Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

O2 Gold Ingredients & Drug Interactions

by AdvoCare

O2 Gold label
See full label image
Other (e.g. Tea Bag) Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking O2 Gold against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

O2 Gold is a dietary supplement by AdvoCare with 5 active ingredients. Its ingredients are commonly taken for muscle building and recovery, increasing daily protein intake, weight management.Based on those ingredients, 1,393 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Golden Root Extract, Eleuthero extract, Beet extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against O2 Gold by AdvoCare

Ask about any prescription or over-the-counter medication and we check it for interactions with O2 Gold by AdvoCare — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of O2 Gold by AdvoCare

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

O2 Gold contains 5 active ingredients: hydrolyzed whey protein (a source of amino acids), inosine (a nucleoside), beet extract (from the beet vegetable), eleuthero extract (from an adaptogenic herb), and golden root extract, also called rhodiola (another adaptogenic herb). The product also contains inactive ingredients — binders, fillers, and capsule materials like microcrystalline cellulose, magnesium stearate, and polyethylene glycol — that help hold the formula together.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: maximize workouts by supporting oxygen use.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, Exercise-induced muscle soreness, Muscle strength, endurance, oxygen utilization — and 1 related terms.
  • The strongest evidence on file: Beet is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Beet is rated "Possibly Effective" for Exercise-induced muscle soreness.
  • Also on file: Whey Protein is rated "Possibly Effective" for Athletic performance.

The evidence for O2 Gold's ingredients is mixed and often limited. Whey protein is possibly effective for athletic performance but possibly ineffective for osteoporosis and chronic obstructive pulmonary disease; evidence is insufficient to rate it for cognitive decline or HIV/AIDS-related wasting.

Beet extract is possibly effective for athletic performance and exercise-related muscle soreness but possibly ineffective for COPD; evidence is insufficient for its effects on cholesterol or cognitive function. Inosine, eleuthero, and rhodiola lack sufficient reliable evidence to establish their effectiveness for the conditions studied.

If you're considering this product for a specific health goal, talk it over with your doctor or pharmacist about what the actual evidence shows.

The evidence, ingredient by ingredient Whey Protein Inosine Beet Eleuthero Rhodiola

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Whey protein is generally well tolerated by healthy adults at normal doses, though concentrated supplements lack long-term safety data — check with your doctor if you're considering high-dose whey. Common side effects include bloating, cramps, diarrhea, nausea, headache, and reduced appetite; whey has also been linked to acne or worsening acne in teenagers and young adults.

Inosine raises uric acid levels, which is a concern if you have gout or kidney problems, and should be avoided in pregnancy and while breastfeeding due to insufficient safety data. Beet extract is generally well tolerated as a food but concentrated supplements lack robust safety data; red or black stools are common and harmless.

Eleuthero and rhodiola are generally well tolerated short-term, though long-term safety is not well studied; both should be avoided during pregnancy and breastfeeding because data is insufficient. Eleuthero may cause nervousness, anxiety, and irritability at higher doses, and has been reported to raise blood pressure.

Rhodiola may cause dizziness or changes in saliva production.

Side effects, ingredient by ingredient Whey Protein Inosine Beet Eleuthero Rhodiola

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Beet, Inosine, Whey Protein, Rhodiola, Eleuthero.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; heart-rhythm medications; Parkinson's medications.
  • For scale: 1,394 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking O2 Gold if you use levodopa (Major interaction with whey protein). Also discuss it if you take antibiotics (quinolone or tetracycline types), bisphosphonates for bone health, antigout drugs, anticoagulants or antiplatelet drugs (blood thinners), immunosuppressants, diabetes medications, digoxin or other heart drugs, antihypertensive drugs (blood pressure medications), or drugs metabolized through liver pathways CYP1A2, CYP2C9, CYP2D6, CYP3A4, or P-glycoprotein transport — all carry documented Moderate interactions, and several Minor ones as well.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

O2 Gold is a multi-ingredient supplement with several active components, each with its own limited effectiveness data and documented medication interactions. It's not suitable during pregnancy or while breastfeeding.

If you take any prescription medications — especially for Parkinson disease, infections, bone health, blood pressure, diabetes, heart rhythm, or blood clotting — check with your own doctor or pharmacist before starting this product.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about O2 Gold, straight from the product label.

Brand AdvoCare
Net contents 60 Caplet(s)
Market status On market
Date entered into DSLD Jun 16, 2022
DSLD ID 265465
Product type Other Combinations
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for O2 Gold by AdvoCare, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Caplet(s)
Maximum serving Sizes:
2 Caplet(s)
Servings per container
30
IngredientAmount% DV
hydrolyzed Whey Protein1000 mg--
Inosine500 mg--
Beet extract150 mg--
Eleuthero extract50 mg--
Golden Root Extract200 mg--

Other ingredients: Calcium Phosphate, Microcrystalline Cellulose, Croscarmellose Sodium, Ethylcellulose, Magnesium Stearate, Hydroxypropyl Methylcellulose, Silicon Dioxide, Stearic Acid, Hydroxypropyl Cellulose, Polyethylene Glycol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

O2 Gold helps maximize workouts by supporting the body's use of oxygen.

Helps support the body's use of oxygen Helps the body adapt to stress Helps increase and maintain energy levels

General Statements

For more information visit advocare.com

Suggested/Recommended/Usage/Directions

Directions For Use: Take 2 caplets 60 minutes before exercise.

Precautions

Caution: Check with your healthcare professional before using this product.

This product is not intended for pregnant or nursing women or for those under 18 years of age.

This product is not intended for pregnant or nursing women or for those under 18 years of age. Keep out of reach of children.

Contains: Milk

Storage

Store away from excessive heat, light and humidity.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Herbal Dietary Supplement

Formula

1,000 mg Hydrolyzed Whey Protein 2 Adaptogens

Seals/Symbols

Informed Sport We Test-You Trust

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

O2 Gold by AdvoCare label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

O2 Gold label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in O2 Gold by AdvoCare

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Caplet(s) Dosage formOther (e.g. Tea Bag) Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Hydrolyzed Whey Protein

Interacts with
53 drugs
1000 mg per serving

Whey protein is a high-quality, complete protein made from cow's milk that can help people meet protein needs and support muscle growth when combined...

Hydrolyzed Whey Protein monograph & interactions

Inosine

Interacts with
9 drugs
500 mg per serving

Inosine is a nucleoside (a building block of DNA and RNA) that the body makes on its own and is also sold as a supplement, mostly marketed for athleti...

Inosine monograph & interactions

Beet extract

Interacts with
861 drugs
150 mg per serving

Beet, especially beetroot juice, is a nitrate-rich food that may modestly lower blood pressure and slightly improve exercise performance in some peopl...

Beet extract monograph & interactions

Eleuthero extract

Interacts with
1,140 drugs
50 mg per serving

Eleuthero is an herb traditionally used as an 'adaptogen' to fight fatigue, boost energy, and help the body handle stress. The scientific evidence beh...

Eleuthero extract monograph & interactions

Golden Root Extract

Interacts with
1,271 drugs
200 mg per serving

Rhodiola is an herb traditionally used to fight fatigue and help the body cope with stress. Some small studies suggest it may modestly reduce fatigue...

Golden Root Extract monograph & interactions

Other (inactive) ingredients: Calcium Phosphate, Microcrystalline Cellulose, Croscarmellose Sodium, Ethylcellulose, Magnesium Stearate, Hydroxypropyl Methylcellulose, Silicon Dioxide, Stearic Acid, Hydroxypropyl Cellulose, Polyethylene Glycol. These complete the product’s ingredient list but are not active constituents.

Interaction report

O2 Gold by AdvoCare Drug Interactions

Want to check YOUR meds against O2 Gold?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,393Drugs
5 Major 1,225 Moderate 163 Minor

Ingredients driving the most interactions

Golden Root Extract 1,271
Eleuthero extract 1,140
Beet extract 861
hydrolyzed Whey Protein 53
Inosine 9

Individual Drug Interactions

The ingredients in O2 Gold interact with 1,393 drugs. Click any drug to see the details.

5 of the 5 ingredients in O2 Gold interact with drugs. Each result below shows which ingredient is responsible. Golden Root Extract Eleuthero extract Beet extract hydrolyzed Whey Protein Inosine

Each ingredient & the kinds of drugs it affects

For each ingredient in O2 Gold with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Golden Root Extract10 drug types · 1,271 drugs

Antidiabetes Drugs

Theoretically, taking rhodiola with antidiabetes drugs might increase the risk of hypoglycemia.
In vitro and animal research shows that rhodiola extract can decrease blood glucose due to alpha-glucosidase activity.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking rhodiola with antihypertensive drugs might increase the risk of hypotension.
In vitro and animal research shows that rhodiola extract inhibits angiotensin-converting enzyme (ACE) and might lower blood pressure.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, rhodiola might increase levels of drugs metabolized by CYP2C9.
In vitro research shows that rhodiola inhibits CYP2C9. This effect is highly variable and appears to be dependent on the rhodiola product studied. Also, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days reduces the metabolism of losartan, a CYP2C9 substrate, by 21% after 4 hours.

Likelihood Possible Evidence B
Immunosuppressants

Theoretically, rhodiola use might interfere with immunosuppressive therapy.
In vitro and animal research show that rhodiola has immunostimulatory effects.

Likelihood Possible Evidence D
Losartan (Cozaar)

Rhodiola might increase the levels and adverse effects of losartan.
A clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days reduces the metabolism of losartan, a CYP2C9 substrate, by 21% after 4 hours.

Likelihood Probable Evidence B
P-Glycoprotein Substrates

Theoretically, rhodiola might increase levels of P-glycoprotein substrates.
In vitro research shows that rhodiola inhibits P-glycoprotein. Theoretically, using rhodiola with P-glycoprotein substrates might increase drug levels and potentially increase the risk of adverse effects.

Likelihood Possible Evidence D
Antidepressant Drugs

Theoretically, rhodiola might increase the risk of adverse effects when taken with antidepressants.
A review of adverse event reports in Poland identified cases of tachyarrhythmias, myalgia, arthralgia, gum pain, restless leg syndrome, swallowing disorders, and changes in consciousness when rhodiola was taken in combination with paroxetine, escitalopram, fluoxetine, sertraline, trazodone, and/or duloxetine.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, rhodiola might increase the risk of adverse effects when taken with CNS depressants.
A review of adverse event reports in Poland identified cases of excessive sedation, myoclonus, hypotension, and hallucinations when rhodiola was taken with haloperidol, diazepam, or alprazolam.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
In vitro research shows that rhodiola inhibits CYP1A2. This effect is highly variable and appears to be dependent on the rhodiola product studied. However, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days does not inhibit the metabolism of caffeine, a CYP1A2 substrate.

Likelihood Possible Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.
In vitro research shows that rhodiola inhibits CYP3A4. This effect is highly variable and appears to be dependent on the rhodiola product studied. However, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days does not inhibit the metabolism of midazolam, a CYP3A4 substrate.

Likelihood Possible Evidence B
Golden Root Extract full monograph & interactions

Eleuthero extract10 drug types · 1,140 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, eleuthero may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research shows that a constituent of eleuthero, dihydroxybenzoic acid, appears to inhibit platelet aggregation. Concomitant use with anticoagulant or antiplatelet drugs might increase the risk of bleeding. This effect has not been reported in humans.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, eleuthero might have additive effects when used with antidiabetes drugs.
Animal research suggests that certain constituents of eleuthero have hypoglycemic activity in both healthy and diabetic animals. A small study in adults with type 2 diabetes also shows that taking eleuthero for 3 months can lower blood glucose levels. However, one very small study in healthy individuals shows that taking powdered eleuthero 3 grams, 40 minutes prior to a 75-gram oral glucose tolerance test, significantly increases postprandial blood glucose levels when compared with placebo. These contradictory findings might be due to patient-specific variability and variability in active ingredient ratios.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
In vitro and animal research suggest that standardized extracts of eleuthero inhibit CYP1A2. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, eleuthero might increase levels of drugs metabolized by CYP2C9.
In vitro and animal research suggest that standardized extracts of eleuthero might inhibit CYP2C9. This effect has not been reported in humans.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Eleuthero might increase serum digoxin levels and increase the risk of side effects.
In one case report, a 74-year-old male who was stabilized on digoxin presented with an elevated serum digoxin level after starting an eleuthero supplement, without symptoms of toxicity. After stopping the supplement, serum digoxin levels returned to normal. It is not clear whether this was due to a pharmacokinetic interaction or to interference with the digoxin assay. Although the product was found to be free of digoxin and digitoxin, it was not tested for other contaminants.

Likelihood Unlikely Evidence D
Immunosuppressants

Theoretically, eleuthero might interfere with immunosuppressive drugs because of its immunostimulant activity.
Animal and in vitro research shows that eleuthero extracts have immunomodulatory effects, including increasing cellular and humoral activity.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, eleuthero might increase levels of P-glycoprotein substrates.
In vitro research suggests that eleuthero can inhibit the multi-drug transporter protein, P-glycoprotein. However, it is too soon to tell if this is clinically important. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, eleuthero might increase levels of drugs metabolized by CYP2D6.
In vitro and animal research suggest that standardized extracts of eleuthero might inhibit CYP2D6. However, research in healthy human volunteers has found that taking eleuthero 485 mg twice daily for 14 days does not inhibit CYP2D6 drug metabolism.

Likelihood Unlikely Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.
In vitro and animal research suggest that standardized extracts of eleuthero might inhibit CYP3A4. However, research in healthy human volunteers has found that taking eleuthero 485 mg twice daily for 14 days does not inhibit CYP3A4 drug metabolism.

Likelihood Unlikely Evidence B
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Theoretically, eleuthero might decrease levels of drugs metabolized by OATP.
In vitro research suggests that eleuthero inhibits OATP2B1, which might reduce the bioavailability of oral drugs that are substrates of OATP2B1. Due to the weak inhibitory effect identified in this study, this interaction is not likely to be clinically significant.

Likelihood Possible Evidence D
Eleuthero extract full monograph & interactions

Beet extract3 drug types · 861 drugs

Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, beet might increase the levels of CYP3A4 substrates.
In vitro research suggests that betanin, the major pigment in beet, competitively inhibits CYP3A4 in a dose-dependent manner similarly to strong CYP3A4 inhibitor ketoconazole.

Likelihood Possible Evidence D
Antihypertensive Drugs

Beet and beetroot contain nitrates, which can cause vasodilation, potentially leading to lower blood pressure. However, a study published in the European Journal of Clinical Nutrition using concentrated beetroot juice found no significant impact on blood pressure or heart rate in different age groups. Other small clinical studies suggest that while beet consumption might transiently lower blood pressure due to vessel dilation, there's no consistent evidence of a lasting effect. Overall, the theoretical risk of reduced blood pressure due to beet's nitrate content exists, but studies generally indicate a low and temporary impact rather than a sustained decrease.

Likelihood Possible Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, beet might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research suggests that beet induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Beet extract full monograph & interactions

hydrolyzed Whey Protein4 drug types · 53 drugs

Levodopa

Theoretically, whey protein might decrease levodopa absorption.
Small clinical studies show that concomitant ingestion of protein or high doses of leucine or isoleucine (100 mg/kg) and levodopa can exacerbate tremor, rigidity, and the "on-off" syndrome in patients with Parkinson disease.

Likelihood Probable Evidence D
Bisphosphonates

Theoretically, whey protein might reduce the absorption of bisphosphonates.
Whey protein contains minerals such as calcium that bind bisphosphonates in the gut. Advise patients to take bisphosphonates at least 30 minutes before whey protein, but preferably at a different time of day.

Likelihood Probable Evidence D
Quinolone Antibiotics

Theoretically, whey protein might decrease quinolone absorption.
Whey protein contains minerals, such as calcium, that can bind to quinolones in the gut. To avoid this interaction, advise patients to take oral quinolones at least 2 hours before or 4-6 hours after whey protein.

Likelihood Probable Evidence D
Tetracycline Antibiotics

Theoretically, whey protein might decrease tetracycline absorption.
Whey protein contains minerals, such as calcium, that bind to tetracyclines in the gut. To avoid this interaction, advise patients to take oral tetracyclines at least 2 hours before or 4-6 hours after whey protein.

Likelihood Probable Evidence D
hydrolyzed Whey Protein full monograph & interactions

Inosine1 drug type · 9 drugs

Antigout Drugs

Inosine might reduce the effects of antigout medications.
Inosine increases uric acid levels in the serum and urine, potentially resulting in hyperuricemia and reducing the effects of medications used for the prevention and treatment of gout.

Likelihood Possible Evidence D
Inosine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for O2 Gold, from the product label.

AdvoCare

Name
AdvoCare International, LLC
City
Richardson
State
TX
ZipCode
75082
Phone Number
800-542-4800
Web Address
advocare.com
Pharmacist Counseling Corner

O2 Gold by AdvoCare: Common Questions

Does O2 Gold by AdvoCare interact with any medications?
Yes. Based on its ingredients, O2 Gold has a known interaction with 1,393 medications, including 5 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
O2 Gold contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What's whey protein actually doing in this supplement?
Whey protein provides amino acids that your body uses to build and repair muscle tissue. In this product it's hydrolyzed, meaning it's been broken down to make it easier to absorb, and it's the ingredient with the most documented medication interactions.
Can I take O2 Gold while pregnant or breastfeeding?
No. Inosine should be avoided in pregnancy because there isn't enough safety data. Inosine and both eleuthero and rhodiola extracts should also be avoided while breastfeeding. Talk to your doctor or pharmacist about whether this product is right for you during these times.
Is this supplement going to help my athletic performance?
Two of the five ingredients—whey protein and beet extract—are possibly effective for athletic performance based on the data we have. The evidence for the others is insufficient to say. Results vary by person, and your doctor or pharmacist can help you think through whether it makes sense for your goals.
What are the most common side effects?
From whey protein you might see bloating, cramps, diarrhea, nausea, or reduced appetite. Inosine can cause high uric acid levels and kidney stones, especially at higher doses. Beet extract commonly causes red or black stools, which is harmless. Eleuthero may cause nervousness or anxiety at higher doses, and rhodiola might cause dizziness.
Does inosine have any special risks I should know about?
Yes. Inosine raises uric acid in your blood and urine, which is a real concern if you have gout or kidney problems—it can trigger gout flares or kidney stones. If either applies to you, talk to your doctor before taking this product.
Why are there so many inactive ingredients listed?
Those are binders, fillers, and capsule materials that help hold the five active ingredients together in the right form. They're standard in supplement tablets and don't add therapeutic benefit.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

O2 Gold label
Go deeper

The Full Monographs Behind O2 Gold’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Whey Protein

Interacts with 53 drugs

Whey protein is a high-quality, complete protein made from cow's milk that can help people meet protein needs and support muscle growth when combined with exercise. It is generally safe for...

Read the full Whey Protein monograph → Herb & supplement monograph

Inosine

Interacts with 9 drugs

Inosine is a nucleoside (a building block of DNA and RNA) that the body makes on its own and is also sold as a supplement, mostly marketed for athletic performance. Solid evidence that it bo...

Read the full Inosine monograph → Herb & supplement monograph

Beet

Interacts with 861 drugs

Beet, especially beetroot juice, is a nitrate-rich food that may modestly lower blood pressure and slightly improve exercise performance in some people. It is generally safe as a food, but s...

Read the full Beet monograph → Herb & supplement monograph

Eleuthero

Interacts with 1,140 drugs

Eleuthero is an herb traditionally used as an 'adaptogen' to fight fatigue, boost energy, and help the body handle stress. The scientific evidence behind these uses is limited and mixed, so...

Read the full Eleuthero monograph → Herb & supplement monograph

Rhodiola

Interacts with 1,271 drugs

Rhodiola is an herb traditionally used to fight fatigue and help the body cope with stress. Some small studies suggest it may modestly reduce fatigue and improve mood, but the evidence is li...

Read the full Rhodiola monograph →
Sources

Sources & How We Checked

O2 Gold's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 83 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Whey Protein 25 references
  1. Martindale W. Martindale the Extra Pharmacopoeia. Pharmaceutical Press, 1999.
  2. Maton PN, Burton ME. Antacids revisited: a review of their clinical pharmacology and recommended therapeutic use. Drugs 1999;57:855-70.
  3. Bell SJ. Whey protein concentrates with and without immunoglobulins: a review. J Med Food 2000;3:1-13. PubMed
  4. Nutt JG, Woodward WR, Hammerstad JP, et al. The "on-off" phenomenon in Parkinson's disease. Relation to levodopa absorption and transport. N Engl J Med 1984;310:483-8. PubMed
  5. Baruzzi A, Contin M, Riva R, et al. Influence of meal ingestion time on pharmacokinetics of orally administered levodopa in parkinsonian patients. Clin Neuropharmacol 1987;10:527-37. PubMed
  6. Juncos JL, Fabbrini G, Mouradian MM, et al. Dietary influences on the antiparkinsonian response to levodopa. Arch Neurol 1987;44:1003-5. PubMed
  7. Eriksson T, Granerus AK, Linde A, et al. "On-off" phenomenon in Parkinson's disease: relationship between dopa and other large neutral amino acids in plasma. Neurology 1988;38:1245-8. PubMed
  8. Semla TP, Beizer JL, Higbee MD. Geriatric Dosage Handbook. 4th ed. Hudson, OH: Lexicomp, 1998.
  9. Pletz MW, Petzold P, Allen A, et al. Effect of calcium carbonate on bioavailability of orally administered gemifloxacin. Antimicrob Agents Chemother 2003;47:2158-60.. PubMed
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Inosine 7 references
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Beet 14 references
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Eleuthero 24 references
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Rhodiola 13 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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