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Dietary supplement

Pregnenolone 25 mg Sublingual Ingredients & Drug Interactions

by Douglas Laboratories

Pregnenolone 25 mg Sublingual label
See full label image
Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pregnenolone 25 mg Sublingual against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pregnenolone 25 mg Sublingual is a dietary supplement by Douglas Laboratories with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, anxiety and stress, anti-aging.Based on those ingredients, 82 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pregnenolone. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pregnenolone 25 mg Sublingual by Douglas Laboratories

Ask about any prescription or over-the-counter medication and we check it for interactions with Pregnenolone 25 mg Sublingual by Douglas Laboratories — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pregnenolone 25 mg Sublingual by Douglas Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: pregnenolone, a naturally occurring hormone precursor your body makes on its own. It's positioned as a building block your body can use to produce other steroid hormones like estrogen, progesterone, and testosterone.

The tablet also contains inactive ingredients (mannitol, cellulose, silica, and vegetable stearate) that help form and deliver the active ingredient — these are standard tablet binders and fillers.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Pregnenolone product and its label doesn't state a use — see Pregnenolone's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold does not establish that pregnenolone is effective for any condition. The data lists several uses it's been studied for — including alcohol use disorder, Alzheimer disease, autism spectrum disorder, back pain, and bipolar disorder — but in each case rates the evidence as insufficient to determine whether it actually works.

If you're considering it for a specific reason, your doctor or pharmacist can discuss what research exists outside our database.

The evidence, ingredient by ingredient Pregnenolone

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pregnenolone is generally well tolerated by mouth, but it is a hormone with limited human safety data — use only under guidance from a healthcare professional. Common side effects reported in trials include acne, agitation, diarrhea, drowsiness, excitement, hair loss, sweating, and tremor.

A few cases of skin rash with a burning sensation and possible sensitivity to sunlight have been reported, though they cleared without treatment. Some people also reported depressive mood, increased appetite, or changes in energy and motor activity, though it's unclear whether pregnenolone caused these.

Pregnancy and breastfeeding: The safety data advises against use during pregnancy due to unknown risks. There isn't enough information to know whether it's safe while breastfeeding — talk with your doctor or pharmacist for personalized advice.

Side effects, ingredient by ingredient Pregnenolone

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pregnenolone.
  • The most serious interaction on file is rated Moderate.
  • For scale: 82 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take estrogens, progestins, progesterone, testosterone, or benzodiazepines. Pregnenolone may theoretically enhance the effects of hormone medications or reduce how well benzodiazepines work — both Moderate concerns that warrant a conversation with your own healthcare provider.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Pregnenolone is a hormone precursor with a limited track record in humans and no established effectiveness for the conditions it's been studied in. It carries moderate interaction risks with hormone medications, birth control, hormone replacement therapy, and benzodiazepines.

If you're considering it, work with your doctor or pharmacist to review your medications and weigh whether the uncertain benefits justify the unknown safety profile and drug interaction potential.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pregnenolone 25 mg Sublingual, straight from the product label.

Brand Douglas Laboratories
Barcode (UPC) 310539011676
Net contents 100 Tablet(s)
Market status On market
Date entered into DSLD Jun 25, 2012
DSLD ID 10164
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pregnenolone 25 mg Sublingual by Douglas Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.5 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
100
UPC/BARCODE
310539011676
IngredientAmount% DV
Pregnenolone25 mg--

Other ingredients: Mannitol, Cellulose, Silica, Vegetable Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

A Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggeted Usage: As a dietary supplement, adults take 1/2 to 1 tablet daily as directed by your physician ONLY! (May be taken sublingually by allowing tablet to dissolve in mouth or with water or juice.)

Precautions

KEEP OUT OF REACH OF CHILDREN.

DO NOT USE IF PREGNANT OR NURSING.

Consult a physician or licensed qualified health care professional before using this product if you have or have a family history of breast cancer, uterine cancer, ovarian cancer, prostate cancer, prostate enlargement, heart disease, low HDL cholesterol ("good cholesterol"), or if you are using any other dietary supplement, prescription drug, or over-the-counter drug. Do not exceed the recommended serving. Exceeding the recommended serving may cause serious adverse health effects. Possible side effects include changes in liver function, acne, hair loss, hair growth on the face (in women), aggressiveness, irritability, and increased levels of estrogen. Discontinue use and call a physician or licensed qualified health care professional immediately if you experience rapid heartbeat, dizziness, blurred vision, or other similar symptoms.

Tamper resistant package, do not use if outer seal is missing.

WARNING: NOT FOR USE BY INDIVIDUALS UNDER THE AGE OF 18 YEARS.

Storage

For optimal storage conditions, store in a cool, dry place. (59(0)-77(0)F/15(0)-25(0)C) (35-65% relative humidity)

General

Formula #83088

Formulation

This product contains NO yeast, wheat gluten, soy protein, milk/dairy, corn, sodium, sugar, starch, artificial coloring, preservatives or flavoring.

General Statements

Meets Douglas Laboratories spec [#83088]. Conforms to USP <2091> for weight. Meets USP <2040> for disintegration.

To report any adverse events call 1-800-332-1088.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pregnenolone 25 mg Sublingual by Douglas Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pregnenolone 25 mg Sublingual label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pregnenolone 25 mg Sublingual by Douglas Laboratories

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.5 Tablet(s) Dosage formTablet Or Pill Servings per container100 Amounts shown are per serving.

Pregnenolone

Interacts with
82 drugs
25 mg per serving

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sol...

Pregnenolone monograph & interactions

Other (inactive) ingredients: Mannitol, Cellulose, Silica, Vegetable Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pregnenolone 25 mg Sublingual by Douglas Laboratories Drug Interactions

Want to check YOUR meds against Pregnenolone 25 mg Sublingual?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
82Drugs
82 Moderate

Ingredients driving the most interactions

Pregnenolone 82

Individual Drug Interactions

The ingredients in Pregnenolone 25 mg Sublingual interact with 82 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pregnenolone 25 mg Sublingual interact with drugs. Each result below shows which ingredient is responsible. Pregnenolone

Each ingredient & the kinds of drugs it affects

For each ingredient in Pregnenolone 25 mg Sublingual with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pregnenolone5 drug types · 82 drugs

Benzodiazepines

Concomitant use of pregnenolone may reduce the effects of benzodiazepines.
Very preliminary clinical research shows that chronic use of pregnenolone reduces sedative effects of diazepam when compared with chronic use of placebo. This effect may be related to the activity of pregnenolone at GABAA receptors.

Likelihood Probable Evidence B
Estrogens

Theoretically, taking pregnenolone might enhance the effects of estrogens.
Pregnenolone is a precursor for several steroid hormones, including estrogens.

Likelihood Possible Evidence D
Progesterone

Theoretically, taking pregnenolone might enhance the effects of progesterone.
In humans, some research shows that oral administration of pregnenolone can increase levels of progesterone. However, other research shows no effect on progesterone levels. It is possible the impact of pregnenolone on progesterone levels may be dose dependent.

Likelihood Possible Evidence D
Progestin

Theoretically, taking pregnenolone might enhance the effects of progestin.
Pregnenolone is a precursor for several steroid hormones, including progestin.

Likelihood Possible Evidence D
Testosterone

Theoretically, taking pregnenolone might enhance the effects of testosterone.
Pregnenolone is a precursor for several steroid hormones, including testosterone. However, preliminary clinical research shows that taking pregnenolone 30-500 mg orally daily for up to 8 weeks does not affect testosterone levels.

Likelihood Possible Evidence D
Pregnenolone full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pregnenolone 25 mg Sublingual, from the product label.

Douglas Laboratories

See all Douglas Laboratories products
Name
Douglas Laboratories
City
Pittsburgh
State
PA
ZipCode
15205
Web Address
www.douglaslabs.com
Pharmacist Counseling Corner

Pregnenolone 25 mg Sublingual by Douglas Laboratories: Common Questions

Does Pregnenolone 25 mg Sublingual by Douglas Laboratories interact with any medications?
Yes. Based on its ingredients, Pregnenolone 25 mg Sublingual has a known interaction with 82 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pregnenolone 25 mg Sublingual contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is pregnenolone and what is it supposed to do?
Pregnenolone is a hormone your body naturally produces. It acts as a building block — your body can theoretically convert it into other steroid hormones like estrogen, progesterone, and testosterone. It's sold as a supplement, but the evidence we hold doesn't show it actually works for any specific condition.
Can I take this if I'm pregnant or breastfeeding?
No — the safety data advises against pregnenolone during pregnancy because the risks are unknown. While breastfeeding, there isn't enough safety information to know either way, so talk with your doctor or pharmacist before taking it.
What side effects might I experience?
Common ones reported in use include acne, agitation, diarrhea, drowsiness, excitement, hair loss, sweating, and tremor. A few people have reported skin rashes or sensitivity to sun exposure. Some also noticed mood changes, appetite changes, or shifts in energy — though it's not always clear these were caused by the supplement itself.
Does this work for Alzheimer disease, bipolar disorder, back pain, or autism?
The evidence we hold is insufficient to say whether pregnenolone is effective for any of these conditions. If you're interested in it for a specific reason, ask your doctor what research exists and whether it might make sense in your situation.
Why do I need to check my medications before taking this?
Pregnenolone is a hormone precursor, so it can theoretically enhance the effects of hormone medications like birth control, hormone replacement therapy, estrogens, progesterone, and testosterone — all Moderate concerns. It may also reduce how well benzodiazepines (sedatives and anti-anxiety drugs) work. Your own doctor or pharmacist can review your specific prescriptions and advise whether it's safe to combine.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pregnenolone 25 mg Sublingual is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pregnenolone 25 mg Sublingual label
Go deeper

The Full Monographs Behind Pregnenolone 25 mg Sublingual’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pregnenolone

Interacts with 82 drugs

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sold as a supplement for memory, mood, and...

Read the full Pregnenolone monograph →
Sources

Sources & How We Checked

Pregnenolone 25 mg Sublingual's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pregnenolone 6 references
  1. Devlin TM, ed. Textbook of Biochemistry With Clinical Correlations. third ed. New York: Wiley-Liss Inc., 1992.
  2. Fung LK, Libove RA, Phillips J, Haddad F, Hardan AY.Brief report: an open-label study of the neurosteroid pregnenolone in adults with autism spectrum disorder. J Autism Dev Disord 2014;44(11):2971-7. PubMed
  3. Brown ES, Park J, Marx CE, et al. A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depression. Neuropsychopharmacology 2014;39(12):2867-73. PubMed
  4. Ritsner MS, Gibel A, Shleifer T, et al. Pregnenolone and dehydroepiandrosterone as an adjunctive treatment in schizophrenia and schizoaffective disorder: an 8-week, double-blind, randomized, controlled, 2-center, parallel-group trial. J Clin Psychiatry 20 PubMed
  5. Meieran SE, Reus VI, Webster R, Shafton R, Wolkowitz OM. Chronic pregnenolone effects in normal humans: attenuation of benzodiazepine-induced sedation. Psychoneuroendocrinology 2004;29(4):486-500. PubMed
  6. Marx CE, Keefe RS, Buchanan RW, et al. Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia. Neuropsychopharmacology 2009;34(8):1885-903. PubMed

See these in context on the Pregnenolone monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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