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Dietary supplement

Pregnenolone Complex Ingredients & Drug Interactions

by Absonutrix

Pregnenolone Complex label
See full label image
Liquid Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pregnenolone Complex against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pregnenolone Complex is a dietary supplement by Absonutrix with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, anxiety and stress, anti-aging.Based on those ingredients, 82 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pregnenolone Complex. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pregnenolone Complex by Absonutrix

Ask about any prescription or over-the-counter medication and we check it for interactions with Pregnenolone Complex by Absonutrix — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pregnenolone Complex by Absonutrix

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “Pregnenolone Complex” is a proprietary blend — the label gives one combined amount (100 mg) without saying how much of each component you get.

Absonutrix Pregnenolone Complex is a liquid with one active ingredient: pregnenolone, a hormone precursor your body naturally makes. Pregnenolone serves as a building block for several other steroid hormones, including estrogen, progesterone, testosterone, and progestin.

The product also contains inactive ingredients (peppermint oil, stevia, potassium sorbate) and water and ethanol as carriers.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Pregnenolone product and its label doesn't state a use — see Pregnenolone's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

Our data shows insufficient reliable evidence to rate pregnenolone for any condition listed — alcohol use disorder, Alzheimer's disease, autism spectrum disorder, back pain, and bipolar disorder. That means studies haven't yet established whether it works for these uses.

If you're considering it for a specific health concern, talk with your pharmacist or doctor about what the current evidence shows.

The evidence, ingredient by ingredient Pregnenolone

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pregnenolone is generally well tolerated when taken by mouth, but it is a hormone with limited human safety data, so use it only under guidance from a healthcare professional. The most common side effects reported in studies include acne, agitation, diarrhea, drowsiness, excitement, hair loss, sweating, and tremor.

Some people have also reported skin rashes, depressive mood changes, and changes in appetite, though it's not always clear these were caused by the supplement. Safety data advises against use during pregnancy due to unknown risks, and there isn't enough safety information to recommend it while breastfeeding — talk with your doctor or pharmacist for personalized advice.

Side effects, ingredient by ingredient Pregnenolone

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pregnenolone.
  • The most serious interaction on file is rated Moderate.
  • For scale: 82 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take Absonutrix Pregnenolone Complex, double-check with your pharmacist if you're on estrogens (Moderate interaction), benzodiazepines (Moderate), progestins (Moderate), testosterone (Moderate), or progesterone (Moderate). The liquid also contains ethanol — let us know what you take so we can run it through our full checker.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Pregnenolone Complex is a hormone supplement that works best under the supervision of a healthcare professional. If you take estrogens, benzodiazepines, progestins, testosterone, or progesterone, check your exact medications with the tool on this page before starting.

Skip it during pregnancy and breastfeeding unless your doctor advises otherwise.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pregnenolone Complex, straight from the product label.

Brand Absonutrix
Barcode (UPC) 709257079301
Net contents 4 Fluid Ounce(s); 118 mL
Market status On market
Date entered into DSLD Feb 23, 2025
DSLD ID 322368
Product type Other Combinations
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pregnenolone Complex by Absonutrix, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.59 mL
Maximum serving Sizes:
0.59 mL
Servings per container
200
UPC/BARCODE
709257079301
IngredientAmount% DV
Water0 NP--
Pregnenolone0 NP--
Ethanol0 NP--
Pregnenolone Complex100 mg--

Other ingredients: Potassium Sorbate, Stevia, Peppermint Oil

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Shake well before using. Take 17 drops once daily. Hold in mouth for 15 seconds and then swallow.

Precautions

Caution: for adults only. Keep out of reach of children.

Consult a physician if you are pregnant/nursing, taking any medications, or have a medical condition.

In the unlikely event that you do experience any side effects or allergies, stop use immediately and promptly seek medical attention.

Keep out of the reach of children.

Do not use if safety seal is damaged or missing.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Made in USA

General Statements

Please recycle

Formulation

Highest quality ingredients Powerful formula Made in USA

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pregnenolone Complex by Absonutrix label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pregnenolone Complex label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pregnenolone Complex by Absonutrix

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.59 mL Dosage formLiquid Servings per container200 Amounts shown are per serving.

Pregnenolone Complex

Interacts with
82 drugs
100 mg per serving

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sol...

Pregnenolone Complex monograph & interactions

Other (inactive) ingredients: Potassium Sorbate, Stevia, Peppermint Oil. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pregnenolone Complex by Absonutrix Drug Interactions

Want to check YOUR meds against Pregnenolone Complex?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
82Drugs
82 Moderate

Ingredients driving the most interactions

Pregnenolone Complex 82

Individual Drug Interactions

The ingredients in Pregnenolone Complex interact with 82 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pregnenolone Complex interact with drugs. Each result below shows which ingredient is responsible. Pregnenolone Complex

Each ingredient & the kinds of drugs it affects

For each ingredient in Pregnenolone Complex with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pregnenolone Complex5 drug types · 82 drugs

Benzodiazepines

Concomitant use of pregnenolone may reduce the effects of benzodiazepines.
Very preliminary clinical research shows that chronic use of pregnenolone reduces sedative effects of diazepam when compared with chronic use of placebo. This effect may be related to the activity of pregnenolone at GABAA receptors.

Likelihood Probable Evidence B
Estrogens

Theoretically, taking pregnenolone might enhance the effects of estrogens.
Pregnenolone is a precursor for several steroid hormones, including estrogens.

Likelihood Possible Evidence D
Progesterone

Theoretically, taking pregnenolone might enhance the effects of progesterone.
In humans, some research shows that oral administration of pregnenolone can increase levels of progesterone. However, other research shows no effect on progesterone levels. It is possible the impact of pregnenolone on progesterone levels may be dose dependent.

Likelihood Possible Evidence D
Progestin

Theoretically, taking pregnenolone might enhance the effects of progestin.
Pregnenolone is a precursor for several steroid hormones, including progestin.

Likelihood Possible Evidence D
Testosterone

Theoretically, taking pregnenolone might enhance the effects of testosterone.
Pregnenolone is a precursor for several steroid hormones, including testosterone. However, preliminary clinical research shows that taking pregnenolone 30-500 mg orally daily for up to 8 weeks does not affect testosterone levels.

Likelihood Possible Evidence D
Pregnenolone Complex full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pregnenolone Complex, from the product label.

Absonutrix

See all Absonutrix products
Name
Absonutrix
Street Address
8905 West Market Street
City
Colfax
State
NC
ZipCode
27235
Phone Number
1-855-368-8749
Web Address
www.absonutrix.com
Pharmacist Counseling Corner

Pregnenolone Complex by Absonutrix: Common Questions

Does Pregnenolone Complex by Absonutrix interact with any medications?
Yes. Based on its ingredients, Pregnenolone Complex has a known interaction with 82 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pregnenolone Complex contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is pregnenolone and what does it do in the body?
Pregnenolone is a hormone your body naturally produces. It's a precursor — a building block — for several other steroid hormones, including estrogen, progesterone, testosterone, and progestin. This supplement provides pregnenolone to theoretically boost those hormone levels.
Can I take this while I'm on birth control or hormone replacement therapy?
Pregnenolone may enhance the effects of estrogens in birth control and HRT, which could increase your risk of hormone-related side effects. Talk with your pharmacist or doctor before combining them — your dose might need adjustment.
Will this affect my anti-anxiety or sleep medication?
Yes. Pregnenolone may reduce how well benzodiazepines (like diazepam) work, meaning you might not get the same calming or sedative effect. Your doctor may need to adjust your dose. Always check before starting.
Is pregnenolone safe to use while I'm pregnant or breastfeeding?
No. The safety data advises against use during pregnancy because the risks are unknown. There also isn't enough safety information to recommend it while breastfeeding. Talk with your doctor or pharmacist for personalized advice.
What side effects might I experience?
The most common side effects reported include acne, agitation, diarrhea, drowsiness, excitement, hair loss, sweating, and tremor. Some people have reported skin rashes, mood changes, and changes in appetite, though it's unclear if pregnenolone caused them.
Does this product contain any fillers or other inactive ingredients?
Yes. Besides pregnenolone, the liquid contains peppermint oil, stevia, potassium sorbate (a preservative), water, and ethanol as inactive ingredients.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pregnenolone Complex label
Go deeper

The Full Monographs Behind Pregnenolone Complex’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pregnenolone

Interacts with 82 drugs

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sold as a supplement for memory, mood, and...

Read the full Pregnenolone monograph →
Sources

Sources & How We Checked

Pregnenolone Complex's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pregnenolone 6 references
  1. Devlin TM, ed. Textbook of Biochemistry With Clinical Correlations. third ed. New York: Wiley-Liss Inc., 1992.
  2. Fung LK, Libove RA, Phillips J, Haddad F, Hardan AY.Brief report: an open-label study of the neurosteroid pregnenolone in adults with autism spectrum disorder. J Autism Dev Disord 2014;44(11):2971-7. PubMed
  3. Brown ES, Park J, Marx CE, et al. A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depression. Neuropsychopharmacology 2014;39(12):2867-73. PubMed
  4. Ritsner MS, Gibel A, Shleifer T, et al. Pregnenolone and dehydroepiandrosterone as an adjunctive treatment in schizophrenia and schizoaffective disorder: an 8-week, double-blind, randomized, controlled, 2-center, parallel-group trial. J Clin Psychiatry 20 PubMed
  5. Meieran SE, Reus VI, Webster R, Shafton R, Wolkowitz OM. Chronic pregnenolone effects in normal humans: attenuation of benzodiazepine-induced sedation. Psychoneuroendocrinology 2004;29(4):486-500. PubMed
  6. Marx CE, Keefe RS, Buchanan RW, et al. Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia. Neuropsychopharmacology 2009;34(8):1885-903. PubMed

See these in context on the Pregnenolone monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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