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Dietary supplement

Petadolex 75 Ingredients & Drug Interactions

by Linpharma

Petadolex 75 label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Petadolex 75 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Petadolex 75 is a dietary supplement by Linpharma with 1 active ingredient. Its ingredients are commonly taken for migraine prevention, hay fever (allergic rhinitis), asthma symptoms.Based on those ingredients, 87 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Extract of Petasites hybridus. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Petadolex 75 by Linpharma

Ask about any prescription or over-the-counter medication and we check it for interactions with Petadolex 75 by Linpharma — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Petadolex 75 by Linpharma

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Petadolex 75 contains one active ingredient: an extract of Petasites hybridus, the plant commonly called butterbur. The inactive ingredients are glycerol, gelatin, medium chain triglycerides, sorbitol, and coloring — these are fillers and capsule material that hold the extract together.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: maintain proper muscle tone in cerebral blood vessels.
  • We looked for evidence on: Migraine headache, cerebrovascular health, vascular tone, headache prevention.
  • The strongest evidence on file: Butterbur is rated "Possibly Effective" for Migraine headache (Natural Medicines).

Butterbur extract in Petadolex 75 is possibly effective for migraine headache and for allergic rhinitis (hay fever). That means some clinical evidence supports its use for these two conditions, though the data isn't conclusive.

If you're considering it for either of these, talk with your pharmacist or doctor about whether it fits your situation.

The evidence, ingredient by ingredient Butterbur

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Butterbur is generally well tolerated orally. The most common side effects are mild: belching, diarrhea, drowsiness, fatigue, headache, itchy eyes, itching, rash, and stomach upset.

A small number of people have reported abdominal pain, nausea, or pain in the joints and limbs. Serious liver damage (hepatotoxicity) is rare but has been tied to pyrrolizidine alkaloids — which is why Petadolex 75 is formulated as PA-free.

Even so, there have been rare reports of liver injury from supplements labeled PA-free, so this product isn't risk-free. During pregnancy, the safety data advises against butterbur — the rating is likely unsafe.

While breastfeeding, safety is unknown, so it's best to avoid it. If you're pregnant or breastfeeding and interested in butterbur for migraines or allergies, talk with your OB or pharmacist for personalized guidance.

Side effects, ingredient by ingredient Butterbur

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Butterbur.
  • The most serious interaction on file is rated Moderate.
  • For scale: 88 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take any CYP3A4 inducers (drugs that speed up how your liver works), check with your pharmacist before adding Petadolex 75. These medications can theoretically increase how your body converts butterbur's alkaloids into toxic forms.

Use the search tool on this page to verify your exact drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Petadolex 75 may help with migraines or hay fever, and it's formulated without the most harmful alkaloid fraction. But if you take any medication — prescription or over-the-counter — check it against the interaction tool before you start.

Don't use it in pregnancy, and avoid it while breastfeeding unless your doctor or pharmacist tells you otherwise.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Petadolex 75, straight from the product label.

Brand Linpharma
Net contents 60 Capsule(s)
Market status Off market
Date entered into DSLD Jul 25, 2012
DSLD ID 11322
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Petadolex 75 by Linpharma, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
IngredientAmount% DV
Extract of Petasites hybridus75 mg--

Other ingredients: Glycerol, Gelatin, Medium Chain Triglycerides, Sorbitol, Coloring

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Adults take 1 capsule 2 times daily.

Storage

Keep tightly closed and stored in a cool dry place.

FDA Statement of Identity

Standardized Herbal Supplement

General Statements

Helps maintain proper muscle tone in cerebral blood vessels

75 mg each

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

If you are pregnant or nursing a baby do not use this product.

This product has been sealed for your protection. Do not purchase if "Pull-up" seal is missing or broken.

General

052011

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Petadolex 75 by Linpharma label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Petadolex 75 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Petadolex 75 by Linpharma

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Extract of Petasites hybridus

Interacts with
87 drugs
75 mg per serving Form: Petasin and Isopetasin

Butterbur is a plant extract most studied for preventing migraines and easing hay fever symptoms, and some standardized products show promise. However...

Extract of Petasites hybridus monograph & interactions

Other (inactive) ingredients: Glycerol, Gelatin, Medium Chain Triglycerides, Sorbitol, Coloring. These complete the product’s ingredient list but are not active constituents.

Interaction report

Petadolex 75 by Linpharma Drug Interactions

Want to check YOUR meds against Petadolex 75?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
87Drugs
87 Moderate

Ingredients driving the most interactions

Extract of Petasites hybridus 87

Individual Drug Interactions

The ingredients in Petadolex 75 interact with 87 drugs. Click any drug to see the details.

1 of the 1 ingredient in Petadolex 75 interact with drugs. Each result below shows which ingredient is responsible. Extract of Petasites hybridus

Each ingredient & the kinds of drugs it affects

For each ingredient in Petadolex 75 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Extract of Petasites hybridus1 drug type · 87 drugs

Cytochrome P450 3A4 (Cyp3A4) Inducers

Theoretically, CYP3A4 inducers might increase the toxicity of butterbur.
The pyrrolizidine alkaloid (PA) constituents found in some butterbur products are substrates of CYP3A4. Theoretically, drugs that induce CYP3A4 might increase the conversion of PAs to toxic metabolites.

Likelihood Possible Evidence D
Extract of Petasites hybridus full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Petadolex 75, from the product label.

Linpharma

See all Linpharma products
Name
Weber & Weber International GmbH & Co.
State
KG
Pharmacist Counseling Corner

Petadolex 75 by Linpharma: Common Questions

Does Petadolex 75 by Linpharma interact with any medications?
Yes. Based on its ingredients, Petadolex 75 has a known interaction with 87 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Petadolex 75 contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is butterbur, and what does it do in this product?
Butterbur is a plant extract included in Petadolex 75 to help prevent migraines and ease allergic rhinitis (hay fever) symptoms. The clinical evidence suggests it's possibly effective for both, though it's not a cure.
Is Petadolex 75 safe to take if I'm pregnant?
No. The safety data rates butterbur as likely unsafe during pregnancy due to possible liver and other risks. If you're pregnant and dealing with migraines or allergies, talk with your OB or pharmacist about safer options.
Can I breastfeed while taking Petadolex 75?
Safety isn't established, so it's best to avoid it while breastfeeding. Speak with your doctor or pharmacist if you're breastfeeding and considering this product.
Why does the label say 'PA-free'?
PA stands for pyrrolizidine alkaloid — a compound in raw butterbur that can damage the liver. Petadolex 75 is processed to remove these, making it the safer form of butterbur. Even so, liver injury from PA-free products is rare but possible.
What side effects might I notice?
Most people tolerate it well. Common mild effects are belching, diarrhea, drowsiness, fatigue, headache, itchy eyes, rash, and stomach upset. Joint or limb pain and nausea are less common. If any symptom bothers you, stop and talk to your pharmacist.
Are there fillers in Petadolex 75?
Yes. The capsule contains glycerol, gelatin, medium chain triglycerides, sorbitol, and coloring as inactive ingredients. These help hold the butterbur extract together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Petadolex 75 label
Go deeper

The Full Monographs Behind Petadolex 75’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Butterbur

Interacts with 87 drugs

Butterbur is a plant extract most studied for preventing migraines and easing hay fever symptoms, and some standardized products show promise. However, raw or unprocessed butterbur contains...

Read the full Butterbur monograph →
Sources

Sources & How We Checked

Petadolex 75's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Butterbur 7 references
  1. Danesch U, Rittinghausen R. Safety of a patented special butterbur root extract for migraine prevention. Headache 2003;43:76-8.. PubMed
  2. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
  3. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
  4. Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005;155:411-20. PubMed
  5. Pothmann R, Danesch U. Migraine Prevention in Children and Adolescents: Results of an Open Study With a Special Butterbur Root Extract. Headache 2005;45:196-203.. PubMed
  6. Oelkers-Ax R, Leins A, Parzer P, et al. Butterbur root extract and music therapy in the prevention of childhood migraine: an explorative study. Eur J Pain 2008;12:301-13. PubMed
  7. Schapowal A. Butterbur Ze339 for the treatment of intermittent allergic rhinitis: dose-dependent efficacy in a prospective, randomized, double-blind, placebo-controlled study. Arch Otolaryngol.Head Neck Surg. 2004;130:1381-86. PubMed

See these in context on the Butterbur monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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