Interactions on record — worth a quick check against your medications. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

PREGNOSITOL Ingredients & Drug Interactions

by Zazzee Naturals

PREGNOSITOL label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking PREGNOSITOL against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

PREGNOSITOL is a dietary supplement by Zazzee Naturals with 3 active ingredients. Its ingredients are commonly taken for preventing neural tube birth defects, treating or preventing folate deficiency, supporting pregnancy health.Based on those ingredients, 126 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Myo-Inositol, Folic Acid. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against PREGNOSITOL by Zazzee Naturals

Ask about any prescription or over-the-counter medication and we check it for interactions with PREGNOSITOL by Zazzee Naturals — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of PREGNOSITOL by Zazzee Naturals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Pregnositol contains three active ingredients: folic acid, myo-inositol, and D-chiro-inositol. Folic acid is a B vitamin needed to prevent folate deficiency and reduce the risk of birth defects like neural tube defects.

The two inositol compounds are sugar-like molecules that may support reproductive health and metabolic function. There are no other inactive ingredients in this powder.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Support female fertility and reproductive health.
  • We looked for evidence on: Infertility, Polycystic ovary syndrome (PCOS), Folate deficiency, Neural tube birth defects, Fetal and premature infant mortality, Low birth weight — and 4 related terms.
  • The strongest evidence on file: Folic Acid is rated "Effective" for Folate deficiency (Natural Medicines).
  • Also on file: Folic Acid is rated "Likely Effective" for Neural tube birth defects.
  • Also on file: Inositol is rated "Possibly Effective" for Polycystic ovary syndrome (PCOS), Preterm labor.

Folic acid in this product is effective for preventing folate deficiency and likely effective at standard prenatal doses for preventing neural tube birth defects — which is why it's recommended during pregnancy. It's also possibly effective for depression and for reducing certain medication side effects.

The inositol ingredients (myo-inositol and D-chiro-inositol) are possibly effective for polycystic ovary syndrome (PCOS), metabolic syndrome, and preterm labor, though the evidence isn't as strong. For anxiety and depression, the inositols are rated possibly ineffective based on the data we hold.

The evidence, ingredient by ingredient Folic Acid Inositol

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Folic acid is generally well tolerated at recommended doses for most adults and is considered safe during pregnancy at standard prenatal doses to help prevent birth defects. It's also safe at normal recommended doses while breastfeeding.

At lower doses (under 1 mg daily), side effects are rare. At higher doses (5 mg daily or more), some people report abdominal cramps, diarrhea, and rash; at 15 mg daily, bitter taste, confusion, and sleep disturbances have been reported.

The inositol ingredients are generally well tolerated with mostly mild digestive side effects like diarrhea, gas, and nausea. However, inositol use in pregnancy is only possibly safe and should only happen under medical supervision since full safety data aren't established.

There isn't enough reliable information about inositol for lactation, so check with your doctor if you're breastfeeding.

Side effects, ingredient by ingredient Folic Acid Inositol

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Inositol, Folic Acid.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 126 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Pregnositol, check with your doctor or pharmacist if you're on seizure medications (phenytoin, phenobarbital, primidone), cancer medications (methotrexate, capecitabine, 5-fluorouracil), the antiparasitic pyrimethamine (Daraprim), or diabetes medications. These are the drug types where documented interactions exist.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Pregnositol is a prenatal-support powder that combines folic acid with two inositol compounds — a reasonable choice if you're trying to conceive or in early pregnancy. The main caution is if you take seizure medications or cancer drugs: those need a conversation with your doctor or pharmacist before you start.

If you're on diabetes medication, mention this product too, since the inositols may lower blood sugar. Talk with your own healthcare provider before adding it to your routine.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about PREGNOSITOL, straight from the product label.

Brand Zazzee Naturals
Barcode (UPC) X0021XXIL3
Net contents 16.62 Ounce(s); 471 Gram(s)
Market status On market
Date entered into DSLD Nov 22, 2022
DSLD ID 277092
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult Female (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for PREGNOSITOL by Zazzee Naturals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1025.1 Gram(s)
Maximum serving Sizes:
2050.2 Gram(s)
Servings per container
230
UPC/BARCODE
X0021XXIL3
IngredientAmount% DV
Folic Acid200 mcg83%
Myo-Inositol2000 mg--
D-Chiro-Inositol50 mg--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Usage: Take 1 level scoop once per day. A pre-measured scoop is included to ensure perfect serving size. Mix contents with water or other beverage and consume with or in between meals. Stir well until completely dissolved before drinking.

Formula

PREGNOSITOL is a scientifically formulated blend that helps support female fertility and overall reproductive health.

PREGNOSITOL combines the following active ingredients: Myo-inositol has been shown, in numerous studies, to be a natural way to support healthy hormone balance, ovarian function, and egg quality. D-chiro inositol has been shown to enhance the overall effectiveness of myo-inositol when taken in the ideal 40:1 ratio with myo-inositol. Folic acid has a long history as a natural fertility support nutrient. Studies show that folic acid may reduce the risk of birth defects, as well as support healthy fertility.

Optimal 40:1 Inositol Blend Myo-Inositol D-Chiro Inositol Folic Acid

Precautions

Allergen Information: Contains carob derivatives. Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish, or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Caution: In case of exceeding the suggested usage, sensitive individuals may experience mild gastrointestinal distress or diarrhea. If this occurs reduce dose to 1/2 level scoop or discontinue use.

Warning: For adults only.

Consult physician if pregnant/nursing, taking medication, or have a medical condition.

Keep out of reach of children.

Do not eat freshness packet. Keep in bottle.

Formulation

Premium grade fertility support Supports female fertility & reproductive health Supports healthy ovarian function

Natural color variation may occur in this product.

Gluten free Non GMO Soy free Dairy free

100% vegan

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish, or tree nut ingredients.

FDA Statement of Identity

Dietary Supplement

Storage

Store in a cool, dry place.

General Statements

Please recycle. This product is sold by weight, not volume.

Please recycle.

Brand IP Statement(s)

Caronositol is a registered trademark of BIOSEARCH, S.A.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

GMP Good Manufacturing Practice Consistent Quality Made in USA

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

PREGNOSITOL by Zazzee Naturals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

PREGNOSITOL label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in PREGNOSITOL by Zazzee Naturals

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1025.1 Gram(s) Dosage formPowder Servings per container230 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Folic Acid

Interacts with
40 drugs
200 mcg per serving

Folic acid is the man-made form of vitamin B9 and is one of the most well-studied supplements, especially for preventing serious birth defects when ta...

Folic Acid monograph & interactions

Myo-Inositol

Interacts with
86 drugs
2000 mg per serving

Inositol is a sugar alcohol made naturally in the body and found in many foods, and it is sold as a supplement (often myo-inositol) mainly for PCOS, m...

Myo-Inositol monograph & interactions

D-Chiro-Inositol

Interacts with
86 drugs
50 mg per serving

Inositol is a sugar alcohol made naturally in the body and found in many foods, and it is sold as a supplement (often myo-inositol) mainly for PCOS, m...

D-Chiro-Inositol monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

PREGNOSITOL by Zazzee Naturals Drug Interactions

Want to check YOUR meds against PREGNOSITOL?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
126Drugs
126 Moderate

Ingredients driving the most interactions

Myo-Inositol 86
Folic Acid 40

Individual Drug Interactions

The ingredients in PREGNOSITOL interact with 126 drugs. Click any drug to see the details.

2 of the 3 ingredients in PREGNOSITOL interact with drugs. Each result below shows which ingredient is responsible. Myo-Inositol Folic Acid

Each ingredient & the kinds of drugs it affects

For each ingredient in PREGNOSITOL with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Myo-Inositol1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking inositol with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that inositol lowers blood glucose levels and glycated hemoglobin (HbA1c) levels in patients with diabetes.

Likelihood Possible Evidence A
Myo-Inositol full monograph & interactions

Folic Acid7 drug types · 40 drugs

5-Fluorouracil

Theoretically, high doses of folic acid might increase the toxicity of 5-fluorouracil.
Increases in gastrointestinal side effects of 5-fluorouracil, such as stomatitis and diarrhea, have been described in two clinical studies when leucovorin, a form of folic acid, was administered with 5-fluorouracil.

Likelihood Possible Evidence D
Capecitabine (Xeloda)

Use of high-dose folic acid might contribute to capecitabine toxicity.
Clinical research suggests that higher serum folate levels are associated with an increased risk for moderate or severe toxicity during capecitabine-based treatment for colorectal cancer. Additionally, in one case report, taking folic acid 15 mg daily might have contributed to increased toxicity, including severe diarrhea, vomiting, edema, hand-foot syndrome, and eventually death, in a patient prescribed capecitabine.

Likelihood Possible Evidence D
Methotrexate (Trexall, Others)

Folic acid might reduce the efficacy of methotrexate as a cancer treatment when given concurrently.
Methotrexate exerts its cytotoxic effects by preventing conversion of folic acid to the active form needed by cells. There is some evidence that folic acid supplements reduce the efficacy of methotrexate in the treatment of acute lymphoblastic leukemia, and theoretically they could reduce its efficacy in the treatment of other cancers. Advise cancer patients to consult their oncologist before using folic acid supplements. In patients treated with long-term, low-dose methotrexate for rheumatoid arthritis (RA) or psoriasis, folic acid supplements can reduce the incidence of side effects, without reducing efficacy.

Likelihood Probable Evidence B
Phenobarbital (Luminal)

Folic acid might have antagonistic effects on phenobarbital and increase the risk for seizures.
Folic acid can have direct convulsant activity in some people, reversing the effects of phenobarbital and worsening seizure control. Monitor closely for increased seizure activity.

Likelihood Probable Evidence B
Phenytoin (Dilantin)

Folic acid might reduce serum levels of phenytoin in some patients.
Folic acid may be a cofactor in phenytoin metabolism. Folic acid, in doses of 1 mg daily or more, can reduce serum levels of phenytoin in some patients. Increases in seizure frequency have been reported. If folic acid supplements are added to established phenytoin therapy, monitor serum phenytoin levels closely. If phenytoin and folic acid are started at the same time and continued together, adverse changes in phenytoin pharmacokinetics are avoided. Note that phenytoin also reduces serum folate levels.

Likelihood Probable Evidence B
Primidone (Mysoline)

Folic acid might have antagonistic effects on primidone and increase the risk for seizures.
Folic acid can have direct convulsant activity in some people, reversing the effects of primidone and worsening seizure control. Monitor closely for increased seizure activity. Note that primidone also reduces serum folate levels.

Likelihood Probable Evidence B
Pyrimethamine (Daraprim)

Folic acid might antagonize the effects of pyrimethamine.
Folic acid can antagonize the antiparasitic effects of pyrimethamine against toxoplasmosis and Pneumocystis carinii pneumonia. Folic acid doesn't antagonize the effects of pyrimethamine in the treatment of malaria, because malarial parasites cannot use exogenous folic acid. Use folinic acid as an alternative to folic acid when indicated.

Likelihood Probable Evidence D
Folic Acid full monograph & interactions
The maker

Brand information

Manufacturer and brand details for PREGNOSITOL, from the product label.

Zazzee Naturals

See all Zazzee Naturals products
Name
Zazzee Naturals
Street Address
616 Corporate Way Suite 2, Dept. 4604
City
Valley Cottage
State
NY
ZipCode
10989
Pharmacist Counseling Corner

PREGNOSITOL by Zazzee Naturals: Common Questions

Does PREGNOSITOL by Zazzee Naturals interact with any medications?
Yes. Based on its ingredients, PREGNOSITOL has a known interaction with 126 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
PREGNOSITOL contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this product safe to take while trying to get pregnant?
The folic acid in Pregnositol is considered safe and is actually recommended at standard prenatal doses to help prevent birth defects. The two inositol ingredients are rated possibly safe in pregnancy, but the safety data isn't complete — that's why they should only be used under medical supervision if you're pregnant. Talk with your doctor about whether this product is right for your situation.
Can I take this while breastfeeding?
Folic acid is considered safe at normal recommended doses while breastfeeding. However, there isn't enough reliable information about the inositol ingredients during lactation, so check with your doctor or pharmacist if you're nursing.
What are the inositol ingredients supposed to do?
Myo-inositol and D-chiro-inositol are possibly effective for polycystic ovary syndrome (PCOS), metabolic syndrome, and preterm labor based on the data we hold. They're included in prenatal supplements because they may support reproductive and metabolic health, though the evidence is still being studied.
What side effects might I experience?
Folic acid at normal doses is generally well tolerated. At higher doses (5 mg daily or more), some people report abdominal cramps, diarrhea, and rash. The inositols commonly cause mild digestive upset — diarrhea, gas, and nausea. These are usually mild and may settle over time.
I take diabetes medication — is this safe for me?
The inositol ingredients in this product lower blood glucose levels, so there's a theoretical risk of low blood sugar (hypoglycemia) if you combine them with diabetes medications. Talk with your own doctor before starting, as your blood sugar and medication dose may need monitoring.
Will this interact with my birth control?
The product facts we have don't include interaction data for birth control medications, so we can't tell you either way. That's a good question to ask your own pharmacist or doctor before you start.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

PREGNOSITOL label
Go deeper

The Full Monographs Behind PREGNOSITOL’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Folic Acid

Interacts with 40 drugs

Folic acid is the man-made form of vitamin B9 and is one of the most well-studied supplements, especially for preventing serious birth defects when taken before and during early pregnancy. I...

Read the full Folic Acid monograph → Herb & supplement monograph

Inositol

Interacts with 86 drugs

Inositol is a sugar alcohol made naturally in the body and found in many foods, and it is sold as a supplement (often myo-inositol) mainly for PCOS, mood, and metabolic concerns. The stronge...

Read the full Inositol monograph →
Sources

Sources & How We Checked

PREGNOSITOL's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 70 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Folic Acid 56 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Duhra P. Treatment of gastrointestinal symptoms associated with methotrexate therapy for psoriasis. J Am Acad Dermatol 1993;28:466-9. PubMed
  3. Morgan SL, Baggott JE, Vaughn WH, et al. Supplementation with folic acid during methotrexate therapy for rheumatoid arthritis. A double-blind, placebo-controlled trial. Ann Intern Med 1994;121:833-41. PubMed
  4. Froscher W, Maier V, Laage M, et al. Folate deficiency, anticonvulsant drugs, and psychiatric morbidity. Clin Neuropharmacol 1995;18:165-82. PubMed
  5. Lewis DP, Van Dyke DC, Willhite LA, et al. Phenytoin-folic acid interaction. Ann Pharmacother 1995;29:726-35. PubMed
  6. Berg MJ, Stumbo PJ, Chenard CA, et al. Folic acid improves phenytoin pharmacokinetics. J Am Diet Assoc 1995;95:352-6. PubMed
  7. Berg MJ, Fincham RW, Ebert BE, et al. Phenytoin pharmacokinetics: Before and after folic acid administration. Epilepsia 1992;33:712-20. PubMed
  8. Shafer RB, Nuttall FQ. Calcium and folic acid absorption in patients taking anticonvulsant drugs. J Clin Endocrinol Metab 1975;41:1125-9. PubMed
  9. Leeb BF, Witzmann G, Ogris E, et al. Folic acid and cyanocobalamin levels in serum and erythrocytes during low-dose methotrexate therapy of rheumatoid arthritis and psoriatic arthritis patients. Clin Exp Rheumatol 1995;13:459-63.
  10. Morgan SL, Baggott JE, Lee JY, Alarcón GS. Folic acid supplementation prevents deficient blood folate levels and hyperhomocysteinemia during longterm, low dose methotrexate therapy for rheumatoid arthritis: implications for cardiovascular disease preventi
  11. Dijkmans BA. Folate supplementation and methotrexate. Br J Rheumatol 1995;34:1172-4. PubMed
  12. Segal S, Kaminski S. Drug-nutrient interactions. American Druggist 1996 Jul;42-8.
  13. Lambie DG, Johnson RH. Drugs and folate metabolism. Drugs 1985;30:145-55. PubMed
  14. Amer College of Rheumatology ad hoc committee on clinical guidelines. Guidelines for monitoring drug therapy in rheumatoid arthritis. Arthritis Rheum 1996;39:723-31. DOI
  15. Suitor CW, Bailey LB. Dietary folate equivalents: interpretation and application. J Am Diet Assoc 2000;100:88-94. PubMed
  16. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  17. Sandoval M, Charbonnet RM, Okuhama NN, et al. Cat's claw inhibits TNFalpha production and scavenges free radicals: role in cytoprotection. Free Radic Biol Med 2000;29:71-78.
  18. Antony AC. Megaloblastic Anemias. In: Hoffman R, Benz Jr EJ, Shattil SJ, et al. Hematology: Basic Principles and Practice. 3rd ed. New York, NY: Churchill Livingstone 2000: 451-79.
  19. Reynolds EH. Neurological aspects of folate and vitamin B12 metabolism. Clin Haematol 1976;5:661-96. DOI
  20. Reynolds EH. Folate metabolism and anticonvulsant therapy. Proc R Soc Med 1974;67:68.
  21. Ortiz Z, Shea B, Suarez Almazor M, et al. Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis (Cochrane Review). Cochrane Database Syst Rev 2000;2:CD000951. PubMed
  22. Van Delden C, Hirschel B. Folinic acid supplements to pyrimethamine-sulfadiazine for Toxoplasma encephalitis are associated with better outcome (letter). J Infect Dis 1996;173:1294-5. PubMed
  23. Schroder H, Clausen N, Ostergard E, Pressler T. Folic acid supplements in vitamin tablets: a determinant of hematological drug tolerance in maintenance therapy of childhood acute lymphoblastic leukemia. Ped Hematol Oncol 1986;3:241-7. PubMed
  24. Lange H, Suryapranata H, De Luca G, et al. Folate therapy and in-stent restenosis after coronary stenting. N Engl J Med 2004;350:2673-81. PubMed
  25. Morris MC, Evans DA, Bienias JL, et al. Dietary folate and vitamin B12 intake and cognitive decline among community-dwelling older persons. Arch Neurol 2005;62:641-5. PubMed
  26. Bonaa KH, Njolstad I, Ueland PM, et al. NORVIT: Homocysteine lowering and cardiovascular events after acute myocardial infarction. N Enlg J Med 2006;354:1578-88. PubMed
  27. Lawson KA, Wright ME, Subar A, et al. Multivitamin use and risk of prostate cancer in the National Institutes of Health-AARP Diet and Health Study. J Natl Cancer Inst 2007;99:754-64. PubMed
  28. Figueiredo JC, Grau MV, Haile RW, et al. Folic acid and risk of prostate cancer: Results from a randomized clinical trial. J Natl Cancer Inst 2009;101:432-5. PubMed
  29. Clippe C, Freyer G, Milano G, Trillet-Lenoir V. Lethal toxicity of capecitabine due to abusive folic acid prescription. Clin Oncol (R Coll Radiol) 2003;15:299-300. PubMed
  30. Bedford Laboratories. Leucovorin calcium [package insert]. Bedford, OH. September 2008. Available at: http://www.bedfordlabs.com/BedfordLabsWeb/products/inserts/LCV-P02.pdf.
  31. Ebbing M, Bonaa KH, Nygard O, et al. Cancer incidence and mortality after treatment with folic acid and vitamin B12. JAMA 2009;302:2119-26.
  32. Haberg, S. E., London, S. J., Stigum, H., Nafstad, P., and Nystad, W. Folic acid supplements in pregnancy and early childhood respiratory health. Arch Dis.Child 2009;94(3):180-184. PubMed
  33. Whitrow, M. J., Moore, V. M., Rumbold, A. R., and Davies, M. J. Effect of supplemental folic acid in pregnancy on childhood asthma: a prospective birth cohort study. Am J Epidemiol. 12-15-2009;170(12):1486-1493. PubMed
  34. Collin, S. M., Metcalfe, C., Refsum, H., Lewis, S. J., Zuccolo, L., Smith, G. D., Chen, L., Harris, R., Davis, M., Marsden, G., Johnston, C., Lane, J. A., Ebbing, M., Bonaa, K. H., Nygard, O., Ueland, P. M., Grau, M. V., Baron, J. A., Donovan, J. L., Nea
  35. Baggott, J. E., Oster, R. A., and Tamura, T. Meta-analysis of cancer risk in folic acid supplementation trials. Cancer Epidemiol. 2012;36(1):78-81. PubMed
  36. Fonseca VA, Lavery LA, Thethi TK, et al. Metanx in type 2 diabetes with peripheral neuropathy: A randomized trial. Am J Med 2013;126(2):141-9. PubMed
  37. Hankey GJ, Eikelboom JW, Yi Q, et al. Treatment with B vitamins and incidence of cancer in patients with previous stroke or transient ischemic attack: Results of a randomized placebo-controlled trial. Stroke 2012;43(6):1572-7. PubMed
  38. Taneja S, Strand TA, Kumar T, et al. Folic acid and vitamin B-12 supplementation and common infections in 6-30-mo-old children in India: a randomized placebo-controlled trial. Am J Clin Nutr 2013;98(3):731-7. PubMed
  39. van Wijngaarden JP, Swart KM, Enneman AW, et al. Effect of daily vitamin B-12 and folic acid supplementation on fracture incidence in elderly individuals with an elevated plasma homocysteine concentration: B-PROOF, a randomized controlled trial. Am J Clin
  40. Qin X, Fan F, Cui Y, Chen F, Chen Y, Cheng X, Li Y, Wang B, Xu X, Xu X, Huo Y, Wang X. Folic acid supplementation with and without vitamin B6 and revascularization risk: a meta-analysis of randomized controlled trials. Clin Nutr. 2014;33(4):603-12. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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