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Dietary supplement

Organic Papaya Leaf Liquid Extract Ingredients & Drug Interactions

by Herbal Goodness

Organic Papaya Leaf Liquid Extract label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Organic Papaya Leaf Liquid Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Organic Papaya Leaf Liquid Extract is a dietary supplement by Herbal Goodness with 1 active ingredient. Its ingredients are commonly taken for digestive upset and indigestion, constipation, wound and skin care (topical).Based on those ingredients, 92 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Papaya leaf extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Organic Papaya Leaf Liquid Extract by Herbal Goodness

Ask about any prescription or over-the-counter medication and we check it for interactions with Organic Papaya Leaf Liquid Extract by Herbal Goodness — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Organic Papaya Leaf Liquid Extract by Herbal Goodness

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: papaya leaf extract. The extract is made from papaya leaves and delivered in a liquid form suspended in glycerin and purified water.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Papaya's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: digestion and blood platelet function.
  • We looked for evidence on: Intestinal parasite infection, Thrombocytopenia, Wound healing, indigestion, constipation, bleeding disorders.
  • The closest evidence on file: Papaya is rated "Insufficient Reliable Evidence To Rate" for Intestinal parasite infection (Natural Medicines).
  • Also on file: Papaya is rated "Insufficient Reliable Evidence To Rate" for Thrombocytopenia, Wound healing.

The evidence for papaya leaf extract is not established in the data we hold. Effectiveness ratings for aging skin, hair loss, gallbladder cancer, colorectal cancer, and diabetes all show insufficient reliable evidence to rate.

The evidence, ingredient by ingredient Papaya

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Ripe papaya fruit eaten as food is generally well tolerated, and the leaf extract itself seems to be generally well tolerated in most people. The most common side effects from the leaf extract are nausea and vomiting.

Rare severe allergic reactions have been reported. Avoid unripe (green) papaya, papaya latex, and papaya seeds — these are less well studied and carry more risk.

Little reliable safety information exists for supplement amounts, so moderate ripe fruit is likely fine but concentrated supplements are best approached with caution. No safety data on file for use during pregnancy or breastfeeding.

Side effects, ingredient by ingredient Papaya

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Papaya.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 92 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, double-check if you take blood thinners like warfarin, diabetes medications, amiodarone for heart rhythm, or levothyroxine for thyroid. These have moderate-severity interactions with papaya leaf extract documented in our data.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product works best for people who want to try papaya leaf extract and don't take blood thinners, diabetes drugs, amiodarone, or thyroid medication. If you do take any of those, check with your pharmacist first — the interaction risks are real.

Talk to your pharmacist before starting, especially if you're on any regular medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 14, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Organic Papaya Leaf Liquid Extract, straight from the product label.

Brand Herbal Goodness
Barcode (UPC) 798304169089
Net contents 16 Fluid Ounce(s); 473 mL
Market status On market
Date entered into DSLD Dec 14, 2023
DSLD ID 301080
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher, Organic, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Organic Papaya Leaf Liquid Extract by Herbal Goodness, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
15 mL
Maximum serving Sizes:
15 mL
Servings per container
32
UPC/BARCODE
798304169089
IngredientAmount% DV
Calories40 Calorie(s)--
Total Carbohydrates12 Gram(s)4%
Papaya leaf extract1000 mg--

Other ingredients: Glycerin, Papaya, Water, Purified

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Papaya has been cultivated for centuries for its amazing health benefits. Papaya leaves contain the enzymes papain, chymopapain and fibrin that aid digestion and promote blood platelet function. With its high degree of absorption and bio-availability, our organic papaya leaf glycerin-based extract is made only from premium quality papayas.

Certified Kosher by Earth Kosher

General Statements

100% women owned, 10% of profits & ethical trade

Impact We do right by others We believe in business for social good and give 10% of profits to support the education of African girls. Sustainablity We respect Mother Earth We believe in the enviornment and fairtrade practices.

Women owned

100% satisfaction guaranteed

Formulation

Quality We only use the best Made from the highest quality herbs, our products are tested to the highest standard by 3rd party certifiers.

Made with non-GMO ingredients

Blood platelet support, immune and digestion aid

Certified Organic by Oregon Tilth

Gluten free

Seals/Symbols

Packaged in the USA Fairly traded

USDA Organic

EarthKosher

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take 1 tablespoon, 2 to 3 times a day with food. May be diluted with water or juice.

Precautions

Do not use if tamper evident inner seal under cap is broken or missing.

Keep out of reach of children.

Warning: If you are pregnant or have a medical condition consult your physician before using this product.

Storage

Store tightly closed in a cool dry place.

Use within 90 days of opening.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Organic Papaya Leaf Liquid Extract by Herbal Goodness label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Organic Papaya Leaf Liquid Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Organic Papaya Leaf Liquid Extract by Herbal Goodness

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size15 mL Dosage formLiquid Servings per container32 Amounts shown are per serving.

Papaya leaf extract

Interacts with
92 drugs
1000 mg per serving

Papaya is a tropical fruit that is nutritious and generally safe to eat as food, and it contains an enzyme called papain used as a digestive aid and m...

Papaya leaf extract monograph & interactions

Other (inactive) ingredients: Glycerin, Papaya, Water, Purified. These complete the product’s ingredient list but are not active constituents.

Interaction report

Organic Papaya Leaf Liquid Extract by Herbal Goodness Drug Interactions

Want to check YOUR meds against Organic Papaya Leaf Liquid Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
92Drugs
92 Moderate

Ingredients driving the most interactions

Papaya leaf extract 92

Individual Drug Interactions

The ingredients in Organic Papaya Leaf Liquid Extract interact with 92 drugs. Click any drug to see the details.

1 of the 1 ingredient in Organic Papaya Leaf Liquid Extract interact with drugs. Each result below shows which ingredient is responsible. Papaya leaf extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Organic Papaya Leaf Liquid Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Papaya leaf extract4 drug types · 92 drugs

Amiodarone (Cordarone)

Theoretically, papaya extract may increase the levels and clinical effects of amiodarone.
Animal research in rats shows that a single oral dose of papaya extract, as well as multiple doses of papaya extract daily over 14 days, prior to a single dose of amiodarone delays the time to maximum amiodarone concentration. However, only the 14-day papaya extract regimen increases systemic amiodarone exposure by 60% to 70%. This interaction has not been reported in humans.

Likelihood Probable Evidence D
Antidiabetes Drugs

Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects. It is unclear if other forms of papaya have the same effect.
A small low-quality clinical study in patients with type 2 diabetes who are taking glibenclamide shows that taking a fermented papaya preparation 3 grams daily for 2 months decreases fasting and postprandial blood glucose levels when compared to baseline. Additionally, of the 25 patients in the study, 9 required a reduction in glibenclamide dose.

Likelihood Probable Evidence B
Levothyroxine (Synthroid, Others)

Theoretically, consuming large quantities of papaya fruit can reduce the clinical effects of levothyroxine.
In one case-report, a 37-year-old male with a history of thyroidectomy who was stabilized on levothyroxine for 5 years presented with hypothyroidism after consuming 5-6 papaya fruits daily for 14 days during vacation. In a controlled re-challenge test involving 5-6 papayas daily, the patient remained euthyroid for 7 days, but developed mild hypothyroidism after 14 days. Both times, thyroid levels normalized 40-45 days after discontinuing papaya.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, concomitant use of warfarin with papain-containing papaya extract might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Papaya leaf extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Organic Papaya Leaf Liquid Extract, from the product label.

Herbal Goodness

See all Herbal Goodness products
Name
Herbal Goodness
Street Address
2150 S. Central Expressway, Suite 200
City
McKinney
State
TX
ZipCode
75070
Phone Number
800-820-4829
Web Address
herbalgoodnessco.com
Pharmacist Counseling Corner

Organic Papaya Leaf Liquid Extract by Herbal Goodness: Common Questions

Does Organic Papaya Leaf Liquid Extract by Herbal Goodness interact with any medications?
Yes. Based on its ingredients, Organic Papaya Leaf Liquid Extract has a known interaction with 92 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Organic Papaya Leaf Liquid Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What side effects might I notice from this extract?
Most people tolerate it well. Nausea and vomiting are the most commonly reported side effects. Rare severe allergic reactions have been reported. If you have a latex allergy, be aware that papaya can trigger hypersensitivity reactions more commonly in latex-sensitive people.
Is the liquid extract safe to take during pregnancy?
We don't hold safety data for this ingredient during pregnancy. Some sources caution against large amounts during pregnancy, so it's best to talk with your doctor or pharmacist before using it if you're pregnant or planning to become pregnant.
Can I use this instead of the fruit?
Ripe papaya fruit eaten in normal food amounts is generally safe, but concentrated supplements like this extract are less well studied. If you prefer the fruit, moderate amounts are likely fine — but if you're on medications that interact with papaya, check with your pharmacist either way.
What is papaya leaf extract actually used for?
The evidence for its effectiveness at treating aging skin, hair loss, cancer, or diabetes is insufficient to rate. If you're considering it for one of those reasons, talk with your pharmacist about whether the evidence supports it.
Should I avoid unripe papaya?
Yes. Unripe (green) papaya, papaya latex, and papaya seeds should be avoided — they're less well studied and carry more risk than ripe fruit or leaf extract.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Organic Papaya Leaf Liquid Extract is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Organic Papaya Leaf Liquid Extract label
Go deeper

The Full Monographs Behind Organic Papaya Leaf Liquid Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Papaya

Interacts with 92 drugs

Papaya is a tropical fruit that is nutritious and generally safe to eat as food, and it contains an enzyme called papain used as a digestive aid and meat tenderizer. Papaya leaf extract is b...

Read the full Papaya monograph →
Sources

Sources & How We Checked

Organic Papaya Leaf Liquid Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Papaya 14 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Blanco C, Diaz-Perales A, Collada C, et al. Class I chitinases as potential panallergens involved in the latex-fruit syndrome. J Allergy Clin Immunol 1999;103(3 Pt 1):507-13. PubMed
  6. Diaz-Perales A, Collada C, Blanco C, et al. Cross-reactions in the latex-fruit syndrome: A relevant role of chitinases but not of complex asparagine-linked glycans. J Allergy Clin Immunol 1999;104:681-7. PubMed
  7. Castillo, R., Delgado, J., Quiralte, J., Blanco, C., and Carrillo, T. Food hypersensitivity among adult patients: epidemiological and clinical aspects. Allergol.Immunopathol.(Madr.) 1996;24(3):93-97.
  8. Oderinde, O., Noronha, C., Oremosu, A., Kusemiju, T., and Okanlawon, O. A. Abortifacient properties of aqueous extract of Carica papaya (Linn) seeds on female Sprague-Dawley rats. Niger.Postgrad.Med J 2002;9(2):95-98. DOI
  9. Danese, C., Esposito, D., D'Alfonso, V., Cirene, M., Ambrosino, M., and Colotto, M. Plasma glucose level decreases as collateral effect of fermented papaya preparation use. Clin Ter. 2006;157(3):195-198.
  10. Iliev, D. and Elsner, P. Generalized drug reaction due to papaya juice in throat lozenges. Dermatology 1997;194(4):364-366. PubMed
  11. Andersen HA, Bernatz PE, Grindlay JH. Perforation of the esophagus after use of a digestant agent: report of case and experimental study. Ann Otol Rhinol Laryngol 1959;68:890-6. PubMed
  12. Deiana L, Marini S, Mariotti S. Ingestion of large amounts of papaya fruit and impaired effectiveness of levothyroxine therapy. Endocr Pract 2012;18(1):98-100. PubMed
  13. Rodrigues M, Alves G, Francisco J, Fortuna A, Falcão A. Herb-drug pharmacokinetic interaction between Carica papaya extract and amiodarone in rats. J Pharm Pharm Sci 2014;17(3):302-15. PubMed
  14. Rajapakse S, de Silva NL, Weeratunga P, Rodrigo C, Sigera C, Fernando SD. Carica papaya extract in dengue: a systematic review and meta-analysis. BMC Complement Altern Med. 2019;19(1):265. PubMed

See these in context on the Papaya monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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