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Dietary supplement

Original Pure Cod Liver Oil Ingredients & Drug Interactions

by Seven Seas

Original Pure Cod Liver Oil label
See full label image
Liquid Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Original Pure Cod Liver Oil against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Original Pure Cod Liver Oil is a dietary supplement by Seven Seas with 1 active ingredient. Its ingredients are commonly taken for source of omega-3 fatty acids, vitamin a and d supplementation, heart health.Based on those ingredients, 375 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Cod Liver Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Original Pure Cod Liver Oil by Seven Seas

Ask about any prescription or over-the-counter medication and we check it for interactions with Original Pure Cod Liver Oil by Seven Seas — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Original Pure Cod Liver Oil by Seven Seas

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.

This product contains one active ingredient: cod liver oil, a fatty oil extracted from fish livers that's rich in omega-3 fatty acids and vitamins A and D. There are no inactive fillers or other ingredients.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Cod Liver Oil's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: relief of joint pains and stiffness.
  • We looked for evidence on: Osteoarthritis, Rheumatoid arthritis (RA), musculoskeletal pain, joint inflammation.
  • The closest evidence on file: Cod Liver Oil is rated "Insufficient Reliable Evidence To Rate" for Osteoarthritis (Natural Medicines).
  • Also on file: Cod Liver Oil is rated "Insufficient Reliable Evidence To Rate" for Rheumatoid arthritis (RA).

The data we hold shows insufficient reliable evidence to rate cod liver oil for age-related macular degeneration, hay fever, irregular heartbeat (arrhythmia), or burns. For COVID-19, it's rated possibly ineffective.

The research on its other potential uses hasn't reached a clear conclusion in the sources we have on file.

The evidence, ingredient by ingredient Cod Liver Oil

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Cod liver oil is generally well tolerated when taken by mouth. The most common side effects are mild—flatulence, heartburn, nausea, and stomach upset.

The main safety concern is its vitamin A content: high doses over time can accumulate and cause harm. During pregnancy, high vitamin A intake can harm the baby, so if you're pregnant or planning to become pregnant, use cod liver oil only under medical supervision.

There's one case report of severe bleeding in someone taking a very high combined dose of omega-3 supplements (over 21 grams daily). Older data from Norway suggested long-term use might be linked to asthma development, though that cod liver oil had unusually high vitamin A levels.

Side effects, ingredient by ingredient Cod Liver Oil

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Cod Liver Oil.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 375 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take blood thinners (anticoagulants) or antiplatelet drugs like warfarin or aspirin—cod liver oil may increase bleeding risk at high doses. Also double-check if you're on blood pressure medications or diabetes drugs, as cod liver oil may strengthen their effects.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Cod liver oil may appeal to you if you're looking for omega-3s and vitamins A and D, but it's not right for everyone. If you take blood thinners, blood pressure medications, or diabetes drugs, or if you're pregnant or planning to be, talk it over with your doctor or pharmacist before starting—the vitamin A content and drug interactions need individual review.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Original Pure Cod Liver Oil, straight from the product label.

Brand Seven Seas
Net contents 170 mL
Market status On market
Date entered into DSLD Nov 25, 2013
DSLD ID 27735
Product type Fat/fatty Acid
Supplement form Liquid
Dietary claims / uses Nutrient, All Other
Intended target group(s) Children 4 or More Years of Age, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Original Pure Cod Liver Oil by Seven Seas, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0 Not Present
Maximum serving Sizes:
0 Not Present
IngredientAmount% DV
Cod Liver Oil0 NP--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

YOU MUST BE especially careful: If you are taking any medicines including ones you have bough yourself as well as those you have on prescription from your doctor.

If any of these conditions apply to you, please discuss your treatment with your doctor or pharmacist before taking this medicine.

DO NOT TAKE Seven Seas Original Pure Cod Liver Oil: If you are receiving medical treatment for having too much Calcium or vitamin A, D E in your blood.

DO NOT TAKE Seven Seas Original Pure Cod Liver Oil: If you know you are allergic to any f the ingredients of this medicine (see ingredients section).

DO NOT TAKE Seven Seas Original Pure Cod Liver Oil: If you are taking water tablets (thiazide diuretics) such as chlorothiazide or bendroflumethlazied which are used to treat high blood pressure.

Seals/Symbols

OCEAN GOLD(TM) ULTRA PURE

General Statements

Good health - naturally! A traditional remedy for the relief of muscular pains, joint pains and stiffness.

for the relief of joint pains and stiffness

e

- For the relief of joint pain and stiffness - Healthy hair, skin and nails - Building resistance to infections such as coughs and colds - Good vision - Strong bones

Formula

Provides a source of vitamins A, D and E and the unsaturated fatty acids EPA and DHA which are essential dietary components.

It can be used in children over 15 years and adults with poor dietary status and int he treatment of combined vitamins A, D and E deficiencies.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Original Pure Cod Liver Oil by Seven Seas label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Original Pure Cod Liver Oil label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Original Pure Cod Liver Oil by Seven Seas

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0 Not Present Dosage formLiquid Amounts shown are per serving.

Cod Liver Oil

Interacts with
375 drugs
0 NP per serving

Cod liver oil supplies omega-3 fatty acids (EPA and DHA) along with vitamins A and D, and is popular for heart, joint, and general health support. Evi...

Cod Liver Oil monograph & interactions
Interaction report

Original Pure Cod Liver Oil by Seven Seas Drug Interactions

Want to check YOUR meds against Original Pure Cod Liver Oil?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
375Drugs
375 Moderate

Ingredients driving the most interactions

Cod Liver Oil 375

Individual Drug Interactions

The ingredients in Original Pure Cod Liver Oil interact with 375 drugs. Click any drug to see the details.

1 of the 1 ingredient in Original Pure Cod Liver Oil interact with drugs. Each result below shows which ingredient is responsible. Cod Liver Oil

Each ingredient & the kinds of drugs it affects

For each ingredient in Original Pure Cod Liver Oil with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Cod Liver Oil3 drug types · 375 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, cod liver oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
High doses of cod liver oil, 20-40 mL daily, have been associated with prolonged bleeding time and reduced platelet aggregation in healthy volunteers.

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, taking cod liver oil with antidiabetes drugs might increase the risk of hypoglycemia.
Some clinical research shows that cod liver oil may lower blood glucose levels in women with gestational diabetes who are already taking antidiabetes drugs when used for at least 12 weeks. However, it does not appear to have any effect on blood glucose when used for shorter durations. Until more is known, use caution.

Likelihood Possible Evidence A
Antihypertensive Drugs

Theoretically, taking cod liver oil with antihypertensive drugs might increase the risk of hypotension.
Cod liver oil can lower blood pressure and might have additive effects in patients treated with antihypertensives; use with caution.

Likelihood Probable Evidence B
Cod Liver Oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Original Pure Cod Liver Oil, from the product label.

Seven Seas

See all Seven Seas products
Name
Seven Seas
Pharmacist Counseling Corner

Original Pure Cod Liver Oil by Seven Seas: Common Questions

Does Original Pure Cod Liver Oil by Seven Seas interact with any medications?
Yes. Based on its ingredients, Original Pure Cod Liver Oil has a known interaction with 375 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Original Pure Cod Liver Oil contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is cod liver oil safe to take during pregnancy?
The data shows it's rated possibly safe and possibly unsafe—the concern is its vitamin A content, which can harm a developing baby if doses are too high. There isn't enough certainty to say yes or no, so talk with your doctor or pharmacist before taking it if you're pregnant or trying to become pregnant. They'll help you decide what's safe for your situation.
What are the most common side effects?
The usual ones are mild: flatulence, heartburn, nausea, and general stomach upset. These are rare enough that most people tolerate it without trouble, but if you're prone to heartburn or an upset stomach, it's worth knowing.
Can I take this if I'm breastfeeding?
The data rates it possibly safe during lactation. If you're breastfeeding and thinking about adding this product, check with your doctor or pharmacist to make sure it's right for you and your baby.
Does cod liver oil actually work for anything?
The evidence we have on file is mixed. For most uses—including age-related macular degeneration, hay fever, arrhythmia, and burns—the research hasn't yet established how well it works. For COVID-19, the available evidence suggests it's probably not effective.
Why is vitamin A a concern with this product?
Vitamin A accumulates in your body over time, and high doses can cause harm—especially during pregnancy, where excess vitamin A can damage the baby. That's why the safety notes stress dosing with your doctor's guidance, particularly the omega-3 dose, because high amounts increase your vitamin A intake.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Original Pure Cod Liver Oil is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Original Pure Cod Liver Oil label
Go deeper

The Full Monographs Behind Original Pure Cod Liver Oil’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Cod Liver Oil

Interacts with 375 drugs

Cod liver oil supplies omega-3 fatty acids (EPA and DHA) along with vitamins A and D, and is popular for heart, joint, and general health support. Evidence is strongest for its nutrient cont...

Read the full Cod Liver Oil monograph →
Sources

Sources & How We Checked

Original Pure Cod Liver Oil's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 20 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Cod Liver Oil 20 references
  1. Prisco D, Paniccia R, Bandinelli B, et al. Effect of medium-term supplementation with a moderate dose of n-3 polyunsaturated fatty acids on blood pressure in mild hypertensive patients. Thromb Res 1998;1:105-12.
  2. Toft I, Bonaa KH, Ingebretsen OC, et al. Effects of n-3 polyunsaturated fatty acids on glucose homeostasis and blood pressure in essential hypertension. A randomized, controlled trial. Ann Intern Med 1995;123:911-8.
  3. Dawson JK, Abernethy VE, Graham DR, Lynch MP. A woman who took cod-liver oil and smoked. Lancet 1996;347:1804. PubMed
  4. Stammers T, Sibbald B, Freeling P. Efficacy of cod liver oil as an adjunct to non-steroidal anti-inflammatory drug treatment in the management of osteoarthritis in general practice. Ann Rheum Dis 1992;51:128-9. PubMed
  5. Jensen T, Stender S, Goldstein K, et al. Partial normalization by dietary cod-liver oil of increased microvascular albumin leakage in patients with insulin-dependent diabetes and albuminuria. N Engl J Med 1989;321:1572-7. PubMed
  6. Brox JH, Killie JE, Gunnes S, Nordoy A. The effect of cod liver oil and corn oil on platelets and vessel wall in man. Thromb Haemost 1981;46:604-11. DOI
  7. Sanders TA, Vickers M, Haines AP. Effect on blood lipids and haemostasis of a supplement of cod-liver oil, rich in eicosapentainoic and docosahexaenoic acids, in healthy young men. Clin Sci (Colch) 1981;61:317-24.
  8. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  9. Brox JH, Killie JE, Osterud B, et al. Effects of cod liver oil on platelets and coagulation in familial hypercholesterolemia (type IIa). Acta Med Scand 1983;213:137-44.. PubMed
  10. Lorenz R, Spengler U, Fischer S, Duhm J, Weber PC. Platelet function, thromboxane formation and blood pressure control during supplementation of the Western diet with cod liver oil. Circulation 1983;67(3):504-11. PubMed
  11. Ahmed AA, Holub BJ. Alteration and recovery of bleeding times, platelet aggregation and fatty acid composition of individual phospholipids in platelets of human subjects receiving a supplement of cod-liver oil. Lipids 1984;19(8):617-24. PubMed
  12. Ross AC, Taylor CL, Yaktine AL, Del Valle HB (eds). Dietary reference intakes for calcium and vitamin D. Institute of Medicine, 2011. Available at: www.nap.edu/catalog/13050/dietary-reference-intakes-for-calcium-and-vitamin-d (accessed April 17, 2016). DOI
  13. Detopoulou P, Papamikos V. Gastrointestinal bleeding after high intake of omega-3 fatty acids, cortisone and antibiotic therapy: a case study. Int J Sport Nutr Exerc Metab 2014;24(3):253-7. PubMed
  14. Mai XM, Langhammer A, Chen Y, Camargo CA. Cod liver oil intake and incidence of asthma in Norwegian adults - the HUNT study. Thorax 2013;68(1):25-30. PubMed
  15. Gruenwald J, Graubaum HJ, Harde A. Effect of cod liver oil on symptoms of rheumatoid arthritis. Adv Ther 2002;19(2):101-7. PubMed
  16. Foti C, Bonamonte D, Conserva A, Pepe ML, Angelini G. Allergic contact dermatitis to cod liver oil contained in a topical ointment. Contact Dermatitis 2007;57(4):281-2. PubMed
  17. Helland IB, Saugstad OD, Saarem K, et al. Supplementation of n-3 fatty acids during pregnancy and lactation reduces maternal plasma lipid levels and provides DHA to the infants. J Matern Fetal Neonatal Med 2006;19(7):397-406. PubMed
  18. Olafsdottir AS, Thorsdottir I, Wagner KH, Elmadfa I. Polyunsaturated fatty acids in the diet and breast milk of lactating Icelandic women with traditional fish and cod liver oil consumption. Ann Nutr Metab 2006;50(3):270-6. PubMed
  19. Yang S, Lin R, Si L, et al. Cod-liver oil improves metabolic indices and hs-CRP levels in gestational diabetes mellitus patients: A double-blind randomized controlled trial. J Diabetes Res. 2019;2019:7074042. PubMed
  20. Conus N, Burgher-Kennedy N, van den Berg F, Kaur Datta G. A randomized trial comparing omega-3 fatty acid plasma levels after ingestion of emulsified and non-emulsified cod liver oil formulations. Curr Med Res Opin. 2019;35(4):587-593. PubMed

See these in context on the Cod Liver Oil monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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