Interactions on record — worth a quick check against your medications. Based on 5 of 11 ingredients. Check your meds →
Dietary supplement

Prebiotic Plus Probiotic 2 Billion Ingredients & Drug Interactions

by Spring Valley

Prebiotic Plus Probiotic 2 Billion label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Prebiotic Plus Probiotic 2 Billion against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Prebiotic Plus Probiotic 2 Billion is a dietary supplement by Spring Valley with 11 active ingredients. Its ingredients are commonly taken for digestive health and regularity, infant colic and gut support, diarrhea (including antibiotic-related).Based on those ingredients, 268 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bifidobacterium breve, Lactobacillus acidophilus, Bifidobacterium longum. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Prebiotic Plus Probiotic 2 Billion by Spring Valley

Ask about any prescription or over-the-counter medication and we check it for interactions with Prebiotic Plus Probiotic 2 Billion by Spring Valley — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Prebiotic Plus Probiotic 2 Billion by Spring Valley

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 11 active ingredients.
  • “Proprietary Probiotic Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

Prebiotic Plus Probiotic 2 Billion contains 11 active ingredients: a proprietary probiotic blend of six live bacterial strains (Bifidobacterium breve, Lactobacillus acidophilus, Bifidobacterium longum, Bifidobacterium animalis lactis, Lactobacillus plantarum, Lactobacillus casei, Lactobacillus paracasei, Lactobacillus rhamnosus, Lactobacillus reuteri, and Lactobacillus gasseri) plus inulin, a prebiotic fiber that feeds the beneficial bacteria. The inactive ingredients are rice dextrin, a vegetarian capsule, and magnesium stearate.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: promote regularity, healthy digestion and immune support.
  • We looked for evidence on: Antibiotic-associated diarrhea, Constipation, Diarrhea, Dyspepsia, Inflammatory bowel disease (IBD), Irritable bowel syndrome (IBS) — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Irritable bowel syndrome (IBS).
  • Also on file: Inulin is rated "Possibly Effective" for Constipation.

The evidence for these probiotics is mixed. Lactobacillus acidophilus is rated possibly effective for irritable bowel syndrome, Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis.

Inulin is rated possibly effective for obesity, constipation, and diabetes. The other probiotic strains — Bifidobacterium breve, Bifidobacterium longum, Lactobacillus gasseri, and the species we could not check — have insufficient evidence or are rated possibly ineffective for the conditions studied so far.

Your results may depend on your specific health situation.

The evidence, ingredient by ingredient Bifidobacterium Breve Lactobacillus Acidophilus Bifidobacterium Longum Lactobacillus Gasseri Inulin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

These probiotics are generally well tolerated in healthy adults and children, though caution is advised if you're critically ill or have a compromised immune system — there have been rare cases of infection from these bacteria in very sick patients and vulnerable infants. The most common side effects are gastrointestinal: bloating, flatulence, abdominal discomfort, and gas, especially when you first start or at higher doses.

Inulin in particular often causes these symptoms. Limited safety data exist, so talk with your doctor before use if you have any serious health conditions or are pregnant or breastfeeding.

Side effects, ingredient by ingredient Bifidobacterium Breve Lactobacillus Acidophilus Bifidobacterium Longum Lactobacillus Gasseri Inulin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Lactobacillus Acidophilus, Inulin, Bifidobacterium Breve, Bifidobacterium Longum, Lactobacillus Gasseri.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 268 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications if you take antibiotic drugs — probiotics work better when separated from antibiotics by a few hours. If you're on any antidiabetes drugs, talk to your pharmacist about inulin, as it may affect blood sugar control.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is a reasonable choice if you're looking for a multi-strain probiotic and prebiotic combination, especially for digestive support. If you're taking antibiotics, space them out from this product.

If you take diabetes medication or are very ill or immunocompromised, check with your pharmacist first. Start with a low dose to see how your stomach handles it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 11 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Prebiotic Plus Probiotic 2 Billion, straight from the product label.

Brand Spring Valley
Barcode (UPC) 681131156745
Net contents 30 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jul 25, 2018
DSLD ID 178712
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Prebiotic Plus Probiotic 2 Billion by Spring Valley, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
681131156745
IngredientAmount% DV
Proprietary Probiotic Blend0 NP--
Bifidobacterium breve0 NP--
Lactobacillus acidophilus0 NP--
Bifidobacterium longum0 NP--
Bifidobacterium animalis lactis0 NP--
Lactobacillus plantarum0 NP--
Lactobacillus casei0 NP--
Lactobacillus paracasei0 NP--
Lactobacillus rhamnosus0 NP--
Lactobacillus reuteri0 NP--
Lactobacillus gasseri0 NP--
Inulin25 mg--

Other ingredients: Rice Dextrin, Vegetarian Capsule, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Spring Valley Prebiotic Plus Probiotic supplement contains 10 essential probiotic strains and a targeted prebiotic fiber to: Promote regularity and healthy digestion Provide support for a healthy immune system

Quality Guaranteed Spring Valley products are produced under strict quality guidelines. If you are unhappy with this product, we’ll replace it or refund your money.

Formulation

This unique formulation is also designed to maximize its benefit to you by being: Suitable for a Vegan lifestyle Gluten-free Free of major allergens (including eggs, soy, dairy, nut, peanut, wheat, fish, shellfish) Includes inulin prebiotic fiber that support the growth of good bacteria in the digestive system Acid and bile resistant strains Blister sealed capsules for maximum freshness

This unique formulation is also designed to maximize its benefit to you by being: Suitable for a Vegan lifestyle Gluten-free Free of major allergens (including eggs, soy, dairy, nut, peanut, wheat, fish, shellfish) Includes inulin prebiotic fiber that support the growth of good bacteria in the digestive system Acid and bile resistant strains Blister sealed capsules for maximum freshness

No gluten, dairy, soy, peanut, sweetener, preservatives

Formula

This unique formulation is also designed to maximize its benefit to you by being: Suitable for a Vegan lifestyle Gluten-free Free of major allergens (including eggs, soy, dairy, nut, peanut, wheat, fish, shellfish) Includes inulin prebiotic fiber that support the growth of good bacteria in the digestive system Acid and bile resistant strains Blister sealed capsules for maximum freshness

Formulated for inulin as a prebiotic fiber

General Statements

What are probiotics? The human digestive system is home to trillions of bacteria that perform many helpful functions. The healthy balance of good bacteria can be disrupted by diet, travel or stress. Probiotics are beneficial bacteria that can help replenish and support a healthy balance. Probiotic strains are different types of bacteria, each of which may provide different health benefits.

Please recycle

Prebiotic Plus Probiotic 2 Billion active cultures per capsule 10 strains Digestive health Promotes healthy digestion and immune systems.

Delayed release capsules are targeted release Actual size

Product of Canada

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Warning: Consult your physician before using this product if you are pregnant, nursing, trying to conceive, taking medication or have a medical condition.

Keep out of reach of children.

Do not use if seal is broken.

Storage

Store at 73(0)F or below. Do not expose to excessive heat or moisture. No refrigeration required.

General

548643

Suggested/Recommended/Usage/Directions

Suggested Use: For adults, take one (1) capsule daily at mealtime.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Prebiotic Plus Probiotic 2 Billion by Spring Valley label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Prebiotic Plus Probiotic 2 Billion label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Prebiotic Plus Probiotic 2 Billion by Spring Valley

These are the 11 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Probiotic Blend

0 NP per serving

Inulin

Interacts with
86 drugs
25 mg per serving

Inulin is a type of plant fiber (a prebiotic) found naturally in foods like chicory root, onions, and garlic, and it is widely added to supplements an...

Inulin monograph & interactions

Other (inactive) ingredients: Rice Dextrin, Vegetarian Capsule, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Prebiotic Plus Probiotic 2 Billion by Spring Valley Drug Interactions

Want to check YOUR meds against Prebiotic Plus Probiotic 2 Billion?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
268Drugs
182 Moderate 86 Minor

Ingredients driving the most interactions

Bifidobacterium breve 182
Lactobacillus acidophilus 182
Bifidobacterium longum 182
Lactobacillus gasseri 182
Inulin 86

Individual Drug Interactions

The ingredients in Prebiotic Plus Probiotic 2 Billion interact with 268 drugs. Click any drug to see the details.

5 of the 11 ingredients in Prebiotic Plus Probiotic 2 Billion interact with drugs. Each result below shows which ingredient is responsible. Bifidobacterium breve Lactobacillus acidophilus Bifidobacterium longum Lactobacillus gasseri Inulin

Each ingredient & the kinds of drugs it affects

For each ingredient in Prebiotic Plus Probiotic 2 Billion with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Bifidobacterium breve1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B. breve.
Since B. breve preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. breve preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium breve full monograph & interactions

Lactobacillus acidophilus1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus full monograph & interactions

Bifidobacterium longum1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B. longum.
Since B. longum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. longum preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium longum full monograph & interactions

Lactobacillus gasseri1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus gasseri with antibiotic drugs might decrease the effectiveness of L. gasseri.
Lactobacillus gasseri preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. gasseri preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus gasseri full monograph & interactions

Inulin1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, inulin might increase the risk of hypoglycemia with antidiabetes drugs.
Some clinical research shows that inulin improves glycemic control in patients with diabetes; however, it is unclear if it has hypoglycemic effects.

Likelihood Unlikely Evidence D
Inulin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Prebiotic Plus Probiotic 2 Billion, from the product label.

Spring Valley

See all Spring Valley products
Name
Wal-Mart Stores, Inc.
City
Bentonville
State
AR
ZipCode
72716
Phone Number
1-866-251-1662
Web Address
Walmart.com/springvalley
Pharmacist Counseling Corner

Prebiotic Plus Probiotic 2 Billion by Spring Valley: Common Questions

Does Prebiotic Plus Probiotic 2 Billion by Spring Valley interact with any medications?
Yes. Based on its ingredients, Prebiotic Plus Probiotic 2 Billion has a known interaction with 268 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Prebiotic Plus Probiotic 2 Billion contains 11 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this probiotic work if I'm also taking antibiotics?
Not optimally. Antibiotics kill the live bacteria in this product, which defeats the purpose. If your doctor prescribes antibiotics, take them at a different time of day — ideally several hours apart. Once you finish the antibiotic course, you can resume this probiotic.
What does the prebiotic do?
The inulin is a prebiotic fiber that acts as food for the probiotic bacteria, helping them survive and flourish in your gut. Together, the two work as a team to support your digestive system.
Is this product safe during pregnancy?
Bifidobacterium longum is rated possibly safe in pregnancy. We don't have safety data on file for the other probiotic strains or inulin in pregnancy. Talk with your doctor before taking this product while pregnant.
Why am I getting so much gas and bloating?
Bloating, flatulence, and gas are the most common side effects of both probiotics and inulin, especially when you first start or at higher doses. These usually improve as your gut adjusts. Start with one capsule and increase gradually if needed.
Can I take this if I have diabetes?
Inulin in this product may theoretically lower blood sugar. If you're on diabetes medication, talk to your pharmacist before starting this supplement — you may need your blood sugar monitored more closely.
Is this product safe for very sick people?
Caution is needed. There have been rare cases of serious infection from these probiotic bacteria in critically ill patients and vulnerable infants. If you're very ill or have a compromised immune system, check with your doctor before use.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Prebiotic Plus Probiotic 2 Billion is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Prebiotic Plus Probiotic 2 Billion label
Go deeper

The Full Monographs Behind Prebiotic Plus Probiotic 2 Billion’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bifidobacterium Breve

Interacts with 182 drugs

Bifidobacterium breve is a 'friendly' gut bacterium taken as a probiotic, most often to support digestion and balance the gut microbiome. Some studies suggest possible benefits for certain d...

Read the full Bifidobacterium Breve monograph → Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph → Herb & supplement monograph

Bifidobacterium Longum

Interacts with 182 drugs

Bifidobacterium longum is a 'friendly' bacterium found naturally in the human gut and used as a probiotic. It is generally well tolerated and is most studied for digestive issues, though evi...

Read the full Bifidobacterium Longum monograph → Herb & supplement monograph

Lactobacillus Gasseri

Interacts with 182 drugs

Lactobacillus gasseri is a 'friendly' probiotic bacterium found naturally in the human gut, mouth, and vaginal tract, and in some fermented foods. Early research suggests it may help with di...

Read the full Lactobacillus Gasseri monograph → Herb & supplement monograph

Inulin

Interacts with 86 drugs

Inulin is a type of plant fiber (a prebiotic) found naturally in foods like chicory root, onions, and garlic, and it is widely added to supplements and processed foods. It may help with regu...

Read the full Inulin monograph →
Sources

Sources & How We Checked

Prebiotic Plus Probiotic 2 Billion's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 74 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bifidobacterium Breve 9 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  4. Ohishi A, Takahashi S, Ito Y, et al. Bifidobacterium septicemia associated with postoperative probiotic therapy in a neonate with omphalocele. J Pediatr. 2010;156(4):679-81. PubMed
  5. Sakurai Y, Watanabe T, Miura Y, et al. Clinical and bacteriologic characteristics of six cases of Bifidobacterium breve bacteremia due to probiotic administration in the neonatal intensive care unit. Pediatr Infect Dis J 2022;41(1):62-65. PubMed
  6. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
  7. Wakabayashi Y, Nakayama S, Yamamoto A, et al. First case of necrotizing fasciitis and bacteremia caused by Bifidobacteriumbreve. Anaerobe 2022;76:102613.
  8. Takeda Y, Ota K, Kondo A, et al. A case of necrotizing fasciitis caused by Bifidobacterium breve. IDCases 2022;31:e01667. PubMed
  9. Suwantarat N, Romagnoli M, Wakefield T, Carroll KC. Ventriculoperitoneal shunt infection caused by Bifidobacterium breve. Anaerobe 2014;28:1-3. PubMed

See these in context on the Bifidobacterium Breve monograph →

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Bifidobacterium Longum 21 references
  1. Ha GY, Yang CH, Kim H, Chong Y. Case of sepsis caused by Bifidobacterium longum. J Clin Microbiol 1999;37:1227-8.
  2. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  3. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  4. Rautava S, Kainonen E, Salminen S, Isolauri E. Maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of eczema in the infant. J Allergy Clin Immunol. 2012;130(6):1355-60. PubMed
  5. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  6. Pellonperä O, Vahlberg T, Mokkala K, et al. Weight gain and body composition during pregnancy: a randomised pilot trial with probiotics and/or fish oil. Br J Nutr. 2020 Nov 4:1-11. PubMed
  7. Pellonperä O, Mokkala K, Houttu N, et al. Efficacy of fish oil and/or probiotic intervention on the incidence of gestational diabetes mellitus in an at-risk group of overweight and obese women: A randomized, placebo-controlled, double-blind clinical trial PubMed
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
  10. Enomoto T, Sowa M, Nishimori K, et al. Effects of bifidobacterial supplementation to pregnant women and infants in the prevention of allergy development in infants and on fecal microbiota. Allergol Int 2014;63(4):575-85. PubMed
  11. US Food and Drug Administration (FDA). Dear Healthcare Provider Letter: Warning Regarding Use of Probiotics in Preterm Infants. September 2023. Available at: https://www.fda.gov/media/172606/download?attachment. Accessed November 1, 2023.
  12. Pillai A, Tan J, Paquette V, Panczuk J. Does probiotic bacteremia in premature infants impact clinically relevant outcomes? A case report and updated review of literature. Clin Nutr ESPEN. 2020;39:255-259. PubMed
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Lactobacillus Gasseri 12 references
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Inulin 17 references
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See these in context on the Inulin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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