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Dietary supplement

Pregnenolone 50 mg Ingredients & Drug Interactions

by LifeLink

Pregnenolone 50 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pregnenolone 50 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pregnenolone 50 mg is a dietary supplement by LifeLink with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, anxiety and stress, anti-aging.Based on those ingredients, 82 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pregnenolone. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pregnenolone 50 mg by LifeLink

Ask about any prescription or over-the-counter medication and we check it for interactions with Pregnenolone 50 mg by LifeLink — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pregnenolone 50 mg by LifeLink

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: pregnenolone, a hormone precursor at 50 mg per capsule. Your body normally makes pregnenolone in small amounts and uses it as a raw material to build other steroid hormones like estrogen, progesterone, and testosterone.

The capsule also contains microcrystalline cellulose and gelatin as inactive ingredients — these are standard binders and capsule material.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Pregnenolone's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Memory and cognitive support, stress and mood.
  • We looked for evidence on: Memory, Stress, Aging, Fatigue, Depression.
  • The closest evidence on file: Pregnenolone is rated "Insufficient Reliable Evidence To Rate" for Depression (Natural Medicines).
  • Also on file: Pregnenolone is rated "Insufficient Reliable Evidence To Rate" for Fatigue, Memory, Stress, Aging.

The evidence we hold on pregnenolone covers several conditions — alcohol use disorder, Alzheimer disease, autism spectrum disorder, back pain, and bipolar disorder — but for all of them, the data is insufficient to rate whether it actually works. That means the research so far hasn't given us a clear answer either way.

The evidence, ingredient by ingredient Pregnenolone

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pregnenolone is generally well tolerated when taken by mouth, but it is a hormone with limited human safety data, so it should only be used under guidance from a healthcare professional. The most common side effects reported in trials include acne, agitation, diarrhea, drowsiness, excitement, hair loss, sweating, and tremor.

Less common reports include skin abscesses, a rash with burning sensation (possibly a photosensitivity reaction), changes in mood, and shifts in appetite — though for some of these, it's unclear whether pregnenolone was truly the cause. The safety data advises against use during pregnancy due to unknown risks, and there isn't enough safety information to use it while breastfeeding.

If you're pregnant or breastfeeding, talk with your doctor or pharmacist before considering this product.

Side effects, ingredient by ingredient Pregnenolone

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pregnenolone.
  • The most serious interaction on file is rated Moderate.
  • For scale: 82 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Pregnenolone by LifeLink, double-check with your pharmacist if you take estrogens, progestins, progesterone, or testosterone — all Moderate interactions. Also check if you take benzodiazepines (sedative drugs like diazepam), which may become less effective.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Pregnenolone is a hormone supplement meant for adults interested in hormone support, but only under professional guidance. If you take estrogens, benzodiazepines, progestins, testosterone, or progesterone, you need to check with your pharmacist first — this product may alter how those drugs work.

Talk to your pharmacist or doctor before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 24, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pregnenolone 50 mg, straight from the product label.

Brand LifeLink
Barcode (UPC) 639793203055
Net contents 50 Capsule(s); 50 mg
Market status On market
Date entered into DSLD Aug 24, 2012
DSLD ID 11750
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pregnenolone 50 mg by LifeLink, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
639793203055
IngredientAmount% DV
Pregnenolone50 mg--

Other ingredients: Microcrystalline Cellulose, Gelatin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: 1 capsule in the afternoon or as directed by a health care professional.

General Statements

Pregnenolone is metabolized in two directions: production of DHEA and its metabolites and production of progesterone and its metabolites.

Micronized

Precautions

Do NOT take if at risk for hormonally related cancers such as reproductive or prostate abnormalities, if under the age of 40, or if pregnant, lactating or trying to conceive.

Formula

Pregnenolone 50 mg

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See for yourself

Pregnenolone 50 mg by LifeLink label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pregnenolone 50 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pregnenolone 50 mg by LifeLink

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Pregnenolone

Interacts with
82 drugs
50 mg per serving

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sol...

Pregnenolone monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Gelatin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pregnenolone 50 mg by LifeLink Drug Interactions

Want to check YOUR meds against Pregnenolone 50 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
82Drugs
82 Moderate

Ingredients driving the most interactions

Pregnenolone 82

Individual Drug Interactions

The ingredients in Pregnenolone 50 mg interact with 82 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pregnenolone 50 mg interact with drugs. Each result below shows which ingredient is responsible. Pregnenolone

Each ingredient & the kinds of drugs it affects

For each ingredient in Pregnenolone 50 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pregnenolone5 drug types · 82 drugs

Benzodiazepines

Concomitant use of pregnenolone may reduce the effects of benzodiazepines.
Very preliminary clinical research shows that chronic use of pregnenolone reduces sedative effects of diazepam when compared with chronic use of placebo. This effect may be related to the activity of pregnenolone at GABAA receptors.

Likelihood Probable Evidence B
Estrogens

Theoretically, taking pregnenolone might enhance the effects of estrogens.
Pregnenolone is a precursor for several steroid hormones, including estrogens.

Likelihood Possible Evidence D
Progesterone

Theoretically, taking pregnenolone might enhance the effects of progesterone.
In humans, some research shows that oral administration of pregnenolone can increase levels of progesterone. However, other research shows no effect on progesterone levels. It is possible the impact of pregnenolone on progesterone levels may be dose dependent.

Likelihood Possible Evidence D
Progestin

Theoretically, taking pregnenolone might enhance the effects of progestin.
Pregnenolone is a precursor for several steroid hormones, including progestin.

Likelihood Possible Evidence D
Testosterone

Theoretically, taking pregnenolone might enhance the effects of testosterone.
Pregnenolone is a precursor for several steroid hormones, including testosterone. However, preliminary clinical research shows that taking pregnenolone 30-500 mg orally daily for up to 8 weeks does not affect testosterone levels.

Likelihood Possible Evidence D
Pregnenolone full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pregnenolone 50 mg, from the product label.

LifeLink

See all LifeLink products
Name
LifeLink
City
Grover Beach
State
CA
ZipCode
93433
Web Address
http://www.lifelinknet.com
Pharmacist Counseling Corner

Pregnenolone 50 mg by LifeLink: Common Questions

Does Pregnenolone 50 mg by LifeLink interact with any medications?
Yes. Based on its ingredients, Pregnenolone 50 mg has a known interaction with 82 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pregnenolone 50 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is pregnenolone and what does it do in my body?
Pregnenolone is a hormone your body naturally makes in small amounts. It acts as a building block — your body converts it into other hormones like estrogen, progesterone, and testosterone. This supplement provides 50 mg per dose.
Can I take this if I'm pregnant or breastfeeding?
The safety data advises against pregnenolone during pregnancy because the risks are unknown. There also isn't enough safety information for breastfeeding. Talk with your doctor or pharmacist for personalized advice if you're in either situation.
What side effects might I experience?
Most commonly, people report acne, agitation, diarrhea, drowsiness, excitement, hair loss, sweating, and tremor. Less often, skin abscesses or a rash with burning sensation have been reported. Some people also noticed changes in mood or appetite, though it's not always clear if pregnenolone caused them.
Is there evidence it actually works for the conditions mentioned?
The research we hold covers alcohol use disorder, Alzheimer disease, autism, back pain, and bipolar disorder — but for all of them, the data is currently insufficient to tell whether it works. More research is needed.
Why should I be careful if I take birth control or hormone replacement?
Pregnenolone is a precursor to estrogens and progestins, so it may boost how strong those hormones act in your body. Your birth control or hormone therapy might become more potent. Check with your pharmacist before starting.
I take a benzodiazepine for anxiety or sleep — is that a problem?
Yes, this needs attention. Early studies show that long-term pregnenolone use can weaken the calming effects of benzodiazepines like diazepam. Talk with your pharmacist or doctor before you start.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pregnenolone 50 mg label
Go deeper

The Full Monographs Behind Pregnenolone 50 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pregnenolone

Interacts with 82 drugs

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sold as a supplement for memory, mood, and...

Read the full Pregnenolone monograph →
Sources

Sources & How We Checked

Pregnenolone 50 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pregnenolone 6 references
  1. Devlin TM, ed. Textbook of Biochemistry With Clinical Correlations. third ed. New York: Wiley-Liss Inc., 1992.
  2. Fung LK, Libove RA, Phillips J, Haddad F, Hardan AY.Brief report: an open-label study of the neurosteroid pregnenolone in adults with autism spectrum disorder. J Autism Dev Disord 2014;44(11):2971-7. PubMed
  3. Brown ES, Park J, Marx CE, et al. A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depression. Neuropsychopharmacology 2014;39(12):2867-73. PubMed
  4. Ritsner MS, Gibel A, Shleifer T, et al. Pregnenolone and dehydroepiandrosterone as an adjunctive treatment in schizophrenia and schizoaffective disorder: an 8-week, double-blind, randomized, controlled, 2-center, parallel-group trial. J Clin Psychiatry 20 PubMed
  5. Meieran SE, Reus VI, Webster R, Shafton R, Wolkowitz OM. Chronic pregnenolone effects in normal humans: attenuation of benzodiazepine-induced sedation. Psychoneuroendocrinology 2004;29(4):486-500. PubMed
  6. Marx CE, Keefe RS, Buchanan RW, et al. Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia. Neuropsychopharmacology 2009;34(8):1885-903. PubMed

See these in context on the Pregnenolone monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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