PM Gummies Ingredients & Drug Interactions
What is this page for?
First and foremost: checking PM Gummies against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
PM Gummies is a dietary supplement by Steve's Goods with 4 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 205 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sodium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against PM Gummies by Steve's Goods
Ask about any prescription or over-the-counter medication and we check it for interactions with PM Gummies by Steve's Goods — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of PM Gummies by Steve's Goods
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
PM Gummies has two active ingredients: sodium and cannabinol. Sodium is an essential mineral that plays a role in nerve and muscle function, though the product facts here focus on its use in specific conditions like cystic fibrosis.
Cannabinol (CBN) is a compound derived from cannabis; we hold no interaction data for it. The rest of the gummy is made up of inactive ingredients — tapioca syrup, cane sugar, pear, pectin, citric acid, sodium citrate, malic acid, natural flavors, natural colors, and CBN isolate.
Does it work?
Strong evidence
Sodium is likely effective for cystic fibrosis and possibly effective for reducing amphotericin B nephrotoxicity (kidney damage from an antifungal drug). For bipolar disorder and congestive heart failure, the evidence is too thin to rate — we don't have reliable data yet.
The effectiveness of cannabinol for any condition is not established in the data we hold.
How safe is it?
Well-documented data
Sodium is well tolerated at normal dietary amounts up to the recommended daily limit of 2.3 grams. However, high intake — whether from diet or supplements — is linked to high blood pressure, heart strain, and kidney stress in the long term.
The safety data on cannabinol in pregnancy and lactation shows conflicting results: pregnancy data are insufficient to know either way, but lactation data suggest it may be unsafe — talk to your pharmacist or doctor for personalized advice if you're pregnant or nursing. Rare serious side effects of excess sodium include worsened heart disease, high blood pressure, and kidney problems.
High sodium intake is also associated with an increased risk of gastric cancer in population studies.
Meds to double-check
Moderate interaction found
Before you take this, double-check if you're on any blood pressure drugs — sodium can make them less effective. Also flag it if you take lithium, corticosteroids, didanosine, sodium phosphate, tolvaptan, or any other sodium-containing medications.
These all have documented Moderate interactions with sodium.
The bottom line
Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
PM Gummies might be worth considering if you have cystic fibrosis or need sodium for a specific medical reason, but this isn't a supplement most people should take without talking to their doctor first. If you take blood pressure medication, lithium, or any steroid drug, you especially need to check your medications against the list on this page before starting.
Talk to your pharmacist to make sure it fits your health picture.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about PM Gummies, straight from the product label.
| Brand | Steve's Goods |
|---|---|
| Barcode (UPC) | 850015872860 |
| Net contents | 5.29 Oz(s); 150 Gram(s); 45 Cube(s) |
| Market status | On market |
| Date entered into DSLD | Mar 25, 2021 |
| DSLD ID | 246987 |
| Product type | Other Combinations |
| Supplement form | Gummy Or Jelly |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for PM Gummies by Steve's Goods, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 10 Calorie(s) | -- |
| Total Carbohydrates | 2 Gram(s) | 1% |
| Sugar | 2 Gram(s) | -- |
| Sodium | 15 mg | -- |
| Total Fat | 0 Gram(s) | -- |
| Protein | 0 Gram(s) | -- |
| Cannabinol | 5 mg | -- |
Other ingredients: Tapioca Syrup, Cane Sugar, Pear, Pectin, Citric Acid, Sodium Citrate, Malic Acid, Natural flavors, Natural colors, CBN Isolate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Directions: Take one or two gummies daily, and preferably 30 minutes before bed time.
Formula
Each gummy contains 5mg of Cannabinol (CBN), and is made from Colorado hemp extract isolate. With 45 gummies total, this bottle contains 225mg of Colorado Hemp extract CBN.
CBN Isolate 5mg of CBN per gummy 225mg Total
Precautions
Warning: This product is made with CBN extracted from hemp. It contains <0.3% THC, and is in full compliance with the Farm Bill of 2018. Use with caution if subject to employee or contract urinalysis.
If you are pregnant, nursing, or have a medical condition, seek advice from a medical professional before using this product.
Keep out of reach of children.
Packaged in the same facility as peanuts, tree nuts, wheat, soy, and milk products.
FDA Disclaimer Statement
This product is not intended to diagnose, treat, cure or prevent any disease.
The FDA has not evaluated this product for safety and efficacy.
Formulation
Non GMO
Vegan
Gluten free
Proud product of Colorado.
Storage
Store in a cool, dry place.
Seals/Symbols
Lab Tested for Quality
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
PM Gummies by Steve's Goods label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in PM Gummies by Steve's Goods
These are the 4 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Gummy(ies) Dosage formGummy Or Jelly Servings per container45 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Sugar
Sodium
Interacts with205 drugs
Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...
Sodium monograph & interactionsProtein
Cannabinol
Other (inactive) ingredients: Tapioca Syrup, Cane Sugar, Pear, Pectin, Citric Acid, Sodium Citrate, Malic Acid, Natural flavors, Natural colors, CBN Isolate. These complete the product’s ingredient list but are not active constituents.
PM Gummies by Steve's Goods Drug Interactions
HelloPharmacist Interaction Report
PM Gummies by Steve's Goods contains sodium, which interacts with a number of medications.
The most serious concern is with blood pressure drugs (antihypertensives): high sodium intake can reduce how well they work, potentially making it harder to control your blood pressure.
Read the full breakdown — every affected drug type, severity by severity
Sodium also has Moderate interactions with several other drug types. If you take lithium (a mood stabilizer), sodium can shift its blood levels — high sodium lowers lithium levels, while low sodium can raise them dangerously.
You'll also want to check if you're on corticosteroids, didanosine (an HIV medication), sodium phosphate, tolvaptan (a vasopressin antagonist), or any other sodium-containing drugs, as combining them with extra sodium increases the risk of high blood sodium (hypernatremia).
We could not check the interaction data for cannabinol, the product's second active ingredient.
Altogether, these interactions span 203 individual medications. Use the medication checker on this page to look up your exact drugs before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against PM Gummies?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in PM Gummies interact with 205 drugs. Click any drug to see the details.
1 of the 4 ingredients in PM Gummies interact with drugs. Each result below shows which ingredient is responsible. Sodium
Betamethasone DipropionateSernivo
How Betamethasone Dipropionate interacts with PM Gummies — through 1 ingredient. Tap an ingredient for the detail:
SodiumCorticosteroids Moderate
Interaction Summary
Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Read the full Sodium + Betamethasone Dipropionate interactionBetamethasone Dipropionate, CalcipotrieneEnstilar, Wynzora
How Betamethasone Dipropionate, Calcipotriene interacts with PM Gummies — through 1 ingredient. Tap an ingredient for the detail:
SodiumCorticosteroids Moderate
Interaction Summary
Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Read the full Sodium + Betamethasone Dipropionate, Calcipotriene interactionBetamethasone ValerateLuxiq
How Betamethasone Valerate interacts with PM Gummies — through 1 ingredient. Tap an ingredient for the detail:
SodiumCorticosteroids Moderate
Interaction Summary
Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Read the full Sodium + Betamethasone Valerate interactionBetaxololBetoptic, Kerlone
How Betaxolol interacts with PM Gummies — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Betaxolol interactionBisoprololZebeta
How Bisoprolol interacts with PM Gummies — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Bisoprolol interactionBisoprolol, HydrochlorothiazideZiac
How Bisoprolol, Hydrochlorothiazide interacts with PM Gummies — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Bisoprolol, Hydrochlorothiazide interactionBosentanTracleer
How Bosentan interacts with PM Gummies — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Bosentan interactionBudesonideEntocort EC, Eohilia, Pulmicort, Tarpeyo, Uceris
How Budesonide interacts with PM Gummies — through 1 ingredient. Tap an ingredient for the detail:
SodiumCorticosteroids Moderate
Interaction Summary
Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Read the full Sodium + Budesonide interactionBumetanideBurinex
How Bumetanide interacts with PM Gummies — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Bumetanide interactionBumetanide (iv)Bumex
How Bumetanide (iv) interacts with PM Gummies — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Bumetanide (iv) interactionBumetanide (oral)Bumex
How Bumetanide (oral) interacts with PM Gummies — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Bumetanide (oral) interactionCandesartan CilexetilAmias, Atacand
How Candesartan Cilexetil interacts with PM Gummies — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Candesartan Cilexetil interactionCandesartan Cilexetil, HydrochlorothiazideAtacand HCT
How Candesartan Cilexetil, Hydrochlorothiazide interacts with PM Gummies — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Candesartan Cilexetil, Hydrochlorothiazide interactionCaptoprilAcepril, Capoten
How Captopril interacts with PM Gummies — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Captopril interactionCaptopril, HydrochlorothiazideAcezide, Capozide
How Captopril, Hydrochlorothiazide interacts with PM Gummies — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Captopril, Hydrochlorothiazide interactionCarteololCartrol, Ocupress
How Carteolol interacts with PM Gummies — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Carteolol interactionCarvedilolCoreg, Coreg CR
How Carvedilol interacts with PM Gummies — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Carvedilol interactionCeliprololCelicard
How Celiprolol interacts with PM Gummies — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Celiprolol interactionChlorothiazideDiuril
How Chlorothiazide interacts with PM Gummies — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Chlorothiazide interactionChlorothiazide, MethyldopaAldochlor, Aldoclor 150, Aldoclor 250
How Chlorothiazide, Methyldopa interacts with PM Gummies — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Chlorothiazide, Methyldopa interactionChlorothiazide, ReserpineDiupres
How Chlorothiazide, Reserpine interacts with PM Gummies — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Chlorothiazide, Reserpine interactionChlorthalidoneHygroton, Thalitone
How Chlorthalidone interacts with PM Gummies — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Chlorthalidone interactionChlorthalidone, ClonidineClorpres, Combipres
How Chlorthalidone, Clonidine interacts with PM Gummies — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Chlorthalidone, Clonidine interactionCilazaprilInhibace
How Cilazapril interacts with PM Gummies — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Cilazapril interactionClevidipineCleviprex
How Clevidipine interacts with PM Gummies — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Clevidipine interactionClobetasolClobex, Temovate
How Clobetasol interacts with PM Gummies — through 1 ingredient. Tap an ingredient for the detail:
SodiumCorticosteroids Moderate
Interaction Summary
Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Read the full Sodium + Clobetasol interactionClonidineCatapres
How Clonidine interacts with PM Gummies — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Clonidine interactionCortisone AcetateCortisone Tablets, Cortone
How Cortisone Acetate interacts with PM Gummies — through 1 ingredient. Tap an ingredient for the detail:
SodiumCorticosteroids Moderate
Interaction Summary
Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Read the full Sodium + Cortisone Acetate interactionCryptenamine, MethyclothiazideDiutensen
How Cryptenamine, Methyclothiazide interacts with PM Gummies — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Cryptenamine, Methyclothiazide interactionCyclothiazideAnhydron, Fluidil
How Cyclothiazide interacts with PM Gummies — through 1 ingredient. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Cyclothiazide interactionEach ingredient & the kinds of drugs it affects
For each ingredient in PM Gummies with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Sodium
Antihypertensive Drugs
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.
Corticosteroids
Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.
Didanosine (Videx)
Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.
Lithium
Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.
Sodium Phosphates
Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.
Sodium-Containing Drugs
Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.
Tolvaptan (Samsca)
Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.
Brand information
Manufacturer and brand details for PM Gummies, from the product label.
Steve's Goods
See all Steve's Goods products- Name
- Steve's Distributing LLC
- Street Address
- 1500 Kansas Ave Unit 2-C
- City
- Longmont
- State
- CO
- ZipCode
- 80501
- Phone Number
- (720) 727-9197
- Web Address
- StevesGoods.com
PM Gummies by Steve's Goods: Common Questions
Does PM Gummies by Steve's Goods interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is this safe to take if I'm pregnant or breastfeeding?
What is sodium doing in a gummy?
What's cannabinol (CBN), and does it actually work?
Can I just take this with my normal diet, or will it give me too much sodium?
What if I'm taking blood pressure medication?
Are there any side effects from sodium in these gummies?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if PM Gummies is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind PM Gummies’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
PM Gummies's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 38 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Sodium 38 references
- Garabedian-Ruffalo SM, Ruffalo RL. Drug and nutrient interactions. Am Fam Physician 1986;33:165-74.
- Food and Drug Administration Science Background: Safety of Sodium Phosphates Oral Solution. September 17, 2001. Available at: http://www.fda.gov/cder/drug/safety/sodiumphospate.htm
- Coton T, Mallaret C, Coilliot C, Carre D, Guisset M. Severe acute ulcerated gastritis induced by salt. Presse Med 2009;38(3):499-500. PubMed
- Frings-Meuthen P, Buehlmeier J, Baecker N, et al. High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses. J Appl Physiol 2011;111(2):537-542. PubMed
- Frings-Meuthen P, Baecker N, Heer M. Low-grade metabolic acidosis may be the cause of sodium chloride-induced exaggerated bone resorption. J Bone Miner Res 2008;23(4):517-524. PubMed
- Alam S, Johnson AG. A meta-analysis of randomised controlled trials (RCT) among healthy normotensive and essential hypertensive elderly patients to determine the effect of high salt (NaCl) diet of blood pressure. J Hum Hypertens 1999;13(6):367-74.
- Boudville N, Ward S, Benaroia M, House AA. Increased sodium intake correlates with greater use of antihypertensive agents by subjects with chronic kidney disease. Am J Hypertens 2005;18(10):1300-5. PubMed
- Bennett WM. Drug interactions and consequences of sodium restriction. Am J Clin Nutr 1997;65(2 Suppl):678S-681S. PubMed
- Okusa MD, Crystal LJ. Clinical manifestations and management of acute lithium intoxication. Am J Med 1994;97(4):383-9. PubMed
- Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for water, potassium, sodium, chloride, and sulfate. Washington, DC: National Academy Press, 2005. Available at: http://www.nap.edu/openbook.php?record_id=10925. DOI
- D'Elia L, Rossi G, Ippolito R, Cappuccio FP, Strazzullo P. Habitual salt intake and risk of gastric cancer: a meta-analysis of prospective studies. Clin Nutr 2012;31(4):489-98. PubMed
- Goldsmith SR. Hyponatremia in heart failure: time for a trial. J Card Fail 2013;19(6):398-400. PubMed
- Willocks L, Brettle R, Keen J, Valentine C, Pinching AJ. Formulations of didanosine (ddI) and salt overload. Lancet 1992;339(8786):190.
- Chen L, Zhang Z, Chen W, Whelton PK, Appel LJ. Lower Sodium Intake and Risk of Headaches: Results From the Trial of Nonpharmacologic Interventions in the Elderly. Am J Public Health. 2016;106(7):1270-5. PubMed
- Cook NR, Appel LJ, Whelton PK. Lower levels of sodium intake and reduced cardiovascular risk. Circulation. 2014;129(9):981-9. PubMed
- Cook NR, Appel LJ, Whelton PK. Sodium Intake and All-Cause Mortality Over 20 Years in the Trials of Hypertension Prevention. J Am Coll Cardiol. 2016;68(15):1609-1617. PubMed
- Mente A, O'Donnell M, Rangarajan S, et al. Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension: a pooled analysis of data from four studies. Lancet. 2016;388(10043):465-75. PubMed
- Moosavian SP, Haghighatdoost F, Surkan PJ, Azadbakht L. Salt and obesity: a systematic review and meta-analysis of observational studies. Int J Food Sci Nutr. 2017;68(3):265-277. PubMed
- O'Donnell M, Mente A, Rangarajan S, et al. Urinary sodium and potassium excretion, mortality, and cardiovascular events. N Engl J Med. 2014;371(7):612-23. DOI
- Poggio R, Gutierrez L, Matta MG, Elorriaga N, Irazola V, Rubinstein A. Daily sodium consumption and CVD mortality in the general population: systematic review and meta-analysis of prospective studies. Public Health Nutr. 2015;18(4):695-704. PubMed
- Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad
- Mahtani KR, Heneghan C, Onakpoya I, et al. Reduced Salt Intake for Heart Failure: A Systematic Review. JAMA Intern Med. 2018 Dec 1;178(12):1693-1700. PubMed
- Yancy CW. Sodium Restriction in Heart Failure: Too Much Uncertainty-Do the Trials. JAMA Intern Med. 2018 Dec 1;178(12):1700-1701. PubMed
- He FJ, Campbell NRC, Ma Y, MacGregor GA, Cogswell ME, Cook NR. Errors in estimating usual sodium intake by the Kawasaki formula alter its relationship with mortality: implications for public health. Int J Epidemiol. 2018;47(6):1784-1795. PubMed
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