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Dietary supplement

Organic Lion's Mane Mushroom Ingredients & Drug Interactions

by Purest Vantage

Organic Lion's Mane Mushroom label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Organic Lion's Mane Mushroom against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Organic Lion's Mane Mushroom is a dietary supplement by Purest Vantage with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, nerve health, mood and anxiety.Based on those ingredients, 327 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic Lion's Mane mushroom. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Organic Lion's Mane Mushroom by Purest Vantage

Ask about any prescription or over-the-counter medication and we check it for interactions with Organic Lion's Mane Mushroom by Purest Vantage — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Organic Lion's Mane Mushroom by Purest Vantage

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: organic Lion's Mane mushroom. The capsule itself is made from a vegetarian material.

Lion's Mane is a culinary and medicinal mushroom traditionally used to support cognitive and nervous system health, though the research backing these uses is still developing.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Lion's Mane Mushroom product and its label doesn't state a use — see Lion's Mane Mushroom's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence supporting Lion's Mane mushroom for cognitive function, memory, anxiety, Alzheimer disease, athletic performance, and cancer is currently insufficient — meaning we don't have enough reliable data yet to rate how well it works for these purposes. It's a supplement many people try based on traditional use and emerging research, but stronger clinical evidence is needed before we can say it's proven effective.

The evidence, ingredient by ingredient Lion's Mane Mushroom

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 0 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lion's Mane mushroom is generally well tolerated when taken by mouth, with most people experiencing no problems. Some trial participants reported gastrointestinal discomfort, nausea, or skin rash, though these were not widespread.

Long-term safety as a supplement hasn't been thoroughly studied. The safety data advises against use during pregnancy and breastfeeding because there isn't enough information to know it's safe in those situations — talk with your doctor or pharmacist if you're pregnant, planning pregnancy, or breastfeeding and are interested in this product.

Side effects, ingredient by ingredient Lion's Mane Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lion's Mane Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 327 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you're on a blood thinner (anticoagulant or antiplatelet drug), any diabetes medication, or an immunosuppressant — all three drug types have documented Moderate interactions with lion's mane mushroom that could affect how those medications work or your safety.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and some safety-information gaps remain.

Lion's Mane mushroom may appeal to you if you're interested in cognitive or nervous system support, but the scientific evidence for most of those uses isn't solid yet. If you take a blood thinner, diabetes medication, or immunosuppressant, you'll want to check with your doctor or pharmacist before adding this — the documented interactions are real concerns.

Discuss it with your own healthcare provider to see if it fits your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Organic Lion's Mane Mushroom, straight from the product label.

Brand Purest Vantage
Barcode (UPC) 9369998042968
Net contents 90 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Feb 25, 2021
DSLD ID 243476
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Organic Lion's Mane Mushroom by Purest Vantage, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
30
UPC/BARCODE
9369998042968
IngredientAmount% DV
organic Lion's Mane mushroom1800 mg--

Other ingredients: Vegetarian Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Caution: Pregnant or nursing mothers, those trying to conceive, children under the age of 18, and individuals with a known medical condition should consult a healthcare professional before using this or any dietary supplement.

Caution: Pregnant or nursing mothers, those trying to conceive, children under the age of 18, and individuals with a known medical condition should consult a healthcare professional before using this or any dietary supplement.

Keep out of reach of children.

Do not use if safety seal is damaged or missing.

Formulation

This formula does not contain: Soy, gluten, milk, lactose, egg, shellfish, corn, wheat, yeast, tree nuts, or starch.

Does not contain: GMOs, fillers, binders, preservatives, stearates, artificial ingredients, silicone dioxide or titanium dioxide.

Made in USA with global ingredients

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat cure, or prevent any disease.

Formula

Water extracted from fruiting bodies 1800mg per serving

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 3 capsules daily, or as directed by your healthcare practitioner.

Seals/Symbols

GMP Good Manufacturing Practice

General Statements

Recycle

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Organic Lion's Mane Mushroom by Purest Vantage label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Organic Lion's Mane Mushroom label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Organic Lion's Mane Mushroom by Purest Vantage

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size3 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Organic Lion's Mane mushroom

Interacts with
327 drugs
1800 mg per serving

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and...

Organic Lion's Mane mushroom monograph & interactions

Other (inactive) ingredients: Vegetarian Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Organic Lion's Mane Mushroom by Purest Vantage Drug Interactions

Want to check YOUR meds against Organic Lion's Mane Mushroom?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
327Drugs
327 Moderate

Ingredients driving the most interactions

organic Lion's Mane mushroom 327

Individual Drug Interactions

The ingredients in Organic Lion's Mane Mushroom interact with 327 drugs. Click any drug to see the details.

1 of the 1 ingredient in Organic Lion's Mane Mushroom interact with drugs. Each result below shows which ingredient is responsible. organic Lion's Mane mushroom

Each ingredient & the kinds of drugs it affects

For each ingredient in Organic Lion's Mane Mushroom with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

organic Lion's Mane mushroom3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lion's mane mushroom can reduce serum glucose and increase serum insulin.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.

Likelihood Possible Evidence D
organic Lion's Mane mushroom full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Organic Lion's Mane Mushroom, from the product label.

Purest Vantage

See all Purest Vantage products
Name
Purest Vantage
Street Address
390 North Orange Avenue, Suite 2300-C
City
Orlando
State
FL
ZipCode
32801
Web Address
www.purestvantage.com
Pharmacist Counseling Corner

Organic Lion's Mane Mushroom by Purest Vantage: Common Questions

Does Organic Lion's Mane Mushroom by Purest Vantage interact with any medications?
Yes. Based on its ingredients, Organic Lion's Mane Mushroom has a known interaction with 327 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Organic Lion's Mane Mushroom contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is Lion's Mane mushroom and what is it supposed to do?
Lion's Mane is a mushroom used traditionally to support cognitive and nervous system health. People take it hoping to boost memory, focus, and mental clarity, but the research backing those claims isn't conclusive yet.
Can I take this if I'm pregnant or breastfeeding?
The safety data advises against it — there isn't enough information to know whether it's safe during pregnancy or while breastfeeding. Talk with your doctor or pharmacist about your options if you're interested in using it at those times.
What side effects might I notice?
Most people tolerate it well, but some trial participants reported gastrointestinal discomfort, nausea, or skin rash. These weren't common, but they're worth knowing about.
I take a blood thinner — is this safe for me?
No — there's a documented Moderate interaction. Lion's Mane may increase your bleeding risk when combined with blood thinners. Check with your doctor or pharmacist before considering it.
How long have people been using Lion's Mane safely?
It's eaten as a food in some cultures, so food safety is generally okay. But long-term safety as a supplement specifically hasn't been well studied, so we can't say for certain how safe it is over months or years of use.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Organic Lion's Mane Mushroom is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Organic Lion's Mane Mushroom label
Go deeper

The Full Monographs Behind Organic Lion's Mane Mushroom’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lion's Mane Mushroom

Interacts with 327 drugs

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as...

Read the full Lion's Mane Mushroom monograph →
Sources

Sources & How We Checked

Organic Lion's Mane Mushroom's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lion's Mane Mushroom 6 references
  1. Product information for <em>Niaspan</em>. Abbott Laboratories. North Chicago, IL 60064. April 2015.
  2. Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complement Altern Med. 2013;13:253. PubMed
  3. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009;23(3):367-72.
  4. Mori K, Kikuchi H, Obara Y, et al. Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. Phytomedicine. 2010;17(14):1082-5. PubMed
  5. Li IC, Chang HH, Lin CH, et al. Prevention of early Alzheimer's disease by erinacine A-enriched Hericium erinaceus mycelia pilot double-blind placebo-controlled study. Front Aging Neurosci 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. PubMed
  6. Tian B, Liu R, Xu T, et al. Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice. J Sci Food Agric 2023;103(6):3050-3064.

See these in context on the Lion's Mane Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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