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Dietary supplement

Petadolex Ingredients & Drug Interactions

by Linpharma

Petadolex label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Petadolex against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Petadolex is a dietary supplement by Linpharma with 1 active ingredient. Its ingredients are commonly taken for migraine prevention, hay fever (allergic rhinitis), asthma symptoms.Based on those ingredients, 87 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Extract of Petasites hybridus. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Petadolex by Linpharma

Ask about any prescription or over-the-counter medication and we check it for interactions with Petadolex by Linpharma — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Petadolex by Linpharma

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Petadolex is a single-ingredient supplement: an extract of Petasites hybridus, the plant commonly known as butterbur. The capsule also contains several inactive ingredients—riboflavin, glycerol, gelatin, sorbitol, and medium-chain triglycerides—which serve as fillers and binders.

Crucially, Petadolex is a PA-free standardized product. That matters because raw butterbur can damage your liver; this version has had those harmful pyrrolizidine alkaloids removed.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: helps maintain proper muscle tone in cerebral blood vessels.
  • We looked for evidence on: Migraine headache, Cerebral blood flow, Vascular tone, Tension headaches.
  • The strongest evidence on file: Butterbur is rated "Possibly Effective" for Migraine headache (Natural Medicines).

Butterbur extract in Petadolex carries a "Possibly Effective" rating for two uses: migraine headache prevention and allergic rhinitis (hay fever) symptoms. That means there's some evidence it may help, but the research isn't conclusive yet.

If you're considering it for either of those reasons, talk with your pharmacist or doctor about whether the evidence fits your situation.

The evidence, ingredient by ingredient Butterbur

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Butterbur is generally well tolerated when taken orally. The most common side effects are mild—belching, diarrhea, drowsiness, fatigue, headache, itchy eyes, itching, rash, and stomach upset.

Some people also report abdominal pain, nausea, or regurgitation. Serious liver injury is rare but documented, even in products labeled PA-free.

Butterbur is not safe in pregnancy (rated Likely Unsafe) or while breastfeeding (also Likely Unsafe), so avoid it during both. If you're pregnant, planning pregnancy, or nursing, don't use this product without talking to your doctor or pharmacist first.

Side effects, ingredient by ingredient Butterbur

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Butterbur.
  • The most serious interaction on file is rated Moderate.
  • For scale: 88 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Petadolex, double-check with your pharmacist if you're on any CYP3A4 inducers—medications that speed up your liver's processing of drugs. We have documented interactions with this drug category at Moderate severity.

Use the medication search tool on this page to verify your exact prescriptions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Petadolex may be worth considering if you're dealing with migraines or hay fever and want to explore herbal options—the evidence suggests it might help. If you take any medications, especially ones that induce liver enzymes, run them through our checker first.

Pregnant women and those nursing should skip this product entirely. Check with your pharmacist about whether it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Petadolex, straight from the product label.

Brand Linpharma
Net contents 50 Capsule(s)
Market status Off market
Date entered into DSLD Jul 25, 2012
DSLD ID 11317
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Petadolex by Linpharma, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
IngredientAmount% DV
Extract of Petasites hybridus50 mg--

Other ingredients: Riboflavin, Glycerol, Gelatin, Sorbitol, middle chained Triglycerides

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Adults take 1 capsule 3 times daily with meals. Children ages 10 to 12 years old take 1 capsule twice daily with meals, or as directed by a health care professional.

Precautions

If you are pregnant of nursing a baby do not use this product.

This product has been sealed for your protection. Do not purchase if "Pull-up" seal is missing or broken.

FDA Statement of Identity

Standardized Herbal Supplement

General Statements

Helps maintain proper muscle tone in cerebral blood vessels

Lot No.: Expiration date:

50 mg each

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General

052011

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Petadolex by Linpharma label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Petadolex label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Petadolex by Linpharma

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Extract of Petasites hybridus

Interacts with
87 drugs
50 mg per serving Form: Petasin and Isopetasin

Butterbur is a plant extract most studied for preventing migraines and easing hay fever symptoms, and some standardized products show promise. However...

Extract of Petasites hybridus monograph & interactions

Other (inactive) ingredients: Riboflavin, Glycerol, Gelatin, Sorbitol, Middle chained Triglycerides. These complete the product’s ingredient list but are not active constituents.

Interaction report

Petadolex by Linpharma Drug Interactions

Want to check YOUR meds against Petadolex?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
87Drugs
87 Moderate

Ingredients driving the most interactions

Extract of Petasites hybridus 87

Individual Drug Interactions

The ingredients in Petadolex interact with 87 drugs. Click any drug to see the details.

1 of the 1 ingredient in Petadolex interact with drugs. Each result below shows which ingredient is responsible. Extract of Petasites hybridus

Each ingredient & the kinds of drugs it affects

For each ingredient in Petadolex with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Extract of Petasites hybridus1 drug type · 87 drugs

Cytochrome P450 3A4 (Cyp3A4) Inducers

Theoretically, CYP3A4 inducers might increase the toxicity of butterbur.
The pyrrolizidine alkaloid (PA) constituents found in some butterbur products are substrates of CYP3A4. Theoretically, drugs that induce CYP3A4 might increase the conversion of PAs to toxic metabolites.

Likelihood Possible Evidence D
Extract of Petasites hybridus full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Petadolex, from the product label.

Linpharma

See all Linpharma products
Name
Weber & Weber International GmbH & Co.
State
KG
Pharmacist Counseling Corner

Petadolex by Linpharma: Common Questions

Does Petadolex by Linpharma interact with any medications?
Yes. Based on its ingredients, Petadolex has a known interaction with 87 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Petadolex contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this the real butterbur, or is it safe?
Yes, it's real butterbur extract, and Petadolex is standardized to be PA-free—meaning the harmful liver-damaging compounds have been removed. That's important, because raw butterbur can damage your liver. Even so, rare cases of liver injury have been reported with PA-free products, so it's not a zero-risk supplement.
Can I take this while I'm pregnant or breastfeeding?
No. Butterbur is rated Likely Unsafe during pregnancy and while breastfeeding. There isn't enough safety data, and there are possible liver and other risks. Don't use this product if you're pregnant, planning to become pregnant, or nursing—talk to your doctor first.
What side effects should I expect?
Most people who take butterbur experience mild or no side effects. The ones that do show up are usually minor—belching, diarrhea, drowsiness, fatigue, headache, itching, rash, or stomach upset. Serious liver injury is rare but possible, even with PA-free products.
Does this actually work for migraines?
The evidence suggests it might. Butterbur extract is rated Possibly Effective for migraine prevention, which means there's some research support but it's not definitive yet. Results vary from person to person, so talk to your pharmacist about whether it's worth trying for your situation.
What is butterbur used for?
Petadolex's butterbur extract is used for two main things: preventing migraines and relieving allergic rhinitis (hay fever) symptoms. Both are rated Possibly Effective based on the evidence we have.
Why does it matter that this is PA-free?
Pyrrolizidine alkaloids (PAs) are compounds in raw butterbur that can seriously damage your liver. Petadolex removes them so you're getting the benefits of butterbur without that major risk. It's an important safety step.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Petadolex label
Go deeper

The Full Monographs Behind Petadolex’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Butterbur

Interacts with 87 drugs

Butterbur is a plant extract most studied for preventing migraines and easing hay fever symptoms, and some standardized products show promise. However, raw or unprocessed butterbur contains...

Read the full Butterbur monograph →
Sources

Sources & How We Checked

Petadolex's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Butterbur 7 references
  1. Danesch U, Rittinghausen R. Safety of a patented special butterbur root extract for migraine prevention. Headache 2003;43:76-8.. PubMed
  2. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
  3. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
  4. Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005;155:411-20. PubMed
  5. Pothmann R, Danesch U. Migraine Prevention in Children and Adolescents: Results of an Open Study With a Special Butterbur Root Extract. Headache 2005;45:196-203.. PubMed
  6. Oelkers-Ax R, Leins A, Parzer P, et al. Butterbur root extract and music therapy in the prevention of childhood migraine: an explorative study. Eur J Pain 2008;12:301-13. PubMed
  7. Schapowal A. Butterbur Ze339 for the treatment of intermittent allergic rhinitis: dose-dependent efficacy in a prospective, randomized, double-blind, placebo-controlled study. Arch Otolaryngol.Head Neck Surg. 2004;130:1381-86. PubMed

See these in context on the Butterbur monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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