Phosphatidyl Choline 420 mg Ingredients & Drug Interactions
by Bluebonnet
What is this page for?
First and foremost: checking Phosphatidyl Choline 420 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Phosphatidyl Choline 420 mg is a dietary supplement by Bluebonnet with 3 active ingredients. Its ingredients are commonly taken for high cholesterol, liver health, brain and memory support.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Oleic Acid. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Phosphatidyl Choline 420 mg by Bluebonnet
Ask about any prescription or over-the-counter medication and we check it for interactions with Phosphatidyl Choline 420 mg by Bluebonnet — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Phosphatidyl Choline 420 mg by Bluebonnet
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Partial disclosure
This softgel contains 420 mg of phosphatidyl choline, a blend of six phospholipid compounds. The main actives are phosphatidylcholine (the namesake ingredient, which your cells use to maintain their membranes), oleic acid (a heart-healthy monounsaturated fat also found in olive oil), and several related phospholipids — phosphatidylinositol, phosphatidylethanolamine, and phosphatidic acid.
Lecithin is also included as a source of these phospholipids. The softgel itself is made from gelatin, glycerin, purified water, and soybean oil.
Does it work?
Insufficient evidence
Phosphatidylcholine has been studied for ulcerative colitis and shows possibly effective evidence — meaning there's some clinical support, though not conclusive. It's also being researched for nonalcoholic fatty liver disease, alcohol-related liver disease, Alzheimer's disease, and anxiety, but the evidence for those isn't yet reliable enough to rate.
Oleic acid (one of the ingredients here) is possibly effective for high cholesterol and heart disease prevention based on studies of oleic-acid-rich diets like the Mediterranean pattern. Keep in mind that most of this research comes from eating foods like olive oil rather than concentrated supplements.
How safe is it?
Well-documented data
Phosphatidylcholine is generally well tolerated when taken by mouth. At normal doses, side effects are uncommon, but some people report altered taste, bloating, diarrhea, nausea, and itching.
High doses — particularly 30 grams a day — are more likely to cause digestive upset and diarrhea. Oleic acid in food amounts is considered safe; supplement-level doses haven't been well studied.
For pregnancy, choline (which phosphatidylcholine provides) is needed, but the safety of supplement doses beyond what's in food is not well studied — talk with your doctor before taking this while pregnant. For breastfeeding, there isn't enough reliable data on supplement use; check with your healthcare provider first.
Meds to double-check
Moderate interaction found
Before you start this product, double-check it with your doctor or pharmacist if you take antidiabetes drugs (blood sugar medications). Oleic acid in this supplement may increase how well those drugs work, which could lower your blood sugar more than intended.
The bottom line
Scorecard at a glancePartially disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Bluebonnet's Phosphatidyl Choline might interest you if you're looking to support cell membrane health or if you have ulcerative colitis (where there's some evidence it may help). If you take blood sugar medication, you'll need to clear it with your doctor or pharmacist first because oleic acid might boost those drugs' effects.
Anyone pregnant, breastfeeding, or taking any prescription medication should talk it over with their own healthcare provider before starting.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Phosphatidyl Choline 420 mg, straight from the product label.
| Brand | Bluebonnet |
|---|---|
| Barcode (UPC) | 743715009301 |
| Net contents | 60 Softgel(s) |
| Market status | On market |
| Date entered into DSLD | Jun 16, 2022 |
| DSLD ID | 268353 |
| Product type | Fat/fatty Acid |
| Supplement form | Softgel Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Phosphatidyl Choline 420 mg by Bluebonnet, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 10 Calorie(s) | -- |
| Total Fat | 1 Gram(s) | 2% |
| Lecithin | 1200 mg | -- |
| Linoleic Acid | 525 mg | -- |
| Oleic Acid | 125 mg | -- |
| Phosphatidylinositol | 0 NP | -- |
| Phosphatidylcholine | 420 mg | -- |
| Phosphatidylethanolamine | 0 NP | -- |
| Saturated Fat | 150 mg | 1% |
| Phosphatidic Acid | 0 NP | -- |
Other ingredients: Gelatin, Glycerin, Water, Purified, Soybean Oil
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Directions: As a dietary supplement, take one softgel daily or as directed by a healthcare practitioner.
Formula
Bluebonnet’s Phosphatidylcholine 420 mg Softgels are specially formulated to help support cognitive and liver health with phosphatidylcholine and additional fatty acids (i.e., linoleic, oleic, palmitic and stearic acids) along with phosphatidic acid.
Formulation
May support Brain health
Free of milk, egg, fish, crustacean shellfish, tree nuts, peanuts and wheat. Also free of corn, gluten, barley, rice, sodium and sugar.
Made in USA from imported ingredients.
Brain health
Gluten free
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Precautions
Caution: For adults only.
Consult physician if pregnant/nursing, taking medication, or have a medical condition.
Keep out of reach of children.
Contains: Soybeans
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Phosphatidyl Choline 420 mg by Bluebonnet label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Phosphatidyl Choline 420 mg by Bluebonnet
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Lecithin
No knowninteractions
Lecithin is a natural fatty substance found in foods and made by the body that is widely used as a supplement and food emulsifier. Evidence supporting...
Lecithin monograph & interactions- › Phosphatidylinositol
- › Phosphatidylcholine
- › Phosphatidylethanolamine
- › Phosphatidic Acid
Linoleic Acid
Oleic Acid
Interacts with86 drugs
Oleic acid is a heart-healthy monounsaturated fat found mainly in olive oil, canola oil, avocados, and nuts. As part of a Mediterranean-style diet, it...
Oleic Acid monograph & interactionsOther (inactive) ingredients: Gelatin, Glycerin, Water, Purified, Soybean Oil. These complete the product’s ingredient list but are not active constituents.
Phosphatidyl Choline 420 mg by Bluebonnet Drug Interactions
HelloPharmacist Interaction Report
Bluebonnet's Phosphatidyl Choline 420 mg does interact with medications through its oleic acid content.
The main concern is with antidiabetes drugs (blood sugar medications). Oleic acid may increase how well these drugs work, which means your blood sugar could drop lower than expected — something you'll want to watch for if you take oral diabetes medications.
Read the full breakdown — every affected drug type, severity by severity
The other ingredients in this product — lecithin (a blend of phospholipids), linoleic acid, phosphatidylinositol, phosphatidylcholine, phosphatidylethanolamine, and phosphatidic acid — either have no documented interactions in our data or we don't hold interaction data for them. Altogether, these interactions span 86 individual medications.
If you take any blood sugar medication, run your exact prescriptions through the checker below before you start this product. Even though the interaction is moderate rather than severe, your doctor or pharmacist should know you're adding it so they can monitor your blood sugar and adjust your dose if needed.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Phosphatidyl Choline 420 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Phosphatidyl Choline 420 mg interact with 86 drugs. Click any drug to see the details.
1 of the 3 ingredients in Phosphatidyl Choline 420 mg interact with drugs. Each result below shows which ingredient is responsible. Oleic Acid
AcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Phosphatidyl Choline 420 mg — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Acarbose interactionAcetohexamideDymelor
How Acetohexamide interacts with Phosphatidyl Choline 420 mg — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Acetohexamide interactionAlbiglutideTanzeum
How Albiglutide interacts with Phosphatidyl Choline 420 mg — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Albiglutide interactionAlogliptinNesina
How Alogliptin interacts with Phosphatidyl Choline 420 mg — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Phosphatidyl Choline 420 mg — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Phosphatidyl Choline 420 mg — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Alogliptin, Pioglitazone interactionAntidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
How Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interacts with Phosphatidyl Choline 420 mg — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionCanagliflozinInvokana
How Canagliflozin interacts with Phosphatidyl Choline 420 mg — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Canagliflozin interactionCanagliflozin, MetforminInvokamet
How Canagliflozin, Metformin interacts with Phosphatidyl Choline 420 mg — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Canagliflozin, Metformin interactionCanagliflozin, Metformin HydrochlorideInvokamet XR
How Canagliflozin, Metformin Hydrochloride interacts with Phosphatidyl Choline 420 mg — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Canagliflozin, Metformin Hydrochloride interactionChlorpropamideChlorpropam, Diabinese
How Chlorpropamide interacts with Phosphatidyl Choline 420 mg — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Chlorpropamide interactionDapagliflozinFarxiga
How Dapagliflozin interacts with Phosphatidyl Choline 420 mg — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Dapagliflozin interactionDapagliflozin Propanediol, MetforminXigduo XR
How Dapagliflozin Propanediol, Metformin interacts with Phosphatidyl Choline 420 mg — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Dapagliflozin Propanediol, Metformin interactionDapagliflozin Propanediol, Saxagliptin HydrochlorideQtern
How Dapagliflozin Propanediol, Saxagliptin Hydrochloride interacts with Phosphatidyl Choline 420 mg — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Dapagliflozin Propanediol, Saxagliptin Hydrochloride interactionDapagliflozin, Metformin Hydrochloride, Saxagliptin HydrochlorideQternmet XR
How Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interacts with Phosphatidyl Choline 420 mg — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionDasiglucagon HydrochlorideZegalogue
How Dasiglucagon Hydrochloride interacts with Phosphatidyl Choline 420 mg — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Dasiglucagon Hydrochloride interactionDulaglutideTrulicity
How Dulaglutide interacts with Phosphatidyl Choline 420 mg — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Dulaglutide interactionEmpagliflozinJardiance
How Empagliflozin interacts with Phosphatidyl Choline 420 mg — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Empagliflozin interactionEmpagliflozin, Linagliptin, Metformin HydrochlorideTrijardy XR
How Empagliflozin, Linagliptin, Metformin Hydrochloride interacts with Phosphatidyl Choline 420 mg — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Empagliflozin, Linagliptin, Metformin Hydrochloride interactionEmpagliflozin, MetforminSynjardy
How Empagliflozin, Metformin interacts with Phosphatidyl Choline 420 mg — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Empagliflozin, Metformin interactionEmpagliflozin, Metformin HydrochlorideSynjardy XR
How Empagliflozin, Metformin Hydrochloride interacts with Phosphatidyl Choline 420 mg — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Empagliflozin, Metformin Hydrochloride interactionErtugliflozinSteglatro
How Ertugliflozin interacts with Phosphatidyl Choline 420 mg — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Ertugliflozin interactionErtugliflozin, Metformin HydrochlorideSegluromet
How Ertugliflozin, Metformin Hydrochloride interacts with Phosphatidyl Choline 420 mg — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Ertugliflozin, Metformin Hydrochloride interactionExenatideBydureon, Byetta
How Exenatide interacts with Phosphatidyl Choline 420 mg — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Exenatide interactionExenatide SyntheticBydureon BCISE
How Exenatide Synthetic interacts with Phosphatidyl Choline 420 mg — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Exenatide Synthetic interactionGliclazideDiamicron
How Gliclazide interacts with Phosphatidyl Choline 420 mg — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Gliclazide interactionGlimepirideAmaryl
How Glimepiride interacts with Phosphatidyl Choline 420 mg — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Glimepiride interactionGlipizideGlucotrol, Glucotrol XL
How Glipizide interacts with Phosphatidyl Choline 420 mg — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Glipizide interactionGlipizide, MetforminMetaglip
How Glipizide, Metformin interacts with Phosphatidyl Choline 420 mg — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Glipizide, Metformin interactionGlucagonBaqsimi, Glucagon
How Glucagon interacts with Phosphatidyl Choline 420 mg — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Glucagon interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Phosphatidyl Choline 420 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Oleic Acid
Antidiabetes Drugs
Theoretically, oleic acid might increase the effects of antidiabetes drugs. Preliminary clinical research in patients with type 2 diabetes taking oral hypoglycemic drugs shows that eating a diet rich in oleic acid from olive oil decreases fasting blood glucose levels when compared to eating a diet rich in linoleic acid from sunflower oil. It is unknown if taking oleic acid supplements would have this effect or if this change is clinically significant. Until more is known, use caution. Dose adjustment may be necessary. Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, metformin (Glucophage), pioglitazone (Actos), rosiglitazone (Avandia), and others.
Brand information
Manufacturer and brand details for Phosphatidyl Choline 420 mg, from the product label.
Bluebonnet
- Name
- Bluebonnet Nutrition Corporation
- Street Address
- 12915 Dairy Ashford
- City
- Sugar Land
- State
- TX
- ZipCode
- 77478
- Web Address
- www.bluebonnetnutrition.com
Phosphatidyl Choline 420 mg by Bluebonnet: Common Questions
Does Phosphatidyl Choline 420 mg by Bluebonnet interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will this help with my cholesterol or heart health?
What are the side effects I might notice?
Is it safe to take while I'm pregnant or breastfeeding?
What is phosphatidylcholine and what does it do?
Can I take this with my blood sugar medication?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Phosphatidyl Choline 420 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Phosphatidyl Choline 420 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Lecithin
Lecithin is a natural fatty substance found in foods and made by the body that is widely used as a supplement and food emulsifier. Evidence supporting most of its health claims is limited, t...
Read the full Lecithin monograph → Herb & supplement monographPhosphatidylcholine
Phosphatidylcholine is a phospholipid that is part of every cell membrane and a source of choline. People take it for liver, brain, and gut health, but solid human evidence is limited for mo...
Read the full Phosphatidylcholine monograph → Herb & supplement monographOleic Acid
Interacts with 86 drugsOleic acid is a heart-healthy monounsaturated fat found mainly in olive oil, canola oil, avocados, and nuts. As part of a Mediterranean-style diet, it is widely viewed as a healthier replace...
Read the full Oleic Acid monograph →Sources & How We Checked
Phosphatidyl Choline 420 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 43 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Lecithin 9 references
- Buchman AL, Dubin M, Jenden D, et al. Lecithin increases plasma free choline and decreases hepatic steatosis in long-term total parenteral nutrition patients. Gastroenterology 1992;102:1363-70.
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
- Chatellier G, Lacomblez L. Tacrine (tetrahydroaminoacridine; THA) and lecithin in senile dementia of the Alzheimer type: a multicentre trial. Groupe Francais d'Etude de la Tetrahydroaminoacridine. BMJ 1990;300:495-9.
- Gelenberg AJ, Dorer DJ, Wojcik JD, et al. A crossover study of lecithin treatment of tardive dyskinesia. J Clin Psychiatry 1990;51:149-53.
- Little A, Levy R, Chuaqui-Kidd P, Hand D. A double-blind, placebo controlled trial of high-dose lecithin in Alzheimer's disease. J Neurol Neurosurg Psychiatry 1985;48:736-42. PubMed
- Palm M, Moneret-Vautrin DA, Kanny G, et al. Food allergy to egg and soy lecithins. Allergy 1999;54:1116-7. PubMed
- Drachman DA, Glosser G, Fleming P, et al. Memory decline in the aged: treatment with lecithin and physostigmine. Neurology 1982;32:944-50. PubMed
- Gelenberg, A. J., Doller-Wojcik, J. C., and Growdon, J. H. Choline and lecithin in the treatment of tardive dyskinesia: preliminary results from a pilot study. Am J Psychiatry 1979;136(6):772-776. PubMed
- Electronic Code of Federal Regulations. Title 21, Chapter 1, Subchapter B, Part 184: Direct food substances affirmed as Generally Recognized as Safe. Subpart B - listing of specific substances affirmed as GRAS. Sec. 184.1400 Lecithin. Available at: https:
Oleic Acid 19 references
- Madigan C, Ryan M, Owens D, et al. Dietary unsaturated fatty acids in type 2 diabetes: higher levels of postprandial lipoprotein on a linoleic acid-rich sunflower oil diet compared with an oleic acid-rich olive oil diet. Diabetes Care 2000;23:1472-7. PubMed
- Gillingham, L. G., Gustafson, J. A., Han, S. Y., Jassal, D. S., and Jones, P. J. High-oleic rapeseed (canola) and flaxseed oils modulate serum lipids and inflammatory biomarkers in hypercholesterolaemic subjects. Br J Nutr 2011;105(3):417-427. PubMed
- Jones PJ, Senanayake VK, Pu S, Jenkins DJ, Connelly PW, Lamarche B, Couture P, Charest A, Baril-Gravel L, West SG, Liu X, Fleming JA, McCrea CE, Kris-Etherton PM. DHA-enriched high-oleic acid canola oil improves lipid profile and lowers predicted cardiova
- Cater, N. B., Heller, H. J., and Denke, M. A. Comparison of the effects of medium-chain triacylglycerols, palm oil, and high oleic acid sunflower oil on plasma triacylglycerol fatty acids and lipid and lipoprotein concentrations in humans. Am.J Clin.Nutr PubMed
- Mozaffarian D, Clarke R. Quantitative effects on cardiovascular risk factors and coronary heart disease risk of replacing partially hydrogenated vegetable oils with other fats and oils. Eur J Clin Nutr. 2009;63(Suppl 2):S22-33. PubMed
- Cao Y, Hou L, Wang W. Dietary total fat and fatty acids intake, serum fatty acids and risk of breast cancer: A meta-analysis of prospective cohort studies. Int J Cancer. 2016;138(8):1894-904. doi: 10.1002/ijc.29938. PubMed
- FDA completes review of qualified health claim petition for oleic acid and the risk of coronary heart disease. November 2018. Available at: www.fda.gov/Food/NewsEvents/ConstituentUpdates/ucm624758.htm. Accessed January 25, 2019.
- Liu X, Kris-Etherton PM, West SG, et al. Effects of canola and high-oleic-acid canola oils on abdominal fat mass in individuals with central obesity. Obesity. 2016;24(11):2261-2268. PubMed
- Bowen KJ, Kris-Etherton PM, West SG, et al. Diets enriched with conventional or high-oleic acid canola oils lower atherogenic lipids and lipoproteins compared to a diet with a western fatty acid profile in adults with central adiposity. J Nutr. 2019;149(3 PubMed
- Steffen BT, Duprez D, Szklo M, Guan W, Tsai MY. Circulating oleic acid levels are related to greater risks of cardiovascular events and all-cause mortality: The Multi-Ethnic Study of Atherosclerosis. J Clin Lipidol. 2018;12(6):1404-1412. PubMed
- Banim PJ, Luben R, Khaw KT, Hart AR. Dietary oleic acid is inversely associated with pancreatic cancer - Data from food diaries in a cohort study. Pancreatology. 2018;18(6):655-660. PubMed
- Morin SJ, Gaziano JM, Djoussé L. Relation between plasma phospholipid oleic acid and risk of heart failure. Eur J Nutr. 2018;57(8):2937-2942. PubMed
- Samieri C, Féart C, Proust-Lima C, et al. Olive oil consumption, plasma oleic acid, and stroke incidence: the Three-City Study. Neurology. 2011;77(5):418-25. PubMed
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