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Dietary supplement

Pregnenolone 25 mg Ingredients & Drug Interactions

by Adaptogen Research

Pregnenolone 25 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pregnenolone 25 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pregnenolone 25 mg is a dietary supplement by Adaptogen Research with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, anxiety and stress, anti-aging.Based on those ingredients, 82 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pregnenolone. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pregnenolone 25 mg by Adaptogen Research

Ask about any prescription or over-the-counter medication and we check it for interactions with Pregnenolone 25 mg by Adaptogen Research — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pregnenolone 25 mg by Adaptogen Research

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Pregnenolone 25 mg is a single-ingredient supplement. Pregnenolone is a steroid hormone precursor your body naturally produces—it sits early in the pathway that makes other hormones like estrogen, progesterone, and testosterone.

The capsule itself contains microcrystalline cellulose (a binder), ascorbyl palmitate (a form of vitamin C used as a preservative), and a vegetarian capsule shell.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Pregnenolone product and its label doesn't state a use — see Pregnenolone's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for pregnenolone isn't established in our data. The product facts list six conditions—alcohol use disorder, Alzheimer disease, autism spectrum disorder, back pain, and bipolar disorder—but for all of them, the rating is the same: insufficient reliable evidence to rate.

That means there's not yet enough quality research to say whether pregnenolone works for any of these uses. If you're thinking about it for a specific condition, talk with your doctor about what the current research shows and whether it makes sense for you.

The evidence, ingredient by ingredient Pregnenolone

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pregnenolone is generally well tolerated when taken by mouth. The most common side effects reported in studies include acne, agitation, diarrhea, drowsiness, excitement, hair loss, sweating, and tremor.

A few people have reported skin abscesses, rashes (possibly triggered by sun exposure), changes in appetite, and mood shifts, though it's unclear in all cases whether pregnenolone was the cause. Because this is a hormone with limited human safety data, the facts advise using it only under guidance from a healthcare professional.

During pregnancy, hormone supplements should be avoided due to unknown risks. While breastfeeding, there isn't enough safety information, so it should be avoided as well.

If you're pregnant, planning to become pregnant, or breastfeeding, talk with your doctor or pharmacist before considering this product.

Side effects, ingredient by ingredient Pregnenolone

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pregnenolone.
  • The most serious interaction on file is rated Moderate.
  • For scale: 82 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking pregnenolone, check with your doctor or pharmacist if you take benzodiazepines (sedatives like diazepam or alprazolam)—pregnenolone may reduce how well they work. Also double-check if you're on estrogens, progestins, progesterone, or testosterone products, as pregnenolone may enhance their effects.

Run your complete medication list through the search tool on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Pregnenolone is a hormone precursor with a modest side-effect profile but limited evidence for specific health claims. It's most important to check your medications first—particularly if you take benzodiazepines, birth control, hormone therapy, or testosterone—because of Moderate-severity interaction risks.

This is a hormone supplement best used only under guidance from your own doctor or pharmacist, who can weigh the potential benefits and risks for your individual situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 23, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pregnenolone 25 mg, straight from the product label.

Brand Adaptogen Research
Barcode (UPC) 828054774261
Net contents 100 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jun 23, 2021
DSLD ID 247242
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pregnenolone 25 mg by Adaptogen Research, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
100
UPC/BARCODE
828054774261
IngredientAmount% DV
Pregnenolone25 mg--

Other ingredients: Microcrystalline Cellulose, Vegetarian Capsule, Ascorbyl Palmitate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Micronized

Free of the following common allergens: milk/casein, eggs, fish, shellfish, tree nuts, peanuts, wheat, gluten, soybeans and corn. Contains no artificial colors, flavors, or preservatives.

Notice: Color, size or shape may appear different between lots.

FDA Statement of Identity

Dietary Supplement

General Statements

Professional Use Only

Produced under a strict quality management system in compliance with Good Manufacturing Practices (GMPs) and third-party quality certifications.

Precautions

Caution: Not for use by individuals under the age of 18 years of age.

Do not use if pregnant, may become pregnant, breastfeeding, or have a history of seizures.

This product is not intended for long-term daily use. If you have a medical condition (including a family history of breast, uterine, ovarian, prostate or heart disease) have low HDL cholesterol, or are taking prescription drugs, consult your physician before using this product.

Keep out of reach of children.

Report any adverse reactions to (302) 213-0030.

Do not use if shrinkwrap is broken or missing.

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, Adults: 1 capsule, 1 to 2 times daily with food or as directed by a healthcare practitioner.

Storage

Store in a cool, dry place (59 degrees F-85 degrees F) away from direct sunlight.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pregnenolone 25 mg by Adaptogen Research label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pregnenolone 25 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pregnenolone 25 mg by Adaptogen Research

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.

Pregnenolone

Interacts with
82 drugs
25 mg per serving Form: Wild Yam

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sol...

Pregnenolone monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Vegetarian Capsule, Ascorbyl Palmitate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pregnenolone 25 mg by Adaptogen Research Drug Interactions

Want to check YOUR meds against Pregnenolone 25 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
82Drugs
82 Moderate

Ingredients driving the most interactions

Pregnenolone 82

Individual Drug Interactions

The ingredients in Pregnenolone 25 mg interact with 82 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pregnenolone 25 mg interact with drugs. Each result below shows which ingredient is responsible. Pregnenolone

Each ingredient & the kinds of drugs it affects

For each ingredient in Pregnenolone 25 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pregnenolone5 drug types · 82 drugs

Benzodiazepines

Concomitant use of pregnenolone may reduce the effects of benzodiazepines.
Very preliminary clinical research shows that chronic use of pregnenolone reduces sedative effects of diazepam when compared with chronic use of placebo. This effect may be related to the activity of pregnenolone at GABAA receptors.

Likelihood Probable Evidence B
Estrogens

Theoretically, taking pregnenolone might enhance the effects of estrogens.
Pregnenolone is a precursor for several steroid hormones, including estrogens.

Likelihood Possible Evidence D
Progesterone

Theoretically, taking pregnenolone might enhance the effects of progesterone.
In humans, some research shows that oral administration of pregnenolone can increase levels of progesterone. However, other research shows no effect on progesterone levels. It is possible the impact of pregnenolone on progesterone levels may be dose dependent.

Likelihood Possible Evidence D
Progestin

Theoretically, taking pregnenolone might enhance the effects of progestin.
Pregnenolone is a precursor for several steroid hormones, including progestin.

Likelihood Possible Evidence D
Testosterone

Theoretically, taking pregnenolone might enhance the effects of testosterone.
Pregnenolone is a precursor for several steroid hormones, including testosterone. However, preliminary clinical research shows that taking pregnenolone 30-500 mg orally daily for up to 8 weeks does not affect testosterone levels.

Likelihood Possible Evidence D
Pregnenolone full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pregnenolone 25 mg, from the product label.

Adaptogen Research

See all Adaptogen Research products
Name
Adaptogen Research
Street Address
625 Barksdale Road, Suite 113
City
Newark
State
DE
ZipCode
19711
Phone Number
302-213-0030
Pharmacist Counseling Corner

Pregnenolone 25 mg by Adaptogen Research: Common Questions

Does Pregnenolone 25 mg by Adaptogen Research interact with any medications?
Yes. Based on its ingredients, Pregnenolone 25 mg has a known interaction with 82 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pregnenolone 25 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is pregnenolone, and what does it do in my body?
Pregnenolone is a steroid hormone your body naturally makes. It acts as a starting point for producing other hormones like estrogen, progesterone, and testosterone. This product provides 25 mg per capsule, though evidence for its effectiveness in treating specific conditions isn't established yet.
Can I take this while I'm on birth control or hormone therapy?
Pregnenolone may enhance the effects of estrogens and progestins, which are in many birth control pills and hormone therapies. That's a Moderate-severity concern, so talk with your doctor or pharmacist before adding it—they'll know your exact medications and can advise whether it's appropriate for you.
What side effects should I expect?
The most common are acne, agitation, drowsiness, diarrhea, excitement, hair loss, and sweating. Less often, people report skin abscesses, rashes (possibly sun-triggered), and mood or appetite changes, though it's not always clear pregnenolone caused them. Most users tolerate it well overall.
Is pregnenolone safe during pregnancy or breastfeeding?
No. Hormone supplements should be avoided in pregnancy because the risks aren't known, and there isn't enough safety information to use it while breastfeeding. If you're pregnant, planning pregnancy, or nursing, talk with your doctor before considering pregnenolone.
Does pregnenolone actually raise testosterone levels?
Pregnenolone is a precursor to testosterone, so theoretically it might boost testosterone effects. However, one preliminary study found that taking 30–500 mg daily for up to 8 weeks didn't actually change testosterone levels in people. The picture isn't clear yet.
Will this interfere with my sedatives or sleeping pills?
Yes—preliminary research shows that chronic pregnenolone use may reduce the sedative effects of benzodiazepines like diazepam. This is a Moderate-severity concern, so if you take any sedatives or anti-anxiety medications, check with your doctor or pharmacist first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pregnenolone 25 mg label
Go deeper

The Full Monographs Behind Pregnenolone 25 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pregnenolone

Interacts with 82 drugs

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sold as a supplement for memory, mood, and...

Read the full Pregnenolone monograph →
Sources

Sources & How We Checked

Pregnenolone 25 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pregnenolone 6 references
  1. Devlin TM, ed. Textbook of Biochemistry With Clinical Correlations. third ed. New York: Wiley-Liss Inc., 1992.
  2. Fung LK, Libove RA, Phillips J, Haddad F, Hardan AY.Brief report: an open-label study of the neurosteroid pregnenolone in adults with autism spectrum disorder. J Autism Dev Disord 2014;44(11):2971-7. PubMed
  3. Brown ES, Park J, Marx CE, et al. A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depression. Neuropsychopharmacology 2014;39(12):2867-73. PubMed
  4. Ritsner MS, Gibel A, Shleifer T, et al. Pregnenolone and dehydroepiandrosterone as an adjunctive treatment in schizophrenia and schizoaffective disorder: an 8-week, double-blind, randomized, controlled, 2-center, parallel-group trial. J Clin Psychiatry 20 PubMed
  5. Meieran SE, Reus VI, Webster R, Shafton R, Wolkowitz OM. Chronic pregnenolone effects in normal humans: attenuation of benzodiazepine-induced sedation. Psychoneuroendocrinology 2004;29(4):486-500. PubMed
  6. Marx CE, Keefe RS, Buchanan RW, et al. Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia. Neuropsychopharmacology 2009;34(8):1885-903. PubMed

See these in context on the Pregnenolone monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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