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Dietary supplement

Petadolex 75 Ingredients & Drug Interactions

by Linpharma

Petadolex 75 label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Petadolex 75 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Petadolex 75 is a dietary supplement by Linpharma with 1 active ingredient. Its ingredients are commonly taken for migraine prevention, hay fever (allergic rhinitis), asthma symptoms.Based on those ingredients, 87 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Purple Butterbur root extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Petadolex 75 by Linpharma

Ask about any prescription or over-the-counter medication and we check it for interactions with Petadolex 75 by Linpharma — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Petadolex 75 by Linpharma

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Petadolex 75 contains one active ingredient: purple butterbur root extract. Butterbur has been studied for migraine prevention and allergy symptom relief.

The product also includes several inactive ingredients — medium-chain triglycerides, gelatin, glycerol, sorbitol, olive oil, and natural mixed carotenoids — which serve as the capsule matrix and carriers.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: maintain proper muscle tone in cerebral blood vessels.
  • We looked for evidence on: Migraine headache, Cerebrovascular tone, Vascular headache, Tension headache.
  • The strongest evidence on file: Butterbur is rated "Possibly Effective" for Migraine headache (Natural Medicines).

Purple butterbur root extract is rated possibly effective for migraine headache prevention and for allergic rhinitis (hay fever) symptoms. The evidence supports a potential benefit for both conditions, though more research would help confirm how well it works compared to other options.

The evidence, ingredient by ingredient Butterbur

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Butterbur is generally well tolerated when taken by mouth, though some people experience belching, diarrhea, drowsiness, fatigue, headache, itchy eyes, rash, stomach upset, or mild pain. Importantly, only PA-free standardized butterbur products should be used — raw butterbur can damage the liver.

Even PA-free products carry a rare risk of liver injury. The safety data advises against Petadolex 75 during pregnancy and while breastfeeding because of insufficient safety information and possible liver and other risks.

If you're pregnant, planning to become pregnant, or nursing, talk with your doctor or pharmacist about whether this product is right for you.

Side effects, ingredient by ingredient Butterbur

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Butterbur.
  • The most serious interaction on file is rated Moderate.
  • For scale: 88 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Petadolex 75, check with your pharmacist if you take any CYP3A4 inducers — medications that speed up liver metabolism, including certain anti-seizure drugs, antibiotics like rifampin, some HIV medications, and St. John's Wort.

These drugs may theoretically increase butterbur's toxic effects on your liver.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Petadolex 75 may be worth considering if you're looking for a supplement for migraine prevention or allergy relief and your doctor agrees it's appropriate. However, it interacts with a significant number of medications, especially CYP3A4 inducers, so check your prescriptions with your pharmacist first.

It's not safe during pregnancy or breastfeeding. Always use a PA-free product like this one to protect your liver.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Petadolex 75, straight from the product label.

Brand Linpharma
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Apr 25, 2018
DSLD ID 175545
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Petadolex 75 by Linpharma, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
IngredientAmount% DV
Purple Butterbur root extract75 mg--

Other ingredients: Medium-Chain Triglycerides, Gelatin, Glycerol, Sorbitol, Olive Oil, Natural Mixed Carotenoids

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Adults take 1 capsule 2 times daily.

Precautions

If you are pregnant or nursing a baby do not use this product.

This product has been sealed for your protection. Do not purchase if "pull-up" seal is missing or broken.

Storage

Keep tightly closed and stored in a cool dry place.

FDA Statement of Identity

Standardized Herbal Supplement

General Statements

Helps maintain proper muscle tone in cerebral blood vessels

(75 mg each)

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General

112012

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Petadolex 75 by Linpharma label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Petadolex 75 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Petadolex 75 by Linpharma

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Purple Butterbur root extract

Interacts with
87 drugs
75 mg per serving Form: Petasin and Isopetasin

Butterbur is a plant extract most studied for preventing migraines and easing hay fever symptoms, and some standardized products show promise. However...

Purple Butterbur root extract monograph & interactions

Other (inactive) ingredients: Medium-Chain Triglycerides, Gelatin, Glycerol, Sorbitol, Olive Oil, Natural Mixed Carotenoids. These complete the product’s ingredient list but are not active constituents.

Interaction report

Petadolex 75 by Linpharma Drug Interactions

Want to check YOUR meds against Petadolex 75?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
87Drugs
87 Moderate

Ingredients driving the most interactions

Purple Butterbur root extract 87

Individual Drug Interactions

The ingredients in Petadolex 75 interact with 87 drugs. Click any drug to see the details.

1 of the 1 ingredient in Petadolex 75 interact with drugs. Each result below shows which ingredient is responsible. Purple Butterbur root extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Petadolex 75 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Purple Butterbur root extract1 drug type · 87 drugs

Cytochrome P450 3A4 (Cyp3A4) Inducers

Theoretically, CYP3A4 inducers might increase the toxicity of butterbur.
The pyrrolizidine alkaloid (PA) constituents found in some butterbur products are substrates of CYP3A4. Theoretically, drugs that induce CYP3A4 might increase the conversion of PAs to toxic metabolites.

Likelihood Possible Evidence D
Purple Butterbur root extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Petadolex 75, from the product label.

Linpharma

See all Linpharma products
Name
Weber & Weber International GmbH & Co.
State
KG
Pharmacist Counseling Corner

Petadolex 75 by Linpharma: Common Questions

Does Petadolex 75 by Linpharma interact with any medications?
Yes. Based on its ingredients, Petadolex 75 has a known interaction with 87 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Petadolex 75 contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is purple butterbur root extract, and what is it used for?
Purple butterbur is a plant extract that's been studied for two main uses: preventing migraine headaches and relieving allergy symptoms like those from hay fever. The evidence suggests it may be helpful for both, though more research would strengthen that case.
Is Petadolex 75 safe to take if I'm pregnant or breastfeeding?
No. The safety data advises against it during pregnancy because of insufficient safety information and possible liver and other risks. The same applies to breastfeeding. If you're pregnant, planning pregnancy, or nursing, talk with your doctor or pharmacist before taking this product.
What side effects might I experience?
Most people tolerate butterbur well. Common side effects include belching, diarrhea, drowsiness, fatigue, headache, itchy eyes, rash, and stomach upset. Serious liver injury is rare but has been reported even in PA-free products, so your liver is worth monitoring if you use this supplement regularly.
Why does the label say 'PA-free' and why does that matter?
PA stands for pyrrolizidine alkaloids — compounds in raw butterbur that can damage your liver. PA-free products have these removed, which is why only standardized, PA-free butterbur should be used. Even so, rare cases of liver injury have occurred with PA-free supplements, so it's not a guarantee of zero risk.
Does Petadolex 75 interact with my medications?
Butterbur has a documented Moderate interaction with CYP3A4 inducers — medications that speed up liver metabolism, including certain anti-seizure drugs, antibiotics, some HIV medications, and St. John's Wort. Use the medication checker on this page to see if any of your prescriptions are affected.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Petadolex 75 label
Go deeper

The Full Monographs Behind Petadolex 75’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Butterbur

Interacts with 87 drugs

Butterbur is a plant extract most studied for preventing migraines and easing hay fever symptoms, and some standardized products show promise. However, raw or unprocessed butterbur contains...

Read the full Butterbur monograph →
Sources

Sources & How We Checked

Petadolex 75's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Butterbur 7 references
  1. Danesch U, Rittinghausen R. Safety of a patented special butterbur root extract for migraine prevention. Headache 2003;43:76-8.. PubMed
  2. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
  3. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
  4. Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005;155:411-20. PubMed
  5. Pothmann R, Danesch U. Migraine Prevention in Children and Adolescents: Results of an Open Study With a Special Butterbur Root Extract. Headache 2005;45:196-203.. PubMed
  6. Oelkers-Ax R, Leins A, Parzer P, et al. Butterbur root extract and music therapy in the prevention of childhood migraine: an explorative study. Eur J Pain 2008;12:301-13. PubMed
  7. Schapowal A. Butterbur Ze339 for the treatment of intermittent allergic rhinitis: dose-dependent efficacy in a prospective, randomized, double-blind, placebo-controlled study. Arch Otolaryngol.Head Neck Surg. 2004;130:1381-86. PubMed

See these in context on the Butterbur monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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