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Dietary supplement

Papain Ingredients & Drug Interactions

by Herbadiet

Papain label
See full label image
Powder Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Papain against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Papain is a dietary supplement by Herbadiet with 1 active ingredient. Its ingredients are commonly taken for digestive support for protein digestion, wound cleaning (debridement of dead tissue), sore throat and inflammation.Based on those ingredients, 2 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Papain Extract, Powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Papain by Herbadiet

Ask about any prescription or over-the-counter medication and we check it for interactions with Papain by Herbadiet — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Papain by Herbadiet

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: papain extract in powder form. Papain is an enzyme from papaya that's been studied for a range of conditions — from dental health to muscle soreness to wound healing — though the evidence for most of these uses hasn't yet been established reliably.

There are no inactive ingredients listed.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Papain's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Supports protein digestion.
  • We looked for evidence on: Intestinal parasite infection, Wound healing, Proteolytic enzyme deficiency, Dyspepsia.
  • The closest evidence on file: Papain is rated "Insufficient Reliable Evidence To Rate" for Intestinal parasite infection (Natural Medicines).
  • Also on file: Papain is rated "Insufficient Reliable Evidence To Rate" for Wound healing.

The evidence we hold on papain doesn't yet establish it as effective for any of the conditions it's been studied for — cancer, dental caries (cavities), radiation dermatitis, exercise-induced muscle soreness, herpes zoster (shingles), or intestinal parasite infection. The data on file rates all of these as having insufficient reliable evidence.

That doesn't mean papain doesn't work; it means the science isn't settled enough yet to make a confident claim.

The evidence, ingredient by ingredient Papain

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

When used short-term at normal doses, papain is generally well tolerated — it's eaten as a food — but the supplement form can irritate your digestive tract and trigger allergic reactions in sensitive people. High oral doses may not be safe.

Allergic symptoms can include itchy watery eyes, runny nose, sneezing, abdominal cramps, sweating, and diarrhea. Rare but serious reactions at high doses include esophageal perforation (a tear in your food pipe) and severe gastritis (stomach inflammation).

If you're pregnant, concentrated papain and unripe papaya products are best avoided due to safety concerns. If you're breastfeeding, there isn't enough reliable safety data, so talk with your doctor or pharmacist about whether this product is right for you.

Anyone exposed to airborne papain dust (like in occupational settings) may also develop respiratory allergic reactions — rhinitis, wheezing, cough, and asthma symptoms.

Side effects, ingredient by ingredient Papain

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Papain.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 2 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take warfarin (Coumadin) or any other blood thinner (anticoagulant), do not start this product without clearing it with your doctor or pharmacist. Papain may increase how much your blood thinner works, raising your bleeding risk.

Check your exact medication on this page's search tool before you take this powder.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Papain is a natural enzyme that's eaten safely in food, but the supplement form carries risks for people on blood thinners and those with papain sensitivity. If you're on warfarin or any other anticoagulant, check with your doctor or pharmacist before taking this.

Those who are pregnant, breastfeeding, or prone to allergies should also talk it over with their healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Papain, straight from the product label.

Brand Herbadiet
Net contents 0 Not Present
Market status On market
Date entered into DSLD Feb 25, 2021
DSLD ID 244373
Product type Non-nutrient/non-botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Papain by Herbadiet, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
200 mg
Maximum serving Sizes:
400 mg
IngredientAmount% DV
Papain Extract, Powder200 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Supports Protein Digestion Standardized Extract Powder

Free of fillers, binders, artificial ingredients, dairy, soy, wheat, gluten, yeast

V Vegan

Ethically Sourced Scientifically Tested Premium Grade Ingredients

Derived from Carica Papaya Fruit

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take up to 400 mg daily, or as directed by physician.

Precautions

Keep out of reach of children.

Warning: Pregnant or lactating women should consult your physician before use.

Storage

Store in a dry, cool & dark.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Batch No. ARK-P41

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Papain by Herbadiet label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Papain label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Papain by Herbadiet

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size200 mg Dosage formPowder Amounts shown are per serving.

Papain Extract, Powder

Interacts with
2 drugs
200 mg per serving

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food an...

Papain Extract, Powder monograph & interactions
Interaction report

Papain by Herbadiet Drug Interactions

Want to check YOUR meds against Papain?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2Drugs
2 Moderate

Ingredients driving the most interactions

Papain Extract, Powder 2

Individual Drug Interactions

The ingredients in Papain interact with 2 drugs. Click any drug to see the details.

1 of the 1 ingredient in Papain interact with drugs. Each result below shows which ingredient is responsible. Papain Extract, Powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Papain with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Papain Extract, Powder1 drug type · 2 drugs

Warfarin (Coumadin)

Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Papain Extract, Powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Papain, from the product label.

Herbadiet

See all Herbadiet products
Name
Arkure Health Care
Street Address
11, Sector - 14
City
Rohtak
State
Haryana
ZipCode
124001
Web Address
www.herbadiet.in
Pharmacist Counseling Corner

Papain by Herbadiet: Common Questions

Does Papain by Herbadiet interact with any medications?
Yes. Based on its ingredients, Papain has a known interaction with 2 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Papain contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Papain if I'm on warfarin?
Not without checking with your doctor or pharmacist first. Papain may strengthen warfarin's effects and increase your bleeding risk — we even have a case report of someone whose clotting level spiked dangerously after taking a papain supplement. Your prescriber needs to know before you start.
Does this help with muscle soreness after exercise?
The evidence we hold doesn't yet establish papain as effective for exercise-related muscle soreness. While it's been studied for this, the data we have rates it as having insufficient reliable evidence, so we can't make a confident claim either way.
Can I take this while pregnant?
Concentrated papain and unripe papaya products are best avoided in pregnancy due to safety concerns. Talk with your doctor or pharmacist about whether this supplement is right for you during pregnancy.
What side effects should I watch for?
Most commonly, allergic reactions — itchy watery eyes, runny nose, sneezing, belly cramps, sweating, or diarrhea — if you're sensitive to papain. At high doses, rare but serious effects like esophageal perforation or severe stomach inflammation are possible. Stop and call your doctor if you have severe chest or abdominal pain.
Is papain the same thing as eating papaya?
Papain is an enzyme from papaya that's safe when eaten as part of the whole fruit. The concentrated supplement form, especially at high doses, carries different risks — it can irritate your digestive tract more readily and trigger stronger allergic reactions in sensitive people.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Papain is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Papain label
Go deeper

The Full Monographs Behind Papain’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Papain

Interacts with 2 drugs

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food and laboratory uses, strong human evidence...

Read the full Papain monograph →
Sources

Sources & How We Checked

Papain's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Papain 11 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  3. Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
  6. Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
  7. Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
  8. Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
  9. Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
  10. Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
  11. Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed

See these in context on the Papain monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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