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Dietary supplement

Extra Strength Artichoke 20:1 Extract Ingredients & Drug Interactions

by Zazzee Naturals

Extra Strength Artichoke 20:1 Extract label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Extra Strength Artichoke 20:1 Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Extra Strength Artichoke 20:1 Extract is a dietary supplement by Zazzee Naturals with 1 active ingredient. Its ingredients are commonly taken for high cholesterol, indigestion and heartburn, constipation and bloating.Based on those ingredients, 364 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Artichoke Leaf Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Extra Strength Artichoke 20:1 Extract by Zazzee Naturals

Ask about any prescription or over-the-counter medication and we check it for interactions with Extra Strength Artichoke 20:1 Extract by Zazzee Naturals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Extra Strength Artichoke 20:1 Extract by Zazzee Naturals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Oct 1, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: artichoke leaf extract in a concentrated 20:1 form, meaning the extract is made from 20 pounds of artichoke leaf to yield 1 pound of extract. The inactive ingredients are rice powder, cellulose, silica, and magnesium stearate, which serve as fillers and flow agents in the capsule.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: support healthy digestion and normal liver function.
  • We looked for evidence on: Dyspepsia, Hyperlipidemia, Nonalcoholic fatty liver disease (NAFLD), Irritable bowel syndrome (IBS), Biliary disorders, cholesterol management — and 3 related terms.
  • The strongest evidence on file: Artichoke is rated "Possibly Effective" for Dyspepsia (Natural Medicines).
  • Also on file: Artichoke is rated "Possibly Effective" for Hyperlipidemia.
  • Also on file: Artichoke is rated "Insufficient Reliable Evidence To Rate" for Biliary disorders, Nonalcoholic fatty liver disease (NAFLD), Irritable bowel syndrome (IBS).

The evidence we hold supports artichoke leaf extract as possibly effective for high cholesterol (hyperlipidemia) and indigestion (dyspepsia). A meta-analysis of small studies showed it can modestly lower both systolic and diastolic blood pressure and reduce fasting blood sugar.

For nonalcoholic fatty liver disease, the evidence isn't yet established in our data.

The evidence, ingredient by ingredient Artichoke

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Artichoke extract is generally well tolerated, though side effects from digestive upset—abdominal pain, diarrhea, gas, and nausea—occur in some people. A small number of individuals sensitive to inulin (a component in artichoke) have reported rare severe allergic reactions including anaphylaxis.

If you're allergic to plants in the ragweed family (chrysanthemums, marigolds, daisies, and others), you may be at higher risk of an allergic reaction to artichoke. During pregnancy, not enough safety information exists, so the data advises against using this supplement.

Safety during breastfeeding has not been established, so it's best avoided then too. Talk with your doctor or pharmacist if you're pregnant, planning to become pregnant, or breastfeeding before taking this product.

Side effects, ingredient by ingredient Artichoke

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Artichoke.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 364 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, check with your pharmacist or doctor if you take any blood pressure medications, diabetes medications, or drugs metabolized by your liver via CYP2C19 or CYP2B6 pathways. These are moderate-severity interactions.

If you're sensitive to plants in the ragweed family or have a known inulin allergy, let your healthcare provider know before taking this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you have high cholesterol or indigestion and are looking for a plant-based option, artichoke extract may be worth discussing with your doctor. However, if you take blood pressure or diabetes medications, or if your liver metabolizes drugs through CYP2C19 or CYP2B6 pathways, you'll want to clear this with your own pharmacist or doctor first.

Avoid it during pregnancy and breastfeeding unless your healthcare provider advises otherwise.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Extra Strength Artichoke 20:1 Extract, straight from the product label.

Brand Zazzee Naturals
Barcode (UPC) X003W8NZA5
Net contents 150 Veggie Cap(s)
Market status On market
Date entered into DSLD Sep 25, 2024
DSLD ID 318705
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Extra Strength Artichoke 20:1 Extract by Zazzee Naturals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veggie Capsule(s)
Maximum serving Sizes:
1 Veggie Capsule(s)
Servings per container
150
UPC/BARCODE
X003W8NZA5
IngredientAmount% DV
Artichoke Leaf Extract450 mg--

Other ingredients: Rice, Powder, Cellulose, Silica, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Usage: Take 1 capsule daily with food, or as recommended by your healthcare practitioner.

Formula

Zazzee Naturals Extra Strength Artichoke Extract is a potent herbal supplement commonly used to support healthy digestion and normal liver function. For maximum potency, our Extra Strength Artichoke is standardized to a minimum of 5% caffeoylquinic acid, and made from a powerful 20:1 standardized extract, equivalent to 9000mg of whole artichoke leaf powder.

Extra Strength Artichoke 20:1 Extract 9000mg Strength Standardized to 5% Caffeoylquinic Acid

Precautions

Warnings: For adults only. Keep out of reach of children.

Consult physician if pregnant or nursing, taking medication, or have a medical condition.

Allergen Information: Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish, tree nut or sesame ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Formulation

Natural color variation may occur in this product.

Supports healthy digestion Supports normal liver function

Allergen Information: Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish, tree nut or sesame ingredients.

Made with non GMO ingredients

Storage

Store in a cool, dry place after opening.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Good Manufacturing Practice GMP Consistent Quality Made in USA

General Statements

New

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Extra Strength Artichoke 20:1 Extract by Zazzee Naturals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Extra Strength Artichoke 20:1 Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Extra Strength Artichoke 20:1 Extract by Zazzee Naturals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Veggie Capsule(s) Dosage formCapsule Servings per container150 Amounts shown are per serving.

Artichoke Leaf Extract

Interacts with
364 drugs
450 mg per serving Form: Cynara scolymus Leaf Extract

Artichoke leaf extract is a generally well-tolerated supplement that may have a mild cholesterol-lowering effect and is often used for indigestion, th...

Artichoke Leaf Extract monograph & interactions

Other (inactive) ingredients: Rice, Powder, Cellulose, Silica, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Extra Strength Artichoke 20:1 Extract by Zazzee Naturals Drug Interactions

Want to check YOUR meds against Extra Strength Artichoke 20:1 Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
364Drugs
364 Moderate

Ingredients driving the most interactions

Artichoke Leaf Extract 364

Individual Drug Interactions

The ingredients in Extra Strength Artichoke 20:1 Extract interact with 364 drugs. Click any drug to see the details.

1 of the 1 ingredient in Extra Strength Artichoke 20:1 Extract interact with drugs. Each result below shows which ingredient is responsible. Artichoke Leaf Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Extra Strength Artichoke 20:1 Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Artichoke Leaf Extract4 drug types · 364 drugs

Antidiabetes Drugs

Theoretically, artichoke leaf extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
A meta-analysis of small clinical studies shows that taking artichoke leaf extract for 8-12 weeks can modestly reduce fasting plasma glucose when compared with placebo.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
A meta-analysis of small clinical studies in patients with hypertension shows that taking artichoke can reduce systolic blood pressure by around 3 mmHg and diastolic blood pressure by around 2 mmHg when compared with placebo.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2B6.
In vitro research shows that artichoke leaf extract inhibits CYP2B6 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2C19.
In vitro research shows that artichoke leaf extract inhibits CYP2C19 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Artichoke Leaf Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Extra Strength Artichoke 20:1 Extract, from the product label.

Zazzee Naturals

See all Zazzee Naturals products
Name
Zazzee Naturals
Street Address
400 Rella Blvd Ste 123 Box 182
City
Montebello
State
NY
Web Address
ZazzeeNaturals.com
Pharmacist Counseling Corner

Extra Strength Artichoke 20:1 Extract by Zazzee Naturals: Common Questions

Does Extra Strength Artichoke 20:1 Extract by Zazzee Naturals interact with any medications?
Yes. Based on its ingredients, Extra Strength Artichoke 20:1 Extract has a known interaction with 364 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Extra Strength Artichoke 20:1 Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will artichoke extract lower my blood pressure too much if I'm already on a blood pressure medication?
It's possible—studies show artichoke can lower blood pressure modestly, and combined with your medication, the effect could add up. That's why you need to check with your doctor or pharmacist before starting it if you take any blood pressure drugs.
Can I take this if I have diabetes and use diabetes medication?
Artichoke extract itself can lower blood sugar, so there's a moderate risk of your blood sugar dropping too far if you're already on diabetes medication. Talk with your doctor or pharmacist about whether it's safe for you.
What are the most common side effects?
Most people tolerate it well, but some experience digestive complaints like stomach pain, diarrhea, gas, or nausea. Severe allergic reactions are rare but have been reported, especially in people with inulin sensitivity or allergies to plants in the ragweed family.
Does artichoke extract actually help with high cholesterol or indigestion?
The evidence we hold rates it as possibly effective for both. Small clinical studies suggest it may modestly help, but it's not a substitute for medication or a guaranteed fix for everyone.
Is it safe to take during pregnancy or while breastfeeding?
No. There isn't enough safety information to know either way during pregnancy, so the data advises against it. Safety during breastfeeding hasn't been established either. Talk with your doctor or pharmacist if you're pregnant, planning to become pregnant, or breastfeeding.
Will this interact with other drugs my liver breaks down?
Artichoke extract inhibits two liver enzyme systems (CYP2C19 and CYP2B6) in the lab, which could theoretically raise levels of drugs that those enzymes process. This hasn't been reported in people yet, but it's worth checking your exact medications with your pharmacist to be sure.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Extra Strength Artichoke 20:1 Extract is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Extra Strength Artichoke 20:1 Extract label
Go deeper

The Full Monographs Behind Extra Strength Artichoke 20:1 Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Artichoke

Interacts with 364 drugs

Artichoke leaf extract is a generally well-tolerated supplement that may have a mild cholesterol-lowering effect and is often used for indigestion, though the evidence is modest. It is not a...

Read the full Artichoke monograph →
Sources

Sources & How We Checked

Extra Strength Artichoke 20:1 Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Artichoke 16 references
  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. Walker AF, Middleton RW, Petrowicz O. Artichoke leaf extract reduces symptoms of irritable bowel syndrome in a post-marketing surveillance study. Phytother Res 2001;15:58-61. PubMed
  3. Pittler MH, White AR, Stevinson C, Ernst E. Effectiveness of artichoke extract in preventing alcohol-induced hangovers: a randomized controlled trial. CMAJ 2003;169:1269-73.
  4. Romano, C., Ferrara, A., and Falagiani, P. A case of allergy to globe artichoke and other clinical cases of rare food allergy. J Investig.Allergol.Clin Immunol. 2000;10(2):102-104.
  5. Miralles, J. C., Garcia-Sells, J., Bartolome, B., and Negro, J. M. Occupational rhinitis and bronchial asthma due to artichoke (Cynara scolymus). Ann Allergy Asthma Immunol. 2003;91(1):92-95. PubMed
  6. Franck, P., Moneret-Vautrin, D. A., Morisset, M., Kanny, G., Megret-Gabeaux, M. L., and Olivier, J. L. Anaphylactic reaction to inulin: first identification of specific IgEs to an inulin protein compound. Int Arch Allergy Immunol 2005;136(2):155-158. PubMed
  7. Meding, B. Allergic contact dermatitis from artichoke, Cynara scolymus. Contact Dermatitis 1983;9(4):314.
  8. Quirce, S., Tabar, A. I., Olaguibel, J. M., and Cuevas, M. Occupational contact urticaria syndrome caused by globe artichoke (Cynara scolymus). J Allergy Clin Immunol. 1996;97(2):710-711. PubMed
  9. Held C. Von der 1. Deutsche-Ungarischen Phytopharmakon-Konferenz, Budapest, 20. November 1991. Z Klin Med 1992;47:92-93.
  10. Barrat E, Zaïr Y, Ogier N, et al. A combined natural supplement lowers LDL cholesterol in subjects with moderate untreated hypercholesterolemia: a randomized placebo-controlled trial. Int J Food Sci Nutr. 2013;64(7):882-9. PubMed
  11. Huber R, Müller M, Naumann J, Schenk T, Lüdtke R. Artichoke leave extract for chronic hepatitis C - a pilot study. Phytomedicine. 2009 Sep;16(9):801-4. PubMed
  12. Caputo F, Barranco R, Bonsignore A, Fraternali Orcioni G, Ventura F. A rare case of fatal bowel obstruction secondary to a colonic bezoar. Am J Forensic Med Pathol. 2018;39(1):38-40. PubMed
  13. Elsebai MF, Abass K, Hakkola J, Atawia AR, Farag MA. The wild Egyptian artichoke as a promising functional food for the treatment of hepatitis C virus as revealed via UPLC-MS and clinical trials. Food Funct. 2016;7(7):3006-16. PubMed
  14. Moradi M, Sohrabi G, Golbidi M, et al. Effects of artichoke on blood pressure: a systematic review and meta-analysis. Complement Ther Med 2021;57:102668. PubMed
  15. Jalili C, Moradi S, Babaei A, et al. Effects of Cynara scolymus L. on glycemic indices: a systematic review and meta-analysis of randomized clinical trials. Complement Ther Med 2020;52:102496. PubMed
  16. Gallo R, Oddenino G, Trave I, Gasparini G, Guadagno A, Parodi A. Contact sensitivity to sesquiterpene lactone mix and artichoke in a patient with severe recurrent dermatitis: A puzzling case. Contact Dermatitis 2023;88(2):156-158. PubMed

See these in context on the Artichoke monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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