.XTEND-LIFE.COM
Pharmacist Counseling Corner

NR6 by Xtendlife: Common Questions

Does NR6 by Xtendlife interact with any medications?
Yes. Based on its ingredients, NR6 has a known interaction with 1,155 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
NR6 contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take NR6 if I'm pregnant or breastfeeding?
There isn't enough safety data for concentrated nicotinamide riboside or trans-resveratrol supplements in pregnancy or breastfeeding, so both should be avoided. Piperine (black pepper) isn't well studied at supplement strength in pregnancy or while nursing either. Vitamin B12, on the other hand, is actually needed at normal recommended amounts in both situations and is considered safe. Talk with your doctor or midwife about whether this product is right for you.
What does each ingredient in NR6 do?
Folate and vitamin B12 support energy and cell function. Trans-resveratrol is an antioxidant from grapes. Piperine (black pepper) may enhance absorption of other compounds and has anti-inflammatory properties. Nicotinamide riboside supports cellular energy production. Dimethylglycine HCl is thought to support energy and athletic function. Together, they're meant to work as an anti-aging and energy blend.
Does NR6 actually work for weight loss or anti-aging?
Trans-resveratrol is possibly effective for obesity based on the evidence we hold, but it's not proven. For anti-aging and most of the other conditions the blend targets, the evidence is either possibly ineffective (like cardiovascular disease) or we don't have enough data to rate it. NR6 isn't a proven weight-loss or anti-aging cure—it's a supplement with modest support for some uses.
What side effects might I get from NR6?
At typical supplement doses, most users tolerate it well. You might notice diarrhea, bloating, nausea, digestive discomfort, or a burning aftertaste, especially if you take higher doses. Muscle soreness, itching, and mild changes in stools have been reported in trials. If you're sensitive to black pepper, allergic reactions are rare but possible.
Is NR6 safe to take long-term?
Vitamin B12 is very safe long-term because excess is shed in urine. Trans-resveratrol and piperine from food are well tolerated, but long-term safety of the concentrated supplement forms in NR6 isn't fully known. Nicotinamide riboside appears well tolerated in short-term studies, but long-term data is limited. If you plan to take this for months or years, discuss it with your pharmacist first.
Will NR6 affect my diabetes or blood pressure medication?
If you take metformin for type 2 diabetes, NR6's vitamin B12 may help because metformin can lower B12 over time. If you take blood pressure medication, nicotinamide riboside might add a mild lowering effect. Piperine can raise blood levels of some specific medications, so confirm your full list with your pharmacist before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

NR6 label
Go deeper

The Full Monographs Behind NR6’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Resveratrol

Interacts with 822 drugs

Resveratrol is a plant compound found in red grapes, berries, and peanuts that is popular for heart health, anti-aging, and antioxidant support. While lab and animal studies are promising, s...

Read the full Resveratrol monograph → Herb & supplement monograph

Black Pepper

Interacts with 1,019 drugs

Black pepper is a common kitchen spice that is generally safe in the amounts used in food. Its extract, piperine, is mostly added to supplements to help the body absorb other ingredients (li...

Read the full Black Pepper monograph → Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph → Herb & supplement monograph

Nicotinamide Riboside

Interacts with 172 drugs

Nicotinamide riboside (NR) is a form of vitamin B3 that the body converts into NAD+, a molecule involved in cellular energy and repair. Early human studies show it can reliably raise NAD+ le...

Read the full Nicotinamide Riboside monograph →
Sources

Sources & How We Checked

NR6's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 90 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Resveratrol 24 references
  1. Soleas GJ, Diamandis EP, Goldberg DM. Resveratrol: a molecule whose time has come? And gone? Clin Biochem 1997;30:91-113.
  2. Pace-Asciak CR, Rounova O, Hahn SE, et al. Wines and grape juices as modulators of platelet aggregation in healthy human subjects. Clin Chim Acta 1996;246:163-82. PubMed
  3. Bertelli AA, Giovannini L, Bernini W, et al. Antiplatelet activity of cis-resveratrol. Drugs Exp Clin Res 1996;22:61-3.
  4. Pace-Asciak CR, Hahn S, Diamandis EP, et al. The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease. Clin Chim Acta 1995;235:207-19.
  5. Bertelli A, Bertelli AA, Gozzini A, Giovannini L. Plasma and tissue resveratrol concentrations and pharmacological activity. Drugs Exp Clin Res 1998;24:133-8.
  6. Bertelli AA, Giovannini L, Giannessi D, et al. Antiplatelet activity of synthetic and natural resveratrol in red wine. Int J Tissue React 1995;17:1-3.
  7. Piver B, Berthou F, Dreano Y, Lucas D. Inhibition of CYP3A, CYP1A and CYP2E1 activities by resveratrol and other non volatile red wine components. Toxicol Lett 2001;125:83-91. PubMed
  8. Chang, T. K., Chen, J., and Lee, W. B. Differential inhibition and inactivation of human CYP1 enzymes by trans-resveratrol: evidence for mechanism-based inactivation of CYP1A2. J.Pharmacol.Exp.Ther. 2001;299(3):874-882.
  9. Dobrydneva, Y., Williams, R. L., and Blackmore, P. F. trans-Resveratrol inhibits calcium influx in thrombin-stimulated human platelets. Br.J.Pharmacol. 1999;128(1):149-157.
  10. Kirk, R. I., Deitch, J. A., Wu, J. M., and Lerea, K. M. Resveratrol decreases early signaling events in washed platelets but has little effect on platalet in whole food. Blood Cells Mol.Dis. 2000;26(2):144-150.
  11. Zbikowska, H. M. and Olas, B. Antioxidants with carcinostatic activity (resveratrol, vitamin E and selenium) in modulation of blood platelet adhesion. J Physiol Pharmacol. 2000;51(3):513-520.
  12. Olas, B., Wachowicz, B., Saluk-Juszczak, J., and Zielinski, T. Effect of resveratrol, a natural polyphenolic compound, on platelet activation induced by endotoxin or thrombin. Thromb.Res 8-15-2002;107(3-4):141-145. PubMed
  13. Yu, C., Shin, Y. G., Kosmeder, J. W., Pezzuto, J. M., and van Breemen, R. B. Liquid chromatography/tandem mass spectrometric determination of inhibition of human cytochrome P450 isozymes by resveratrol and resveratrol-3-sulfate. Rapid Commun.Mass Spectro PubMed
  14. Ma, Z. H. and Ma, Q. Y. Resveratrol: a medical drug for acute pancreatitis. World J Gastroenterol. 6-7-2005;11(21):3171-3174. PubMed
  15. la, Porte C., Voduc, N., Zhang, G., Seguin, I., Tardiff, D., Singhal, N., and Cameron, D. W. Steady-State pharmacokinetics and tolerability of trans-resveratrol 2000 mg twice daily with food, quercetin and alcohol (ethanol) in healthy human subjects. Cli PubMed
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Nicotinamide Riboside 7 references
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See these in context on the Nicotinamide Riboside monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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