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Dietary supplement

Pregnenolone 100 mg Ingredients & Drug Interactions

by Supplement Spot

Pregnenolone 100 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pregnenolone 100 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pregnenolone 100 mg is a dietary supplement by Supplement Spot with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, anxiety and stress, anti-aging.Based on those ingredients, 82 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pregnenolone. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pregnenolone 100 mg by Supplement Spot

Ask about any prescription or over-the-counter medication and we check it for interactions with Pregnenolone 100 mg by Supplement Spot — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pregnenolone 100 mg by Supplement Spot

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: pregnenolone 100 mg per capsule. Pregnenolone is a hormone precursor — meaning your body uses it as a starting material to make other hormones like estrogen, progesterone, and testosterone.

The capsule also contains gelatin, rice bran, and magnesium stearate as inactive ingredients.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Pregnenolone's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: supports hormonal balance and cognitive function.
  • We looked for evidence on: Memory, Stress, Fatigue, Aging, hormone regulation, mental clarity.
  • The closest evidence on file: Pregnenolone is rated "Insufficient Reliable Evidence To Rate" for Fatigue (Natural Medicines).
  • Also on file: Pregnenolone is rated "Insufficient Reliable Evidence To Rate" for Memory, Stress, Aging.

The evidence we hold on pregnenolone's effectiveness is not established. We have ratings for several conditions — including alcohol use disorder, Alzheimer disease, autism spectrum disorder, back pain, and bipolar disorder — and for all of them the data is insufficient to draw a reliable conclusion.

If you're considering this supplement for a specific health goal, talk with your doctor about what research does exist and whether it's a fit for you.

The evidence, ingredient by ingredient Pregnenolone

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pregnenolone is generally well tolerated when taken by mouth. The most commonly reported side effects in studies include acne, agitation, diarrhea, drowsiness, excitement, hair loss, sweating, and tremor.

A few people have reported skin rashes (one possibly related to sun sensitivity) and changes in mood or appetite, though it's unclear in all cases whether pregnenolone caused them. Because pregnenolone is a hormone with limited human safety data, use it only under guidance from a healthcare professional.

The safety data advises against it during pregnancy due to unknown risks. There isn't enough information to know whether it's safe while breastfeeding — talk with your doctor or pharmacist before use if you're nursing.

Side effects, ingredient by ingredient Pregnenolone

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pregnenolone.
  • The most serious interaction on file is rated Moderate.
  • For scale: 82 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you're on estrogens or birth control (Moderate interaction), benzodiazepines like diazepam or lorazepam used for anxiety or sleep (Moderate), progestin-based medications (Moderate), testosterone therapy (Moderate), or progesterone or progesterone-like drugs (Moderate). Pregnenolone may enhance or reduce the effects of these medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Pregnenolone may be worth considering if you're curious about hormone precursors and have discussed it with your doctor — but the evidence for specific health conditions isn't solid yet. If you take any birth control, hormone therapy, anti-anxiety, or psychiatric medications, you'll want to check with your own doctor or pharmacist before adding this product, as the interactions are real enough to change how those drugs work.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 19, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pregnenolone 100 mg, straight from the product label.

Brand Supplement Spot
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD May 19, 2022
DSLD ID 265192
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pregnenolone 100 mg by Supplement Spot, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
90
IngredientAmount% DV
Pregnenolone100 mg--

Other ingredients: Gelatin, Rice Bran, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Take 1 capsule daily with food and water, or as recommended by your health care professional.

Precautions

Note: Long-term Pregnenolone supplementation should be guided by a healthcare professional's advice as well as regular hormone level testing once or twice per year.

Consult a healthcare professional before using this product, especially if you are pregnant or lactating.

Keep out of reach of children.

Do not use this product if the safety seal on the bottle is broken.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Supports hormonal balance and cognitive function

Formula

Pregnenolone 100 mg per serving

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Formulated in USA

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pregnenolone 100 mg by Supplement Spot label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pregnenolone 100 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pregnenolone 100 mg by Supplement Spot

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Pregnenolone

Interacts with
82 drugs
100 mg per serving

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sol...

Pregnenolone monograph & interactions

Other (inactive) ingredients: Gelatin, Rice Bran, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pregnenolone 100 mg by Supplement Spot Drug Interactions

Want to check YOUR meds against Pregnenolone 100 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
82Drugs
82 Moderate

Ingredients driving the most interactions

Pregnenolone 82

Individual Drug Interactions

The ingredients in Pregnenolone 100 mg interact with 82 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pregnenolone 100 mg interact with drugs. Each result below shows which ingredient is responsible. Pregnenolone

Each ingredient & the kinds of drugs it affects

For each ingredient in Pregnenolone 100 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pregnenolone5 drug types · 82 drugs

Benzodiazepines

Concomitant use of pregnenolone may reduce the effects of benzodiazepines.
Very preliminary clinical research shows that chronic use of pregnenolone reduces sedative effects of diazepam when compared with chronic use of placebo. This effect may be related to the activity of pregnenolone at GABAA receptors.

Likelihood Probable Evidence B
Estrogens

Theoretically, taking pregnenolone might enhance the effects of estrogens.
Pregnenolone is a precursor for several steroid hormones, including estrogens.

Likelihood Possible Evidence D
Progesterone

Theoretically, taking pregnenolone might enhance the effects of progesterone.
In humans, some research shows that oral administration of pregnenolone can increase levels of progesterone. However, other research shows no effect on progesterone levels. It is possible the impact of pregnenolone on progesterone levels may be dose dependent.

Likelihood Possible Evidence D
Progestin

Theoretically, taking pregnenolone might enhance the effects of progestin.
Pregnenolone is a precursor for several steroid hormones, including progestin.

Likelihood Possible Evidence D
Testosterone

Theoretically, taking pregnenolone might enhance the effects of testosterone.
Pregnenolone is a precursor for several steroid hormones, including testosterone. However, preliminary clinical research shows that taking pregnenolone 30-500 mg orally daily for up to 8 weeks does not affect testosterone levels.

Likelihood Possible Evidence D
Pregnenolone full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pregnenolone 100 mg, from the product label.

Supplement Spot

See all Supplement Spot products
Name
Supplement Spot, LLC
Street Address
1828 Touby Pike
City
Kokomo
State
IN
ZipCode
46901
Phone Number
866-285-1998
Web Address
supplementspot.com
Pharmacist Counseling Corner

Pregnenolone 100 mg by Supplement Spot: Common Questions

Does Pregnenolone 100 mg by Supplement Spot interact with any medications?
Yes. Based on its ingredients, Pregnenolone 100 mg has a known interaction with 82 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pregnenolone 100 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is pregnenolone and what does it do in my body?
Pregnenolone is a hormone precursor — a raw material your body converts into other hormones like estrogen, progesterone, and testosterone. It's naturally produced in your adrenal glands and brain. This supplement provides an extra dose of that precursor, though we don't yet have solid evidence that taking it improves specific health conditions.
Can I take this if I'm on birth control?
No — there's a Moderate interaction. Pregnenolone may enhance the effects of estrogens in birth control because it's a building block for those hormones. You need to talk with your doctor or pharmacist before using this product if you're on any birth control or hormone therapy.
Will this help with anxiety or sleep?
We don't have reliable evidence that pregnenolone helps with either. If you take benzodiazepines (like diazepam or lorazepam) for anxiety or sleep, adding pregnenolone could actually reduce how well those medications work, so check with your doctor first.
What are the most common side effects?
The most commonly reported side effects in studies include acne, agitation, drowsiness, diarrhea, excitement, hair loss, sweating, and tremor. A few people have reported skin rashes and mood or appetite changes, though it's not always clear whether pregnenolone caused them.
Is it safe to take if I'm pregnant or breastfeeding?
No — the safety data advises against pregnenolone during pregnancy due to unknown risks. If you're breastfeeding, there isn't enough information to know either way, so talk with your doctor or pharmacist for personalized advice.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pregnenolone 100 mg is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pregnenolone 100 mg label
Go deeper

The Full Monographs Behind Pregnenolone 100 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pregnenolone

Interacts with 82 drugs

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sold as a supplement for memory, mood, and...

Read the full Pregnenolone monograph →
Sources

Sources & How We Checked

Pregnenolone 100 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pregnenolone 6 references
  1. Devlin TM, ed. Textbook of Biochemistry With Clinical Correlations. third ed. New York: Wiley-Liss Inc., 1992.
  2. Fung LK, Libove RA, Phillips J, Haddad F, Hardan AY.Brief report: an open-label study of the neurosteroid pregnenolone in adults with autism spectrum disorder. J Autism Dev Disord 2014;44(11):2971-7. PubMed
  3. Brown ES, Park J, Marx CE, et al. A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depression. Neuropsychopharmacology 2014;39(12):2867-73. PubMed
  4. Ritsner MS, Gibel A, Shleifer T, et al. Pregnenolone and dehydroepiandrosterone as an adjunctive treatment in schizophrenia and schizoaffective disorder: an 8-week, double-blind, randomized, controlled, 2-center, parallel-group trial. J Clin Psychiatry 20 PubMed
  5. Meieran SE, Reus VI, Webster R, Shafton R, Wolkowitz OM. Chronic pregnenolone effects in normal humans: attenuation of benzodiazepine-induced sedation. Psychoneuroendocrinology 2004;29(4):486-500. PubMed
  6. Marx CE, Keefe RS, Buchanan RW, et al. Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia. Neuropsychopharmacology 2009;34(8):1885-903. PubMed

See these in context on the Pregnenolone monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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