Interactions on record — worth a quick check against your medications. Based on 1 of 5 ingredients. Check your meds →
Dietary supplement

PinePower Plus Ingredients & Drug Interactions

by North American Herb & Spice

PinePower Plus label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking PinePower Plus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

PinePower Plus is a dietary supplement by North American Herb & Spice with 5 active ingredients. Its ingredients are commonly taken for blood sugar support, weight management, digestive upset.Based on those ingredients, 162 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Apple Cider Vinegar, Raw. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against PinePower Plus by North American Herb & Spice

Ask about any prescription or over-the-counter medication and we check it for interactions with PinePower Plus by North American Herb & Spice — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of PinePower Plus by North American Herb & Spice

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 5 active ingredients.

PinePower Plus is a 5-ingredient liquid formula. The active ingredient we have data on is raw apple cider vinegar, a fermented apple product.

The product also contains purified water, an ingredient called P73, red and white pine needle extract (raw), and spruce needle extract (raw). We don't hold detailed information on P73, the pine extracts, or the spruce extract, so we can't tell you exactly what role they play in this formula.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: healthy immune support and cleansing.
  • We looked for evidence on: immune function, pathogen clearance.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The effectiveness data we hold for apple cider vinegar covers six potential uses — acne, athletic performance, cognitive function, dental plaque, depression, and atopic dermatitis (eczema) — but for all of them, the evidence is insufficient to rate. That means research either hasn't been done on these uses, or the studies so far don't give us a clear answer.

We don't hold effectiveness ratings for the other ingredients in this product.

The evidence, ingredient by ingredient Apple Cider Vinegar

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Apple cider vinegar in food amounts is generally well tolerated. However, at larger medicinal doses or when used long-term, safety is less clear.

Serious side effects are rare but have been reported with long-term high-dose use: low potassium levels, elevated renin (a kidney hormone), and osteoporosis. One documented case involved someone drinking 250 mL (about 8 ounces) per day for 6 years.

Topically (on skin), apple cider vinegar can cause chemical burns and skin irritation — never apply it directly to your skin without medical guidance. We don't hold pregnancy or breastfeeding safety data for any ingredient in this product, so talk with your doctor or pharmacist if you're pregnant, planning to become pregnant, or breastfeeding.

Side effects, ingredient by ingredient Apple Cider Vinegar

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Apple Cider Vinegar.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; heart-rhythm medications.
  • For scale: 162 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking PinePower Plus, double-check with your doctor or pharmacist if you take diuretic drugs (water pills) or digoxin (Lanoxin) — both carry a Moderate interaction risk with the apple cider vinegar in this product. Also check if you take insulin or antidiabetes drugs, as a Minor interaction is possible.

No interactions are documented for the other ingredients we reviewed.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

PinePower Plus may be worth considering if you're interested in apple cider vinegar's potential benefits, but it's not appropriate if you take diuretics, digoxin, insulin, or other diabetes medications without first checking with your doctor or pharmacist. The evidence for its claimed uses isn't established yet.

Have a conversation with your own healthcare provider about whether this product fits your health situation before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about PinePower Plus, straight from the product label.

Brand North American Herb & Spice
Barcode (UPC) 635824009184
Net contents 8 Fluid Ounce(s); 240 mL
Market status On market
Date entered into DSLD Mar 22, 2024
DSLD ID 307957
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for PinePower Plus by North American Herb & Spice, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablespoon(s)
Maximum serving Sizes:
1 Tablespoon(s)
Servings per container
23
UPC/BARCODE
635824009184
IngredientAmount% DV
Water, Purified0 NP--
P730 NP--
Apple Cider Vinegar, Raw0 NP--
Red & White Pine Needle Extract, Raw0 NP--
Spruce Needle Extract, Raw, Wild0 NP--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Take one tablespoon daily in juice, water, or smoothies. Do not put in hot water, as this will kill the enzymes. Shake well before using.

Formula

Raw, red and white, Pine Power Plus pine needle extract is fresh, wild, handpicked pine needles from northern forests. It is unique due to all of the tree energy being retained within the extract (no heat used). Fortified with raw, wild spruce needle extract, use this fresh infusion to support the health of all the cleansing mechanisms and immune support. Pine needle extract has traditionally been used to support healthy detoxification. Pine Power Plus contains naturally occurring terpenes, shikimic acid, is high in antioxidants and supports a healthy cardiovascular system.

Raw red & white pine needle extract

Natural source of wild terpenes-plus

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

Healthy immune support & cleansing

A 100% raw, wild food extract

Remote-source, non-GMO, solvent-free

FDA Statement of Identity

Dietary Supplement

General Statements

1-847-473-4700

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

PinePower Plus by North American Herb & Spice label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

PinePower Plus label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in PinePower Plus by North American Herb & Spice

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablespoon(s) Dosage formLiquid Servings per container23 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Water, Purified

0 NP per serving

P73

0 NP per serving Form: Oregano Oil, Wild

Apple Cider Vinegar, Raw

Interacts with
162 drugs
0 NP per serving

Apple cider vinegar is a fermented apple product that many people use hoping to help with blood sugar, weight, or digestion. The evidence for most of...

Apple Cider Vinegar, Raw monograph & interactions

Red & White Pine Needle Extract, Raw

0 NP per serving

Spruce Needle Extract, Raw, Wild

0 NP per serving
Interaction report

PinePower Plus by North American Herb & Spice Drug Interactions

Want to check YOUR meds against PinePower Plus?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
162Drugs
89 Moderate 73 Minor

Ingredients driving the most interactions

Apple Cider Vinegar, Raw 162

Individual Drug Interactions

The ingredients in PinePower Plus interact with 162 drugs. Click any drug to see the details.

1 of the 5 ingredients in PinePower Plus interact with drugs. Each result below shows which ingredient is responsible. Apple Cider Vinegar, Raw

Each ingredient & the kinds of drugs it affects

For each ingredient in PinePower Plus with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Apple Cider Vinegar, Raw4 drug types · 162 drugs

Digoxin (Lanoxin)

Theoretically, concomitant use of apple cider vinegar with digoxin might increase the risk of cardiac toxicity.
A case of hypokalemia related to chronic use of apple cider vinegar has been reported. Theoretically, overuse of apple cider vinegar could decrease potassium levels, increasing the risk of toxicity with digoxin.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, concomitant use of apple cider vinegar with diuretic drugs might increase the risk of hypokalemia.
A case of hypokalemia related to chronic use of apple cider vinegar has been reported. There is some concern that people taking apple cider vinegar along with potassium depleting diuretics might have an increased risk for hypokalemia.

Likelihood Possible Evidence D
Insulin

Theoretically, concomitant use of apple cider vinegar with insulin might increase the risk of hypokalemia.
A case of hypokalemia related to chronic use of apple cider vinegar has been reported. Theoretically, overuse of apple cider vinegar concomitantly with insulin might increase the risk of hypokalemia.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking apple cider vinegar with antidiabetes drugs might increase the risk of hypoglycemia.
Apple cider vinegar might reduce fasting and postprandial blood glucose levels and decrease gastric emptying in people with diabetes. However, not all research agrees. Theoretically, it might have additive effects on glucose levels when used with antidiabetes drugs.

Likelihood Possible Evidence B
Apple Cider Vinegar, Raw full monograph & interactions
The maker

Brand information

Manufacturer and brand details for PinePower Plus, from the product label.

North American Herb & Spice

See all North American Herb & Spice products
Name
North American Herb & Spice
Street Address
13900 W. Polo Trail Drive
City
Lake Forest
State
IL
ZipCode
60045
Phone Number
1-800-243-5242
Web Address
www.oreganol.com
Pharmacist Counseling Corner

PinePower Plus by North American Herb & Spice: Common Questions

Does PinePower Plus by North American Herb & Spice interact with any medications?
Yes. Based on its ingredients, PinePower Plus has a known interaction with 162 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
PinePower Plus contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is apple cider vinegar supposed to do?
We hold effectiveness data for six potential uses — acne, athletic performance, cognitive function, dental plaque, depression, and eczema — but for all of them, the evidence is currently insufficient to rate. That means we don't have strong research backing any of these claims yet. Talk with your doctor about what you're hoping this product will do for you.
Is apple cider vinegar safe to take every day?
In food amounts, yes — it's generally well tolerated. But we know little about the safety of large supplement doses taken long-term. High-dose chronic use has been linked to low potassium, kidney changes, and bone loss in rare cases. If you're thinking about taking this regularly, check with your doctor or pharmacist first.
Can I put this on my skin?
No. Apple cider vinegar applied directly to skin can cause chemical burns, irritation, and skin erosion. Never use this product topically without explicit guidance from your doctor.
What are P73, the pine needle extract, and spruce needle extract in this product?
We don't hold detailed information on those ingredients, so we can't tell you exactly what they're meant to do or whether they interact with medications. Contact the manufacturer or your pharmacist if you want specifics about them.
Is it safe to take if I'm pregnant or breastfeeding?
We don't hold pregnancy or breastfeeding safety data for any ingredient in this product. Talk with your doctor or pharmacist before taking it if you're pregnant, planning pregnancy, or breastfeeding — they can give you personalized advice.
What's inside the bottle besides apple cider vinegar?
Purified water, an ingredient called P73, red and white pine needle extract (raw), and spruce needle extract (raw). There are no inactive fillers or binders listed.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if PinePower Plus is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

PinePower Plus label
Go deeper

The Full Monographs Behind PinePower Plus’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Apple Cider Vinegar

Interacts with 162 drugs

Apple cider vinegar is a fermented apple product that many people use hoping to help with blood sugar, weight, or digestion. The evidence for most of these uses is limited and mixed, and the...

Read the full Apple Cider Vinegar monograph →
Sources

Sources & How We Checked

PinePower Plus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Apple Cider Vinegar 11 references
  1. Lhotta K, Hofle G, Gasser R, Finkenstedt G. Hypokalemia, hyperreninemia, and osteoporosis in a patient ingesting large amounts of cider vinegar. Nephron 1998;80:242-3. PubMed
  2. Hill LL, Woodruff LH, Foote JC, Barreto-Alcoba M. Esophageal injury by apple cider vinegar tablets and subsequent evaluation of products. J Am Diet Assoc 2005;105:1141-4. PubMed
  3. Hlebowicz J, Darwiche G, Björgell O, Almér LO. Effect of apple cider vinegar on delayed gastric emptying in patients with type 1 diabetes mellitus: a pilot study. BMC Gastroenterol 2007;7:46. PubMed
  4. Johnston CS, Kim CM, Buller AJ. Vinegar improves insulin sensitivity to a high-carbohydrate meal in subjects with insulin resistance or type 2 diabetes. Diabetes Care 2004;27:281-2. PubMed
  5. Lhotta, K., Hofle, G., Gasser, R., and Finkenstedt, G. Hypokalemia, hyperreninemia and osteoporosis in a patient ingesting large amounts of cider vinegar. Nephron 1998;80(2):242-243. PubMed
  6. Bunick CG, Lott JP, Warren CB, et al. Chemical burn from topical apple cider vinegar. J Am Acad Dermatol 2012;67(4):e143-4. PubMed
  7. Feldstein S, Afshar M, Krakowski AC. Chemical Burn from Vinegar Following an Internet-based Protocol for Self-removal of Nevi. J Clin Aesthet Dermatol. 2015 Jun;8(6):50.
  8. Luu LA, Flowers RH, Kellams AL, et al. Apple cider vinegar soaks [0.5%] as a treatment for atopic dermatitis do not improve skin barrier integrity. Pediatr Dermatol. 2019;36(5):634-639. PubMed
  9. Hadi A, Pourmasoumi M, Najafgholizadeh A, Clark CCT, Esmaillzadeh A. The effect of apple cider vinegar on lipid profiles and glycemic parameters: a systematic review and meta-analysis of randomized clinical trials. BMC Complement Med Ther 2021;21(1):179. PubMed
  10. Feise NK, Johnston CS. Commercial vinegar tablets do not display the same physiological benefits for managing postprandial glucose concentrations as liquid vinegar. J Nutr Metab 2020;2020:9098739. PubMed
  11. Gheflati A, Bashiri R, Ghadiri-Anari A, Reza JZ, Kord MT, Nadjarzadeh A. The effect of apple vinegar consumption on glycemic indices, blood pressure, oxidative stress, and homocysteine in patients with type 2 diabetes and dyslipidemia: A randomized contro

See these in context on the Apple Cider Vinegar monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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