Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Probiotic Gummies Ingredients & Drug Interactions

by Spring Valley

Probiotic Gummies label
See full label image
Gummy Or Jelly Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Probiotic Gummies against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Probiotic Gummies is a dietary supplement by Spring Valley with 2 active ingredients. Its ingredients are commonly taken for constipation, irritable bowel syndrome (ibs), diarrhea.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bacillus coagulans IS-2. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Probiotic Gummies by Spring Valley

Ask about any prescription or over-the-counter medication and we check it for interactions with Probiotic Gummies by Spring Valley — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Probiotic Gummies by Spring Valley

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.

These gummies contain one active ingredient: Bacillus coagulans IS-2, a beneficial bacterial strain often used to support digestion and gut health. The gummies also include several inactive ingredients—fruit juice, glucose syrup, sugar, gelatin, starch, and a mix of other standard gummy binders and colorants—to make them palatable and shelf-stable.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Bacillus Coagulans's overall clinical evidence instead.

Moderate

Some clinical evidence supports Bacillus Coagulans for:

Why this rating?
  • The label markets general wellness (“digestive health”), not a specific health condition, so there is no single claim to grade against clinical-evidence data.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Constipation — rated "Possibly Effective" (Natural Medicines).
  • On file: Irritable bowel syndrome (IBS) — rated "Possibly Effective" (Natural Medicines).

The data shows Bacillus coagulans is possibly effective for two digestive concerns: constipation and irritable bowel syndrome (IBS). For other uses—antibiotic-associated diarrhea, athletic performance, cancer support, and nonalcoholic fatty liver disease—there isn't enough reliable evidence yet to say whether it helps or not.

The evidence, ingredient by ingredient Bacillus Coagulans

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bacillus coagulans is generally well tolerated in healthy adults, though evidence and product quality can vary across brands. The main safety caveat is that live probiotic organisms carry a small theoretical risk of infection in people with severely weakened immune systems, central venous catheters, or critical illness—including preterm infants.

Healthy people with intact immune systems have very few reports of problems. Because safety data isn't extensive, talk with your doctor or pharmacist before starting, especially if you have any serious health conditions or a compromised immune system.

Side effects, ingredient by ingredient Bacillus Coagulans

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Bacillus Coagulans.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antibiotics, you must separate them from these gummies—the antibiotic will reduce the probiotic's effectiveness. Discuss the best timing with your doctor or pharmacist.

Run any other medications through the checker below before starting.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Spring Valley Probiotic Gummies may help with constipation and IBS symptoms if Bacillus coagulans works for you. The key catch is antibiotics—they can kill the live organisms, so you'll need to time them separately.

If you're generally healthy and not on antibiotics, these gummies are likely okay, but it's worth confirming with your own doctor or pharmacist first, especially if you have any immune concerns.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Probiotic Gummies, straight from the product label.

Brand Spring Valley
Barcode (UPC) 681131133487
Net contents 60 Pectin-Based Gummie(s)
Market status On market
Date entered into DSLD Jul 25, 2018
DSLD ID 178713
Product type Non-nutrient/non-botanical
Supplement form Gummy Or Jelly
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Adult (18 - 50 Years), Gluten Free, Dairy Free, Children more than 1 but less than 4
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Probiotic Gummies by Spring Valley, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Gummy(ies)
Maximum serving Sizes:
2 Gummy(ies)
UPC/BARCODE
681131133487
IngredientAmount% DV
Calories20 Calorie(s), 10 Calorie(s)--
Total Carbohydrates4 Gram(s), 2 Gram(s)1%, 1%
Added Sugars3 Gram(s), 1 Gram(s)6%, 4%
Total Sugars3 Gram(s), 1 Gram(s)--
Bacillus coagulans IS-20 NP--
Bacillus coagulans IS-20 NP--

Other ingredients: Natural fruit juice, Glucose Syrup, Sugar, Gelatin, Starch, Water, Sodium Citrate, Citric Acid, Natural Flavors, Colors added, Pectin, fractionated Coconut Oil, Carnauba Wax, Beeswax

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Do not use if safety seal under cap is broken or missing.

Contains coconut oil.

Not for children under 3 years of age due to the risk of choking.

Warning: Pregnant or nursing women, individuals taking medication(s) or persons who have a health condition should consult their doctor before using this product.

Not for children under 3 years of age due to risk of choking. Excessive consumption may have a laxative effect in children. Always consult your pediatrician before giving your child dietary supplements. Keep out of reach of children.

General Statements

Please recycle

Natural flavors Digestive health Dietary probiotic supplement that helps maintain digestive health 10X better survivability vs. yogurt

Product of Australia

Because the probiotic in Probiotic Gummies reaches your intestines alive, they are able to provide digestive and immune health benefits where you need them. Probiotic Gummies help lessen minor abdominal discomfort, bloating, and may relieve occasional diarrhea.

Quality Guaranteed

Percent Daily Values are based on a 2,000 calorie diet.

Delicious, naturally flavored gummies

General

PLD-A444C LB004588 483524

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Formula

Contains coconut oil.

Scientifically studied B. coagulans probiotic strain

Suggested/Recommended/Usage/Directions

Suggested Use: Adults and children 4 years and up: Chew two gummies daily. Children 3 years of age: Chew one gummy daily.

Formulation

No gluten, dairy, soy

Storage

Store at room temperature 25(0)C (77(0)F). Store in a cool dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Probiotic Gummies by Spring Valley label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Probiotic Gummies label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Probiotic Gummies by Spring Valley

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Gummy(ies) Dosage formGummy Or Jelly Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Bacillus coagulans IS-2

Interacts with
182 drugs
0 NP per serving

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, a...

Bacillus coagulans IS-2 monograph & interactions

Bacillus coagulans IS-2

Interacts with
182 drugs
0 NP per serving

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, a...

Bacillus coagulans IS-2 monograph & interactions

Other (inactive) ingredients: Natural fruit juice, Glucose Syrup, Sugar, Gelatin, Starch, Water, Sodium Citrate, Citric Acid, Natural Flavors, Colors added, Pectin, Fractionated Coconut Oil, Carnauba Wax, Beeswax. These complete the product’s ingredient list but are not active constituents.

Interaction report

Probiotic Gummies by Spring Valley Drug Interactions

Want to check YOUR meds against Probiotic Gummies?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Bacillus coagulans IS-2 182

Individual Drug Interactions

The ingredients in Probiotic Gummies interact with 182 drugs. Click any drug to see the details.

1 of the 2 ingredients in Probiotic Gummies interact with drugs. Each result below shows which ingredient is responsible. Bacillus coagulans IS-2

Each ingredient & the kinds of drugs it affects

For each ingredient in Probiotic Gummies with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Bacillus coagulans IS-21 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B. coagulans.
B. coagulans preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. coagulans preparations by at least two hours.

Likelihood Probable Evidence D
Bacillus coagulans IS-2 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Probiotic Gummies, from the product label.

Spring Valley

See all Spring Valley products
Name
Wal-Mart Stores, Inc.
City
Bentonville
State
AR
ZipCode
72716
Phone Number
1-866-251-1662
Web Address
Walmart.com/springvalley
Pharmacist Counseling Corner

Probiotic Gummies by Spring Valley: Common Questions

Does Probiotic Gummies by Spring Valley interact with any medications?
Yes. Based on its ingredients, Probiotic Gummies has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Probiotic Gummies contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my IBS or constipation?
Bacillus coagulans is possibly effective for both irritable bowel syndrome and constipation, so it may help—but results vary from person to person. It's worth trying, and your doctor or pharmacist can suggest how long to give it before deciding whether it's working for you.
Can I take these with my antibiotic?
Not at the same time. Antibiotics will kill off the live bacteria in the probiotic, making it much less effective. Take them several hours apart—your doctor or pharmacist can give you a specific schedule that works with your antibiotic course.
Are probiotics safe if I have a weak immune system?
Generally, yes, for healthy people—but if you're severely ill, have a central venous catheter, or have a significantly weakened immune system, live probiotics carry a small risk. Talk with your doctor or pharmacist before using if any of that applies to you.
What's actually in these gummies besides the probiotic?
The active ingredient is Bacillus coagulans IS-2. The rest is standard gummy stuff: fruit juice, glucose syrup, sugar, gelatin, pectin, and various binders and colorants to hold them together and add flavor and color.
Is there enough data to know probiotics are safe long-term?
Not completely. They're generally well tolerated in healthy adults, but the evidence and safety data aren't as extensive as we'd like. It's a good reason to check in with your doctor or pharmacist before starting, especially if you take other medications or have any health conditions.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Probiotic Gummies is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Probiotic Gummies label
Go deeper

The Full Monographs Behind Probiotic Gummies’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bacillus Coagulans

Interacts with 182 drugs

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, and certain types of diarrhea. The eviden...

Read the full Bacillus Coagulans monograph →
Sources

Sources & How We Checked

Probiotic Gummies's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 20 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bacillus Coagulans 20 references
  1. Saxelin M, Chuang NH, Chassy B, et al. Lactobacilli and bacteremia in southern Finland 1989-1992. Clin Infect Dis 1996;22:564-6. PubMed
  2. Tynkkynen S, Singh KV, Varmanen P. Vancomycin resistance factor of Lactobacillus rhamnosus GG in relation to enterococcal vancomycin resistance (van) genes. Int J Food Microbiol 1998;41:195-204. PubMed
  3. Klein G, Zill E, Schindler R, et al. Peritonitis associated with vancomycin-resistant Lactobacillus rhamnosus in a continuous ambulatory peritoneal dialysis patient; organism identification, antibiotic therapy, and case report. J Clin Microbiol 1998;36:
  4. Kalima P, Masterton RG, Roddie PH, et al. Lactobacillus rhamnosus infection in a child following bone marrow transplant. J Infect 1996;32:165-7. PubMed
  5. Goldin BR. Health Benefits of probiotics. Br J Nutr 1998;80:S203-7. DOI
  6. Rautio M, Jousimies-Somer H, Kauma H, et al. Liver abscess due to Lactobacillus rhamnosus strain indistinguishable from L. rhamnosus strain GG. Clin Infect Dis 1999;28:1159-60.
  7. MacGregor G, Smith AJ, Thakker B, Kinsella J. Yoghurt biotherapy: contraindicated in immunosuppressed patients? Postgrad Med J 2002;78:366-7. PubMed
  8. Land MH, Rouster-Stevens K, Woods CR, et al. Lactobacillus sepsis associated with probiotic therapy. Pediatrics 2005;115:178-81.
  9. De Groote MA, Frank DN, Dowell E, et al. Lactobacillus rhamnosus GG bacteremia associated with probiotic use in a child with short gut syndrome. Pediatr Infect Dis J 2005;24:278-80. PubMed
  10. Vahabnezhad E, Mochon AB, Wozniak LJ, Ziring DA. Lactobacillus bacteremia associated with probiotic use in a pediatric patient with ulcerative colitis. J Clin Gastroenterol. 2013;47(5):437-9. PubMed
  11. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  12. Sendil S, Shrimanker I, Mansoora Q, Goldman J, Nookala VK. Lactobacillus rhamnosus bacteremia in an immunocompromised renal transplant patient. Cureus. 2020;12(2):e6887. PubMed
  13. Albarillo FS, Shah U, Joyce C, Slade D. Lactobacillus rhamnosus Infection: A single-center 4-year descriptive analysis. J Glob Infect Dis. 2020;12(3):119-123. PubMed
  14. Pasala S, Singer L, Arshad T, Roach K. Lactobacillus endocarditis in a healthy patient with probiotic use. IDCases. 2020;22:e00915. PubMed
  15. Agrawal S, Tuchman ES, Bruce MJ, Theodorou ME. Fatal Lactobacillus endocarditis in a patient with transcatheter aortic valve replacement. BMJ Case Rep. 2020;13(11):e236835.
  16. Antoun M, Hattab Y, Akhrass FA, Hamilton LD. Uncommon pathogen, Lactobacillus, causing infective endocarditis: Case report and review. Case Rep Infect Dis. 2020;2020:8833948. PubMed
  17. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  18. Franko B, Vaillant M, Recule C, Vautrin E, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics. Med Mal Infect. 2013;43(4):171-3. PubMed
  19. Campbell RE, Miller A, Afroze A. Native valve endocarditis secondary to Lactobacillus paracasei bacteremia. Consultant. 2020;60(9):27-8. DOI
  20. Kato K, Funabashi N, Takaoka H, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics with advanced and severe bicuspid aortic valve stenosis complicated with diffuse left ventricular mid-layer fibrosis. Int J Cardiol. 2016;224:157-161. PubMed

See these in context on the Bacillus Coagulans monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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