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Dietary supplement

+Probiotic Optiflora DI Ingredients & Drug Interactions

by Shaklee

+Probiotic Optiflora DI label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking +Probiotic Optiflora DI against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

+Probiotic Optiflora DI is a dietary supplement by Shaklee with 4 active ingredients. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus acidophilus La-14. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against +Probiotic Optiflora DI by Shaklee

Ask about any prescription or over-the-counter medication and we check it for interactions with +Probiotic Optiflora DI by Shaklee — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of +Probiotic Optiflora DI by Shaklee

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 4 active ingredients.
  • “Digestive & Immune Enhanced Proprietary Blend” is a proprietary blend — the label gives one combined amount (96 mg) without saying how much of each component you get.

This capsule contains 4 active probiotic ingredients: Lactobacillus acidophilus La-14, Lactobacillus plantarum Lp-115, Lactobacillus rhamnosus GG, and Bifidobacterium lactis HN019. These are live beneficial bacteria intended to support digestive and immune health.

The capsule also holds microcrystalline cellulose, hydroxypropyl methylcellulose, and water as inactive ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: digestive and immune health support.
  • We looked for evidence on: Antibiotic-associated diarrhea, Constipation, Irritable bowel syndrome (IBS), Lactose intolerance, Respiratory tract infections, Travelers' diarrhea — and 3 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Irritable bowel syndrome (IBS).
  • Also on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Respiratory tract infections, Constipation, Lactose intolerance, Travelers' diarrhea, and more.

Lactobacillus acidophilus La-14 is possibly effective for irritable bowel syndrome (IBS), Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis based on the evidence we hold. It's been rated possibly ineffective for atopic disease (allergic conditions), and the evidence for acute respiratory distress syndrome is insufficient to rate.

We have no effectiveness data on file for the other three probiotic strains in this product.

The evidence, ingredient by ingredient Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus is generally well tolerated in healthy adults and children. That said, there is some concern about the risk of bacterial infection in certain patients, since live organisms can theoretically move into the bloodstream—cases of bacteremia, sepsis, and other serious infections have been reported, though most are thought to occur in people with underlying conditions.

Orally, this probiotic may cause mild gastrointestinal side effects like stomach discomfort, bloating, flatulence, or diarrhea in some people, but these are uncommon. One trial reported a couple of cases of rash and itching, though it's unclear whether those were due to the probiotic itself.

For pregnancy, the data suggests it's possibly safe; safety data during breastfeeding isn't on file.

Side effects, ingredient by ingredient Lactobacillus Acidophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lactobacillus Acidophilus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Antibiotics are the main medication type to watch. Taking them at the same time as this probiotic may reduce how well the beneficial bacteria work, so space out your doses and confirm the timing with your doctor or pharmacist.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help with IBS, antibiotic-associated diarrhea, or bacterial vaginosis if the evidence pans out for you. If you take antibiotics, timing matters—separate the doses from this probiotic by a few hours if you can.

Check your exact medications with the tool on this page, then talk with your own doctor or pharmacist before starting, especially if you have a weakened immune system or underlying infections.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about +Probiotic Optiflora DI, straight from the product label.

Brand Shaklee
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Feb 23, 2022
DSLD ID 261195
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for +Probiotic Optiflora DI by Shaklee, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
IngredientAmount% DV
Lactobacillus acidophilus La-140 NP--
Lactobacillus plantarum Lp-1150 NP--
Lactobacillus rhamnosus GG0 NP--
Bifidobacterium lactis HN0190 NP--
Digestive & Immune Enhanced Proprietary Blend96 mg--

Other ingredients: Microcrystalline Cellulose, Hydroxypropyl Methylcellulose, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Dual digestive and immune support Proprietary blend of four beneficial probiotics, including clinically proven levels of B. lactis HN019, shown to activate immune function and reduce gas and bloating associated with occasional irregularity.

10 billion CFU blend Tested to survive stomach acid

Star-K (Kosher)

Formulation

Gluten free

Clinically proven probiotic for digestive and immune health

No artificial flavors, sweeteners, colors, or preservatives added.

B. lactis was tested in laboratory study to survive stomach acid.

Brand IP Statement(s)

Shaklee Safe - Proven 100% Guaranteed Since 1956

FDA Statement of Identity

Dietary Supplement

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Take 1 capsule daily.

Seals/Symbols

Star-K (Kosher)

General Statements

See clinical studies on B. lactis HN019 at Shaklee.com.

Precautions

Manufactured in a facility that may also handle ingredients containing peanuts, tree nuts, milk, egg, soy, wheat, shellfish, and fish.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

+Probiotic Optiflora DI by Shaklee label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

+Probiotic Optiflora DI label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in +Probiotic Optiflora DI by Shaklee

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Digestive & Immune Enhanced Proprietary Blend

96 mg per serving

Other (inactive) ingredients: Microcrystalline Cellulose, Hydroxypropyl Methylcellulose, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

+Probiotic Optiflora DI by Shaklee Drug Interactions

Want to check YOUR meds against +Probiotic Optiflora DI?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Lactobacillus acidophilus La-14 182

Individual Drug Interactions

The ingredients in +Probiotic Optiflora DI interact with 182 drugs. Click any drug to see the details.

1 of the 4 ingredients in +Probiotic Optiflora DI interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus acidophilus La-14

Each ingredient & the kinds of drugs it affects

For each ingredient in +Probiotic Optiflora DI with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus acidophilus La-141 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus La-14 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for +Probiotic Optiflora DI, from the product label.

Shaklee

See all Shaklee products
Name
Shaklee Corporation
Street Address
4747 Willow Road
City
Pleasanton
State
CA
ZipCode
94588
Phone Number
925.734.3638
Pharmacist Counseling Corner

+Probiotic Optiflora DI by Shaklee: Common Questions

Does +Probiotic Optiflora DI by Shaklee interact with any medications?
Yes. Based on its ingredients, +Probiotic Optiflora DI has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
+Probiotic Optiflora DI contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm on antibiotics?
You can, but timing helps. Antibiotics can kill the live bacteria in this probiotic, so separating doses by a few hours may preserve the probiotic's benefit. Talk with your pharmacist about the best spacing for your specific antibiotic.
Is this safe during pregnancy?
The data we hold suggests Lactobacillus acidophilus is possibly safe in pregnancy. We don't have safety information for the other three probiotic strains during pregnancy. Since each person's situation is different, check with your doctor before starting.
What does this probiotic actually do?
The Lactobacillus acidophilus in this product is possibly effective for IBS, antibiotic-associated diarrhea, bacterial vaginosis, and Helicobacter pylori infection. We don't have effectiveness data on the other three strains, so we can't say what they specifically do.
Can this cause side effects?
Mild gastrointestinal side effects like stomach discomfort, bloating, or diarrhea are uncommon but possible. There's also a theoretical concern about infection in certain patients with weakened immune systems, though this is rare.
What are the inactive ingredients?
The capsule contains microcrystalline cellulose, hydroxypropyl methylcellulose, and water—standard fillers and binders. There are no artificial dyes, allergens, or unnecessary additives listed.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if +Probiotic Optiflora DI is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

+Probiotic Optiflora DI label
Go deeper

The Full Monographs Behind +Probiotic Optiflora DI’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph →
Sources

Sources & How We Checked

+Probiotic Optiflora DI's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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