Organic Chitrak Powder Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Organic Chitrak Powder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Organic Chitrak Powder is a dietary supplement by Banyan Botanicals with 1 active ingredient. Its ingredients are commonly taken for digestive complaints and poor appetite, skin conditions and wounds (applied to the skin), joint pain and swelling.Based on those ingredients, 1,097 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Chitrak root powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Organic Chitrak Powder by Banyan Botanicals
Ask about any prescription or over-the-counter medication and we check it for interactions with Organic Chitrak Powder by Banyan Botanicals — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Organic Chitrak Powder by Banyan Botanicals
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: chitrak root powder, also known as Ceylon leadwort. Traditionally, it's been used in Ayurvedic medicine, though the specific effects are not well established in the research we hold.
The powder comes with no inactive fillers or other ingredients listed.
Does it work?
Couldn't assess
The evidence isn't established in our data for this ingredient. Chitrak has been traditionally used for asthma, but we have insufficient reliable evidence to rate whether it actually works for that purpose.
How safe is it?
Some data gaps
Ceylon leadwort contains plumbagin, a compound that can irritate your skin and digestive tract and may be toxic at higher doses. The safety data advises against using this product during pregnancy because it has been traditionally used to cause abortion.
There isn't enough safety information to recommend it while breastfeeding — talk with your doctor or pharmacist before using it in either situation.
Meds to double-check
Moderate interaction found
Before taking this product, check with your doctor or pharmacist if you take any medications metabolized by CYP2D6, CYP1A2, CYP2C9, or CYP3A4 (a very large group), blood thinners or antiplatelet drugs, hormone therapy, immunosuppressants, or diabetes medications. These are theoretical risks shown in lab work but not yet confirmed in humans — that's why confirmation with your own provider is essential.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and some safety-information gaps remain.
This is a single-ingredient traditional remedy with limited evidence of effectiveness and several documented interactions with medications affecting your liver's drug-processing enzymes. If you take any prescription medication — especially blood thinners, hormone therapy, diabetes drugs, or immunosuppressants — check with your doctor or pharmacist before starting.
Pregnant and breastfeeding people should not use it.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2019.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Organic Chitrak Powder, straight from the product label.
| Brand | Banyan Botanicals |
|---|---|
| Net contents | 0 Not Present |
| Market status | On market |
| Date entered into DSLD | Apr 25, 2019 |
| DSLD ID | 199497 |
| Product type | Botanical |
| Supplement form | Powder |
| Dietary claims / uses | No Claim |
| Intended target group(s) | Adult (18 - 50 Years), Organic |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Organic Chitrak Powder by Banyan Botanicals, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Chitrak root powder | 0.5 Teaspoon(s) | -- |
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Ayurvedic herbs
Formula
(Plumbago zeylanica)
Suggested/Recommended/Usage/Directions
Suggested use: 1/4 to 1/2 teaspoon with warm water, once or twice daily, or as directed by your health practitioner.
FDA Statement of Identity
Dietary Supplement
Brand IP Statement(s)
2011 Banyan Botanicals
Formulation
Certified Organic by New Mexico Department of Agriculture
Seals/Symbols
USDA Organic
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Organic Chitrak Powder by Banyan Botanicals label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Organic Chitrak Powder by Banyan Botanicals
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size0.5 Teaspoon(s) Dosage formPowder Amounts shown are per serving.
Chitrak root powder
Interacts with1,097 drugs
Ceylon Leadwort (Plumbago zeylanica) is a plant long used in Ayurvedic and other traditional medicine systems, mainly for digestion, skin problems, an...
Chitrak root powder monograph & interactionsOrganic Chitrak Powder by Banyan Botanicals Drug Interactions
HelloPharmacist Interaction Report
Organic Chitrak Powder by Banyan Botanicals contains chitrak root powder (Ceylon leadwort), which has documented interactions with medications.
The most serious concern involves how plumbagin, its active compound, may slow the liver's ability to clear certain drugs — potentially raising their levels in your bloodstream. This affects four major enzyme systems (CYP2D6, CYP1A2, CYP2C9, and CYP3A4 substrates), though these interactions have only been shown in lab studies, not yet confirmed in humans.
Read the full breakdown — every affected drug type, severity by severity
Additionally, Ceylon leadwort may interfere with blood thinners and antiplatelet drugs (medications that prevent clotting), possibly increasing bleeding risk — again, this has been seen in animals but not yet in people. It may also interfere with hormone therapy by blocking estrogen activity, and could theoretically affect immunosuppressants and diabetes medications by either reducing or enhancing their effects.
Because plumbagin's effects on drug metabolism haven't been tested in living patients yet, it's especially important to check your exact medications before you start. Altogether, these interactions span 1,098 individual medications.
Talk with your doctor or pharmacist about whether this product is right for you alongside any prescriptions you're taking.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Organic Chitrak Powder?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Organic Chitrak Powder interact with 1,097 drugs. Click any drug to see the details.
1 of the 1 ingredient in Organic Chitrak Powder interact with drugs. Each result below shows which ingredient is responsible. Chitrak root powder
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Organic Chitrak Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderImmunosuppressants Moderate
Interaction Summary
Plumbagin, a constituent of Ceylon leadwort, has demonstrated immunosuppressant activity in animal research.
Read the full Chitrak Root Powder + 6-mercaptopurine interactionAdo-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Organic Chitrak Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 3A4 (CYP3A4) in vitro.
Read the full Chitrak Root Powder + Ado-trastuzumab Emtansine interactionAbciximabReoPro
How Abciximab interacts with Organic Chitrak Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
There is some concern that Ceylon leadwort might potentiate the effects of anticoagulant and antiplatelet drugs and possibly increase the risk of bleeding.
Read the full Chitrak Root Powder + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Organic Chitrak Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 3A4 (CYP3A4) in vitro.
Read the full Chitrak Root Powder + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Organic Chitrak Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 3A4 (CYP3A4) in vitro.
Read the full Chitrak Root Powder + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Organic Chitrak Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 3A4 (CYP3A4) in vitro.
Read the full Chitrak Root Powder + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Organic Chitrak Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderCytochrome P450 2c9 (cyp2c9) Substrates, Anticoagulant/antiplatelet Drugs +1 Moderate
Interaction Summary
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 2C9 (CYP2C9) in vitro.
Read the full Chitrak Root Powder + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Organic Chitrak Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 3A4 (CYP3A4) in vitro.
Read the full Chitrak Root Powder + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Organic Chitrak Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderAntidiabetes Drugs Moderate
Interaction Summary
Ceylon leadwort root extract has been shown to both increase and decrease blood glucose levels in animal research.
Read the full Chitrak Root Powder + Acarbose interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Organic Chitrak Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
There is some concern that Ceylon leadwort might potentiate the effects of anticoagulant and antiplatelet drugs and possibly increase the risk of bleeding.
Read the full Chitrak Root Powder + Acenocoumarol interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Organic Chitrak Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 2E1 (CYP2E1) in vitro.
Read the full Chitrak Root Powder + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Organic Chitrak Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates +1 Moderate
Interaction Summary
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 1A2 (CYP1A2) in vitro.
Read the full Chitrak Root Powder + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Organic Chitrak Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Moderate
Interaction Summary
There is some concern that Ceylon leadwort might potentiate the effects of anticoagulant and antiplatelet drugs and possibly increase the risk of bleeding.
Read the full Chitrak Root Powder + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Organic Chitrak Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 2E1 (CYP2E1) in vitro.
Read the full Chitrak Root Powder + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Organic Chitrak Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 2E1 (CYP2E1) in vitro.
Read the full Chitrak Root Powder + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Organic Chitrak Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 2E1 (CYP2E1) in vitro.
Read the full Chitrak Root Powder + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Organic Chitrak Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 1A2 (CYP1A2) in vitro.
Read the full Chitrak Root Powder + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Organic Chitrak Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 2E1 (CYP2E1) in vitro.
Read the full Chitrak Root Powder + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Organic Chitrak Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates +1 Moderate
Interaction Summary
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 2D6 (CYP2D6) in vitro.
Read the full Chitrak Root Powder + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Organic Chitrak Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +2 Moderate
Interaction Summary
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 2E1 (CYP2E1) in vitro.
Read the full Chitrak Root Powder + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Organic Chitrak Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +2 Moderate
Interaction Summary
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 3A4 (CYP3A4) in vitro.
Read the full Chitrak Root Powder + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Organic Chitrak Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +2 Moderate
Interaction Summary
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 2E1 (CYP2E1) in vitro.
Read the full Chitrak Root Powder + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Organic Chitrak Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Moderate
Interaction Summary
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 3A4 (CYP3A4) in vitro.
Read the full Chitrak Root Powder + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Organic Chitrak Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates +1 Moderate
Interaction Summary
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 1A2 (CYP1A2) in vitro.
Read the full Chitrak Root Powder + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Organic Chitrak Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates +1 Moderate
Interaction Summary
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 3A4 (CYP3A4) in vitro.
Read the full Chitrak Root Powder + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Organic Chitrak Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 1A2 (CYP1A2) in vitro.
Read the full Chitrak Root Powder + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Organic Chitrak Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Moderate
Interaction Summary
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 2D6 (CYP2D6) in vitro.
Read the full Chitrak Root Powder + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Organic Chitrak Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates +2 Moderate
Interaction Summary
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 1A2 (CYP1A2) in vitro.
Read the full Chitrak Root Powder + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Organic Chitrak Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 2D6 (CYP2D6) in vitro.
Read the full Chitrak Root Powder + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Organic Chitrak Powder — through 1 ingredient. Tap an ingredient for the detail:
Chitrak Root PowderCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 2E1 (CYP2E1) in vitro.
Read the full Chitrak Root Powder + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Organic Chitrak Powder with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Chitrak root powder
Anticoagulant/Antiplatelet Drugs
There is some concern that Ceylon leadwort might potentiate the effects of anticoagulant and antiplatelet drugs and possibly increase the risk of bleeding. Ceylon leadwort root extract has been shown to decrease platelet adhesion and prolong bleeding in animals. However, this effect has not yet been demonstrated in humans. Until more is known, use cautiously in patients taking anticoagulant or antiplatelet drugs. Some of these drugs include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.
Antidiabetes Drugs
Ceylon leadwort root extract has been shown to both increase and decrease blood glucose levels in animal research. This effect has not yet been demonstrated in humans. Theoretically, Ceylon leadwort might reduce or potentiate the effects of antidiabetes drugs. Monitor blood glucose levels closely. Medication dose adjustments may be necessary. Some antidiabetes drugs include glimepiride (Amaryl), glyburide (Diabeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), and others.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 1A2 (CYP1A2) in vitro. So far, this interaction has not been reported in humans. Theoretically, Ceylon leadwort might increase the levels of drugs metabolized by CYP1A2. Some substrates of CYP1A2 include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), zileuton (Zyflo), zolmitriptan (Zomig), and others.
Cytochrome P450 2B6 (Cyp2B6) Substrates
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 2B6 (CYP2B6) in vitro. So far, this interaction has not been reported in humans. Theoretically, Ceylon leadwort might increase the levels of drugs metabolized by CYP2B6. Drugs that are metabolized by CYP2B6 include ketamine (Ketalar), phenobarbital, orphenadrine (Norflex), secobarbital (Seconal), and dexamethasone (Decadron).
Cytochrome P450 2C9 (Cyp2C9) Substrates
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 2C9 (CYP2C9) in vitro. So far, this interaction has not been reported in humans. Theoretically, Ceylon leadwort might increase the levels of drugs metabolized by CYP2C9. Drugs that are metabolized by CYP2C9 include celecoxib (Celebrex), diclofenac (Voltaren), fluvastatin (Lescol), glipizide (Glucotrol), ibuprofen (Advil, Motrin), irbesartan (Avapro), losartan (Cozaar), phenytoin (Dilantin), piroxicam (Feldene), tamoxifen (Nolvadex), tolbutamide (Tolinase), torsemide (Demadex), and S-warfarin (Coumadin).
Cytochrome P450 2D6 (Cyp2D6) Substrates
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 2D6 (CYP2D6) in vitro. So far, this interaction has not been reported in humans. Theoretically, Ceylon leadwort might increase the levels of drugs metabolized by CYP2D6. Some drugs metabolized by CYP2D6 include amitriptyline (Elavil), codeine, desipramine (Norpramin), flecainide (Tambocor), fluoxetine (Prozac), ondansetron (Zofran), tramadol (Ultram), and others.
Cytochrome P450 2E1 (Cyp2E1) Substrates
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 2E1 (CYP2E1) in vitro. So far, this interaction has not been reported in humans. Theoretically, Ceylon leadwort might increase the levels of drugs metabolized by CYP2E1. Some drugs metabolized by CYP2E1 include acetaminophen, chlorzoxazone (Parafon Forte), ethanol, theophylline, and anesthetics such as enflurane (Ethrane), halothane (Fluothane), isoflurane (Forane), methoxyflurane (Penthrane).
Cytochrome P450 3A4 (Cyp3A4) Substrates
Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 3A4 (CYP3A4) in vitro. So far, this interaction has not been reported in humans. Theoretically, Ceylon leadwort might increase the levels of drugs metabolized by CYP3A4. Some drugs metabolized by CYP3A4 include lovastatin (Mevacor), clarithromycin (Biaxin), indinavir (Crixivan), sildenafil (Viagra), triazolam (Halcion), and numerous others.
Estrogens
Laboratory research suggests that Ceylon leadwort root extract has anti-estrogenic activity. Theoretically, Ceylon leadwort may interfere with hormone therapy.
Immunosuppressants
Plumbagin, a constituent of Ceylon leadwort, has demonstrated immunosuppressant activity in animal research. Theoretically, Ceylon leadwort might interfere with immunosuppressive therapy. Immunosuppressant drugs include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), corticosteroids (glucocorticoids), and others.
Brand information
Manufacturer and brand details for Organic Chitrak Powder, from the product label.
Banyan Botanicals
See all Banyan Botanicals products- Name
- Banyan Botanicals
- City
- Albuquerque
- State
- NM
- ZipCode
- 87113
- Phone Number
- 1-800-953-6424
- Web Address
- www.banyanbotanicals.com
Organic Chitrak Powder by Banyan Botanicals: Common Questions
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Sources & How We Checked
Organic Chitrak Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 10 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Ceylon Leadwort 10 references
- Mandavkar, YD, Jalalpure, SS. A comprehensive review on Plumbago zeylanica Linn. African J. Pharmacy and Pharmacology. 2011;5(25):2738-2747. DOI
- Kumar SS, Shanmugasundaram KR. Amrita Bindu-an antioxidant inducer therapy in asthma children. J. Ethnopharmacol. 2004;90:105-114. PubMed
- Sandeep G, Dheeraj A, Sharma NK, Jhade D, Bharti A. Effect of plumbagin free alcohol extract of Plumbago zeylanica Linn. root on reproductive system of female Wistar rats. Asian Pac J Trop Med. 2011 Dec;4(12):978-84. PubMed
- Vijayakumar R, Senthilvelan M, Ravindran R, Devi RS. Plumbago zeylanica action on blood coagulation profile with and without blood volume reduction. Vascul Pharmacol. 2006 Aug;45(2):86-90. PubMed
- Olagunju JA, Jobi AA, Oyedapo OO. An investigation into the biochemical basis of the observed hyperglycaemia in rats treated with ethanol root extract of plumbago zeylanica. Phytother Res. 1999 Jun;13(4):346-8.
- Chen A, Zhou X, Tang S, Liu M, Wang X. Evaluation of the inhibition potential of plumbagin against cytochrome P450 using LC-MS/MS and cocktail approach. Sci Rep. 2016 Jun 22;6:28482. PubMed
- Sunil C, Duraipandiyan V, Agastian P, Ignacimuthu S. Antidiabetic effect of plumbagin isolated from Plumbago zeylanica L. root and its effect on GLUT4 translocation in streptozotocin-induced diabetic rats. Food Chem Toxicol. 2012 Dec;50(12):4356-63. PubMed
- Checker R, Sharma D, Sandur SK, Khanam S, Poduval TB. Anti-inflammatory effects of plumbagin are mediated by inhibition of NF-kappaB activation in lymphocytes. Int Immunopharmacol. 2009 Jul;9(7-8):949-58. PubMed
- Jia Y, Jing J, Bai Y, Li Z, Liu L, Luo J, Liu M, Chen H. Amelioration of experimental autoimmune encephalomyelitis by plumbagin through down-regulation of JAK-STAT and NF-?B signaling pathways. PLoS One. 2011;6(10):e27006. PubMed
- Poosarla A, D N R, Athota RR, Sunkara VG. Modulation of T cell proliferation and cytokine response by Plumbagin, extracted from Plumbago zeylanica in collagen induced arthritis. BMC Complement Altern Med. 2011 Nov 16;11:114. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC