Interactions on record — worth a quick check against your medications. Based on 7 of 18 ingredients. Check your meds →
Dietary supplement

Peptiva + Prodigest Ingredients & Drug Interactions

by Peptiva

Peptiva + Prodigest label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Peptiva + Prodigest against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Peptiva + Prodigest is a dietary supplement by Peptiva with 18 active ingredients. Its ingredients are commonly taken for inflammation and swelling, sinus and nasal congestion, digestion support.Based on those ingredients, 1,147 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Artichoke extract and Ginger extract, Bromelain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Peptiva + Prodigest by Peptiva

Ask about any prescription or over-the-counter medication and we check it for interactions with Peptiva + Prodigest by Peptiva — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Peptiva + Prodigest by Peptiva

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 19 active ingredients.
  • “Digestive Enzyme Blend” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “Artichoke extract and Ginger extract” is listed as a grouped ingredient — the label gives one combined amount (320 mg) without saying how much of each component you get.

Peptiva + Prodigest contains 19 active digestive enzymes and plant extracts designed to support food breakdown and digestion. The enzyme blend includes proteases (protein-digesting enzymes), lipase (fat digestion), lactase (for breaking down milk sugar), amylase (carbohydrate digestion), and a mix of others like cellulase, phytase, and hemicellulase that target different fiber and plant compounds.

It also includes ginger extract for digestive comfort and artichoke extract for liver and digestive support. Inactive ingredients include maltodextrin, dicalcium phosphate, hypromellose, microcrystalline cellulose, sodium croscarmellose, silica, and magnesium stearate.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Digestive enzyme support for food breakdown.
  • We looked for evidence on: Dyspepsia, Lactose intolerance, Diarrhea, Constipation, Irritable bowel syndrome (IBS), Exercise-induced muscle soreness — and 4 related terms.
  • The strongest evidence on file: Lactase is rated "Effective" for Lactose intolerance (Natural Medicines).
  • Also on file: Artichoke is rated "Possibly Effective" for Dyspepsia.
  • Also on file: Ginger is rated "Possibly Ineffective" for Exercise-induced muscle soreness.

The evidence for most ingredients in this product is limited. Lactase is effective for lactose intolerance — if you have trouble digesting milk, it works.

Ginger extract shows possibly effective evidence for pregnancy-related nausea and vomiting, period pain (dysmenorrhea), and osteoarthritis, though it was rated possibly ineffective for exercise muscle soreness. Artichoke extract is possibly effective for high cholesterol (hyperlipidemia) and indigestion (dyspepsia).

For the other enzymes — bromelain, lipase, phytase, proteases, and several others — the evidence we hold does not establish whether they work for specific conditions, or the data simply isn't there yet.

The evidence, ingredient by ingredient Bromelain Lipase Lactase Phytase Proteolytic Enzymes (proteases) Artichoke Ginger

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 7 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of the digestive enzymes in this product are generally well tolerated when taken as directed. Bromelain may cause diarrhea, flatulence, stomach upset, or headache, and rarely can trigger allergic reactions including asthma or throat swelling if inhaled.

Ginger extract is generally well tolerated at typical doses, though higher amounts (5 grams per day or more) increase the risk of abdominal discomfort, heartburn, diarrhea, and a burning feeling in the mouth and throat. Artichoke extract may cause abdominal pain, diarrhea, flatulence, or nausea; rarely, severe allergic reactions have been reported in people sensitive to plants in the daisy family (ragweed, chrysanthemums, marigolds, daisies).

Lactase is generally well tolerated; one case of allergic reaction has been reported in a worker exposed to powdered lactase. We could not check the safety data for amylase, cellulase, invertase, glucoamylase, alpha-galactosidase, xylanase, pectinase, hemicellulase, diastase, or beta-glucanase.

Side effects, ingredient by ingredient Bromelain Lipase Lactase Phytase Proteolytic Enzymes (proteases) Artichoke Ginger

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 7 matched ingredients can interact with medications — Artichoke, Bromelain, Ginger.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,148 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this product if you use blood thinners like warfarin or phenprocoumon, or antiplatelet drugs — bromelain and ginger may increase bleeding risk (Moderate severity). Also flag any blood pressure medications you take, any diabetes medications, heart medications including nifedipine, losartan, or certain cancer drugs, and any medications that rely on liver metabolism through CYP3A4, CYP2C19, or CYP2B6 enzymes or P-glycoprotein transport — ginger and artichoke may alter their levels or effects (all Moderate severity).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help with digestion and is well tolerated for most adults, but the ingredient bromelain, ginger, and artichoke all interact with common medications — particularly blood thinners, blood pressure drugs, and diabetes medications. Before you start, check with your doctor or pharmacist, especially if you take prescriptions for your heart, blood sugar, or bleeding.

If you're pregnant or breastfeeding, talk with your healthcare provider first — the safety data are limited or advise caution for several ingredients here.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 9 of 19 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 23, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Peptiva + Prodigest, straight from the product label.

Brand Peptiva
Net contents 30 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jun 23, 2021
DSLD ID 249998
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Peptiva + Prodigest by Peptiva, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
Servings per container
30
IngredientAmount% DV
Amylase0 NP--
Bromelain0 NP--
Lipase0 NP--
Lactase0 NP--
Cellulase0 NP--
Invertase0 NP--
Glucoamylase0 NP--
Alpha-Galactosidase0 NP--
Xylanase0 NP--
Pectinase0 NP--
Phytase0 NP--
Hemicellulase0 NP--
Digestive Enzyme Blend0 NP--
Protease 30 NP--
Ginger extract0 NP--
Artichoke extract0 NP--
Diastase0 NP--
Beta-Glucanase0 NP--
Protease0 NP--
Neutral Lipase, Bacterial0 NP--
Artichoke extract and Ginger extract320 mg--

Other ingredients: Maltodextrin, Dicalcium Phosphate, Hypromellose, Microcrystalline Cellulose, Sodium Croscarmellose, Silica, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Adult Usage: Take one (1) capsule immediately before your heaviest meal.

Formula

Contains: wheat, soy & milk (lactose) (from enzyme blend fermentation medium).

Precautions

Contains: wheat, soy & milk (lactose) (from enzyme blend fermentation medium).

Precautions: For adult use only.

Consult a healthcare practitioner before use if you have any medical condition, including bile obstruction or gallstones, or use any medications.

Keep out of the reach of children.

Formulation

Made in the UK

Did you know? Your body needs a full spectrum of enzymes to properly digest foods. Otherwise, you may experience occasional gas, bloating, and discomfort. Our advanced formula can help break down proteins, fats, fiber, carbohydrates and milk sugars. Restore critical enzymes Digestive enzymes formula Full spectrum enzyme blend Helps break down proteins, fats, fiber & carbohydrates Provides digestive relief

Storage

Keep product at room temperature and humidity [59-77 degrees F (15-25 degrees C), 60% RH].

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Prodigest is a registered trademark of Indena S.p.A., Italy.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Peptiva + Prodigest by Peptiva label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Peptiva + Prodigest label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Peptiva + Prodigest by Peptiva

These are the 18 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Digestive Enzyme Blend

0 NP per serving

Artichoke extract and Ginger extract

Interacts with
363 drugs
320 mg per serving

Artichoke leaf extract is a generally well-tolerated supplement that may have a mild cholesterol-lowering effect and is often used for indigestion, th...

Artichoke extract and Ginger extract monograph & interactions

Other (inactive) ingredients: Maltodextrin, Dicalcium Phosphate, Hypromellose, Microcrystalline Cellulose, Sodium Croscarmellose, Silica, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Peptiva + Prodigest by Peptiva Drug Interactions

Want to check YOUR meds against Peptiva + Prodigest?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,147Drugs
1,061 Moderate 86 Minor

Ingredients driving the most interactions

Artichoke extract and Ginger extract 363
Bromelain 141

Individual Drug Interactions

The ingredients in Peptiva + Prodigest interact with 1,147 drugs. Click any drug to see the details.

2 of the 18 ingredients in Peptiva + Prodigest interact with drugs. Each result below shows which ingredient is responsible. Artichoke extract and Ginger extract Bromelain

Each ingredient & the kinds of drugs it affects

For each ingredient in Peptiva + Prodigest with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Artichoke extract and Ginger extract4 drug types · 363 drugs

Antidiabetes Drugs

Theoretically, artichoke leaf extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
A meta-analysis of small clinical studies shows that taking artichoke leaf extract for 8-12 weeks can modestly reduce fasting plasma glucose when compared with placebo.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
A meta-analysis of small clinical studies in patients with hypertension shows that taking artichoke can reduce systolic blood pressure by around 3 mmHg and diastolic blood pressure by around 2 mmHg when compared with placebo.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2B6.
In vitro research shows that artichoke leaf extract inhibits CYP2B6 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2C19.
In vitro research shows that artichoke leaf extract inhibits CYP2C19 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Artichoke extract and Ginger extract full monograph & interactions

Bromelain2 drug types · 141 drugs

Anticoagulant/Antiplatelet Drugs

Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
There is one case report of a patient experiencing minor bruising while taking bromelain with naproxen. Bromelain is thought to have antiplatelet activity. Whether this interaction is of concern with topical bromelain is unclear. Interference with coagulation of burn wounds has been reported in a patient receiving bromelain-based enzymatic debridement. However, observational research has found that topical bromelain debridement is not associated with increases or decreases in laboratory markers of coagulation when compared with surgical debridement.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, bromelain might increase levels of tetracycline antibiotics.
Laboratory research suggests that bromelain might increase the absorption of tetracycline antibiotics. However, a study in healthy adults reported no difference in tetracycline plasma levels when a 500 mg dose was taken with or without bromelain 80 mg.

Likelihood Possible Evidence B
Bromelain full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Peptiva + Prodigest, from the product label.

Peptiva

See all Peptiva products
Name
Adaptive Health
City
Charlotte
State
NC
ZipCode
28202
Phone Number
1-800-355-6050
Web Address
www.peptivaprobiotics.com
Pharmacist Counseling Corner

Peptiva + Prodigest by Peptiva: Common Questions

Does Peptiva + Prodigest by Peptiva interact with any medications?
Yes. Based on its ingredients, Peptiva + Prodigest has a known interaction with 1,147 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Peptiva + Prodigest contains 18 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this product safe to take if I'm pregnant or breastfeeding?
Safety data vary by ingredient. Bromelain should be avoided during pregnancy — there isn't enough data to know it's safe. Ginger is likely safe in pregnancy and likely safe while breastfeeding, though check with your doctor about amounts. Lactase is likely safe in pregnancy. For artichoke, lipase, phytase, and proteases, data are too limited — talk with your doctor or pharmacist for personalized advice before taking any supplement regularly during pregnancy or while nursing.
What does bromelain do, and why is it in this product?
Bromelain is an enzyme from pineapple that helps break down protein during digestion. It's included in digestive enzyme blends to support food breakdown, though the evidence for treating specific conditions like allergies, burns, or wound healing is not yet established in our data.
Can this product help with lactose intolerance?
Yes — lactase, one of the enzymes in this product, is effective for lactose intolerance. If you have trouble digesting milk or dairy products, the lactase in here can help break down that milk sugar (lactose) so your body can tolerate it better.
What are the most common side effects I might notice?
The digestive enzymes can cause mild stomach upset including diarrhea, gas, flatulence, or abdominal discomfort. Ginger may also cause heartburn, burping, or a burning sensation in the mouth and throat, especially at higher doses. These symptoms are usually mild and may improve with continued use.
Does this product work for indigestion or dyspepsia?
Artichoke extract in this blend is possibly effective for indigestion (dyspepsia), and the digestive enzymes are intended to support digestion overall. However, evidence is limited for most of the other enzymes — we can't say they've been proven to work for any specific condition in the data we hold.
What's the difference between this product and other digestive enzyme supplements?
We can only tell you what's in this product — 19 active enzymes plus ginger and artichoke extracts — rather than compare it to others. The blend covers multiple types of food breakdown (protein, fat, carbohydrates, fiber), and includes plant extracts for added digestive support, but the strength of evidence for each ingredient varies widely.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Peptiva + Prodigest is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Peptiva + Prodigest label
Go deeper

The Full Monographs Behind Peptiva + Prodigest’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bromelain

Interacts with 141 drugs

Bromelain is a group of protein-digesting enzymes from pineapple that people take mainly for inflammation, swelling, and sinus problems. Some early studies are promising, but the overall evi...

Read the full Bromelain monograph → Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph → Herb & supplement monograph

Lactase

Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...

Read the full Lactase monograph → Herb & supplement monograph

Phytase

Phytase is an enzyme that breaks down phytic acid (phytate) found in grains, beans, nuts, and seeds, which can free up minerals like iron, zinc, and calcium for absorption. It is widely used...

Read the full Phytase monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Artichoke

Interacts with 363 drugs

Artichoke leaf extract is a generally well-tolerated supplement that may have a mild cholesterol-lowering effect and is often used for indigestion, though the evidence is modest. It is not a...

Read the full Artichoke monograph → Herb & supplement monograph

Ginger

Interacts with 1,007 drugs

Ginger is a widely used culinary spice with a long history in traditional medicine, and it has the strongest evidence for helping with nausea and vomiting, including from motion sickness, pr...

Read the full Ginger monograph →
Sources

Sources & How We Checked

Peptiva + Prodigest's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 111 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bromelain 19 references
  1. Nettis E, Napoli G, Ferrannini A, Tursi A. IgE-mediated allergy to bromelain. Allergy 2001;56:257-8. PubMed
  2. Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol 1988;22:191-203.. PubMed
  3. Bradbrook ID, Morrison PJ, Rogers HJ. The effect of bromelain on the absorption of orally administered tetracycline. Br J Clin Pharmacol 1978;6:552-4. PubMed
  4. Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5.
  5. Brien S, Lewith G, Walker AF, et al. Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study. QJM 2006;99:841-50. PubMed
  6. Mori S, Ojima Y, Hirose T, et al. The clinical effect of proteolytic enzyme containing bromelain and trypsin on urinary tract infection evaluated by double blind method. Acta Obstet Gynaecol Jpn 1972;19:147-53.
  7. Glaser D, Hilberg T. The influence of bromelain on platelet count and platelet activity in vitro. Platelets 2006;17:37-41. PubMed
  8. Heinicke R M, van der Wal L, Yokoyama M. Effect of bromelain (Ananase) on human platelet aggregation. Experientia 1972;28:844-5. PubMed
  9. Gailhofer, G., Wilders-Truschnig, M., Smolle, J., and Ludvan, M. Asthma caused by bromelain: an occupational allergy. Clin Allergy 1988;18(5):445-450. PubMed
  10. Mattei, O., Fabri, G., and Farina, G. [Occupational health experience regarding four cases of asthma due to bromelain (author's transl)]. Medicina del Lavoro 1979;70(5):404-409.
  11. Galleguillos, F. and Rodriguez, J. C. Asthma caused by bromelin inhalation. Clin Allergy 1978;8(1):21-24. PubMed
  12. Perez-Camo I, Quirce S, Duran MA, and et al. Latex allergy: evidence of cross-reactivity with papain and bromelain [abstract]. Allergy 1996;51(suppl 31):48.
  13. Martin GJ, Ehrenreich J, and Asbell N. Bromelain: pineapple proteases with anti-edema activity. Exp Med Surg 1962;20:227-247.
  14. Kasemsuk T, Saengpetch N, Sibmooh N, Unchern S. Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis. Clin Rheumatol. 2016 Oct;35(10):2531-40. PubMed
  15. Kutlu Ö, DemirbaS A, Elmas ÖF, Güvenç U, Metin A. Fixed drug eruption: a new side effect of bromelain. Contact Dermatitis 2020. Online ahead of print. PubMed
  16. Shoham Y, Shapira E, Haik J, et al. Bromelain-based enzymatic debridement of chronic wounds: Results of a multicentre randomized controlled trial. Wound Repair Regen 2021;29(6):899-907. PubMed
  17. Pfister P, Garcia Wendel PD, Kim BS, et al. Coagulation side effects of enzymatic debridement in burned patients. Burns 2022. PubMed
  18. Hasham S, Riyat H, Fletcher A, O'Boyle CP, Alexander S. To bleed or not to bleed? Case series and discussion of haemorrhage risk with enzymatic debridement in burn injuries. Scars Burn Heal 2023;9:20595131231168333. PubMed
  19. Leelakanok N, Petchsomrit A, Janurai T, Saechan C, Sunsandee N. Efficacy and safety of bromelain: A systematic review and meta-analysis. Nutr Health 2023. PubMed

See these in context on the Bromelain monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Lactase 1 reference
  1. Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed

See these in context on the Lactase monograph →

Phytase 7 references
  1. Lei XG, Weaver JD, Mullaney E, Ullah AH, Azain MJ. Phytase, a new life for an "old" enzyme. Annu Rev Anim Biosci. 2013;1:283-309. PubMed
  2. Smuts CM, Matsungo TM, Malan L, et al. Effect of small-quantity lipid-based nutrient supplements on growth, psychomotor development, iron status, and morbidity among 6- to 12-mo-old infants in South Africa: a randomized controlled trial. Am J Clin Nutr. 2 PubMed
  3. van Heemst RC, Sander I, Rooyackers J, et al. Hypersensitivity pneumonitis caused by occupational exposure to phytase. Eur Respir J. 2009;33(6):1507-9. PubMed
  4. Baur X, Melching-Kollmuss S, Koops F, Strassburger K, Zober A. IgE-mediated allergy to phytase -- a new animal feed additive. Allergy. 2002;57(10):943-5. PubMed
  5. Doekes G, Kamminga N, Helwegen L, Heederik D. Occupational IgE sensitisation to phytase, a phosphatase derived from Aspergillus niger. Occup Environ Med. 1999;56(7):454-9. PubMed
  6. Brnic M, Hurrell RF, Songré-Ouattara LT, et al. Effect of phytase on zinc absorption from a millet-based porridge fed to young Burkinabe children. Eur J Clin Nutr. 2017;71(1):137-141. PubMed
  7. Koshy JC, Sharabi SE, Feldman EM, Hollier LH Jr, Patrinely JR, Soparkar CN. Effect of dietary zinc and phytase supplementation on botulinum toxin treatments. J Drugs Dermatol. 2012;11(4):507-12.

See these in context on the Phytase monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Ginger 64 references
  1. Fischer-Rasmussen W, Kjaer SK, Dahl C, Asping U. Ginger treatment of hyperemesis gravidarum. Eur J Obstet Gynecol Reprod Biol 1991;38:19-24. PubMed
  2. Jewell D, Young G. Interventions for nausea and vomiting in early pregnancy. Cochrane Database Syst Rev 2000;(2):CD000145. PubMed
  3. Vutyavanich T, Kraisarin T, Ruangsri R. Ginger for nausea and vomiting in pregnancy: randomized, double-masked, placebo-controlled trial. Obstet Gynecol 2001;97:577-82. DOI
  4. Backon J. Ginger in preventing nausea and vomiting of pregnancy; a caveat due to its thromboxane synthetase activity and effect on testosterone binding. Eur J Obstet Gynecol Reprod Biol 1991;42:163-4. PubMed
  5. Srivastava KC. Effect of onion and ginger consumption on platelet thromboxane production in humans. Prostaglandins Leukot Essent Fatty Acids 1989;35:183-5. PubMed
  6. Stewart JJ, Wood MJ, Wood CD, Mims ME. Effects of ginger on motion sickness susceptibility and gastric function. Pharmacology 1991;42:111-20. PubMed
  7. Smith C, Crowther C, Willson K, et al. A randomized controlled trial of ginger to treat nausea and vomiting in pregnancy. Obstet Gynecol 2004;103:639-45. PubMed
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See these in context on the Ginger monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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