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Dietary supplement

Lemon Balm 10:1 Extract 500 mg Ingredients & Drug Interactions

by Zazzee Naturals

Lemon Balm 10:1 Extract 500 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lemon Balm 10:1 Extract 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lemon Balm 10:1 Extract 500 mg is a dietary supplement by Zazzee Naturals with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, sleep problems, digestive upset.Based on those ingredients, 264 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lemon Balm extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Lemon Balm 10:1 Extract 500 mg by Zazzee Naturals

Ask about any prescription or over-the-counter medication and we check it for interactions with Lemon Balm 10:1 Extract 500 mg by Zazzee Naturals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Lemon Balm 10:1 Extract 500 mg by Zazzee Naturals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: lemon balm extract in a 10:1 concentration at 500 mg per capsule. The extract is made from the lemon balm plant (Melissa officinalis), a mint family herb traditionally used for relaxation and emotional balance.

The capsules also contain inactive ingredients — organic pullulan, organic rice powder, and organic rice — which serve as the capsule material and filler.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: support calm, relaxed, stress-free mood and focus.
  • We looked for evidence on: Anxiety, Stress, Insomnia, Cognitive function, Attention deficit-hyperactivity disorder (ADHD), Nervousness — and 2 related terms.
  • The strongest evidence on file: Lemon Balm is rated "Possibly Effective" for Stress (Natural Medicines).
  • Also on file: Lemon Balm is rated "Insufficient Reliable Evidence To Rate" for Anxiety, Attention deficit-hyperactivity disorder (ADHD), Cognitive function, Insomnia.

Lemon balm extract is possibly effective for cold sores (herpes labialis) when used topically or orally, and possibly effective for stress and depression based on the evidence we have on file. That said, 'possibly effective' means the research suggests a benefit, but more or larger studies would strengthen the case.

If you're considering this for any of those uses, talk with your doctor or pharmacist about whether it fits your situation and how it compares to other options.

The evidence, ingredient by ingredient Lemon Balm

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lemon balm is generally well tolerated for short-term use in most healthy adults, though high doses and long-term safety haven't been well studied. In clinical trials, dizziness and sedation were reported, but they occurred no more often than with placebo.

A rare case of heart rhythm changes (atrioventricular block and QT prolongation) was reported in a young woman using a multi-ingredient product containing lemon balm, though symptoms resolved once she stopped the product. During pregnancy, there isn't enough reliable safety data, so it's best avoided unless your doctor advises otherwise.

If you're breastfeeding, limited safety information exists — talk with your doctor before using. Topically, a small number of trial participants reported irritation or cold sore worsening with lemon balm cream, but these effects were no more common than with placebo.

Side effects, ingredient by ingredient Lemon Balm

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lemon Balm.
  • The most serious interaction on file is rated Moderate.
  • For scale: 264 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check it with any CNS depressants you're on (sedatives, sleep aids, anti-anxiety drugs, opioids, or other medications that slow your nervous system) — lemon balm may add to their drowsy or sedating effect. Also check if you're taking thyroid hormone replacement therapy, since lemon balm may interfere with how it works.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Lemon balm extract may help with cold sores, stress, or low mood, but the evidence is still developing. If you take a CNS depressant (sedative, sleep aid, anti-anxiety medication, or opioid) or thyroid hormone replacement, check with your doctor or pharmacist before starting — lemon balm could interact with both.

It's generally well tolerated short-term in healthy adults, but avoid it in pregnancy unless your doctor gives the go-ahead, and talk with your healthcare provider if you're breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lemon Balm 10:1 Extract 500 mg, straight from the product label.

Brand Zazzee Naturals
Barcode (UPC) X0028GF15J
Net contents 150 Veggie Cap(s)
Market status On market
Date entered into DSLD Oct 24, 2022
DSLD ID 276101
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Organic, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lemon Balm 10:1 Extract 500 mg by Zazzee Naturals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veggie Capsule(s)
Maximum serving Sizes:
1 Veggie Capsule(s)
Servings per container
150
UPC/BARCODE
X0028GF15J
IngredientAmount% DV
Lemon Balm extract500 mg--

Other ingredients: organic Pullulan, organic Rice powder, organic Rice

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested usage: Take 1 capsule 1-2 times daily with food, or as recommended by your healthcare practitioner.

Formula

Zazzee Naturals Lemon Balm is an all-natural herbal supplement commonly used to support a calm, relaxed, stress-free mood. Research suggests that lemon balm extract also supports healthy memory function and optimal focus and concentration. Our product is made with organic Lemon Balm, derived from a potent 10:1 extract, equivalent to 5,000 mg (5 g) of fresh lemon balm leaves.

Precautions

Warnings: For adults only.

Consult physician if pregnant or nursing, trying to conceive, under the age of 18, taking blood thinners, sedatives or other medications, or have a medical condition.

If you are diabetic or hypoglycemic, use only under a physician's supervision. Do not drive, operate machinery or consume alcohol when taking this product.

Keep out of reach of children.

Allergen information: Not manufactured with wheat, corn, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Do not eat freshness packet.

Consult physician if pregnant or nursing, trying to conceive, under the age of 18, taking blood thinners, sedatives or other medications, or have a medical condition.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Certified Organic by ECOCERT SA

Supports a calm and relaxed mood Supports healthy memory & focus

Made with organic lemon balm

Allergen information: Not manufactured with wheat, corn, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients.

Natural color variation may occur in this product.

Made with non GMO ingredients

Seals/Symbols

USDA Organic

GMP Good Manufacturing Practice Consistent Quality

Made in USA

ECOCERT Certified Organic by ECOCERT SA

FDA Statement of Identity

Dietary Supplement

Storage

Store in a cool, dry place after opening.

Keep in bottle.

General Statements

Please recycle.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lemon Balm 10:1 Extract 500 mg by Zazzee Naturals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lemon Balm 10:1 Extract 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lemon Balm 10:1 Extract 500 mg by Zazzee Naturals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Veggie Capsule(s) Dosage formCapsule Servings per container150 Amounts shown are per serving.

Lemon Balm extract

Interacts with
264 drugs
500 mg per serving

Lemon balm is a gentle, lemon-scented mint-family herb traditionally used to ease stress, support sleep, and calm digestion, and topically for cold so...

Lemon Balm extract monograph & interactions

Other (inactive) ingredients: Organic Pullulan, Organic Rice powder, Organic Rice. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lemon Balm 10:1 Extract 500 mg by Zazzee Naturals Drug Interactions

Want to check YOUR meds against Lemon Balm 10:1 Extract 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
264Drugs
264 Moderate

Ingredients driving the most interactions

Lemon Balm extract 264

Individual Drug Interactions

The ingredients in Lemon Balm 10:1 Extract 500 mg interact with 264 drugs. Click any drug to see the details.

1 of the 1 ingredient in Lemon Balm 10:1 Extract 500 mg interact with drugs. Each result below shows which ingredient is responsible. Lemon Balm extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Lemon Balm 10:1 Extract 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lemon Balm extract2 drug types · 264 drugs

Cns Depressants

Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Lemon balm seems to have CNS depressant activity in animals and in humans.

Likelihood Possible Evidence B
Thyroid Hormone

Theoretically, lemon balm might interfere with thyroid hormone replacement therapy.
In vitro, constituents of lemon balm extract bind to thyroid stimulating hormone (TSH), preventing TSH receptor-binding and leading to the inhibition of TSH-stimulated adenylate cyclase activity. In animals, lemon balm extract has been shown to decrease levels of circulating TSH and inhibit thyroid secretion.

Likelihood Possible Evidence D
Lemon Balm extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lemon Balm 10:1 Extract 500 mg, from the product label.

Zazzee Naturals

See all Zazzee Naturals products
Name
Zazzee Naturals
Street Address
400 Rella Boulevard Suite 123 Dept. 182
City
Montebello
State
NY
ZipCode
10901
Pharmacist Counseling Corner

Lemon Balm 10:1 Extract 500 mg by Zazzee Naturals: Common Questions

Does Lemon Balm 10:1 Extract 500 mg by Zazzee Naturals interact with any medications?
Yes. Based on its ingredients, Lemon Balm 10:1 Extract 500 mg has a known interaction with 264 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lemon Balm 10:1 Extract 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is lemon balm extract used for?
Based on the research we have, lemon balm is possibly effective for cold sores, stress, and depression. Most studies have looked at short-term use, so if you're thinking about taking it longer-term, that's worth discussing with your doctor.
Can I take this while pregnant?
There isn't enough reliable safety data to recommend lemon balm during pregnancy, so it's best avoided unless your doctor advises otherwise. Talk with your healthcare provider before taking it if you're pregnant or trying to become pregnant.
Is it safe to use while breastfeeding?
Limited safety information exists for lemon balm during breastfeeding. Before you use it, talk with your doctor or pharmacist to get personalized advice based on your situation.
What side effects might I experience?
In clinical trials, some people reported dizziness and sedation, but these didn't happen more often with lemon balm than with placebo. A rare case of heart rhythm changes was reported, though symptoms resolved when the product was stopped. Most healthy adults tolerate it well short-term.
Can I use this with alcohol?
Research shows that lemon balm used with alcohol doesn't affect reaction time or cognitive performance, so a drink or two alongside this supplement shouldn't pose that particular risk. That said, if you're taking a CNS depressant along with the lemon balm, adding alcohol would compound the drowsy effect — best to ask your pharmacist.
How long does it take to work?
The product facts don't specify how long lemon balm typically takes to show an effect. A pharmacist or your doctor can give you a better timeline based on what you're using it for.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Lemon Balm 10:1 Extract 500 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lemon Balm 10:1 Extract 500 mg label
Go deeper

The Full Monographs Behind Lemon Balm 10:1 Extract 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lemon Balm

Interacts with 264 drugs

Lemon balm is a gentle, lemon-scented mint-family herb traditionally used to ease stress, support sleep, and calm digestion, and topically for cold sores. Early studies are promising but gen...

Read the full Lemon Balm monograph →
Sources

Sources & How We Checked

Lemon Balm 10:1 Extract 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lemon Balm 12 references
  1. Wolbling RH, Leonhardt K. Local therapy of herpes simplex with dried extract from Melissa officinalis. Phytomedicine 1994;1:25-31.
  2. Akhondzadeh S, Noroozian M, Mohammadi M, et al. Melissa officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease: a double blind, randomised, placebo controlled trial. J Neurol Neurosurg Psychiatry 2003;74:863-6. PubMed
  3. Kennedy DO, Scholey AB, Tildesley NT, et al. Modulation of mood and cognitive performance following acute administration of Melissa officinalis (lemon balm). Pharmacol Biochem Behav 2002;72:953-64. PubMed
  4. Albrecht M, Berger W, Laux P, Schmidt U, et al. Psychopharmaka und Verkehrssicherheit. Der Einfluß von Euvegal® - Dragees forte auf die Fahrtüchtigkeit und Kombinationswirkungen mit Alkohol Z Allg Med 1995;71:1215-25.
  5. Herberg, KW. Nebenwirkungen pflanzlicher Beruhigungsmittel/ Leistung und Befinden nach Einnahme einer Baldrian-Hopfen-Kombination. Z.Allg Med 1996;72:234-240.
  6. Soulimani R, Fleurentin J, Mortier F, et al. Neurotropic action of the hydroalcoholic extract of Melissa officinalis in the mouse. Planta Med. 1991 Apr;57:105-9.
  7. Sourgens H, Winterhoff H, Gumbinger HG, et al. Antihormonal effects of plant extracts. TSH- and prolactin-suppressing properties of Lithospermum officinale and other plants. Planta Med. 1982 Jun;45:78-86. DOI
  8. Auf'mkolk M, Ingbar JC, Amir SM, et al. Inhibition by certain plant extracts of the binding and adenylate cyclase stimulatory effect of bovine thyrotropin in human thyroid membranes. Endocrinology. 1984 Aug;115:527-34. PubMed
  9. Santini F, Vitti P, Ceccarini G, et al. In vitro assay of thyroid disruptors affecting TSH-stimulated adenylate cyclase activity. J Endocrinol Invest. 2003 Oct;26:950-5. PubMed
  10. Alijaniha F, et al. Heart palpitation relief with Melissa officinalis leaf extract: double blind, randomized, placebo controlled trial of efficacy and safety. J Ethnopharmacol. 2015;164:378-384. doi: 10.1016/j.jep.2015.02.007. Epub 2015 Feb 11. PubMed
  11. Araj-Khodaei M, Noorbala AA, Yarani R, et al. A double-blind, randomized pilot study for comparison of Melissa officinalis L. and Lavandula angustifolia Mill. with Fluoxetine for the treatment of depression. BMC Complement Med Ther. 2020;20(1):207. PubMed
  12. Kucuk U, Pham M, Raza Raja MH, Saad Shaukat MH, Clark R. Transient complete atrioventricular block associated with herbal supplement use. S D Med 2023;76(7):311-313.

See these in context on the Lemon Balm monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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