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Dietary supplement

Picrorhiza Ingredients & Drug Interactions

by Herbal Terra

Picrorhiza label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Picrorhiza against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Picrorhiza is a dietary supplement by Herbal Terra with 1 active ingredient. Its ingredients are commonly taken for liver support, digestive complaints, asthma and breathing problems.Based on those ingredients, 207 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Picrorhiza (Picrorhiza kurroa) dried rhizome liquid extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Picrorhiza by Herbal Terra

Ask about any prescription or over-the-counter medication and we check it for interactions with Picrorhiza by Herbal Terra — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Picrorhiza by Herbal Terra

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: picrorhiza (Picrorhiza kurroa) dried rhizome liquid extract. Picrorhiza is an herb used traditionally to support liver health and immune function.

The formulation includes menstruum (the liquid base used to extract the herb's active compounds).

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Picrorhiza's overall clinical evidence instead.

Moderate

Some clinical evidence supports Picrorhiza for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Vitiligo — rated "Possibly Effective" (Natural Medicines).

The evidence for picrorhiza is limited. It's rated possibly effective for vitiligo.

For asthma, it's rated possibly ineffective. For chronic obstructive pulmonary disease (COPD) and hepatitis, we don't have enough reliable evidence to rate it either way — the data simply isn't established in our holdings.

The evidence, ingredient by ingredient Picrorhiza

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Picrorhiza is used in traditional medicine, but human safety data are limited, so use it with care and watch for side effects. Oral use may cause vomiting, rash, loss of appetite, diarrhea, itching, and dizziness.

The safety information is too sparse during pregnancy and breastfeeding — the data advises against use in both cases. If you're pregnant, planning to become pregnant, or breastfeeding, talk with your doctor or pharmacist before taking this.

Side effects, ingredient by ingredient Picrorhiza

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Picrorhiza.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 207 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before using picrorhiza if you take immunosuppressant drugs (like cyclosporine or tacrolimus) or antidiabetes medications (like insulin, metformin, or sulfonylureas). Both interactions are Moderate severity and could reduce how well your medications work or cause your blood sugar to drop too low.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Picrorhiza might be worth considering if you're exploring traditional remedies for vitiligo and you don't take immunosuppressants or diabetes medications. If you're on either of those drug types, this product isn't a fit without your doctor's supervision.

Talk with your pharmacist before starting, especially if you have any chronic health conditions or take multiple medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Picrorhiza, straight from the product label.

Brand Herbal Terra
Barcode (UPC) 617503517937
Net contents 4 Fluid Ounce(s); 120 mL
Market status On market
Date entered into DSLD Sep 25, 2020
DSLD ID 234110
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Picrorhiza by Herbal Terra, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
1 mL
Servings per container
120
UPC/BARCODE
617503517937
IngredientAmount% DV
Picrorhiza (Picrorhiza kurroa) dried rhizome liquid extract970 mg--

Other ingredients: Menstruum

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Origin of plant material: Nepal.

Manufactured in the USA in an FDA registered facility

Sugar free

Dried herb/menstruum ratio: 1:3 Expertly extracted Laboratory tested 330 mg/1 mL Premium product Super concentrated liquid herbal extract

Non GMO

No artificial ingredients, GMO, gluten, color additives, fillers, preservatives or binders. Natural Gluten Free

Suggested/Recommended/Usage/Directions

Direction Shake well before use. Adults take up to 30 drops (1 mL, one full squeeze of the dropper bulb) in 3-4 fl. oz of juice or water up to 4 times a day. We recommend to seek expert medical advice before taking this or any other herbal supplements.

FDA Disclaimer Statement

Notice This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Caution May have contraindications.

Do not use if you are allergic to any ingredients.

Consult a physician before using during pregnancy, if nursing, or if you are on any medications.

Keep out of the reach of children.

Storage

Store in a cool, dry, dark place.

Formula

Picrorhiza kurroa

FDA Statement of Identity

Herbal Supplement

Seals/Symbols

Made in USA Made in an FDA registered facility Natural Gluten Free

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Picrorhiza by Herbal Terra label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Picrorhiza label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Picrorhiza by Herbal Terra

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 mL Dosage formLiquid Servings per container120 Amounts shown are per serving.

Picrorhiza (Picrorhiza kurroa) dried rhizome liquid extract

Interacts with
207 drugs
970 mg per serving

Picrorhiza (Picrorhiza kurroa) is a bitter Himalayan herb used in Ayurvedic medicine, mainly for liver and digestive complaints. Early lab and small h...

Picrorhiza (Picrorhiza kurroa) dried rhizome liquid extract monograph & interactions

Other (inactive) ingredients: Menstruum. These complete the product’s ingredient list but are not active constituents.

Interaction report

Picrorhiza by Herbal Terra Drug Interactions

Want to check YOUR meds against Picrorhiza?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
207Drugs
207 Moderate

Ingredients driving the most interactions

Picrorhiza (Picrorhiza kurroa) dried rhizome liquid extract 207

Individual Drug Interactions

The ingredients in Picrorhiza interact with 207 drugs. Click any drug to see the details.

1 of the 1 ingredient in Picrorhiza interact with drugs. Each result below shows which ingredient is responsible. Picrorhiza (Picrorhiza kurroa) dried rhizome liquid extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Picrorhiza with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Picrorhiza (Picrorhiza kurroa) dried rhizome liquid extract2 drug types · 207 drugs

Antidiabetes Drugs

Evidence from animal research suggests that an extract of picrorhiza can reduce fasting and non-fasting blood sugar levels. Theoretically, picrorhiza might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia. Monitor blood glucose levels closely. Dose adjustments might be necessary. Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), and others.

Likelihood Possible Evidence D
Immunosuppressants

Picrorhiza seems to have immunostimulating activity. Theoretically, picrorhiza may interfere with immunosuppressant therapy. Immunosuppressant drugs include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), and other corticosteroids (glucocorticoids).

Likelihood Possible Evidence D
Picrorhiza (Picrorhiza kurroa) dried rhizome liquid extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Picrorhiza, from the product label.

Herbal Terra

See all Herbal Terra products
Name
Herbal Terra
Pharmacist Counseling Corner

Picrorhiza by Herbal Terra: Common Questions

Does Picrorhiza by Herbal Terra interact with any medications?
Yes. Based on its ingredients, Picrorhiza has a known interaction with 207 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Picrorhiza contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Picrorhiza if I'm on immunosuppressant medication?
No — not without talking to your doctor first. Picrorhiza seems to rev up your immune system, which could interfere with drugs like cyclosporine or tacrolimus that are meant to calm it down. This is a Moderate severity interaction, so it's not something to manage on your own.
Will Picrorhiza lower my blood sugar?
Animal research suggests it could. If you take diabetes medications, combining them with picrorhiza might drop your blood sugar too low. You'd need to monitor closely and possibly adjust your dose with your doctor's help.
What side effects might I experience?
Common ones from oral use include vomiting, rash, loss of appetite, diarrhea, itching, and dizziness. Stop and talk to your doctor if any of these happen or don't go away.
Is picrorhiza safe during pregnancy or breastfeeding?
No — there isn't enough safety information. The data advise against it in both cases. If you're pregnant, planning pregnancy, or breastfeeding, skip this product and talk with your doctor or pharmacist about safer alternatives.
Does picrorhiza work for asthma or COPD?
For asthma, it's rated possibly ineffective. For COPD, we don't have enough reliable evidence to say one way or the other. If you're looking for asthma support, there are better-studied options to discuss with your doctor.
What's the 'menstruum' listed in the ingredients?
That's the liquid base used to extract picrorhiza's active compounds — it's a standard inactive ingredient in liquid herbal extracts, not a therapeutic agent itself.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Picrorhiza label
Go deeper

The Full Monographs Behind Picrorhiza’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Picrorhiza

Interacts with 207 drugs

Picrorhiza (Picrorhiza kurroa) is a bitter Himalayan herb used in Ayurvedic medicine, mainly for liver and digestive complaints. Early lab and small human studies suggest possible liver-prot...

Read the full Picrorhiza monograph →
Sources

Sources & How We Checked

Picrorhiza's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Picrorhiza 7 references
  1. Sharma ML, Rao CS, Duda PL. Immunostimulatory activity of Picrorhiza kurroa leaf extract. J Ethnopharmacol 1994;41:185-92. PubMed
  2. Bedi KL, Zutshi U, Chopra CL, Amla V. Picrorhiza kurroa, an ayurvedic herb, may potentiate photochemotherapy in vitiligo. J Ethnopharmacol 1989;27:347-52. PubMed
  3. Vaidya AB, Antarkar DS, Doshi JC, et al. Picrorhiza kurroa (Kutaki) Royle ex Benth as a hepatoprotective agent--experimental & clinical studies. J Postgrad Med 1996;42:105-8.
  4. Baruah CC, Gupta PP, Nath A, et al. Anti-allergic and anti-anaphylactic activity of picroliv--a standardised iridoid glycoside fraction of Picrorhiza kurroa. Pharmacol Res 1998;38:487-92.
  5. Doshi VB, Shetye VM, Mahashur AA, Kamat SR. Picrorrhiza kurroa in bronchial asthma. J Postgrad Med 1983;29:89-95.
  6. Joy, K. L. and Kuttan, R. Anti-diabetic activity of Picrorrhiza kurroa extract. J Ethnopharmacol 11-1-1999;67(2):143-148. PubMed
  7. Brockwell C, Ampikaipakan S, Sexton DW, Price D, Freeman D, Thomas M, Ali M, Wilson AM. Adjunctive treatment with oral AKL1, a botanical nutraceutical, in chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis 2014;9:715-21. PubMed

See these in context on the Picrorhiza monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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